Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0165 | 0.1029 | 0.4154 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0632 | 0.7657 | 0.7657 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.0165 | 0.1029 | 0.1029 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0267 | 0.2477 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0165 | 0.1029 | 0.1029 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0267 | 0.2477 | 0.2185 |
Trypanosoma brucei | uridine phosphorylase | 0.0165 | 0.1029 | 0.4154 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0797 | 1 | 0.5 |
Brugia malayi | MTAP | 0.0165 | 0.1029 | 0.1029 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0267 | 0.2477 | 0.2477 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.0632 | 0.7657 | 0.7657 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0267 | 0.2477 | 1 |
Leishmania major | trypanothione reductase | 0.0267 | 0.2477 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0165 | 0.1029 | 0.1029 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0165 | 0.1029 | 0.1029 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.0165 | 0.1029 | 0.1029 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0165 | 0.1029 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0165 | 0.1029 | 0.1029 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0165 | 0.1029 | 0.5 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.4154 |
Plasmodium falciparum | thioredoxin reductase | 0.0267 | 0.2477 | 1 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0165 | 0.1029 | 0.4154 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.0165 | 0.1029 | 0.1029 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0165 | 0.1029 | 0.4154 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0165 | 0.1029 | 0.4154 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0267 | 0.2477 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0165 | 0.1029 | 0.1029 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0797 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.5 |
Treponema pallidum | pfs protein (pfs) | 0.0165 | 0.1029 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0797 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0092 | 0 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0797 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0267 | 0.2477 | 0.2477 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0092 | 0 | 0.5 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0165 | 0.1029 | 0.4154 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.0165 | 0.1029 | 0.1029 |
Brugia malayi | glutathione reductase | 0.0267 | 0.2477 | 0.2477 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.1029 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0165 | 0.1029 | 0.1029 |
Chlamydia trachomatis | AMP nucleosidase | 0.0165 | 0.1029 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.1029 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.4154 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0165 | 0.1029 | 0.4154 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0632 | 0.7657 | 0.7657 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.1029 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0165 | 0.1029 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0267 | 0.2477 | 0.2185 |
Entamoeba histolytica | hypothetical protein | 0.0165 | 0.1029 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Giardia lamblia | UPL-1 | 0.0165 | 0.1029 | 0.1029 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.4154 |
Plasmodium vivax | glutathione reductase, putative | 0.0267 | 0.2477 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0165 | 0.1029 | 0.4154 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.1029 |
Brugia malayi | uridine phosphorylase family protein | 0.0165 | 0.1029 | 0.1029 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.1029 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.0165 | 0.1029 | 0.1029 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.0165 | 0.1029 | 0.1029 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.1029 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.1029 |
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.0165 | 0.1029 | 0.1029 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.0165 | 0.1029 | 0.1029 |
Brugia malayi | Thioredoxin reductase | 0.0267 | 0.2477 | 0.2477 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0267 | 0.2477 | 0.2477 |
Loa Loa (eye worm) | hypothetical protein | 0.0632 | 0.7657 | 1 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0165 | 0.1029 | 0.4154 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0267 | 0.2477 | 1 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.0165 | 0.1029 | 0.1029 |
Mycobacterium leprae | probable uridine phosphorylase | 0.0165 | 0.1029 | 0.1029 |
Trypanosoma brucei | trypanothione reductase | 0.0267 | 0.2477 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.0165 | 0.1029 | 0.1029 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0797 | 1 | 1 |
Toxoplasma gondii | phosphorylase family protein | 0.0165 | 0.1029 | 0.4154 |
Toxoplasma gondii | phosphorylase family protein | 0.0165 | 0.1029 | 0.4154 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0797 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0165 | 0.1029 | 0.1029 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.0165 | 0.1029 | 0.1029 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 | Compound was tested for inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
IC50 (binding) | > 100 uM | Inhibition of [3H]-DCKA binding to NMDA receptor of rat brain membranes. | ChEMBL. | 8917657 |
IC50 (binding) | > 100 uM | Inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
IC50 (binding) | > 100 uM | Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranes | ChEMBL. | 8765507 |
IC50 (binding) | > 100 uM | Inhibition of [3H]-DCKA binding to NMDA receptor of rat brain membranes. | ChEMBL. | 8917657 |
IC50 (binding) | > 100 uM | Inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
IC50 (binding) | > 100 uM | Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranes | ChEMBL. | 8765507 |
Log (binding) | = -2 1/IC50 | Compound was tested for inhibition of [3H]-DCKA binding to N-methyl-D-aspartate glutamate receptor | ChEMBL. | 12699379 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.