Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 1 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.362 | 0.5 | |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.362 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.362 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.362 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.362 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.362 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.362 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0.0503 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 1 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.362 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.362 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.362 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.362 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.362 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0503 | 0.139 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.362 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0021 | 0.0503 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0021 | 0.0503 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0027 | 0.362 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.362 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.362 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.362 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.362 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.