Detailed information for compound 61366

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 499.604 | Formula: C29H33N5O3
  • H donors: 5 H acceptors: 3 LogP: 3.32 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)NCCCC(C(=O)NC1CCc2c1ccc(c2)O)NC(=O)C(c1ccccc1)c1ccccc1
  • InChi: 1S/C29H33N5O3/c30-29(31)32-17-7-12-25(27(36)33-24-16-13-21-18-22(35)14-15-23(21)24)34-28(37)26(19-8-3-1-4-9-19)20-10-5-2-6-11-20/h1-6,8-11,14-15,18,24-26,35H,7,12-13,16-17H2,(H,33,36)(H,34,37)(H4,30,31,32)
  • InChiKey: RBPMEBGHTHSYIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide Y receptor Y1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor neuropeptide Y receptor Y1 384 aa 345 aa 22.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0321 0.5686 0.7767
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0225 0.0164
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0225 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0295 0.055
Schistosoma mansoni hypothetical protein 0.001 0.0097 0.002
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.013 0.0042
Onchocerca volvulus 0.0322 0.5704 1
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0016 0.0201 0.0159
Echinococcus granulosus lamin dm0 0.0028 0.0422 0.0472
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0295 0.0296
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0295 0.0296
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.047 0.0931
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Trichomonas vaginalis thymidine kinase, putative 0.0262 0.463 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0295 0.0274
Echinococcus multilocularis neuropeptide s receptor 0.0321 0.5686 0.7767
Schistosoma mansoni hypothetical protein 0.0321 0.5686 0.717
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0288 0.0286
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0295 0.0274
Trypanosoma brucei ribonuclease H1 0.0043 0.0696 0.0768
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0225 0.0316
Brugia malayi G-protein coupled receptor 0.0321 0.5686 0.5651
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.013 0.0153
Echinococcus granulosus thymidylate synthase 0.0322 0.5704 0.7791
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0009 0.0074 0.0056
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0295 0.0296
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.1966 1
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Schistosoma mansoni ap endonuclease 0.0021 0.0288 0.0264
Brugia malayi putative neuropeptide receptor NPR1 0.0321 0.5686 0.5651
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0295 0.0296
Loa Loa (eye worm) hypothetical protein 0.0018 0.0235 0.0193
Onchocerca volvulus 0.0321 0.5686 0.9969
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1966 0.4247
Loa Loa (eye worm) hypothetical protein 0.0021 0.0295 0.0253
Loa Loa (eye worm) hypothetical protein 0.0021 0.0295 0.0253
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0225 0.0322
Entamoeba histolytica DNA polymerase zeta catalytic subunit, putative 0.0007 0.0043 0.0092
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0097 0.0022
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.1966 0.3275
Echinococcus granulosus neuropeptide Y receptor 0.0321 0.5686 0.7767
Schistosoma mansoni opsin-like receptor 0.0321 0.5686 0.717
Brugia malayi hypothetical protein 0.0321 0.5686 0.5651
Echinococcus granulosus biogenic amine 5HT receptor 0.0321 0.5686 0.7767
Echinococcus granulosus serotonin receptor 0.0321 0.5686 0.7767
Echinococcus multilocularis rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Trypanosoma cruzi thymidine kinase, putative 0.0262 0.463 0.8104
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0808 0.0768
Trypanosoma brucei trypanothione reductase 0.005 0.0808 0.0912
Schistosoma mansoni neuropeptide F-like receptor 0.0321 0.5686 0.717
Trypanosoma cruzi thymidine kinase, putative 0.0262 0.463 0.8104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0097 0.0022
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0016 0.0201 0.028
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0321 0.5686 0.7767
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0808 0.1007
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.1966 0.2412
Echinococcus granulosus fmrfamide receptor 0.0321 0.5686 0.7767
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Echinococcus multilocularis rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Brugia malayi PXA domain containing protein 0.0021 0.0295 0.0216
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0295 0.0296
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0081 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Schistosoma mansoni hypothetical protein 0.0321 0.5686 0.717
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Leishmania major ribonuclease H1, putative 0.0043 0.0696 0.1154
Echinococcus multilocularis lamin dm0 0.0028 0.0422 0.0472
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Echinococcus granulosus bloom syndrome protein 0.0022 0.0316 0.0326
Echinococcus granulosus g protein coupled receptor 0.0321 0.5686 0.7767
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0146 0.0104
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0016 0.0201 0.0345
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Brugia malayi phosphofructokinase 0.0114 0.1966 0.1901
