Detailed information for compound 615839

Basic information

Technical information
  • TDR Targets ID: 615839
  • Name: 1-(2-dimethylaminoethyl)-3-hydroxy-4-(5-methy lfuran-2-carbonyl)-5-(4-prop-2-enoxyphenyl)-5 H-pyrrol-2-one
  • MW: 410.463 | Formula: C23H26N2O5
  • H donors: 1 H acceptors: 3 LogP: 3.44 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOc1ccc(cc1)C1N(CCN(C)C)C(=O)C(=C1C(=O)c1ccc(o1)C)O
  • InChi: 1S/C23H26N2O5/c1-5-14-29-17-9-7-16(8-10-17)20-19(21(26)18-11-6-15(2)30-18)22(27)23(28)25(20)13-12-24(3)4/h5-11,20,27H,1,12-14H2,2-4H3
  • InChiKey: FAMODBAOOGKSET-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(4-allyloxyphenyl)-1-(2-dimethylaminoethyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-5H-pyrrol-2-one
  • 5-(4-allyloxyphenyl)-1-(2-dimethylaminoethyl)-3-hydroxy-4-[(5-methyl-2-furyl)-oxomethyl]-5H-pyrrol-2-one
  • 5-(4-allyloxyphenyl)-1-(2-dimethylaminoethyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-3-pyrrolin-2-one
  • 1-(2-dimethylaminoethyl)-3-hydroxy-4-(5-methylfuran-2-yl)carbonyl-5-(4-prop-2-enoxyphenyl)-5H-pyrrol-2-one
  • STOCK3S-90489

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0021 0.0065
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Loa Loa (eye worm) hypothetical protein 0.0055 0.0072 0.0072
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0107 0.0191 0.2067
Schistosoma mansoni lamin 0.006 0.0084 0.0255
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0107 0.0191 0.2067
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0107 0.0191 0.2067
Trypanosoma brucei DNA topoisomerase ii 0.0107 0.0191 0.0312
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0107 0.0191 0.2067
Trypanosoma cruzi heat shock protein 85, putative 0.0526 0.1148 0.2813
Loa Loa (eye worm) heat shock protein 90 0.0526 0.1148 0.1148
Brugia malayi hypothetical protein 0.0055 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0028 0.001 0.001
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0072 0.0445
Schistosoma mansoni intermediate filament proteins 0.006 0.0084 0.0255
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0021 0.0065
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0067 0.0067
Brugia malayi Probable DNA topoisomerase II 0.0107 0.0191 0.0191
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0664 0.1461 0.3741
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0067 0.0067
Trypanosoma cruzi heat shock protein, putative 0.0216 0.0439 0.0959
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0107 0.0191 0.0312
Schistosoma mansoni smad1 5 8 and 0.0053 0.0066 0.02
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0664 0.1461 0.3633
Trypanosoma brucei Heat shock protein 83, putative 0.0526 0.1148 0.2813
Schistosoma mansoni endoplasmin 0.0526 0.1148 0.3463
Leishmania major heat shock protein, putative 0.0216 0.0439 0.1113
Plasmodium vivax heat shock protein 90, putative 0.0216 0.0439 0.3704
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0006
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1731 0.3897 1
Onchocerca volvulus 0.006 0.0084 0.1555
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0067 0.0067
Entamoeba histolytica heat shock protein 90, putative 0.0526 0.1148 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.0664 0.1461 0.4409
Brugia malayi MH2 domain containing protein 0.0772 0.1709 0.1709
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0107 0.0191 0.2067
Loa Loa (eye worm) MH1 domain-containing protein 0.0053 0.0066 0.0066
Giardia lamblia Heat shock protein HSP 90-alpha 0.0419 0.0903 0.7443
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Onchocerca volvulus 0.0053 0.0067 0.1241
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0107 0.0191 0.2067
Loa Loa (eye worm) MH2 domain-containing protein 0.0772 0.1709 0.1709
Schistosoma mansoni heat shock protein 0.0216 0.0439 0.1323
Plasmodium vivax DNA topoisomerase II, putative 0.0107 0.0191 0.1505
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0084 0.0084
Trypanosoma cruzi DNA topoisomerase II, putative 0.0107 0.0191 0.0312
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0107 0.0191 0.111
Plasmodium falciparum heat shock protein 90, putative 0.0216 0.0439 0.341
Trichomonas vaginalis set domain proteins, putative 0.0261 0.0542 0.3674
Schistosoma mansoni smad1 5 8 and 0.0053 0.0066 0.02
Trichomonas vaginalis heat shock protein, putative 0.0419 0.0903 0.7443
Toxoplasma gondii Hsp90 domain-containing protein 0.0216 0.0439 0.3704
Echinococcus granulosus lamin 0.006 0.0084 0.0255
