TDR Targets

Basic information

Technical information

TDR Targets ID: 615899
Name: ethyl 1-(3,4-dichlorophenyl)-4-hydroxypyrazol e-3-carboxylate
MW: 301.125 | Formula: C12H10Cl2N2O3
H donors: 1 H acceptors: 3 LogP: 3.9 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1nn(cc1O)c1ccc(c(c1)Cl)Cl
InChi: 1S/C12H10Cl2N2O3/c1-2-19-12(18)11-10(17)6-16(15-11)7-3-4-8(13)9(14)5-7/h3-6,17H,2H2,1H3
InChiKey: YXYAKMPHOMSLKD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 1-(3,4-dichlorophenyl)-4-hydroxy-pyrazole-3-carboxylate
1-(3,4-dichlorophenyl)-4-hydroxy-3-pyrazolecarboxylic acid ethyl ester
1-(3,4-dichlorophenyl)-4-hydroxy-pyrazole-3-carboxylic acid ethyl ester
Oprea1_749867
ZINC01465565

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0165	0.6827
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0259	0.182	0.182
Onchocerca volvulus		0.0114	0.0735	0.1526
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0259	0.182	0.4172
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0259	0.182	0.182
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0213	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0735	0.1685
Brugia malayi	conserved hypotetical protein	0.0114	0.0735	0.1685
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0082	0.0187
Echinococcus multilocularis	nuclear receptor nhr 48	0.0114	0.0735	0.0735
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0145	0.097	0.097
Echinococcus multilocularis	FTZ F1 alpha	0.0259	0.182	0.182
Schistosoma mansoni	thyroid hormone receptor	0.0259	0.182	0.182
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0114	0.0735	0.0735
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0114	0.0735	0.0735
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0259	0.182	0.182
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0071	0.0415	0.0951
Loa Loa (eye worm)	hypothetical protein	0.0259	0.182	0.4172
Brugia malayi	Fli-1 protein	0.0215	0.1494	0.3425
Loa Loa (eye worm)	hypothetical protein	0.0145	0.097	0.2223
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0259	0.182	0.4172
Echinococcus multilocularis	Smad4	0.0016	0.0004	0.0004
Schistosoma mansoni	nuclear hormone receptor	0.0114	0.0735	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0735	0.1685
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0259	0.182	0.182
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0114	0.0735	0.0735
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0129	0.444
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0082	0.0187
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0259	0.182	0.182
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0146	0.556
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0259	0.182	0.4172
Echinococcus granulosus	FTZ F1 alpha	0.0259	0.182	0.182
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0114	0.0735	0.0735
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0259	0.182	0.182
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0259	0.182	0.182
Giardia lamblia	GTOR	0.0044	0.0213	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0259	0.182	0.4172
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0259	0.182	0.4172
Echinococcus multilocularis	GA binding protein alpha chain	0.0071	0.0415	0.0415
Brugia malayi	ecdysteroid receptor	0.0598	0.4363	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0114	0.0735	0.0735
Brugia malayi	Ets-domain containing protein	0.0071	0.0415	0.0951
Brugia malayi	MH1 domain containing protein	0.0016	0.0004	0.0009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0146	0.556
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0146	0.556
Echinococcus granulosus	thyroid hormone receptor alpha	0.0431	0.311	0.311
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0213	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0259	0.182	0.4172
Brugia malayi	photoreceptor-specific nuclear receptor	0.0259	0.182	0.4172
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0016	0.0004	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0129	0.444
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0259	0.182	0.182
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0249	0.0571
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0259	0.182	0.182
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0134	0.0307
Schistosoma mansoni	coup transcription factor	0.0259	0.182	0.182
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0114	0.0735	0.0735
Echinococcus granulosus	nuclear receptor nhr 48	0.0114	0.0735	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0735	0.1685
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0246	0.0564
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0062	0.0018
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0259	0.182	0.406
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0259	0.182	0.182
Brugia malayi	hypothetical protein	0.0114	0.0735	0.1685
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0134	0.0307
Onchocerca volvulus		0.0048	0.0246	0.0384
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0259	0.182	0.182
Schistosoma mansoni	nuclear receptor	0.0114	0.0735	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0735	0.1685
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0259	0.182	0.4172
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.0004	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0259	0.182	0.4172
Onchocerca volvulus		0.0114	0.0735	0.1526
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0259	0.182	0.4172
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0044	0.0213	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0234	0.1635	0.3747