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.047 0.0931
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.1966 0.3335
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0016 0.0201 0.0166
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Loa Loa (eye worm) G-protein coupled receptor 0.0321 0.5686 0.5668
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0321 0.5686 0.7767
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.1951 0.3307
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0321 0.5686 0.717
Schistosoma mansoni amine GPCR 0.0321 0.5686 0.717
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0295 0.0274
Mycobacterium tuberculosis Hypothetical protein 0.0153 0.2669 0.4588
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0146 0.0064
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0288 0.0245
Onchocerca volvulus 0.0321 0.5686 0.9969
Brugia malayi hypothetical protein 0.0321 0.5686 0.5651
Loa Loa (eye worm) G-protein coupled receptor 0.0321 0.5686 0.5668
Entamoeba histolytica hypothetical protein 0.0021 0.0295 0.0637
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.001 0.0097 0.0022
Echinococcus multilocularis G protein coupled receptor 139 0.0321 0.5686 0.7767
Brugia malayi G-protein coupled receptor 0.0321 0.5686 0.5651
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0097 0.0022
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0097 0.0022
Echinococcus multilocularis neuropeptide Y receptor 0.0321 0.5686 0.7767
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0295 0.0274
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.047 0.0931
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0288 0.0286
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0288 0.0254
Onchocerca volvulus 0.0321 0.5686 0.9969
Onchocerca volvulus Ribonuclease H1 homolog 0.0043 0.0696 0.1069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Echinococcus granulosus rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Brugia malayi Melatonin receptor type 1A 0.0321 0.5686 0.5651
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0321 0.5686 0.7767
Trypanosoma brucei hypothetical protein, conserved 0.0053 0.0877 0.1
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0097 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0288 0.0534
Echinococcus granulosus neuropeptide s receptor 0.0321 0.5686 0.7767
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0025 0.0367 0.0572
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0295 0.0296
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0295 0.0296
Brugia malayi G protein-coupled receptor 0.0321 0.5686 0.5651
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0016 0.0201 0.0121
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0288 0.0454
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0146 0.0104
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0225 0.0394
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.0043 0.0683 0.1197
Echinococcus multilocularis expressed protein 0.041 0.7298 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.047 0.0931
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0321 0.5686 0.7767
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0081 0.0142
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0021 0.0303 0.0283
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Brugia malayi hypothetical protein 0.0153 0.2669 0.2609
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.001 0.0097 0.0034
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0097 0.0022
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0225 0.0199
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0225 0.0322
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0225 0.012
Echinococcus multilocularis neuropeptide FF receptor 2 0.0321 0.5686 0.7767
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0097 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0321 0.5686 0.717
Trichomonas vaginalis ribonuclease H1, putative 0.0043 0.0696 0.1423
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0016 0.0201 0.0134
Echinococcus multilocularis O glycosyltransferase 0.0043 0.0692 0.0846
Echinococcus granulosus rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0808 0.1007
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0016 0.0201 0.028
Brugia malayi hypothetical protein 0.0321 0.5686 0.5651
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0288 0.0534
Loa Loa (eye worm) hypothetical protein 0.0028 0.0412 0.0371
Giardia lamblia O-linked GlcNAc transferase 0.0025 0.0365 0.0624
Echinococcus granulosus rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0322 0.5704 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0081 0.0068
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0225 0.007
Toxoplasma gondii exonuclease III APE 0.0021 0.0288 0.0504
Echinococcus granulosus neuropeptide receptor 0.0321 0.5686 0.7767
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0295 0.0296
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0295 0.0296
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0225 0.0141
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.047 0.0824
Echinococcus granulosus neuropeptide Y receptor 0.0321 0.5686 0.7767
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0295 0.0296
Toxoplasma gondii thioredoxin reductase 0.005 0.0808 0.1416