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0216 0.0439 0.8085
Brugia malayi MH1 domain containing protein 0.0029 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0067
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0107 0.0191 0.1505
Loa Loa (eye worm) hypothetical protein 0.0075 0.0117 0.0117
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0025 0.0076
Echinococcus granulosus heat shock protein 90 0.0419 0.0903 0.2725
Onchocerca volvulus 0.0053 0.0067 0.1241
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0107 0.0191 0.0576
Loa Loa (eye worm) hypothetical protein 0.006 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0013
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0067 0.0067
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0664 0.1461 0.3633
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0021 0.0065
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0107 0.0191 0.3521
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0117 0.0117
Trypanosoma brucei heat shock protein 90, putative 0.0526 0.1148 0.2813
Brugia malayi Pre-SET motif family protein 0.023 0.047 0.047
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0107 0.0191 0.0312
Echinococcus multilocularis GPCR, family 2 0.0035 0.0025 0.0076
Toxoplasma gondii DNA topoisomerase 2, putative 0.0107 0.0191 0.1505
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0664 0.1461 0.3633
Schistosoma mansoni hypothetical protein 0.0035 0.0025 0.0076
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0613 0.1344 0.1344
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0013 0.0039
Brugia malayi MH2 domain containing protein 0.0053 0.0066 0.0066
Echinococcus multilocularis mitogen activated protein kinase 14 0.0664 0.1461 0.4409
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0419 0.0903 0.2307
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.4406 1 1
Schistosoma mansoni hypothetical protein 0.0025 0.0003 0.0008
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0419 0.0903 0.2725
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0419 0.0903 1
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0021 0.0065
Brugia malayi MH2 domain containing protein 0.0053 0.0066 0.0066
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.047 0.047
Mycobacterium leprae Probable two-component sensor kinase 0.0107 0.0191 0.2067
Mycobacterium ulcerans two component regulator - sensor kinase 0.0107 0.0191 0.2067
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0067 0.0067
Giardia lamblia Grp94/Hsp90 0.0419 0.0903 0.7443
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0195 0.0195
Echinococcus multilocularis mitogen activated protein kinase 11 0.0664 0.1461 0.4409
Trypanosoma cruzi DNA topoisomerase II, putative 0.0107 0.0191 0.0312
Brugia malayi Pre-SET motif family protein 0.0033 0.0021 0.0021
Plasmodium falciparum heat shock protein 90, putative 0.0216 0.0439 0.341
Mycobacterium tuberculosis Conserved protein 0.0107 0.0191 0.2067
Trypanosoma cruzi heat shock protein 90, putative 0.0311 0.0655 0.1526
Onchocerca volvulus Chorion peroxidase homolog 0.0053 0.0067 0.1241
Echinococcus granulosus microtubule associated protein 2 0.1476 0.3314 1
Onchocerca volvulus Peroxidase homolog 0.0053 0.0067 0.1241
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Loa Loa (eye worm) hypothetical protein 0.0033 0.0021 0.0021
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0107 0.0191 0.0576
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0025 0.0025
Onchocerca volvulus Peroxidase homolog 0.0053 0.0067 0.1241
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.002 0.002
Loa Loa (eye worm) nuclear factor I 0.0029 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0006
Schistosoma mansoni heat shock protein 0.0526 0.1148 0.3463
Schistosoma mansoni smad1 5 8 and 0.0053 0.0066 0.02
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0067
Loa Loa (eye worm) intermediate filament protein 0.006 0.0084 0.0084
Onchocerca volvulus 0.0053 0.0067 0.1241
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1731 0.3897 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0107 0.0191 0.0191
Mycobacterium tuberculosis Possible two component sensor kinase 0.0107 0.0191 0.2067
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0003 0.0008
Echinococcus multilocularis heat shock protein 90 0.0526 0.1148 0.3463
Mycobacterium ulcerans putative regultory protein 0.0107 0.0191 0.2067
Trypanosoma cruzi heat shock protein 90, putative 0.0419 0.0903 0.2174
Echinococcus granulosus mitogen activated protein kinase 14 0.0664 0.1461 0.4409