Echinococcus granulosus	smad	0.0016	0.0004	0.0004
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0044	0.0213	1
Brugia malayi	Nuclear hormone receptor E75	0.0114	0.0735	0.1685
Schistosoma mansoni	ets-related	0.0215	0.1494	0.1494
Brugia malayi	Steroid receptor seven-up type 2	0.0259	0.182	0.4172
Echinococcus granulosus	ecdysone induced protein 78C	0.0259	0.182	0.182
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0114	0.0735	0.1526
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0114	0.0735	0.0735
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0259	0.182	0.4172
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0044	0.0213	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0081	0.1267
Schistosoma mansoni	thyroid hormone receptor	0.0259	0.182	0.182
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0259	0.182	0.4172
Brugia malayi	MH2 domain containing protein	0.0016	0.0004	0.0009
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0259	0.182	0.4172
Brugia malayi	nuclear receptor NHR-88	0.0114	0.0735	0.1685
Loa Loa (eye worm)	steroid hormone receptor	0.0576	0.4195	0.9615
Loa Loa (eye worm)	hypothetical protein	0.0259	0.182	0.4172
Brugia malayi	hypothetical protein	0.0145	0.097	0.2223
Echinococcus granulosus	Smad4	0.0016	0.0004	0.0004
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0004	0.0004
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0145	0.097	0.097
Brugia malayi	Ets-domain containing protein	0.0071	0.0415	0.0951
Brugia malayi	steroid hormone receptor	0.0576	0.4195	0.9615
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0078	0.0179
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0081	0.1267
Schistosoma mansoni	nuclear receptor	0.0114	0.0735	0.0735
Echinococcus granulosus	intermediate filament protein	0.0026	0.0082	0.0082
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0246	0.0246
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0259	0.182	0.182
Loa Loa (eye worm)	DR-78	0.0114	0.0735	0.1685
Brugia malayi	MH2 domain containing protein	0.0016	0.0004	0.0009
Brugia malayi	nuclear hormone receptor	0.0259	0.182	0.4172
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0213	0.0489
Schistosoma mansoni	lamin	0.0026	0.0082	0.0082
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0082	0.0187
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0145	0.097	0.097
Echinococcus multilocularis	lamin	0.0026	0.0082	0.0082
Loa Loa (eye worm)	nuclear hormone receptor	0.0114	0.0735	0.1685
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0259	0.182	0.4172
Brugia malayi	Nuclear hormone receptor-like 1	0.0145	0.097	0.2223
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0114	0.0735	0.1685
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0114	0.0735	0.0735
Brugia malayi	ecdysone receptor	0.0114	0.0735	0.1685
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0259	0.182	0.182
Loa Loa (eye worm)	hypothetical protein	0.0259	0.182	0.4172
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0145	0.097	0.2223
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0016	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0735	0.1685
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0259	0.182	0.4172
Schistosoma mansoni	lamin	0.0026	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0735	0.1685
Onchocerca volvulus	Bile acid receptor homolog	0.0598	0.4363	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0044	0.0213	0.0213
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0004	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0079	0.1138
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0735	0.1685
Brugia malayi	MH1 domain containing protein	0.0016	0.0004	0.0009
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0044	0.0213	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0213	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0145	0.097	0.2223
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0259	0.182	0.4172
Schistosoma mansoni	gabp alpha	0.0071	0.0415	0.0415
Echinococcus multilocularis	smad	0.0016	0.0004	0.0004
Brugia malayi	Smad1	0.0016	0.0004	0.0009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0129	0.444
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0044	0.0213	0.0213
Echinococcus granulosus	GA binding protein alpha chain	0.0071	0.0415	0.0415
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0114	0.0735	0.1685
Loa Loa (eye worm)	transcription factor SMAD2	0.0234	0.1635	0.3747
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0044	0.0213	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0259	0.182	0.182
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0259	0.182	0.182
Schistosoma mansoni	smad	0.0016	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0735	0.1685
Brugia malayi	MH2 domain containing protein	0.0234	0.1635	0.3747
Loa Loa (eye worm)	fli-1 protein	0.0215	0.1494	0.3425
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0735	0.1685
Schistosoma mansoni	zinc finger protein	0.0114	0.0735	0.0735
Brugia malayi	nuclear receptor NHR-67	0.0114	0.0735	0.1685
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0259	0.182	0.182
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0259	0.182	0.182
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0213	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0249	0.0571
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0259	0.182	0.182
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.0004	0.0009
Schistosoma mansoni	hypothetical protein	0.0033	0.0134	0.0134
Echinococcus multilocularis	musashi	0.0026	0.0082	0.0082
