Detailed information for compound 61442

Basic information

Technical information
  • TDR Targets ID: 61442
  • Name: 4-[(1R)-1-hydroxy-2,2-dimethylpropyl]benzoic acid
  • MW: 208.254 | Formula: C12H16O3
  • H donors: 2 H acceptors: 3 LogP: 2.32 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](C(C)(C)C)c1ccc(cc1)C(=O)O
  • InChi: 1S/C12H16O3/c1-12(2,3)10(13)8-4-6-9(7-5-8)11(14)15/h4-7,10,13H,1-3H3,(H,14,15)/t10-/m0/s1
  • InChiKey: WVWUIXUDPBZIMS-JTQLQIEISA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(1R)-1-hydroxy-2,2-dimethyl-propyl]benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0316 0.0316
Brugia malayi Doublecortin family protein 0.0021 0.0067 0.0331
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0067 0.2694
Giardia lamblia DNA polymerase alpha subunit A 0.0046 0.0285 0.0267
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0244 0.1976 0.9783
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0316 0.0316
Brugia malayi AMP-binding enzyme family protein 0.005 0.0316 0.1567
Schistosoma mansoni survival motor neuron protein 0.0051 0.0324 0.031
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0301 0.2471 0.2471
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0316 0.2533
Loa Loa (eye worm) hypothetical protein 0.0037 0.0208 0.1032
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0015 0.0018 0.0192
Schistosoma mansoni microtubule-associated protein tau 0.0726 0.6106 0.61
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0015 0.0015
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0015 0.0018 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0015 0.0072
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0316 0.2444
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0055 0.0357 0.0342
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0072
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0015 0.0022 0.0007
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0348 0.0348
Echinococcus multilocularis microtubule associated protein 2 0.0726 0.6106 0.61
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1111 0.1111
Brugia malayi DNA polymerase family B containing protein 0.0015 0.0018 0.0091
Schistosoma mansoni polycystin 1-related 0.0021 0.0067 0.0052
Schistosoma mansoni lipoxygenase 0.0021 0.0067 0.0052
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0018 0.0018
Schistosoma mansoni rab6-interacting 0.0021 0.0067 0.0052
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0348 0.0334
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0348 0.0334
Echinococcus granulosus tumor protein p63 0.0355 0.2933 0.2923
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0059 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0316 0.2444
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.1111 0.1111
Mycobacterium ulcerans hypothetical protein 0.005 0.0316 0.2533
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0015 0.0018 0.0004
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0018 0.0018
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0348 0.0348
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0015 0.0018 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0348 0.0334
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0015 0.0018 0.0146
Schistosoma mansoni rab6-interacting 0.0021 0.0067 0.0052
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.0015 0.0117
Plasmodium vivax DNA polymerase alpha, putative 0.0044 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0208 0.1032
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0024 0.0093 0.0093
Loa Loa (eye worm) oxidoreductase 0.0015 0.0015 0.0072
Loa Loa (eye worm) hypothetical protein 0.0037 0.0208 0.1032
Loa Loa (eye worm) hypothetical protein 0.0037 0.0208 0.1032
Echinococcus granulosus RUN 0.0021 0.0067 0.0052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0191 0.1428
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0316 0.2533
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0316 0.2533
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0208 0.7638
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.1181 1 1
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0015 0.0018 0.0004
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0018 0.0018
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0059 0.0044
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0067 0.0052
Brugia malayi DNA polymerase delta catalytic subunit 0.0015 0.0018 0.0091
Onchocerca volvulus 0.0021 0.0067 0.101
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.0015 0.0117
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0316 0.0316
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0316 0.2533
Schistosoma mansoni loxhd1 0.0021 0.0067 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0015 0.0072
Schistosoma mansoni hypothetical protein 0.1181 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0015 0.0018 0.0018
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0252 0.0252
Brugia malayi hypothetical protein 0.0021 0.0067 0.0331
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0015 0.0018 0.0004
Giardia lamblia Rrm3p helicase 0.1181 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0331
Echinococcus granulosus microtubule associated protein 2 0.0726 0.6106 0.61
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0348 0.0334
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0191 0.1428
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0059 0.5
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0024 0.0093 0.0079
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0015 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Leishmania major mitochondrial DNA polymerase beta 0.0301 0.2471 0.2471
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.0015 0.0117
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0067 0.0052
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0055 0.0357 0.0342
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0316 1
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0335 0.0321
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0055 0.0357 0.0342
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0015 0.0018 0.0018
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0015 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0249 0.2019 1
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0316 0.2533
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0015 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0072
Echinococcus multilocularis RUN 0.0021 0.0067 0.0052
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0059 0.0044
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0348 0.0334
Brugia malayi hypothetical protein 0.0021 0.0067 0.0331
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0015 0.0018 0.0004
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0348 0.0348
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.0015 0.0117
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0015 0.0022 0.0358
Brugia malayi hypothetical protein 0.0249 0.2019 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0059 0.0044
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0067 0.0052
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0332 0.0332
Echinococcus multilocularis tumor protein p63 0.0355 0.2933 0.2923
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.0015 0.0117
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0024 0.0093 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0015 0.0072
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0387 0.0372
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0015 0.0072
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0208 0.1668
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0015 0.0018 0.0072
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0052 0.0335 0.1658
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.0015 0.0117
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0059 0.5
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0015 0.0015
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0348 0.0348
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0059 0.0469
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.2019 0.2008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0191 0.1428
