Detailed information for compound 615767

Basic information

Technical information
  • TDR Targets ID: 615767
  • Name: 4-(furan-2-carbonyl)-3-hydroxy-5-(3-methoxyph enyl)-1-(5-methyl-1,2-oxazol-3-yl)-5H-pyrrol- 2-one
  • MW: 380.351 | Formula: C20H16N2O6
  • H donors: 1 H acceptors: 4 LogP: 3.1 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C1N(c2noc(c2)C)C(=O)C(=C1C(=O)c1ccco1)O
  • InChi: 1S/C20H16N2O6/c1-11-9-15(21-28-11)22-17(12-5-3-6-13(10-12)26-2)16(19(24)20(22)25)18(23)14-7-4-8-27-14/h3-10,17,24H,1-2H3
  • InChiKey: UDIDNFJXBQEPGW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(furan-2-carbonyl)-3-hydroxy-5-(3-methoxyphenyl)-1-(5-methylisoxazol-3-yl)-5H-pyrrol-2-one
  • 4-(2-furyl-oxomethyl)-3-hydroxy-5-(3-methoxyphenyl)-1-(5-methyl-3-isoxazolyl)-5H-pyrrol-2-one
  • 4-(furan-2-carbonyl)-3-hydroxy-5-(3-methoxyphenyl)-1-(5-methylisoxazol-3-yl)-3-pyrrolin-2-one
  • 4-furan-2-ylcarbonyl-3-hydroxy-5-(3-methoxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)-5H-pyrrol-2-one
  • STOCK3S-86191

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0314 0.3837 0.3749
Mycobacterium ulcerans esterase/lipase LipP 0.0033 0.014 0.0973
Schistosoma mansoni hypothetical protein 0.0268 0.3242 0.3648
Loa Loa (eye worm) hypothetical protein 0.0136 0.15 0.1379
Schistosoma mansoni RAR-like nuclear receptor 0.0314 0.3837 0.4349
Echinococcus granulosus muscleblind protein 0.0138 0.1525 0.1765
Loa Loa (eye worm) hypothetical protein 0.0049 0.0347 0.0209
Schistosoma mansoni microtubule-associated protein tau 0.0678 0.864 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.15 0.1379
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0047 0.0323 0.1405
Loa Loa (eye worm) inositol-1 0.0034 0.0152 0.0012
Mycobacterium tuberculosis Conserved protein 0.0033 0.014 0.056
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0152 0.0661
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0034 0.0152 0.1051
Mycobacterium tuberculosis Conserved protein 0.0033 0.014 0.056
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.014 0.0611
Schistosoma mansoni nuclear hormone receptor 0.0136 0.15 0.16
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0047 0.0323 0.1405
Loa Loa (eye worm) hypothetical protein 0.0314 0.3837 0.3749
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0044 0.0278 0.0406
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0271 0.327 1
Echinococcus granulosus microtubule associated protein 2 0.0678 0.864 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0314 0.3837 0.4441
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0177 0.2038 0.1924
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0044 0.0283 0.0145
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0314 0.3837 0.4441
Loa Loa (eye worm) hypothetical protein 0.0033 0.0142 0.0002
Echinococcus granulosus Nuclear hormone receptor HR96 0.0136 0.15 0.1736
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0034 0.0152 0.5
Mycobacterium ulcerans beta-lactamase 0.0033 0.014 0.0973
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0271 0.327 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0136 0.15 0.1736
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0314 0.3837 0.4349
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0314 0.3837 0.4349
Trichomonas vaginalis esterase, putative 0.0033 0.014 0.043
Loa Loa (eye worm) hypothetical protein 0.0177 0.2038 0.1924
Brugia malayi nuclear hormone receptor 0.0136 0.15 0.1379
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0323 0.0988
Echinococcus multilocularis FTZ F1 alpha 0.0314 0.3837 0.4441
Mycobacterium ulcerans hypothetical protein 0.0033 0.014 0.0973
Schistosoma mansoni thyroid hormone receptor 0.0314 0.3837 0.4349
Loa Loa (eye worm) mbt repeat family protein 0.0044 0.0283 0.0145
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0314 0.3837 0.3749
Loa Loa (eye worm) hypothetical protein 0.0136 0.15 0.1379
Loa Loa (eye worm) hypothetical protein 0.0064 0.055 0.0415
Echinococcus granulosus thyroid hormone receptor alpha 0.0573 0.7256 0.8398
