Detailed information for compound 615214

Basic information

Technical information
  • TDR Targets ID: 615214
  • Name: N-(2-fluorophenyl)-4-piperidin-1-ylsulfonylbe nzamide
  • MW: 362.418 | Formula: C18H19FN2O3S
  • H donors: 1 H acceptors: 3 LogP: 2.85 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)S(=O)(=O)N1CCCCC1)Nc1ccccc1F
  • InChi: 1S/C18H19FN2O3S/c19-16-6-2-3-7-17(16)20-18(22)14-8-10-15(11-9-14)25(23,24)21-12-4-1-5-13-21/h2-3,6-11H,1,4-5,12-13H2,(H,20,22)
  • InChiKey: VADDNNYOZKYYHY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-fluorophenyl)-4-(1-piperidylsulfonyl)benzamide
  • N-(2-fluorophenyl)-4-piperidinosulfonyl-benzamide
  • N-(2-fluorophenyl)-4-piperidin-1-ylsulfonyl-benzamide
  • Oprea1_622732
  • BAS 03365977
  • Oprea1_315344
  • ZINC00879150
  • N-(2-Fluoro-phenyl)-4-(piperidine-1-sulfonyl)-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0052 0.1078 0.3321
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.3156 0.3156
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.1078 0.3128
Loa Loa (eye worm) hypothetical protein 0.0033 0.0525 0.1617
Echinococcus granulosus tar DNA binding protein 0.0127 0.3245 0.3245
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.3156 0.3156
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3245 0.9418
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0525 0.1617
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0977 0.301
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3245 0.9418
Brugia malayi RNA binding protein 0.0127 0.3245 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.2969 0.915
Schistosoma mansoni thyroid hormone receptor 0.0133 0.3446 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3245 0.9418
Schistosoma mansoni hypothetical protein 0.0123 0.3156 0.9159
Echinococcus multilocularis tumor protein p63 0.0358 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0977 0.301
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3245 0.9418
Loa Loa (eye worm) hypothetical protein 0.0049 0.0977 0.301
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.2969 0.915
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.3245 1
Onchocerca volvulus 0.0052 0.1078 0.5
Brugia malayi MH2 domain containing protein 0.0117 0.2969 0.915
Loa Loa (eye worm) TAR-binding protein 0.0127 0.3245 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.3245 0.9418
Echinococcus multilocularis thyroid hormone receptor alpha 0.0133 0.3446 0.3446
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.3245 1
Schistosoma mansoni thyroid hormone receptor 0.0133 0.3446 1
Brugia malayi TAR-binding protein 0.0127 0.3245 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0977 0.301
Echinococcus multilocularis tar DNA binding protein 0.0127 0.3245 0.3245
Schistosoma mansoni hypothetical protein 0.0033 0.0525 0.1523
Loa Loa (eye worm) RNA binding protein 0.0127 0.3245 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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