Brugia malayi Dopamine receptor protein 2 0.0321 0.5686 0.5651
Echinococcus multilocularis ribonuclease H1 0.0043 0.0696 0.0852
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0321 0.5686 0.7767
Brugia malayi Zinc knuckle family protein 0.001 0.0097 0.0016
Brugia malayi reverse transcriptase 0.001 0.0097 0.0016
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0143 0.0062
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.016 0.0109
Loa Loa (eye worm) neuropeptide F receptor 0.0321 0.5686 0.5668
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.047 0.0824
Echinococcus multilocularis neuropeptide receptor A26 0.0321 0.5686 0.7767
Onchocerca volvulus DNA polymerase homolog 0.0016 0.0201 0.0186
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0225 0.0184
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0295 0.0216
Onchocerca volvulus 0.0321 0.5686 0.9969
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0187 0.0107
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.1951 0.3307
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0016 0.0201 0.0166
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0016 0.0201 0.0027
Schistosoma mansoni growth hormone secretagogue receptor 0.0321 0.5686 0.717
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0225 0.0322
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0183 0.0321
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Brugia malayi hypothetical protein 0.0321 0.5686 0.5651
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0321 0.5686 0.717
Echinococcus granulosus intermediate filament protein 0.0028 0.0422 0.0472
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0321 0.5686 0.7767
Brugia malayi Tachykinin-like peptides receptor 99D 0.0321 0.5686 0.5651
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.1966 0.3398
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.2178 0.3712
Echinococcus multilocularis RNA directed DNA polymerase 0.001 0.0097 0.0022
Echinococcus granulosus 7tm_1 domain containing protein 0.0321 0.5686 0.7767
Brugia malayi putative neuropeptide receptor 0.0321 0.5686 0.5651
Plasmodium vivax glutathione reductase, putative 0.005 0.0808 0.1126
Brugia malayi RNase H family protein 0.0043 0.0696 0.062
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.047 0.0754
Brugia malayi neuropeptide F receptor 0.0321 0.5686 0.5651
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0016 0.0201 0.0154
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.1951 0.3307
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.001 0.0097 0.0022
Loa Loa (eye worm) hypothetical protein 0.0013 0.0151 0.0108
Echinococcus multilocularis dro:myosuppressin receptor 0.0321 0.5686 0.7767
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0295 0.0253
Echinococcus multilocularis rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0295 0.055
Echinococcus granulosus expressed protein 0.041 0.7298 1
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0321 0.5686 0.5668
Onchocerca volvulus 0.0321 0.5686 0.9969
Entamoeba histolytica recQ family helicase, putative 0.0012 0.013 0.028
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.047 0.0931
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1966 0.4193
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0225 0.0229
Echinococcus granulosus g protein coupled receptor 0.0321 0.5686 0.7767
Schistosoma mansoni amine GPCR 0.0321 0.5686 0.717
Echinococcus multilocularis g-protein coupled receptor 0.0321 0.5686 0.7767
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0016 0.0201 0.0345
Entamoeba histolytica hypothetical protein 0.0021 0.0295 0.0637
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0009 0.0074 0.0032
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0016 0.0201 0.0166
Plasmodium falciparum glutathione reductase 0.0017 0.0225 0.0322
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.016 0.0109
Trichomonas vaginalis thymidine kinase, putative 0.0262 0.463 1
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0016 0.0201 0.0434
Trichomonas vaginalis thymidine kinase, putative 0.0262 0.463 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0225 0.0322
Echinococcus granulosus neuropeptides capa receptor 0.0321 0.5686 0.7767
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.0043 0.0692 0.0781
Echinococcus granulosus KRAB A domain containing protein 0.001 0.0097 0.0022
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.1966 0.2613
Echinococcus granulosus rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0288 0.0433
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0043 0.0696 1
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0225 0.0397
Schistosoma mansoni histamine h1 receptor 0.0321 0.5686 0.717
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.001 0.0097 0.0034
Onchocerca volvulus 0.0321 0.5686 0.9969
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0225 0.0394
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0225 0.0322
Echinococcus granulosus neuropeptide FF receptor 2 0.0321 0.5686 0.7767
Brugia malayi reverse transcriptase 0.001 0.0097 0.0016
Trypanosoma cruzi ribonuclease H1, putative 0.0043 0.0696 0.1154
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0808 0.1268
Schistosoma mansoni opsin-like receptor 0.0321 0.5686 0.717
Echinococcus multilocularis neuropeptide receptor 0.0321 0.5686 0.7767