Brugia malayi nuclear hormone receptor 0.0314 0.3837 0.3749
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1247 0.1123
Schistosoma mansoni retinoic acid receptor RXR 0.0314 0.3837 0.4349
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0314 0.3837 0.4441
Brugia malayi hypothetical protein 0.0136 0.15 0.1379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0314 0.3837 0.3749
Schistosoma mansoni nuclear hormone receptor 0.0136 0.15 0.16
Mycobacterium tuberculosis Probable lipase LipD 0.0033 0.014 0.056
Loa Loa (eye worm) hypothetical protein 0.0177 0.2038 0.1924
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0314 0.3837 0.3749
Echinococcus granulosus mitogen activated protein kinase 3 0.0047 0.0323 0.0374
Mycobacterium tuberculosis Probable esterase LipL 0.0033 0.014 0.056
Schistosoma mansoni coup transcription factor 0.0314 0.3837 0.4349
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0136 0.15 0.1736
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0323 0.0215
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0314 0.3837 0.4349
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0033 0.014 0.056
Schistosoma mansoni nuclear receptor 0.0136 0.15 0.16
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0271 0.327 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0314 0.3837 0.3749
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0033 0.014 0.0973
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0271 0.327 1
Brugia malayi MH2 domain containing protein 0.0117 0.1247 0.1123
Echinococcus granulosus beta LACTamase domain containing family member 0.0033 0.014 0.0163
Brugia malayi nuclear receptor RXR 0.0177 0.2038 0.1924
Mycobacterium tuberculosis Probable lipase LipE 0.0033 0.014 0.056
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0314 0.3837 0.3749
Brugia malayi tailless protein 0.0136 0.15 0.1379
Loa Loa (eye worm) hypothetical protein 0.0177 0.2038 0.1924
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0314 0.3837 0.3749
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.014 0.043
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.014 0.0611
Echinococcus granulosus mitogen activated protein kinase 0.0047 0.0323 0.0374
Loa Loa (eye worm) hypothetical protein 0.006 0.049 0.0355
Schistosoma mansoni zinc finger protein 0.0136 0.15 0.16
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0271 0.327 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0136 0.15 0.1736
Loa Loa (eye worm) hypothetical protein 0.005 0.0364 0.0227
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0347 0.0209
Echinococcus granulosus inositol monophosphatase 1 0.0034 0.0152 0.0176
Loa Loa (eye worm) hypothetical protein 0.0136 0.15 0.1379
Schistosoma mansoni thyroid hormone receptor 0.0314 0.3837 0.4349
Schistosoma mansoni inositol monophosphatase 0.0034 0.0152 0.0013
Loa Loa (eye worm) hypothetical protein 0.0167 0.1905 0.179
Loa Loa (eye worm) hypothetical protein 0.0044 0.0283 0.0145
Mycobacterium tuberculosis Conserved protein 0.0033 0.014 0.056
Loa Loa (eye worm) hypothetical protein 0.0781 1 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0044 0.0283 0.0328
Loa Loa (eye worm) hypothetical protein 0.0136 0.15 0.1379
Echinococcus multilocularis thyroid hormone receptor alpha 0.0314 0.3837 0.4441
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0314 0.3837 0.4441
Schistosoma mansoni tsg101-related 0.0054 0.0408 0.0315
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0152 0.0661
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0136 0.15 0.1736
Giardia lamblia Fructose-bisphosphate aldolase 0.0271 0.327 1
Mycobacterium ulcerans lipase LipD 0.0033 0.014 0.0973
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0314 0.3837 0.4441
Brugia malayi hypothetical protein 0.0177 0.2038 0.1924
Echinococcus granulosus nuclear receptor nhr 48 0.0136 0.15 0.1736
Echinococcus granulosus SAM and MBT domain containing protein 0.0044 0.0283 0.0328
Brugia malayi conserved hypotetical protein 0.0136 0.15 0.1379
Schistosoma mansoni sex comb on midleg homolog 0.0044 0.0283 0.0168
