Detailed information for compound 615092

Basic information

Technical information
  • TDR Targets ID: 615092
  • Name: pentyl 2-(3-methyl-8-morpholin-4-yl-2,6-dioxo purin-7-yl)acetate
  • MW: 379.411 | Formula: C17H25N5O5
  • H donors: 1 H acceptors: 4 LogP: 1.28 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCOC(=O)Cn1c(nc2c1c(=O)[nH]c(=O)n2C)N1CCOCC1
  • InChi: 1S/C17H25N5O5/c1-3-4-5-8-27-12(23)11-22-13-14(20(2)17(25)19-15(13)24)18-16(22)21-6-9-26-10-7-21/h3-11H2,1-2H3,(H,19,24,25)
  • InChiKey: YCUDSURKQNRWKI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • pentyl 2-(3-methyl-8-morpholino-2,6-dioxo-purin-7-yl)acetate
  • 2-(3-methyl-8-morpholino-2,6-dioxo-7-purinyl)acetic acid pentyl ester
  • 2-(2,6-diketo-3-methyl-8-morpholino-purin-7-yl)acetic acid amyl ester
  • pentyl 2-(3-methyl-8-morpholin-4-yl-2,6-dioxo-purin-7-yl)ethanoate
  • ZINC03212977
  • BAS 00363927
  • EU-0047755
  • (3-Methyl-8-morpholin-4-yl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetic acid pentyl ester
  • MLS000026990
  • SMR000008720

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0521 0.0639
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0228 0.729 0.729
Loa Loa (eye worm) hypothetical protein 0.0108 0.3048 0.3048
Schistosoma mansoni hypothetical protein 0.0305 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.6469 0.8587
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.4944 0.4944
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0178 0.5532 0.5532
Brugia malayi nuclear receptor NHR-88 0.0108 0.3048 0.4045
Loa Loa (eye worm) hypothetical protein 0.0065 0.1541 0.1541
Echinococcus granulosus tar DNA binding protein 0.0062 0.1436 0.1436
Echinococcus granulosus Nuclear hormone receptor HR96 0.0108 0.3048 0.3048
Echinococcus multilocularis GPCR, family 2 0.0065 0.1541 0.1541
Schistosoma mansoni hypothetical protein 0.0065 0.1541 0.1541
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.1541 0.1541
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.1541 0.1541
Echinococcus granulosus thyroid hormone receptor alpha 0.0108 0.3048 0.3048
Schistosoma mansoni coup transcription factor 0.0228 0.729 0.729
Loa Loa (eye worm) hypothetical protein 0.0231 0.7386 0.7386
Schistosoma mansoni hypothetical protein 0.0065 0.1541 0.1541
Brugia malayi nuclear hormone receptor 0.0108 0.3048 0.4045
Onchocerca volvulus Bile acid receptor homolog 0.0228 0.729 0.8911
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0152 0.0201
Loa Loa (eye worm) fli-1 protein 0.0213 0.675 0.675
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0228 0.729 0.729
Brugia malayi hypothetical protein 0.0231 0.7386 0.9804
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0521 0.0639
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0152 0.2912
Schistosoma mansoni hypothetical protein 0.014 0.4188 0.4188
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0152 0.0152
Brugia malayi intermediate filament protein 0.0026 0.0186 0.0247
Loa Loa (eye worm) hypothetical protein 0.0228 0.729 0.729
Loa Loa (eye worm) hypothetical protein 0.0108 0.3048 0.3048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0178 0.5532 0.5532
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0121 0.3502 0.3502
Echinococcus multilocularis snurportin 1 0.0305 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0178 0.5532 0.5532
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.1727 0.1727
Brugia malayi conserved hypotetical protein 0.0108 0.3048 0.4045
Loa Loa (eye worm) hypothetical protein 0.0041 0.0699 0.0699
Loa Loa (eye worm) hypothetical protein 0.0108 0.3048 0.3048
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0521 0.0639
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0186 0.0186
Loa Loa (eye worm) nuclear receptor NHR-67 0.0108 0.3048 0.3048
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0611 0.0611
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.1727 0.1727
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.034 0.034
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0178 0.5532 0.7344
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0228 0.729 0.729
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0108 0.3048 0.3048
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.1541 0.1541
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0121 0.3502 0.3502
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0108 0.3048 0.3048
Onchocerca volvulus 0.0253 0.8158 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.3048 0.3048
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0521 0.0639
Brugia malayi Steroid receptor seven-up type 2 0.0228 0.729 0.9677