Onchocerca volvulus Peroxidasin homolog 0.0053 0.0067 0.1241
Trypanosoma cruzi heat shock protein 85, putative 0.0526 0.1148 0.2813
Trypanosoma cruzi heat shock protein 85, putative 0.0526 0.1148 0.2813
Entamoeba histolytica heat shock protein 90, putative 0.0526 0.1148 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0664 0.1461 0.4409
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0021 0.0065
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0006 0.0006
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Giardia lamblia Heat shock protein HSP 90-alpha 0.0526 0.1148 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0191 0.0191
Brugia malayi Peroxidasin 0.0053 0.0067 0.0067
Echinococcus multilocularis lamin 0.006 0.0084 0.0255
Trypanosoma cruzi heat shock protein 90, putative 0.0526 0.1148 0.2813
Mycobacterium leprae Probable two component sensor kinase MprB 0.0107 0.0191 0.2067
Schistosoma mansoni serine/threonine protein kinase 0.0613 0.1344 0.4055
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0419 0.0903 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0035 0.0025 0.0076
Brugia malayi MH1 domain containing protein 0.0053 0.0066 0.0066
Schistosoma mansoni microtubule-associated protein tau 0.1476 0.3314 1
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0613 0.1344 0.4055
Echinococcus granulosus mitogen activated protein kinase 11 0.0664 0.1461 0.4409
Trichomonas vaginalis heat shock protein, putative 0.0323 0.0683 0.5145
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0107 0.0191 0.0312
Mycobacterium tuberculosis Probable two component sensor kinase 0.0107 0.0191 0.2067
Plasmodium falciparum DNA gyrase subunit B 0.0107 0.0191 0.111
Trichomonas vaginalis heat shock protein, putative 0.0526 0.1148 1
Plasmodium vivax heat shock protein, putative 0.0216 0.0439 0.3704
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Echinococcus granulosus heat shock protein 90 0.0526 0.1148 0.3463
Loa Loa (eye worm) hypothetical protein 0.0028 0.001 0.001
Loa Loa (eye worm) TOPoisomerase family member 0.0107 0.0191 0.0191
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0107 0.0191 0.0312
Trypanosoma brucei heat shock protein, putative 0.0526 0.1148 0.2813
Echinococcus multilocularis microtubule associated protein 2 0.1476 0.3314 1
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0107 0.0191 0.2067
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0072 0.0445
Echinococcus granulosus peroxidasin 0.0053 0.0067 0.0203
Schistosoma mansoni pyruvate dehydrogenase 0.0107 0.0191 0.0576
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0107 0.0191 0.2067
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Trypanosoma brucei heat shock protein, putative 0.0526 0.1148 0.2813
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0053 0.0066 0.02
Plasmodium falciparum DNA topoisomerase 2 0.0107 0.0191 0.111
Trichomonas vaginalis heat shock protein, putative 0.0419 0.0903 0.7443
Echinococcus multilocularis Smad4 0.0053 0.0066 0.02
Brugia malayi hypothetical protein 0.0053 0.0067 0.0067
Echinococcus granulosus mothers against decapentaplegic 5 0.0053 0.0066 0.02
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0006 0.0006
Echinococcus granulosus c-Jun N-terminal kinases 0.0613 0.1344 0.4055
Toxoplasma gondii heat shock protein 75, putative 0.0216 0.0439 0.3704
Onchocerca volvulus 0.0026 0.0006 0.0101
Echinococcus granulosus heat shock protein 0.0526 0.1148 0.3463
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0216 0.0439 0.3792
Echinococcus granulosus smad 0.0053 0.0066 0.02
Loa Loa (eye worm) hypothetical protein 0.0107 0.0191 0.0191
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Echinococcus granulosus lamin dm0 0.006 0.0084 0.0255
Brugia malayi Stress-activated protein kinase jnk-1 0.0613 0.1344 0.1344
Schistosoma mansoni smad 0.0053 0.0066 0.02
Schistosoma mansoni DNA topoisomerase II 0.0107 0.0191 0.0576
Loa Loa (eye worm) hypothetical protein 0.0109 0.0195 0.0195
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Brugia malayi P38 map kinase family protein 2 0.0664 0.1461 0.1461
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0216 0.0439 0.1323
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0107 0.0191 0.2067
Trypanosoma brucei heat shock protein, putative 0.0526 0.1148 0.2813
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0195 0.0195
Onchocerca volvulus 0.0033 0.0021 0.0395
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0107 0.0191 0.2067