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0314 0.3837 0.4441
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0136 0.15 0.1379
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0047 0.0323 0.1405
Loa Loa (eye worm) hypothetical protein 0.0136 0.15 0.1379
Loa Loa (eye worm) hypothetical protein 0.0314 0.3837 0.3749
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1247 0.1123
Echinococcus multilocularis histone acetyltransferase MYST2 0.005 0.0364 0.0421
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0177 0.2038 0.2232
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0314 0.3837 0.3749
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.014 0.043
Leishmania major hypothetical protein, conserved 0.0197 0.2299 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0314 0.3837 0.3749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0314 0.3837 0.3749
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0314 0.3837 0.4441
Loa Loa (eye worm) hypothetical protein 0.0314 0.3837 0.3749
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0152 0.0053
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0033 0.014 0.056
Loa Loa (eye worm) hypothetical protein 0.0136 0.15 0.1379
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0314 0.3837 0.4441
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0314 0.3837 0.3749
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0132 0.1444 0.5755
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.005 0.0364 0.0227
Schistosoma mansoni hypothetical protein 0.0033 0.0142 0.0002
Echinococcus granulosus FTZ F1 alpha 0.0314 0.3837 0.4441
Plasmodium vivax hypothetical protein, conserved 0.0033 0.014 0.5
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0271 0.327 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.15 0.1379
Schistosoma mansoni nuclear receptor 0.0136 0.15 0.16
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0314 0.3837 0.3749
Loa Loa (eye worm) hypothetical protein 0.0314 0.3837 0.3749
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0314 0.3837 0.4441
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0136 0.15 0.16
Trichomonas vaginalis hypothetical protein 0.0031 0.0114 0.035
Echinococcus multilocularis polycomb protein SCMH1 0.0044 0.0283 0.0328
Onchocerca volvulus 0.0044 0.0283 0.0145
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0034 0.0152 0.0623
Brugia malayi mbt repeat family protein 0.0044 0.0283 0.0145
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0314 0.3837 0.3749
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0314 0.3837 0.4441
Echinococcus multilocularis muscleblind protein 0.0138 0.1525 0.1765
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0323 0.0988
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0167 0.1905 0.179
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0177 0.2038 0.2232
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0177 0.2038 0.2359
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0136 0.15 0.1736
Trichomonas vaginalis inositol monophosphatase, putative 0.0034 0.0152 0.0464
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0136 0.15 0.16
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0314 0.3837 0.3749
Loa Loa (eye worm) hypothetical protein 0.012 0.1282 0.1158
Echinococcus multilocularis mitogen activated protein kinase 0.0047 0.0323 0.0374
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0047 0.0323 0.1405
Loa Loa (eye worm) hypothetical protein 0.0223 0.2644 0.254
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0047 0.0323 0.0185
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0323 0.0988
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0271 0.327 1
Brugia malayi nuclear receptor NHR-88 0.0314 0.3837 0.3749
Echinococcus granulosus Nuclear hormone receptor HR96 0.0136 0.15 0.1736
Brugia malayi Muscleblind-like protein 0.0138 0.1525 0.1404
Loa Loa (eye worm) hypothetical protein 0.0314 0.3837 0.3749
Echinococcus granulosus ecdysone induced protein 78C 0.0314 0.3837 0.4441
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0136 0.15 0.1379