Schistosoma mansoni ap endonuclease 0.0021 0.0288 0.0264
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.001 0.0097 0.0117
Echinococcus granulosus tm gpcr rhodopsin 0.0321 0.5686 0.7767
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0187 0.0145
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0016 0.0201 0.0186
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.047 0.0931
Loa Loa (eye worm) hypothetical protein 0.0079 0.1335 0.1298
Echinococcus granulosus g protein coupled receptor 0.0321 0.5686 0.7767
Echinococcus multilocularis neuropeptides capa receptor 0.0321 0.5686 0.7767
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.001 0.0097 0.0022
Brugia malayi hypothetical protein 0.0321 0.5686 0.5651
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0295 0.0216
Treponema pallidum ribonuclease H (rnhA) 0.0043 0.0696 0.2727
Brugia malayi DNA polymerase delta catalytic subunit 0.0016 0.0201 0.0121
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0316 0.0596
Echinococcus granulosus RNA directed DNA polymerase 0.001 0.0097 0.0022
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0295 0.0296
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0295 0.0274
Mycobacterium ulcerans hypothetical protein 0.0017 0.0219 0.0131
Echinococcus granulosus tm gpcr rhodopsin 0.0321 0.5686 0.7767
Loa Loa (eye worm) RecQ helicase 0.0022 0.0316 0.0274
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.0043 0.0689 0.0613
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0321 0.5686 0.7767
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0321 0.5686 0.717
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0321 0.5686 0.5651
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0321 0.5686 0.5651
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0321 0.5686 0.717
Schistosoma mansoni neuropeptide F-like receptor 0.0321 0.5686 0.717
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0097 0.0016
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Onchocerca volvulus 0.0321 0.5686 0.9969
Onchocerca volvulus 0.0321 0.5686 0.9969
Trypanosoma brucei ingi protein (ORF1) 0.0053 0.0877 0.1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0321 0.5686 0.717
Schistosoma mansoni scy1(yeast) protein kinase-like 0.001 0.0097 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0225 0.0322
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0322 0.5704 1
Brugia malayi glutathione reductase 0.005 0.0808 0.0733
Brugia malayi 6-phosphofructokinase 0.0114 0.1966 0.1901
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0295 0.0274
Brugia malayi hypothetical protein 0.0021 0.0295 0.0216
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.1966 0.1932
Trichomonas vaginalis DNA polymerase II, putative 0.0025 0.0367 0.0706
Echinococcus multilocularis rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Loa Loa (eye worm) glutathione reductase 0.005 0.0808 0.0768
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.047 0.0855
Echinococcus granulosus biogenic amine 5HT receptor 0.0321 0.5686 0.7767
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0295 0.055
Brugia malayi hypothetical protein 0.0321 0.5686 0.5651
Brugia malayi Serotonin receptor 0.0321 0.5686 0.5651
Onchocerca volvulus 0.0321 0.5686 0.9969
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0321 0.5686 0.717
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0053 0.0877 0.1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0321 0.5686 0.7767
Schistosoma mansoni amine GPCR 0.0321 0.5686 0.717
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0295 0.0253
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0295 0.0296
Loa Loa (eye worm) hypothetical protein 0.0014 0.016 0.0118
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0016 0.0201 0.0186
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1966 0.4247
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0097 0.0095
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0322 0.5704 1
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0025 0.0367 0.0572
Echinococcus multilocularis neuropeptide Y receptor 0.0321 0.5686 0.7767
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0097 0.0016
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0057 0.0948 0.1202
Echinococcus granulosus rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0295 0.0274
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.001 0.0097 0.0117
Toxoplasma gondii DNA polymerase family B protein 0.0016 0.0201 0.0353
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1966 0.4193
Echinococcus granulosus O glycosyltransferase 0.0043 0.0692 0.0846
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0295 0.0274
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0321 0.5686 0.7767
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0016 0.0201 0.0134
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Trichomonas vaginalis reverse transcriptases, putative 0.001 0.0097 0.0117
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0225 0.0322
Echinococcus multilocularis fmrfamide receptor 0.0321 0.5686 0.7767
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0288 0.0392
Echinococcus multilocularis g protein coupled receptor 0.0321 0.5686 0.7767
Echinococcus granulosus lamin 0.0028 0.0422 0.0472
Brugia malayi G protein-coupled receptor F59B2.13 0.0321 0.5686 0.5651
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.1966 0.2412
