TDR Targets

Basic information

Technical information

TDR Targets ID: 615733
Name: 4-[(4-acetylphenyl)amino]-2-morpholin-4-yl-4- oxobutanoic acid
MW: 320.34 | Formula: C16H20N2O5
H donors: 2 H acceptors: 4 LogP: -2.27 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1)C(=O)C)CC(C(=O)O)N1CCOCC1
InChi: 1S/C16H20N2O5/c1-11(19)12-2-4-13(5-3-12)17-15(20)10-14(16(21)22)18-6-8-23-9-7-18/h2-5,14H,6-10H2,1H3,(H,17,20)(H,21,22)
InChiKey: NXXSFKRJSVQGSF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[(4-acetylphenyl)amino]-2-morpholino-4-oxo-butanoic acid
4-[(4-acetylphenyl)amino]-2-morpholino-4-oxobutanoic acid
4-[(4-acetylphenyl)amino]-4-keto-2-morpholino-butyric acid
4-[(4-ethanoylphenyl)amino]-2-morpholin-4-yl-4-oxo-butanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0251	0.1662	0.4265
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0643	0.1651
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.0586	0.1505
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0251	0.1662	0.1599
Brugia malayi	Nuclear hormone receptor E75	0.0111	0.0643	0.1651
Loa Loa (eye worm)	hypothetical protein	0.014	0.0856	0.2198
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0308	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0251	0.1662	0.1599
Brugia malayi	nuclear hormone receptor family member odr-7	0.0111	0.0643	0.1651
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0251	0.1662	0.4265
Schistosoma mansoni	nuclear hormone receptor	0.0251	0.1662	0.1599
Schistosoma mansoni	retinoic acid receptor RXR	0.0251	0.1662	0.1599
Brugia malayi	Nuclear hormone receptor-like 1	0.014	0.0856	0.2198
Loa Loa (eye worm)	DR-78	0.0111	0.0643	0.1651
Brugia malayi	photoreceptor-specific nuclear receptor	0.0251	0.1662	0.4265
Brugia malayi	hypothetical protein	0.0111	0.0643	0.1651
Loa Loa (eye worm)	hypothetical protein	0.056	0.3896	1
Brugia malayi	nuclear receptor NHR-88	0.0111	0.0643	0.1651
Schistosoma mansoni	nuclear receptor	0.0111	0.0643	0.0573
Brugia malayi	Cytochrome P450 family protein	0.0051	0.0208	0.0534
Schistosoma mansoni	microtubule-associated protein tau	0.1401	1	1
Brugia malayi	tailless protein	0.0111	0.0643	0.1651
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0111	0.0643	0.0573
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0308	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0643	0.1651
Loa Loa (eye worm)	nuclear hormone receptor	0.0111	0.0643	0.1651
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0586	0.1505
Schistosoma mansoni	zinc finger protein	0.0111	0.0643	0.0573
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0251	0.1662	0.4265
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0075	0.0191
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0251	0.1662	0.4265
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.014	0.0856	0.0788
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.0586	0.1505
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0643	0.1651
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0643	0.1651
Echinococcus multilocularis	microtubule associated protein 2	0.1401	1	1
Onchocerca volvulus		0.0251	0.1662	0.3131
Brugia malayi	Steroid receptor seven-up type 2	0.0251	0.1662	0.4265
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1662	0.4265
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1662	0.4265
Echinococcus multilocularis	nuclear receptor nhr 48	0.0111	0.0643	0.0573
Schistosoma mansoni	coup transcription factor	0.0251	0.1662	0.1599
Brugia malayi	latrophilin 2 splice variant baaae	0.0071	0.0349	0.0897
Brugia malayi	nuclear hormone receptor	0.0251	0.1662	0.4265
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.0308	1
Brugia malayi	hypothetical protein	0.0086	0.0462	0.1184
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0251	0.1662	0.4265
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0251	0.1662	0.1599
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0251	0.1662	0.4265
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0251	0.1662	0.4265
Brugia malayi	nuclear receptor NHR-88	0.0251	0.1662	0.4265
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0308	1
Schistosoma mansoni	nuclear receptor	0.0111	0.0643	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1662	0.4265
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0643	0.1651
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1662	0.4265
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0111	0.0643	0.1651
Schistosoma mansoni	nuclear receptor nhr-48	0.0111	0.0643	0.0573
Loa Loa (eye worm)	hypothetical protein	0.014	0.0856	0.2198
Brugia malayi	nuclear receptor RXR	0.014	0.0856	0.2198
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0111	0.0643	0.0573
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0251	0.1662	0.1599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0308	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0251	0.1662	0.3131
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.014	0.0856	0.0788
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0111	0.0643	0.0573
Schistosoma mansoni	hypothetical protein	0.0071	0.0349	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1662	0.4265
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0308	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0643	0.1651
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0251	0.1662	0.3131
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0251	0.1662	0.4265
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.0308	1
Brugia malayi	hypothetical protein	0.014	0.0856	0.2198
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0111	0.0643	0.0573
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0308	1
Schistosoma mansoni	nuclear hormone receptor	0.0111	0.0643	0.0573
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0251	0.1662	0.4265
Brugia malayi	orphan nuclear receptor NR2E1	0.0111	0.0643	0.1651
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1662	0.4265
Brugia malayi	Nuclear hormone receptor-like 1	0.014	0.0856	0.2198
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0251	0.1662	0.1599
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.0267	0.8675
Brugia malayi	nuclear receptor NHR-67	0.0111	0.0643	0.1651
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0075	0.0191