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0016	0.0004	0.0004
Echinococcus granulosus	lamin dm0	0.0026	0.0082	0.0082
Echinococcus multilocularis	tumor protein p63	0.033	0.2354	0.2354
Loa Loa (eye worm)	hypothetical protein	0.0259	0.182	0.4172
Loa Loa (eye worm)	hypothetical protein	0.0259	0.182	0.4172
Echinococcus granulosus	lamin	0.0026	0.0082	0.0082
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0035	0.0146	0.6514
Brugia malayi	hypothetical protein	0.0145	0.097	0.2223
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0735	0.1685
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0259	0.182	0.4172
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0259	0.182	0.182
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0146	0.556
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0114	0.0735	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0338	0.0775
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0259	0.182	0.182
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0259	0.182	0.4172
Schistosoma mansoni	nuclear receptor nhr-48	0.0114	0.0735	0.0735
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0259	0.182	0.4172
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0146	0.556
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0105	0.2856
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0259	0.182	0.4172
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0735	0.1685
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0129	0.444
Loa Loa (eye worm)	hypothetical protein	0.0259	0.182	0.4172
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0259	0.182	0.4172
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0021	0.004	0.0985
Brugia malayi	orphan nuclear receptor NR2E1	0.0114	0.0735	0.1685
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0082	0.0082
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0259	0.182	0.4172
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0044	0.0213	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0082	0.0187
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0098	0.2387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0079	0.1138
Echinococcus multilocularis	lamin dm0	0.0026	0.0082	0.0082
Brugia malayi	nuclear receptor RXR	0.0114	0.0735	0.1685
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0259	0.182	0.182
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0062	0.0018
Schistosoma mansoni	nuclear hormone receptor	0.0114	0.0735	0.0735
Brugia malayi	intermediate filament protein	0.0026	0.0082	0.0187
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0114	0.0735	0.1685
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0114	0.0735	0.0735
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0044	0.0213	0.0213
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0249	0.0571
Loa Loa (eye worm)	Smad1	0.0016	0.0004	0.0009
Brugia malayi	nuclear receptor NHR-88	0.0259	0.182	0.4172
Schistosoma mansoni	microtubule-associated protein tau	0.1351	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0145	0.097	0.2223
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0033	0.0129	0.5
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0735	0.1685
Echinococcus granulosus	mothers against decapentaplegic 5	0.0016	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0114	0.0735	0.1685
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0145	0.097	0.2223
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0259	0.182	0.182
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0044	0.0213	0.5
Brugia malayi	Nuclear hormone receptor E75	0.0114	0.0735	0.1685
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0062	0.0018
Brugia malayi	nuclear hormone receptor	0.0114	0.0735	0.1685
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0114	0.0735	0.1685
Loa Loa (eye worm)	hypothetical protein	0.0598	0.4363	1
Onchocerca volvulus		0.0259	0.182	0.406
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0145	0.097	0.097
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0129	0.444
Loa Loa (eye worm)	hypothetical protein	0.0145	0.097	0.2223
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0735	0.1685
Schistosoma mansoni	Smad4	0.0016	0.0004	0.0004
Echinococcus multilocularis	microtubule associated protein 2	0.1351	1	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0044	0.0213	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0129	0.444
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0114	0.0735	0.0735
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0081	0.1267
Onchocerca volvulus	Protein ultraspiracle homolog	0.0259	0.182	0.406
Brugia malayi	tailless protein	0.0114	0.0735	0.1685
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0016	0.0004	0.0004
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0114	0.0735	0.1526
Schistosoma mansoni	RAR-like nuclear receptor	0.0259	0.182	0.182
Schistosoma mansoni	nuclear hormone receptor	0.0259	0.182	0.182
Brugia malayi	nuclear receptor RXR	0.0145	0.097	0.2223
Brugia malayi	Nuclear hormone receptor-like 1	0.0259	0.182	0.4172
Echinococcus granulosus	tumor protein p63	0.033	0.2354	0.2354
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0129	0.444
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0062	0.0018
Brugia malayi	nuclear hormone receptor family member odr-7	0.0114	0.0735	0.1685
Echinococcus multilocularis	ecdysone induced protein 78C	0.0259	0.182	0.182
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0249	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0145	0.097	0.2223

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 615899