Echinococcus granulosus tachykinin peptides receptor 99D 0.0321 0.5686 0.7767
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0295 0.0296
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0295 0.0274
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0321 0.5686 0.7767
Schistosoma mansoni neuropeptide receptor 0.0321 0.5686 0.717
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0097 0.0016
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0097 0.0016
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.1966 0.2397
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0321 0.5686 0.5651
Brugia malayi Zinc knuckle family protein 0.001 0.0097 0.0016
Plasmodium falciparum glutathione reductase 0.005 0.0808 0.1352
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.2178 0.3712
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.1966 0.1932
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1966 0.4193
Brugia malayi AKH receptor 0.0321 0.5686 0.5651
Echinococcus multilocularis g protein coupled receptor 0.0321 0.5686 0.7767
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0422 0.038
Trypanosoma brucei unspecified product 0.0053 0.0877 0.1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0225 0.007
Brugia malayi sulfakinin receptor protein 0.0321 0.5686 0.5651
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Loa Loa (eye worm) follicle stimulating hormone receptor 0.056 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0321 0.5686 0.717
Brugia malayi larval opioid receptor 0.0321 0.5686 0.5651
Mycobacterium tuberculosis Probable reductase 0.0113 0.1951 0.3307
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0016 0.0208 0.045
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0321 0.5686 0.717
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0295 0.0274
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0295 0.0274
Echinococcus granulosus peptide allatostatin:somatostatin 0.0321 0.5686 0.7767
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0321 0.5686 0.7767
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.047 0.0824
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Brugia malayi hypothetical protein 0.001 0.0097 0.0016
Schistosoma mansoni adenoreceptor 0.0321 0.5686 0.717
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0225 0.0228
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0288 0.0433
Echinococcus granulosus rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0321 0.5686 0.5668
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0016 0.0201 0.028
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0321 0.5686 0.717
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0295 0.0253
Echinococcus multilocularis somatostatin receptor 0.0321 0.5686 0.7767
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0097 0.0016
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.047 0.0514
Schistosoma mansoni neuropeptide receptor 0.0321 0.5686 0.717
Toxoplasma gondii ribonuclease HI protein 0.0043 0.0696 0.122
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0025 0.0367 0.0706
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0225 0.0199
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0016 0.0201 0.028
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0321 0.5686 0.5651
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0321 0.5686 0.7767
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0321 0.5686 0.717
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0321 0.5686 0.717
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0321 0.5686 0.7767
Loa Loa (eye worm) hypothetical protein 0.0009 0.0074 0.0032
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.047 0.0514
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.2178 0.0605
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0225 0.0141
Schistosoma mansoni hypothetical protein 0.0321 0.5686 0.717
Brugia malayi Cytochrome P450 family protein 0.0013 0.0146 0.0066
Loa Loa (eye worm) hypothetical protein 0.0028 0.0422 0.038
Trypanosoma brucei ingi protein (ORF1) 0.0053 0.0877 0.1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0295 0.0253
Schistosoma mansoni hypothetical protein 0.0444 0.7898 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0321 0.5686 0.9969
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0295 0.0296
Onchocerca volvulus 0.0321 0.5686 0.9969
Loa Loa (eye worm) hypothetical protein 0.0021 0.0295 0.0253
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0295 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0295 0.055
Echinococcus granulosus dro:myosuppressin receptor 0.0321 0.5686 0.7767
Onchocerca volvulus 0.0321 0.5686 0.9969
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0097 0.0016
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0322 0.5704 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0288 0.0246
Onchocerca volvulus 0.0321 0.5686 0.9969
Schistosoma mansoni biogenic amine (5HT) receptor 0.0321 0.5686 0.717
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Loa Loa (eye worm) thymidylate synthase 0.0322 0.5704 0.5685
Echinococcus granulosus alpha 1A adrenergic receptor 0.0321 0.5686 0.7767
Schistosoma mansoni biogenic amine receptor 0.0321 0.5686 0.717
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0322 0.5704 1
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Brugia malayi hypothetical protein 0.001 0.0097 0.0016