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.7078 0.7078
Onchocerca volvulus 0.0047 0.0917 0.0917
Echinococcus granulosus lamin 0.0026 0.0186 0.0186
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0132 0.2538
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0152 0.5711
Schistosoma mansoni survival motor neuron protein 0.0047 0.0917 0.0917
Echinococcus granulosus chromobox protein 1 0.0073 0.1827 0.1827
Brugia malayi hypothetical protein 0.0121 0.3502 0.4648
Loa Loa (eye worm) hypothetical protein 0.0108 0.3048 0.3048
Brugia malayi nuclear receptor RXR 0.0121 0.3502 0.4648
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0152 0.2483
Schistosoma mansoni retinoic acid receptor RXR 0.0228 0.729 0.729
Brugia malayi Latrophilin receptor protein 2 0.0065 0.1541 0.2045
Brugia malayi nuclear receptor NHR-88 0.0228 0.729 0.9677
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.1827 0.1827
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.1541 0.2045
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0521 0.8526
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1436 0.1436
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.7386 0.7386
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0152 0.2912
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0808 0.0991
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0152 0.0201
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0026 0.0186 0.0186
Brugia malayi hypothetical protein 0.0108 0.3048 0.4045
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0228 0.729 0.8911
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0108 0.3048 0.3048
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0121 0.3502 0.3502
Loa Loa (eye worm) hypothetical protein 0.014 0.4188 0.4188
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0228 0.729 0.729
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0228 0.729 0.729
Loa Loa (eye worm) hypothetical protein 0.0108 0.3048 0.3048
Brugia malayi nuclear hormone receptor 0.0228 0.729 0.9677
Loa Loa (eye worm) hypothetical protein 0.0121 0.3502 0.3502
Brugia malayi hypothetical protein 0.0108 0.3048 0.4045
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0228 0.729 0.729
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0611 0.0611
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0228 0.729 0.729
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0521 0.0521
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0228 0.729 0.729
Echinococcus granulosus nuclear receptor nhr 48 0.0108 0.3048 0.3048
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.4944 0.4944
Echinococcus granulosus FTZ F1 alpha 0.0228 0.729 0.729
Onchocerca volvulus 0.0108 0.3048 0.3589
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0521 0.0692
Loa Loa (eye worm) hypothetical protein 0.0108 0.3048 0.3048
Loa Loa (eye worm) hypothetical protein 0.0121 0.3502 0.3502
Echinococcus multilocularis chromobox protein 1 0.0073 0.1827 0.1827
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0132 0.4977
Schistosoma mansoni alpha-glucosidase 0.0139 0.4153 0.4153
Schistosoma mansoni zinc finger protein 0.0108 0.3048 0.3048
Schistosoma mansoni alpha-glucosidase 0.0139 0.4153 0.4153
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1436 0.1436
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1436 0.1436
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0178 0.5532 0.5532
Brugia malayi hypothetical protein 0.0038 0.0611 0.0811
Loa Loa (eye worm) DR-78 0.0108 0.3048 0.3048
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0228 0.729 0.729
Onchocerca volvulus 0.0093 0.2547 0.2962
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1436 0.1436
Brugia malayi TAR-binding protein 0.0062 0.1436 0.1907
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0152 0.0152
Brugia malayi Fli-1 protein 0.0213 0.675 0.8961
Brugia malayi Ets-domain containing protein 0.007 0.1727 0.2292
Brugia malayi nuclear hormone receptor family member odr-7 0.0108 0.3048 0.4045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0381 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0279 0.0342
Entamoeba histolytica hypothetical protein 0.0038 0.0611 1
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0521 1
Brugia malayi hypothetical protein 0.0025 0.0132 0.0175
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0521 0.0639
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.4944 0.4944
Brugia malayi Nuclear hormone receptor-like 1 0.0121 0.3502 0.4648
Trichomonas vaginalis chaperonin, putative 0.0025 0.0152 0.0186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0228 0.729 0.729