Brugia malayi Steroid receptor seven-up type 2 0.0314 0.3837 0.3749
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0152 0.0661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0314 0.3837 0.3749
Schistosoma mansoni inositol monophosphatase 0.0034 0.0152 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0314 0.3837 0.3749
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0177 0.2038 0.2359
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0283 0.3436 0.3343
Loa Loa (eye worm) hypothetical protein 0.0136 0.15 0.1379
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0064 0.055 0.0637
Brugia malayi nuclear hormone receptor family member nhr-6 0.0136 0.15 0.1379
Echinococcus multilocularis inositol monophosphatase 1 0.0034 0.0152 0.0176
Echinococcus multilocularis nuclear receptor nhr 48 0.0136 0.15 0.1736
Brugia malayi N-terminal motif family protein 0.0167 0.1905 0.179
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0314 0.3837 0.4349
Schistosoma mansoni tsg101-related 0.0054 0.0408 0.0315
Echinococcus multilocularis neuropeptide receptor A26 0.0428 0.5347 0.6189
Loa Loa (eye worm) DR-78 0.0136 0.15 0.1379
Loa Loa (eye worm) hypothetical protein 0.0136 0.15 0.1379
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0314 0.3837 0.4441
Loa Loa (eye worm) hypothetical protein 0.0136 0.15 0.1379
Onchocerca volvulus Protein ultraspiracle homolog 0.0314 0.3837 0.3749
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.005 0.0364 0.0421
Brugia malayi nuclear receptor RXR 0.0136 0.15 0.1379
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.014 0.043
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0314 0.3837 0.3749
Brugia malayi photoreceptor-specific nuclear receptor 0.0314 0.3837 0.3749
Brugia malayi Nuclear hormone receptor E75 0.0136 0.15 0.1379
Loa Loa (eye worm) steroid hormone receptor 0.075 0.9593 0.9587
Brugia malayi nuclear hormone receptor family member odr-7 0.0136 0.15 0.1379
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0064 0.055 0.0637
Echinococcus granulosus polycomb protein SCMH1 0.0044 0.0283 0.0328
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0132 0.1444 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0314 0.3837 0.3749
Onchocerca volvulus 0.0136 0.15 0.1379
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0031 0.0105 0.0417
Schistosoma mansoni myelin transcription factor 1 myt1 0.005 0.0364 0.0263
Loa Loa (eye worm) nuclear hormone receptor 0.0136 0.15 0.1379
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.014 0.043
Echinococcus multilocularis beta LACTamase domain containing family member 0.0033 0.014 0.0163
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0034 0.0152 0.0464
Mycobacterium leprae conserved hypothetical protein 0.0033 0.014 0.0268
Treponema pallidum fructose-bisphosphate aldolase 0.0271 0.327 0.5
Schistosoma mansoni nuclear hormone receptor 0.0314 0.3837 0.4349
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0314 0.3837 0.4349
Loa Loa (eye worm) hypothetical protein 0.0138 0.1525 0.1404
Loa Loa (eye worm) hypothetical protein 0.0138 0.1525 0.1404
Loa Loa (eye worm) hypothetical protein 0.0177 0.2038 0.1924
Loa Loa (eye worm) hypothetical protein 0.0314 0.3837 0.3749
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0314 0.3837 0.3749
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0271 0.327 1
Echinococcus granulosus neuropeptide s receptor 0.0428 0.5347 0.6189
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0314 0.3837 0.4441
Leishmania major hypothetical protein, conserved 0.0033 0.014 0.0611
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0136 0.15 0.1379
Onchocerca volvulus 0.0314 0.3837 0.3749
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0314 0.3837 0.4441
Brugia malayi Nuclear hormone receptor-like 1 0.0177 0.2038 0.1924
Trypanosoma brucei hypothetical protein, conserved 0.0197 0.2299 1
Brugia malayi orphan nuclear receptor NR2E1 0.0136 0.15 0.1379
Loa Loa (eye worm) hypothetical protein 0.0136 0.15 0.1379
Brugia malayi steroid hormone receptor 0.075 0.9593 0.9587
