Detailed information for compound 615925

Basic information

Technical information
  • TDR Targets ID: 615925
  • Name: 1-(2-dimethylaminoethyl)-5-(4-ethoxy-3-methox yphenyl)-4-(furan-2-carbonyl)-3-hydroxy-5H-py rrol-2-one
  • MW: 414.452 | Formula: C22H26N2O6
  • H donors: 1 H acceptors: 3 LogP: 2.73 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1OC)C1N(CCN(C)C)C(=O)C(=C1C(=O)c1ccco1)O
  • InChi: 1S/C22H26N2O6/c1-5-29-15-9-8-14(13-17(15)28-4)19-18(20(25)16-7-6-12-30-16)21(26)22(27)24(19)11-10-23(2)3/h6-9,12-13,19,26H,5,10-11H2,1-4H3
  • InChiKey: XWYMJWNEDGRWEQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-dimethylaminoethyl)-5-(4-ethoxy-3-methoxy-phenyl)-4-(furan-2-carbonyl)-3-hydroxy-5H-pyrrol-2-one
  • 1-(2-dimethylaminoethyl)-5-(4-ethoxy-3-methoxyphenyl)-4-(2-furyl-oxomethyl)-3-hydroxy-5H-pyrrol-2-one
  • 1-(2-dimethylaminoethyl)-5-(4-ethoxy-3-methoxy-phenyl)-4-(furan-2-carbonyl)-3-hydroxy-3-pyrrolin-2-one
  • 1-(2-dimethylaminoethyl)-5-(4-ethoxy-3-methoxy-phenyl)-4-furan-2-ylcarbonyl-3-hydroxy-5H-pyrrol-2-one
  • STOCK3S-92045