Echinococcus granulosus g-protein coupled receptor 0.0321 0.5686 0.7767
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0295 0.0253
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0097 0.0016
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0295 0.0216
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0321 0.5686 0.7767
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0321 0.5686 0.717
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0225 0.0164
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.047 0.1015
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0097 0.0016
Leishmania major thymidine kinase, putative 0.0262 0.463 0.8104
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0288 0.0621
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0079 0.1335 0.2209
Echinococcus granulosus neuropeptide receptor A26 0.0321 0.5686 0.7767
Loa Loa (eye worm) hypothetical protein 0.0013 0.0151 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0295 0.055
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Schistosoma mansoni lamin 0.0028 0.0422 0.0436
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0321 0.5686 0.717
Entamoeba histolytica hypothetical protein 0.0021 0.0295 0.0637
Loa Loa (eye worm) phosphofructokinase 0.0114 0.1966 0.1932
Schistosoma mansoni hypothetical protein 0.0321 0.5686 0.717
Onchocerca volvulus 0.0321 0.5686 0.9969
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0081 0.0038
Brugia malayi Serotonin receptor 0.0321 0.5686 0.5651
Schistosoma mansoni amine GPCR 0.0321 0.5686 0.717
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Brugia malayi RNase H family protein 0.0043 0.0696 0.062
Loa Loa (eye worm) melatonin receptor type 1A 0.0321 0.5686 0.5668
Echinococcus granulosus neuropeptides capa receptor 0.0321 0.5686 0.7767
Brugia malayi hypothetical protein 0.0321 0.5686 0.5651
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0025 0.0367 0.0346
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0316 0.0237
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0143 0.0062
Brugia malayi hypothetical protein 0.0321 0.5686 0.5651
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.1966 0.3398
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0321 0.5686 0.717
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Brugia malayi Cytochrome P450 family protein 0.0013 0.0146 0.0066
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0146 0.0183
Echinococcus multilocularis serotonin receptor 0.0321 0.5686 0.7767
Schistosoma mansoni phosphoglucomutase 0.0043 0.0696 0.0786
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0057 0.0948 0.1202
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.1951 0.3307
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0422 0.038
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0295 0.0216
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0016 0.0201 0.0154
Brugia malayi Dopamine receptor protein 1 0.0321 0.5686 0.5651
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0232 0.0193
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0009 0.0074 0.0069
Plasmodium falciparum thioredoxin reductase 0.005 0.0808 0.1352
Loa Loa (eye worm) hypothetical protein 0.0009 0.0081 0.0038
Brugia malayi hypothetical protein 0.001 0.0097 0.0016
Echinococcus granulosus tm gpcr rhodopsin 0.0321 0.5686 0.7767
Loa Loa (eye worm) TYRA-2 protein 0.0321 0.5686 0.5668
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0016 0.0201 0.0134
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0321 0.5686 0.7767
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0295 0.0274
Brugia malayi GnHR receptor homolog 0.0321 0.5686 0.5651
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0321 0.5686 0.5668
Schistosoma mansoni opsin-like receptor 0.0321 0.5686 0.717
Leishmania major trypanothione reductase 0.005 0.0808 0.1352
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0097 0.0022
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0321 0.5686 0.717
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0016 0.0208 0.0292
Onchocerca volvulus 0.0321 0.5686 0.9969
Echinococcus multilocularis fmrfamide receptor 0.0321 0.5686 0.7767
Brugia malayi DNA polymerase family B containing protein 0.0016 0.0201 0.0121
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.047 0.0931
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0321 0.5686 0.717
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0225 0.0141
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0225 0.0164
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.013 0.0153
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.013 0.0189
Brugia malayi hypothetical protein 0.0321 0.5686 0.5651
Brugia malayi thymidylate synthase 0.0322 0.5704 0.5669
Loa Loa (eye worm) hypothetical protein 0.0021 0.0295 0.0253
Echinococcus multilocularis allatostatin A receptor 0.0321 0.5686 0.7767
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.001 0.0097 0.0034
Echinococcus multilocularis orexin receptor type 2 0.0321 0.5686 0.7767
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0153 0.2669 0.464
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0321 0.5686 0.9969
Brugia malayi RNase H family protein 0.0043 0.0696 0.062
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0288 0.0433
Schistosoma mansoni hypothetical protein 0.001 0.0097 0.002