Echinococcus multilocularis muscleblind protein 1 0.0138 0.1525 0.1765
Loa Loa (eye worm) MBCTL1 0.005 0.0364 0.0227
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0213 0.251 1
Onchocerca volvulus Bile acid receptor homolog 0.0781 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0271 0.327 1
Brugia malayi hypothetical protein 0.0177 0.2038 0.1924
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0314 0.3837 0.4349
Mycobacterium leprae Probable lipase LipE 0.0033 0.014 0.0268
Brugia malayi hypothetical protein 0.0136 0.15 0.1379
Loa Loa (eye worm) hypothetical protein 0.0136 0.15 0.1379
Trypanosoma brucei protein kinase, putative 0.0047 0.0323 0.0846
Loa Loa (eye worm) nuclear receptor NHR-67 0.0136 0.15 0.1379
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0047 0.0323 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0047 0.0323 0.1405
Trypanosoma cruzi hypothetical protein, conserved 0.0197 0.2299 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0136 0.15 0.1736
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0047 0.0323 0.1405
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0347 0.0209
Brugia malayi MAP kinase sur-1 0.0047 0.0323 0.0185
Echinococcus granulosus neuropeptide receptor A26 0.0428 0.5347 0.6189
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.005 0.0364 0.0421
Loa Loa (eye worm) hypothetical protein 0.0314 0.3837 0.3749
Loa Loa (eye worm) hypothetical protein 0.0177 0.2038 0.1924
Onchocerca volvulus 0.0136 0.15 0.1379
Brugia malayi hypothetical protein 0.0064 0.055 0.0415
Brugia malayi nuclear receptor NHR-67 0.0136 0.15 0.1379
Brugia malayi Inositol-1 0.0034 0.0152 0.0012
Echinococcus multilocularis mitogen activated protein kinase 3 0.0047 0.0323 0.0374
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0323 0.0988
Echinococcus multilocularis neuropeptide s receptor 0.0428 0.5347 0.6189
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0314 0.3837 0.3749
Echinococcus multilocularis ecdysone induced protein 78C 0.0314 0.3837 0.4441
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0103 0.1063 0.1085
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0047 0.0323 0.0846
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.014 0.043
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0136 0.15 0.1379
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0314 0.3837 0.3749
Brugia malayi ecdysone receptor 0.0136 0.15 0.1379
Brugia malayi mbt repeat family protein 0.0044 0.0283 0.0145
Brugia malayi Nuclear hormone receptor-like 1 0.0177 0.2038 0.1924
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0174 0.1996 0.231
Mycobacterium tuberculosis Probable hydrolase 0.0033 0.014 0.056
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0132 0.1444 1
Brugia malayi Nuclear hormone receptor E75 0.0136 0.15 0.1379
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0044 0.0283 0.0168
Trypanosoma cruzi hypothetical protein, conserved 0.0197 0.2299 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0314 0.3837 0.4349
Schistosoma mansoni nuclear receptor nhr-48 0.0136 0.15 0.16
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0034 0.0152 0.0464
Echinococcus granulosus histone acetyltransferase MYST2 0.005 0.0364 0.0421
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0142 0.0002
Echinococcus multilocularis microtubule associated protein 2 0.0678 0.864 1
Brugia malayi nuclear receptor NHR-88 0.0136 0.15 0.1379
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0347 0.0209
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0174 0.1996 0.231
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0136 0.15 0.1736
Schistosoma mansoni tsg101-related 0.0044 0.0278 0.0162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0271 0.327 1
Schistosoma mansoni sex comb on midleg homolog 0.0044 0.0283 0.0168
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0033 0.014 0.056
Brugia malayi Nuclear hormone receptor-like 1 0.0314 0.3837 0.3749

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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