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0228 0.729 0.729
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0121 0.3502 0.3502
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0228 0.729 0.9677
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0228 0.729 0.729
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.0152 0.0186
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0228 0.729 0.729
Schistosoma mansoni lamin 0.0026 0.0186 0.0186
Brugia malayi ecdysteroid receptor 0.0228 0.729 0.9677
Brugia malayi ecdysone receptor 0.0108 0.3048 0.4045
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0152 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0228 0.729 0.9677
Schistosoma mansoni nuclear receptor 0.0108 0.3048 0.3048
Schistosoma mansoni chromobox protein 0.0073 0.1827 0.1827
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.7386 0.7386
Brugia malayi nuclear hormone receptor family member nhr-6 0.0108 0.3048 0.4045
Echinococcus granulosus GA binding protein alpha chain 0.007 0.1727 0.1727
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0381 0.7312
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0108 0.3048 0.3048
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0228 0.729 0.9677
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0228 0.729 0.729
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0917 0.1217
Schistosoma mansoni nuclear receptor nhr-48 0.0108 0.3048 0.3048
Echinococcus multilocularis chromobox protein 1 0.0073 0.1827 0.1827
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0108 0.3048 0.3048
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0228 0.729 0.729
Schistosoma mansoni nuclear hormone receptor 0.0108 0.3048 0.3048
Trichomonas vaginalis set domain proteins, putative 0.0253 0.8158 1
Schistosoma mansoni importin beta-1 0.0029 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0121 0.3502 0.3502
Echinococcus granulosus lamin dm0 0.0026 0.0186 0.0186
Schistosoma mansoni steroid hormone receptor ad4bp 0.0228 0.729 0.729
Brugia malayi Pre-SET motif family protein 0.0222 0.7078 0.9395
Loa Loa (eye worm) hypothetical protein 0.0108 0.3048 0.3048
Loa Loa (eye worm) hypothetical protein 0.0032 0.0388 0.0388
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0228 0.729 0.729
Brugia malayi Heterochromatin protein 1 0.0073 0.1827 0.2426
Entamoeba histolytica hypothetical protein 0.0038 0.0611 1
Schistosoma mansoni nuclear receptor 0.0108 0.3048 0.3048
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0801 0.0801
Brugia malayi tailless protein 0.0108 0.3048 0.4045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0228 0.729 0.729
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0132 0.4977
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.4944 0.4944
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.006 0.1369 0.1369
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0075 0.0092
Onchocerca volvulus 0.0228 0.729 0.8911
Loa Loa (eye worm) hypothetical protein 0.0108 0.3048 0.3048
Loa Loa (eye worm) RNA binding protein 0.0062 0.1436 0.1436
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0132 0.2538
Schistosoma mansoni thyroid hormone receptor 0.0228 0.729 0.729
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0108 0.3048 0.3048
Loa Loa (eye worm) hypothetical protein 0.0228 0.729 0.729
Trichomonas vaginalis chromobox protein, putative 0.0073 0.1827 0.224
Schistosoma mansoni hypothetical protein 0.0065 0.1541 0.1541
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.4188 0.5559
Schistosoma mansoni lamin 0.0026 0.0186 0.0186
Echinococcus granulosus chromobox protein 1 0.0073 0.1827 0.1827
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1436 0.1436
Echinococcus multilocularis nuclear receptor nhr 48 0.0108 0.3048 0.3048
Schistosoma mansoni ets-related 0.0213 0.675 0.675
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0228 0.729 0.9677
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0381 0.0381
Onchocerca volvulus 0.0032 0.0388 0.0253
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0152 0.3983
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0228 0.729 0.9677
Entamoeba histolytica hypothetical protein 0.0023 0.0075 0.1233
Brugia malayi nuclear receptor RXR 0.0108 0.3048 0.4045
Schistosoma mansoni intermediate filament proteins 0.0026 0.0186 0.0186
Schistosoma mansoni gabp alpha 0.007 0.1727 0.1727
Schistosoma mansoni hypothetical protein 0.0065 0.1541 0.1541
Loa Loa (eye worm) hypothetical protein 0.0108 0.3048 0.3048