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0097 0.0022
Echinococcus multilocularis neuropeptide receptor 0.0321 0.5686 0.7767
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0322 0.5704 0.7187
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0288 0.0184
Echinococcus granulosus sex peptide receptor 0.0321 0.5686 0.7767
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0321 0.5686 0.7767
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0422 0.0343
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0321 0.5686 0.717
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0295 0.0296
Entamoeba histolytica thymidine kinase, putative 0.0262 0.463 1
Echinococcus granulosus G protein coupled receptor 139 0.0321 0.5686 0.7767
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0321 0.5686 0.7767
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0016 0.0201 0.028
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.1951 0.3307
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0295 0.0296
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0288 0.0433
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0146 0.0183
Echinococcus granulosus rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0225 0.0322
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.047 1
Brugia malayi Thioredoxin reductase 0.005 0.0808 0.0733
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.1966 0.2613
Echinococcus granulosus allatostatin A receptor 0.0321 0.5686 0.7767
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0295 0.055
Giardia lamblia DNA polymerase alpha subunit A 0.0049 0.079 0.1559
Schistosoma mansoni phosphoglucomutase 0.0043 0.0696 0.0786
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0225 0.012
Schistosoma mansoni neuropeptide receptor 0.0321 0.5686 0.717
Schistosoma mansoni myosin xvIII 0.0321 0.5686 0.717
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0808 0.1126
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0295 0.055
Echinococcus granulosus ribonuclease H1 0.0043 0.0696 0.0852
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0295 0.0274
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1966 0.4247
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0267 0.0397
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0321 0.5686 0.717
Onchocerca volvulus 0.0321 0.5686 0.9969
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0295 0.0274
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0321 0.5686 0.5651
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.047 0.0754
Echinococcus granulosus hypothetical protein 0.0321 0.5686 0.7767
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0017 0.0219 0.0001
Echinococcus multilocularis serotonin receptor 0.0321 0.5686 0.7767
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0016 0.0201 0.0027
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0097 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0321 0.5686 0.7767
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0225 0.0322
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0322 0.5704 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0322 0.5704 1
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0295 0.0296
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0808 0.1352
Trichomonas vaginalis reverse transcriptases, putative 0.001 0.0097 0.0117
Echinococcus multilocularis sex peptide receptor 0.0321 0.5686 0.7767
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0295 0.0216
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0016 0.0201 0.0264
Onchocerca volvulus 0.0028 0.0422 0.058
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0322 0.5704 0.7193
Onchocerca volvulus 0.0321 0.5686 0.9969
Schistosoma mansoni protein kinase 0.001 0.0097 0.002
Echinococcus granulosus neuropeptide receptor 0.0321 0.5686 0.7767
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0016 0.0201 0.0166
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0316 0.0326
Brugia malayi hypothetical protein 0.0021 0.0295 0.0216
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.001 0.0097 0.0022
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0321 0.5686 0.717
Onchocerca volvulus 0.0321 0.5686 0.9969
Brugia malayi neuropeptide F receptor 0.0321 0.5686 0.5651
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0146 0.0104
Brugia malayi hypothetical protein 0.001 0.0097 0.0016
Brugia malayi RE15519p 0.0321 0.5686 0.5651
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0057 0.0948 0.111
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1966 0.4193
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0047 0.0753 0.1321
Loa Loa (eye worm) hypothetical protein 0.0009 0.0074 0.0032
Onchocerca volvulus 0.0028 0.0422 0.058
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0097 0.0016
Schistosoma mansoni alpha-1 adrenergic receptor 0.0321 0.5686 0.717
Brugia malayi hypothetical protein 0.0321 0.5686 0.5651
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0097 0.0016
Brugia malayi ORL1-like opioid receptor 0.0321 0.5686 0.5651
Brugia malayi Dopamine receptor 0.0321 0.5686 0.5651
Plasmodium falciparum thioredoxin reductase 0.0017 0.0225 0.0322
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0225 0.0397
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0016 0.0201 0.0264
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.0043 0.0689 0.0649