Schistosoma mansoni peroxidasin 0.0053 0.0067 0.0203
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0107 0.0191 0.0576
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0003 0.0008
Schistosoma mansoni hypothetical protein 0.0075 0.0117 0.0352
Trypanosoma brucei heat shock protein, putative 0.0526 0.1148 0.2813
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0191 0.1505
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0067
Echinococcus granulosus Smad4 0.0053 0.0066 0.02
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0107 0.0191 0.2067
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0107 0.0191 0.2067
Schistosoma mansoni Smad4 0.0053 0.0066 0.02
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0053 0.0066 0.02
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0067
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0107 0.0191 0.0576
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0021 0.0065
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0107 0.0191 0.2067
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0107 0.0191 0.1505
Echinococcus multilocularis lamin dm0 0.006 0.0084 0.0255
Plasmodium falciparum endoplasmin, putative 0.0323 0.0683 0.5684
Trypanosoma brucei developmentally regulated phosphoprotein 0.0107 0.0191 0.0312
Onchocerca volvulus Peroxidasin homolog 0.0053 0.0067 0.1241
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0067
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0025 0.0076
Trichomonas vaginalis heat shock protein, putative 0.0419 0.0903 0.7443
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0107 0.0191 0.2067
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0107 0.0191 0.3521
Echinococcus multilocularis peroxidasin 0.0053 0.0067 0.0203
Schistosoma mansoni hypothetical protein 0.0035 0.0025 0.0076
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0067
Mycobacterium ulcerans two component sensor kinase MprB 0.0107 0.0191 0.2067
Leishmania major DNA topoisomerase ii 0.0107 0.0191 0.0477
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0419 0.0903 0.0726
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0107 0.0191 0.2067
Toxoplasma gondii heat shock protein 90, putative 0.0526 0.1148 1
Trypanosoma brucei heat shock protein 84, putative 0.0216 0.0439 0.0959
Trypanosoma brucei heat shock protein, putative 0.0526 0.1148 0.2813
Loa Loa (eye worm) hypothetical protein 0.0107 0.0191 0.0191
Echinococcus multilocularis heat shock protein 90 0.0419 0.0903 0.2725
Brugia malayi MH1 domain containing protein 0.0029 0.0013 0.0013
Trypanosoma brucei heat shock protein 90, putative 0.0526 0.1148 0.2813
Leishmania major hypothetical protein, conserved 0.0055 0.0072 0.017
Loa Loa (eye worm) MH2 domain-containing protein 0.0053 0.0066 0.0066
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0195 0.0195
Loa Loa (eye worm) animal heme peroxidase 0.0053 0.0067 0.0067
Brugia malayi MH1 domain containing protein 0.0053 0.0066 0.0066
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0019 0.0056
Toxoplasma gondii heat shock protein HSP90 0.0526 0.1148 1
Plasmodium vivax heat shock protein 86, putative 0.0526 0.1148 1
Brugia malayi hypothetical protein 0.0035 0.0027 0.0027
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0067 0.0067
Onchocerca volvulus 0.006 0.0084 0.1555
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Schistosoma mansoni endoplasmin 0.0526 0.1148 0.3463
Onchocerca volvulus Dual oxidase homolog 0.0053 0.0067 0.1241
Brugia malayi Endoplasmin precursor 0.0526 0.1148 0.1148
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0067
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0664 0.1461 0.1461
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0021 0.0065
Loa Loa (eye worm) hypothetical protein 0.0029 0.0013 0.0013
Echinococcus multilocularis heat shock protein 0.0526 0.1148 0.3463
Echinococcus granulosus GPCR family 2 0.0035 0.0025 0.0076
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0107 0.0191 0.0312
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0107 0.0191 0.0191
Trypanosoma cruzi heat shock protein 85, putative 0.0419 0.0903 0.2174
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0107 0.0191 0.2067
Loa Loa (eye worm) heat shock protein 75 0.0216 0.0439 0.0439
Mycobacterium ulcerans heat shock protein 90 0.0419 0.0903 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.002 0.002
Treponema pallidum heat shock protein 90 0.0419 0.0903 1
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Echinococcus granulosus intermediate filament protein 0.006 0.0084 0.0255