Plasmodium falciparum importin beta, putative 0.0029 0.0266 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0699 0.0857
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0521 0.0521
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 1 1
Echinococcus multilocularis musashi 0.0026 0.0186 0.0186
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0521 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0121 0.3502 0.3502
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0808 0.078
Loa Loa (eye worm) steroid hormone receptor 0.0228 0.729 0.729
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.0152 1
Echinococcus granulosus intermediate filament protein 0.0026 0.0186 0.0186
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1436 0.1436
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0108 0.3048 0.3048
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0152 0.0152
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0266 0.5099
Echinococcus granulosus Nuclear hormone receptor HR96 0.0108 0.3048 0.3048
Brugia malayi orphan nuclear receptor NR2E1 0.0108 0.3048 0.4045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0228 0.729 0.729
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0266 0.5099
Schistosoma mansoni nuclear hormone receptor 0.0228 0.729 0.729
Onchocerca volvulus Protein ultraspiracle homolog 0.0228 0.729 0.8911
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0266 0.5099
Schistosoma mansoni hypothetical protein 0.0047 0.0917 0.0917
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0132 0.2538
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0108 0.3048 0.4045
Plasmodium vivax importin-beta 2, putative 0.0029 0.0266 0.6973
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0521 0.8526
Onchocerca volvulus 0.0044 0.0801 0.0771
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0186 0.0247
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0699 0.0643
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0132 0.3471
Brugia malayi RNA binding protein 0.0062 0.1436 0.1907
Brugia malayi Nuclear hormone receptor-like 1 0.0121 0.3502 0.4648
Loa Loa (eye worm) hypothetical protein 0.0121 0.3502 0.3502
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0228 0.729 0.729
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0228 0.729 0.729
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0075 0.0092
Echinococcus granulosus ecdysone induced protein 78C 0.0228 0.729 0.729
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0228 0.729 0.9677
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0178 0.5532 0.5532
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0228 0.729 0.729
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0228 0.729 0.729
Echinococcus granulosus importin subunit beta 1 0.0029 0.0266 0.0266
Schistosoma mansoni hypothetical protein 0.0038 0.0611 0.0611
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0152 0.2912
Trypanosoma brucei glucosidase, putative 0.0036 0.0521 1
Brugia malayi Ets-domain containing protein 0.007 0.1727 0.2292
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0279 0.0342
Loa Loa (eye worm) hypothetical protein 0.0025 0.0132 0.0132
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0108 0.3048 0.3048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0228 0.729 0.9677
Loa Loa (eye worm) hypothetical protein 0.0108 0.3048 0.3048
Echinococcus multilocularis thyroid hormone receptor alpha 0.0228 0.729 0.729
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0228 0.729 0.9677
Loa Loa (eye worm) hypothetical protein 0.0228 0.729 0.729
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0521 1
Brugia malayi chromobox protein homolog 3 0.0041 0.0699 0.0928
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.7533 0.7533
Loa Loa (eye worm) hypothetical protein 0.0205 0.6469 0.6469
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.1541 0.1541
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0228 0.729 0.729
Leishmania major hypothetical protein, conserved 0.0025 0.0132 0.2538
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0228 0.729 0.729
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.4944 0.6563
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0381 0.0381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0228 0.729 0.729
Schistosoma mansoni nuclear hormone receptor 0.0108 0.3048 0.3048
Entamoeba histolytica hypothetical protein 0.0038 0.0611 1
Echinococcus multilocularis lamin dm0 0.0026 0.0186 0.0186
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0381 0.0381
Brugia malayi Nuclear hormone receptor E75 0.0108 0.3048 0.4045
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0228 0.729 0.729