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0321 0.5686 0.5668
Echinococcus granulosus 7TM GPCR rhodopsin 0.0321 0.5686 0.7767
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0016 0.0201 0.0345
Echinococcus multilocularis g protein coupled receptor 0.0321 0.5686 0.7767
Leishmania major cytochrome p450-like protein 0.0013 0.0146 0.0183
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0016 0.0201 0.0027
Schistosoma mansoni biogenic amine (5HT) receptor 0.0321 0.5686 0.717
Toxoplasma gondii DNA polymerase family B protein 0.0007 0.0043 0.0075
Schistosoma mansoni neuropeptide f receptor 76f 0.0321 0.5686 0.717
Giardia lamblia Thymidine kinase 0.0262 0.463 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0288 0.1438
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.001 0.0097 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0153 0.2669 0.5725
Schistosoma mansoni amine GPCR 0.0321 0.5686 0.717
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0295 0.0216
Brugia malayi PXA domain containing protein 0.0021 0.0295 0.0216
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0225 0.0322
Echinococcus multilocularis neuropeptides capa receptor 0.0321 0.5686 0.7767
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.001 0.0097 0.0034
Echinococcus granulosus somatostatin receptor 0.0321 0.5686 0.7767
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0321 0.5686 0.717
Giardia lamblia O-linked GlcNAc transferase 0.0043 0.0683 0.1323
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0016 0.0201 0.0154
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.047 1
Schistosoma mansoni lamin 0.0028 0.0422 0.0436
Echinococcus multilocularis thymidylate synthase 0.0322 0.5704 0.7791
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0225 0.0164
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0097 0.002
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0288 0.0208
Loa Loa (eye worm) neuropeptide F receptor 0.0321 0.5686 0.5668
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.2178 0.3712
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.001 0.0097 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0295 0.0253
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Trypanosoma brucei thymidine kinase 0.0262 0.463 0.5811
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0225 0.0322
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.047 0.1434
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0016 0.0201 0.028
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0225 0.0322
Brugia malayi DNA polymerase alpha catalytic subunit 0.0047 0.0753 0.0678
Treponema pallidum NADH oxidase 0.0017 0.0225 0.0033
Echinococcus multilocularis lamin 0.0028 0.0422 0.0472
Brugia malayi reverse transcriptase 0.001 0.0097 0.0016
Schistosoma mansoni intermediate filament proteins 0.0028 0.0422 0.0436
Schistosoma mansoni neuropeptide receptor 0.0321 0.5686 0.717
Brugia malayi 6-phosphofructokinase 0.0114 0.1966 0.1901
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0016 0.0201 0.0166
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0225 0.0322
Echinococcus granulosus orexin receptor type 2 0.0321 0.5686 0.7767
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0097 0.0016
Loa Loa (eye worm) hypothetical protein 0.0009 0.008 0.0038
Echinococcus multilocularis G-protein coupled receptor, putative 0.0321 0.5686 0.7767
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0321 0.5686 0.717
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.1966 0.0042
Brugia malayi intermediate filament protein 0.0028 0.0422 0.0343
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0225 0.0145
Echinococcus multilocularis musashi 0.0028 0.0422 0.0472
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0016 0.0201 0.0166
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0288 0.0341
Giardia lamblia Ribonuclease H 0.0043 0.0696 0.1351
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0225 0.0322
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0316 0.0596
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0295 0.0253
Trypanosoma brucei RNA helicase, putative 0.0444 0.7898 1
Schistosoma mansoni biogenic amine receptor 0.0321 0.5686 0.717
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0321 0.5686 0.7767
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0295 0.0296
Loa Loa (eye worm) hypothetical protein 0.0321 0.5686 0.5668
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0321 0.5686 0.7767
Schistosoma mansoni phosphoglucomutase 0.0043 0.0696 0.0786
Toxoplasma gondii DNA polymerase 0.0016 0.0201 0.0353
Giardia lamblia Reverse transcriptase/endonuclease 0.001 0.0097 0.0034
Trypanosoma cruzi ribonuclease H1, putative 0.0043 0.0696 0.1154
Mycobacterium ulcerans thymidylate synthase 0.0322 0.5704 1
Plasmodium vivax DNA polymerase alpha, putative 0.0047 0.0753 0.1028
Brugia malayi Pao retrotransposon peptidase family protein 0.001 0.0097 0.0016
Schistosoma mansoni biogenic amine receptor 0.0321 0.5686 0.717

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1 uM NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay. ChEMBL. 10915060
IC50 (functional) = 1 uM NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay. ChEMBL. 10915060

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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