Trypanosoma brucei heat shock protein, putative 0.0526 0.1148 0.2813
Schistosoma mansoni heat shock protein 0.0526 0.1148 0.3463
Leishmania major mitochondrial DNA topoisomerase II 0.0107 0.0191 0.0477
Mycobacterium ulcerans DNA gyrase subunit B 0.0107 0.0191 0.2067
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0107 0.0191 0.5
Chlamydia trachomatis DNA gyrase subunit B 0.0107 0.0191 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0025 0.0025
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0107 0.0191 0.0312
Leishmania major developmentally regulated phosphoprotein-like protein 0.0107 0.0191 0.0477
Trichomonas vaginalis endoplasmin, putative 0.0323 0.0683 0.5145
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0107 0.0191 0.2067
Echinococcus multilocularis musashi 0.006 0.0084 0.0255
Brugia malayi Blistered cuticle protein 3 0.0053 0.0067 0.0067
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1731 0.3897 1
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0107 0.0191 0.2067
Leishmania major malonyl-coa decarboxylase-like protein 0.1731 0.3897 1
Onchocerca volvulus 0.0261 0.0542 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0082 0.0082
Plasmodium vivax endoplasmin, putative 0.0526 0.1148 1
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0107 0.0191 0.0576
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0006 0.0006
Trypanosoma brucei heat shock protein, putative 0.0526 0.1148 0.2813
Echinococcus multilocularis mothers against decapentaplegic 5 0.0053 0.0066 0.02
Echinococcus multilocularis endoplasmin 0.0419 0.0903 0.2725
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0067 0.0067
Brugia malayi Smad1 0.0053 0.0066 0.0066
Loa Loa (eye worm) endoplasmin 0.0526 0.1148 0.1148
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0067
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0025 0.0076
Leishmania major hypothetical protein, conserved 0.0107 0.0191 0.0477
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0107 0.0191 0.3521
Brugia malayi kinase, mitochondrial precursor 0.0107 0.0191 0.0191
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0084 0.0084
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0107 0.0191 0.2067
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0107 0.0191 0.1505
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0067
Schistosoma mansoni peroxidasin 0.0053 0.0067 0.0203
Loa Loa (eye worm) transcription factor SMAD2 0.0772 0.1709 0.1709
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0216 0.0439 0.1323
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0025
Trichomonas vaginalis heat shock protein, putative 0.0216 0.0439 0.2588
Entamoeba histolytica DNA topoisomerase II, putative 0.0107 0.0191 0.1624
Brugia malayi Hsp90 protein 0.0216 0.0439 0.0439
Chlamydia trachomatis DNA gyrase subunit B 0.0107 0.0191 0.5
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0107 0.0191 0.2067
Schistosoma mansoni lamin 0.006 0.0084 0.0255
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0107 0.0191 0.0312
Brugia malayi Animal haem peroxidase family protein 0.0053 0.0067 0.0067
Loa Loa (eye worm) Smad1 0.0053 0.0066 0.0066
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0025 0.0076
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0067
Trypanosoma cruzi Heat shock protein 83, putative 0.0526 0.1148 0.2813
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0067
Leishmania major heat shock protein 83-1 0.0526 0.1148 0.2935
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.4406 1 1
Brugia malayi heat shock protein 90 0.0526 0.1148 0.1148
Echinococcus multilocularis smad 0.0053 0.0066 0.02
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0067
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0107 0.0191 0.2067
Echinococcus granulosus TGF beta signal transducer SmadC 0.0053 0.0066 0.02
Brugia malayi intermediate filament protein 0.006 0.0084 0.0084
Trypanosoma brucei heat shock protein, putative 0.0526 0.1148 0.2813
Loa Loa (eye worm) hypothetical protein 0.0053 0.0067 0.0067
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0013 0.0039
Plasmodium vivax DNA gyrase subunit B, putative 0.0107 0.0191 0.1505
Echinococcus granulosus endoplasmin 0.0419 0.0903 0.2725
Plasmodium falciparum heat shock protein 90 0.0526 0.1148 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0053 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0035 0.0025 0.0076

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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