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0152 0.2912
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0808 0.0991
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0228 0.729 0.9677
Brugia malayi steroid hormone receptor 0.0228 0.729 0.9677
Brugia malayi Importin beta-1 subunit 0.0029 0.0266 0.0353
Schistosoma mansoni RAR-like nuclear receptor 0.0228 0.729 0.729
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.6469 0.8587
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0108 0.3048 0.3048
Echinococcus granulosus GPCR family 2 0.0065 0.1541 0.1541
Brugia malayi hypothetical protein 0.0121 0.3502 0.4648
Brugia malayi Nuclear hormone receptor-like 1 0.0228 0.729 0.9677
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0186 0.0186
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.1541 0.1541
Leishmania major importin beta-1 subunit, putative 0.0023 0.0075 0.1446
Schistosoma mansoni alpha glucosidase 0.0036 0.0521 0.0521
Brugia malayi Nuclear hormone receptor E75 0.0108 0.3048 0.4045
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0521 0.0521
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.7533 0.7533
Onchocerca volvulus 0.0108 0.3048 0.3589
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0075 0.1446
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0611 0.0611
Entamoeba histolytica hypothetical protein 0.0038 0.0611 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0521 0.0639
Loa Loa (eye worm) hypothetical protein 0.0029 0.0266 0.0266
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1436 0.1436
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0521 0.0639
Loa Loa (eye worm) hypothetical protein 0.0026 0.0169 0.0169
Brugia malayi nuclear receptor NHR-67 0.0108 0.3048 0.4045
Loa Loa (eye worm) hypothetical protein 0.0121 0.3502 0.3502
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0521 0.0639
Echinococcus multilocularis FTZ F1 alpha 0.0228 0.729 0.729
Schistosoma mansoni thyroid hormone receptor 0.0228 0.729 0.729
Loa Loa (eye worm) hypothetical protein 0.0228 0.729 0.729
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0108 0.3048 0.3589
Loa Loa (eye worm) hypothetical protein 0.0228 0.729 0.729
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0521 0.0639
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0228 0.729 0.9677
Brugia malayi Pre-SET motif family protein 0.0032 0.0381 0.0506
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.6469 0.6469
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0108 0.3048 0.3589
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1436 0.1907
Loa Loa (eye worm) hypothetical protein 0.0228 0.729 0.729
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0108 0.3048 0.3048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0178 0.5532 0.5532
Brugia malayi RNA, U transporter 1 0.0081 0.2121 0.2815
Plasmodium vivax SET domain protein, putative 0.0032 0.0381 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0521 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0178 0.5532 0.5532
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1436 0.1436
Loa Loa (eye worm) hypothetical protein 0.0228 0.729 0.729
Loa Loa (eye worm) hypothetical protein 0.0032 0.0381 0.0381
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0178 0.5532 0.5532
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0108 0.3048 0.3048
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0228 0.729 0.9677
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0381 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0699 0.0857
Echinococcus multilocularis lamin 0.0026 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0108 0.3048 0.3048
Schistosoma mansoni chromobox protein 0.0073 0.1827 0.1827
Brugia malayi MH2 domain containing protein 0.0235 0.7533 1
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0152 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0228 0.729 0.9677
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0228 0.729 0.9677
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0075 0.0092
Brugia malayi photoreceptor-specific nuclear receptor 0.0228 0.729 0.9677
Echinococcus multilocularis ecdysone induced protein 78C 0.0228 0.729 0.729
Loa Loa (eye worm) nuclear hormone receptor 0.0108 0.3048 0.3048
Loa Loa (eye worm) hypothetical protein 0.0228 0.729 0.729
Trichomonas vaginalis chromobox protein, putative 0.0073 0.1827 0.224
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0132 0.2538

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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