Toxoplasma gondii DNA polymerase family B protein 0.0015 0.0018 0.0111
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0316 0.2533
Brugia malayi MAP kinase sur-1 0.0054 0.0348 0.1724
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1249 1
Onchocerca volvulus 0.005 0.0316 0.5837
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0348 0.0334
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.1181 1 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0015 0.0072
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0067 0.2058
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0044 0.0268 0.7603
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0059 0.0059
Toxoplasma gondii DNA polymerase 0.0015 0.0018 0.0111
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0015 0.0018 0.0018
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.0015 0.0117
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0015 0.0015
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.1181 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0316 0.0302
Schistosoma mansoni hypothetical protein 0.0051 0.0324 0.031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0191 0.1428
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0348 0.0331
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0015 0.0018 0.0146
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0316 0.0302
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0015 0.0018 0.0072
Trypanosoma brucei protein kinase, putative 0.0054 0.0348 0.0348
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0348 0.1724
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0015 0.0072
Schistosoma mansoni ap endonuclease 0.002 0.0059 0.0044
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0075 0.0532 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0015 0.0015
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.2471 0.2471
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0015 0.0015
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0015 0.0018 0.0004
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0252 0.0252
Entamoeba histolytica hypothetical protein, conserved 0.1181 1 1
Brugia malayi follicle stimulating hormone receptor 0.0244 0.1976 0.9783
Schistosoma mansoni ap endonuclease 0.002 0.0059 0.0044
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0015 0.0018 0.0004
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0015 0.0018 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0316 0.0302
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0015 0.0018 0.0004
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0015 0.0018 0.0091
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0059 0.029
Trichomonas vaginalis DNA polymerase II, putative 0.0024 0.0093 0.0079
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0059 0.0356
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0067 0.0331
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0059 0.0059
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0024 0.0093 0.0093
Toxoplasma gondii hypothetical protein 0.0049 0.0306 0.8723
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.2019 0.2008
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0348 0.0334
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.0015 0.0117
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0348 0.0348
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0208 0.1569
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.1181 1 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0015 0.0015
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.0015 0.0117
Loa Loa (eye worm) hypothetical protein 0.005 0.0316 0.1567
Toxoplasma gondii exonuclease III APE 0.002 0.0059 0.1319
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0348 1
Mycobacterium ulcerans hypothetical protein 0.0159 0.1249 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0316 0.1567
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0015 0.0018 0.0146
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.1181 1 1
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0015 0.0015
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.2471 0.2471
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0015 0.0072
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1111 0.1111
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0018 0.0018
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0059 0.0044
Entamoeba histolytica DNA repair and recombination protein, putative 0.1181 1 1
Schistosoma mansoni hypothetical protein 0.0021 0.0067 0.0052
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0059 0.004
Brugia malayi DNA polymerase alpha catalytic subunit 0.0044 0.0268 0.1328
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0075 0.0532 0.2632
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0387 0.0372
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0059 0.2271
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0015 0.0015
Onchocerca volvulus 0.0052 0.0335 0.6192
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.1181 1 1
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.1181 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0348 0.0334
Loa Loa (eye worm) hypothetical protein 0.0021 0.0067 0.0331
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0208 0.5
Trichomonas vaginalis conserved hypothetical protein 0.1181 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0059 0.1735
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0208 1
Onchocerca volvulus 0.0021 0.0067 0.101
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0015 0.0018 0.0004
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0853 0.7194 0.719
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0067 0.0052
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0324 0.1603
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0316 0.2533
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0015 0.0072
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0252 0.0252
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.002 0.0064 0.005
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0015 0.0018 0.0018
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0059 0.0044
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0059 0.029
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0067 0.0052
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0252 0.0252
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0037 0.0208 0.1032
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0015 0.0117
Loa Loa (eye worm) hypothetical protein 0.005 0.0316 0.1567
Brugia malayi AMP-binding enzyme family protein 0.005 0.0316 0.1567
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.1181 1 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0015 0.0018 0.0004
Onchocerca volvulus 0.0051 0.0324 0.5979
Onchocerca volvulus DNA polymerase homolog 0.0015 0.0018 0.0072
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0067 0.0052
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0316 1
Schistosoma mansoni lipoxygenase 0.0058 0.0387 0.0372
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0348 0.0334
Brugia malayi AMP-binding enzyme family protein 0.005 0.0316 0.1567

Activities

Activity type Activity value Assay description Source Reference
Control (functional) < 23 % Ketone levels were determined in an acute in vivo study for inhibition of gluconeogenesis in normal male Sprague-Dawley rats ChEMBL. 9888840
Control (functional) < 42 % Glucose levels were determined in an acute in vivo study for inhibition of gluconeogenesis in normal male Sprague-Dawley rats ChEMBL. 9888840
Control (functional) < 59 % Testes weight(treated)/body weight(treated)]/[testes weight(control)/body weight(control)] x 100 at a dose of 350 umol/kg/day ChEMBL. 9888840
Efficacy (functional) < 63 % In vivo percentage efficacy of the compound was measured as ability to decrease blood glucose percentage after 11.25 days in rats ChEMBL. 9888840
Efficacy (functional) < 64 % In vivo percentage efficacy, measured as ability to decrease blood glucose percentage after 8.25 days in rats ChEMBL. 9888840

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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