Onchocerca volvulus	Bile acid receptor homolog	0.056	0.3896	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0643	0.1651
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0251	0.1662	0.1599
Trypanosoma cruzi	cysteine peptidase, putative	0.0065	0.0308	1
Brugia malayi	ecdysone receptor	0.0111	0.0643	0.1651
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0251	0.1662	0.1599
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0111	0.0643	0.0573
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0111	0.0643	0.0573
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0111	0.0643	0.0573
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0111	0.0643	0.0573
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0251	0.1662	0.1599
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0643	0.1651
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0308	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.014	0.0856	0.0788
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.0586	0.1505
Loa Loa (eye worm)	steroid hormone receptor	0.0539	0.3749	0.9621
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0111	0.0643	0.0573
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0251	0.1662	0.1599
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0251	0.1662	0.4265
Brugia malayi	steroid hormone receptor	0.0539	0.3749	0.9621
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0111	0.0643	0.0573
Loa Loa (eye worm)	hypothetical protein	0.014	0.0856	0.2198
Schistosoma mansoni	thyroid hormone receptor	0.0251	0.1662	0.1599
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0251	0.1662	0.4265
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0251	0.1662	0.1599
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0251	0.1662	0.1599
Echinococcus multilocularis	FTZ F1 alpha	0.0251	0.1662	0.1599
Trypanosoma cruzi	cruzipain precursor, putative	0.0065	0.0308	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0111	0.0643	0.1651
Brugia malayi	hypothetical protein	0.0111	0.0643	0.1651
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0251	0.1662	0.1599
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0462	0.1184
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0251	0.1662	0.1599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0308	1
Schistosoma mansoni	nuclear hormone receptor	0.0111	0.0643	0.0573
Brugia malayi	hypothetical protein	0.014	0.0856	0.2198
Loa Loa (eye worm)	cytochrome P450 family protein	0.0051	0.0208	0.0534
Loa Loa (eye worm)	hypothetical protein	0.014	0.0856	0.2198
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0251	0.1662	0.4265
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0075	0.0191
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0251	0.1662	0.4265
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0111	0.0643	0.1651
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0251	0.1662	0.4265
Leishmania major	cathepsin L-like protease	0.0065	0.0308	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0251	0.1662	0.1599
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1662	0.4265
Schistosoma mansoni	eyes absent homolog	0.0086	0.0462	0.039
Echinococcus multilocularis	ecdysone induced protein 78C	0.0251	0.1662	0.1599
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0251	0.1662	0.1599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0308	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0643	0.1651
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0111	0.0643	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0349	0.0897
Schistosoma mansoni	RAR-like nuclear receptor	0.0251	0.1662	0.1599
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0251	0.1662	0.1599
Trypanosoma cruzi	major cysteine proteinase, putative	0.0051	0.0207	0.6731
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0251	0.1662	0.1599
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0251	0.1662	0.4265
Brugia malayi	Nuclear hormone receptor E75	0.0111	0.0643	0.1651
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0251	0.1662	0.4265
Echinococcus granulosus	FTZ F1 alpha	0.0251	0.1662	0.1599
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0251	0.1662	0.4265
Echinococcus granulosus	thyroid hormone receptor alpha	0.0399	0.273	0.2675
Leishmania major	cathepsin L-like protease	0.0065	0.0308	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0308	1
Brugia malayi	ecdysteroid receptor	0.056	0.3896	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0065	0.0308	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0251	0.1662	0.4265
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.014	0.0856	0.0788
Schistosoma mansoni	thyroid hormone receptor	0.0251	0.1662	0.1599
Brugia malayi	nuclear hormone receptor	0.0111	0.0643	0.1651
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0251	0.1662	0.1599
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0643	0.1651
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0462	0.1184
Brugia malayi	conserved hypotetical protein	0.0111	0.0643	0.1651
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0075	0.0191
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0251	0.1662	0.4265
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0251	0.1662	0.1599
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0643	0.1651
Brugia malayi	Nuclear hormone receptor-like 1	0.0251	0.1662	0.4265
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0643	0.1651
Leishmania major	cathepsin L-like protease	0.0065	0.0308	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0251	0.1662	0.1599
Loa Loa (eye worm)	hypothetical protein	0.014	0.0856	0.2198
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0643	0.1651
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0111	0.0643	0.1651
Echinococcus granulosus	ecdysone induced protein 78C	0.0251	0.1662	0.1599
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.014	0.0856	0.2198
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0251	0.1662	0.4265
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0251	0.1662	0.1599
Brugia malayi	nuclear receptor RXR	0.0111	0.0643	0.1651
Echinococcus granulosus	nuclear receptor nhr 48	0.0111	0.0643	0.0573

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 615733