Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0025 | 0.1535 | 0.1535 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.1535 | 0.2527 |
Brugia malayi | Hr1 repeat family protein | 0.0025 | 0.1535 | 0.1535 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.1535 | 0.2527 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0025 | 0.1535 | 0.2527 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0025 | 0.1535 | 0.2527 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.1535 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1535 | 0.1535 |
Echinococcus granulosus | nervana 2 | 0.0048 | 0.5218 | 0.859 |
Echinococcus granulosus | nervana 2 | 0.0048 | 0.5218 | 0.859 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0025 | 0.1535 | 0.2527 |
Echinococcus multilocularis | protein kinase c iota type | 0.0025 | 0.1535 | 0.2527 |
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.4869 | 0.4869 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.535 | 0.535 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0053 | 0.6075 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0048 | 0.5218 | 0.859 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0025 | 0.1535 | 0.2527 |
Trypanosoma cruzi | Protein kinase B | 0.0053 | 0.6075 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0053 | 0.6075 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0025 | 0.1535 | 0.1535 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.2874 | 0.2874 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0053 | 0.6075 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0025 | 0.1535 | 0.2527 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0025 | 0.1535 | 0.2527 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0025 | 0.1535 | 0.1535 |
Brugia malayi | Protein kinase domain containing protein | 0.0025 | 0.1535 | 0.1535 |
Brugia malayi | Protein kinase domain containing protein | 0.0025 | 0.1535 | 0.1535 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0077 | 1 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.4869 | 0.8014 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3301 | 0.2086 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2874 | 0.2874 |
Echinococcus granulosus | NDR protein kinase | 0.0025 | 0.1535 | 0.2527 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.535 | 0.535 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0025 | 0.1535 | 0.2527 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0025 | 0.1535 | 0.2527 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0077 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0077 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3301 | 0.2086 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0025 | 0.1535 | 0.2527 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0025 | 0.1535 | 0.2527 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0048 | 0.5218 | 0.859 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0053 | 0.6075 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0053 | 0.6075 | 0.5363 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.4869 | 0.8014 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0025 | 0.1535 | 0.2527 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0048 | 0.5305 | 0.8732 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.4869 | 0.8014 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0025 | 0.1535 | 0.2527 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0048 | 0.5305 | 0.5 |
Echinococcus multilocularis | nervana 2 | 0.0048 | 0.5218 | 0.859 |
Entamoeba histolytica | protein kinase, putative | 0.0072 | 0.923 | 0.909 |
Trichomonas vaginalis | AGC family protein kinase | 0.003 | 0.2306 | 0.1002 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0072 | 0.923 | 0.923 |
Echinococcus granulosus | protein kinase C gamma type | 0.0025 | 0.1535 | 0.2527 |
Echinococcus multilocularis | nervana 2 | 0.0048 | 0.5218 | 0.859 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0048 | 0.5305 | 0.8732 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3301 | 0.2086 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.3301 | 0.5433 |
Giardia lamblia | Kinase, AGC PKA | 0.0048 | 0.5305 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.3301 | 0.2086 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0025 | 0.1535 | 0.2527 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.4869 | 0.8014 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0053 | 0.6075 | 1 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0048 | 0.5305 | 0.5 |
Brugia malayi | protein kinase C II. | 0.0025 | 0.1535 | 0.1535 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.4869 | 0.8014 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0025 | 0.1535 | 0.1535 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.1535 | 0.2527 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0048 | 0.5218 | 0.859 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0025 | 0.1535 | 0.2527 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0025 | 0.1535 | 0.1535 |
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 1 | 1 |
Entamoeba histolytica | protein kinase 2, putative | 0.0048 | 0.5305 | 0.4453 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.1535 | 0.2527 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.4869 | 0.8014 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0025 | 0.1535 | 0.1535 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.1535 | 0.0101 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.535 | 0.535 |
Brugia malayi | hypothetical protein | 0.0036 | 0.3301 | 0.3301 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.4869 | 0.4869 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.1535 | 0.2527 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0025 | 0.1535 | 0.2527 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0053 | 0.6075 | 0.5363 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0072 | 0.923 | 0.923 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0048 | 0.5305 | 0.8732 |
Toxoplasma gondii | AGC kinase | 0.0072 | 0.923 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0025 | 0.1535 | 0.2527 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.535 | 0.535 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.3301 | 0.5433 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.1535 | 0.2527 |
Trichomonas vaginalis | AGC family protein kinase | 0.0077 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.4869 | 0.8014 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.2874 | 0.473 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.3301 | 0.5433 |
Trichomonas vaginalis | AGC family protein kinase | 0.0025 | 0.1535 | 0.0101 |
Schistosoma mansoni | serine/threonine kinase | 0.0025 | 0.1535 | 0.2527 |
Entamoeba histolytica | protein kinase, putative | 0.0077 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0025 | 0.1535 | 0.2527 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.3301 | 0.5433 |
Echinococcus granulosus | protein kinase c iota type | 0.0025 | 0.1535 | 0.2527 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0048 | 0.5218 | 0.859 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.