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0026 0.0094 0.0344
Onchocerca volvulus 0.0745 0.7355 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0099 0.0832 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0026 0.0094 0.0344
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0099 0.0832 0.3051
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0099 0.0832 1
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.1154 0.1791
Leishmania major NADH dehydrogenase, putative 0.0026 0.0094 0.0344
Leishmania major cathepsin L-like protease 0.0065 0.0486 0.1782
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0026 0.0094 0.0094
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0026 0.0094 1
Brugia malayi MH2 domain containing protein 0.0364 0.351 0.545
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0099 0.0832 0.3051
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0026 0.0094 0.0094
Echinococcus multilocularis thioredoxin glutathione reductase 0.029 0.2753 0.2753
Toxoplasma gondii selenide, water dikinase 0.0026 0.0094 0.0344
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0078 0.0078
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0078 0.0078
Schistosoma mansoni intermediate filament proteins 0.0054 0.0375 0.0412
Brugia malayi glutamate synthase 0.0026 0.0094 0.0146
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0094 0.0776 0.0776
Loa Loa (eye worm) pigment dispersing factor receptor c 0.03 0.2858 0.4437
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.0786 0.0786
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0486 0.1782
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0026 0.0094 0.0094
Mycobacterium tuberculosis Probable dehydrogenase 0.0655 0.6442 0.8958
Plasmodium falciparum thioredoxin reductase 0.0287 0.2727 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0099 0.0832 0.3051
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0099 0.0832 0.2835
Schistosoma mansoni hypothetical protein 0.0095 0.0786 0.0864
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0099 0.0832 0.2835
Loa Loa (eye worm) hypothetical protein 0.0147 0.1316 0.2043
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0026 0.0094 0.0344
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0094 0.0344
Schistosoma mansoni hypothetical protein 0.0026 0.0094 0.0103
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0082 0.0301
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0078 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1154 0.1268
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0655 0.6442 0.8958
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0655 0.6441 1
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.0832 0.3051
Echinococcus multilocularis lamin 0.0054 0.0375 0.0375
Echinococcus multilocularis musashi 0.0054 0.0375 0.0375
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0026 0.0094 0.0344
Loa Loa (eye worm) programmed cell death 8 0.0026 0.0094 0.0146
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.0094 0.0044
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0078 0.0121
Leishmania major cathepsin L-like protease 0.0065 0.0486 0.1782
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0776 0.2845
Schistosoma mansoni hypothetical protein 0.0095 0.0786 0.0864
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.0094 0.0344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0486 0.1526
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0026 0.0094 0.0146
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.0786 0.0786
Echinococcus granulosus histone lysine methyltransferase setb 0.0094 0.0776 0.0776
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0094 0.0128
Schistosoma mansoni smad1 5 8 and 0.0025 0.0078 0.0086
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0099 0.0832 0.3051
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0073 0.0565 0.0878
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0099 0.0832 0.3051
Brugia malayi TAR-binding protein 0.0131 0.1154 0.1791
Trichomonas vaginalis apoptosis inducing factor, putative 0.0026 0.0094 0.0128
Echinococcus multilocularis tar DNA binding protein 0.0131 0.1154 0.1154
Echinococcus granulosus thioredoxin glutathione reductase 0.029 0.2753 0.2753
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.0094 0.0044
Entamoeba histolytica disulphide oxidoreductase, putative 0.0026 0.0094 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.0786 0.122
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0375 0.0582
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0099 0.0832 0.3051
Trichomonas vaginalis glutamate synthase, putative 0.0026 0.0094 0.0128
Loa Loa (eye worm) RNA binding protein 0.0131 0.1154 0.1791
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0026 0.0094 0.0094
Brugia malayi MH1 domain containing protein 0.0025 0.0078 0.0121
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0026 0.0094 0.0146
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0082 0.0301
Loa Loa (eye worm) hypothetical protein 0.0025 0.0081 0.0126
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0094 0.0044
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0026 0.0094 0.0094
Brugia malayi Thioredoxin reductase 0.0287 0.2727 0.4234
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0655 0.6442 0.8958
Onchocerca volvulus 0.0147 0.1316 0.1789
Echinococcus multilocularis lamin dm0 0.0054 0.0375 0.0375
Leishmania major hypothetical protein, conserved 0.0026 0.0094 0.0344
Loa Loa (eye worm) transcription factor SMAD2 0.0364 0.351 0.545
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0728 0.718 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0026 0.0094 0.0094
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0026 0.0094 0.0094
Brugia malayi MH2 domain containing protein 0.0025 0.0078 0.0121
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0099 0.0832 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0429 0.1572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0486 0.1526
Loa Loa (eye worm) hypothetical protein 0.0205 0.1899 0.2948
Echinococcus multilocularis Smad4 0.0025 0.0078 0.0078
Onchocerca volvulus 0.0026 0.0094 0.0128
Echinococcus multilocularis smad 0.0025 0.0078 0.0078
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0655 0.6442 0.8958
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.1154 0.1791
Schistosoma mansoni hypothetical protein 0.0095 0.0786 0.0864
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0026 0.0094 0.0094
Schistosoma mansoni lamin 0.0054 0.0375 0.0412
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0099 0.0832 0.3051
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0099 0.0832 0.3051
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0099 0.0832 0.3051
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0026 0.0094 1
Echinococcus multilocularis GPCR, family 2 0.0095 0.0786 0.0786
Trypanosoma cruzi NADH dehydrogenase, putative 0.0026 0.0094 0.0344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0146
Echinococcus granulosus lamin dm0 0.0054 0.0375 0.0375
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0094 0.0776 0.0852
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0091 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0486 0.1526
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0486 0.1526
Schistosoma mansoni glutamate synthase 0.0026 0.0094 0.0103
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0099 0.0832 0.2835
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0026 0.0094 0.0344
Trypanosoma cruzi NADH dehydrogenase, putative 0.0026 0.0094 0.0344
Schistosoma mansoni hypothetical protein 0.0205 0.1899 0.2087
Onchocerca volvulus 0.0054 0.0375 0.0509
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0078 0.0078
Echinococcus multilocularis glutamate synthase 0.0026 0.0094 0.0094
Brugia malayi RNA binding protein 0.0131 0.1154 0.1791
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0776 0.0776
Onchocerca volvulus 0.0094 0.0776 0.1055
Brugia malayi Pre-SET motif family protein 0.0094 0.0776 0.1204
Schistosoma mansoni glutamate synthase 0.0026 0.0094 0.0103
Brugia malayi glutathione reductase 0.0287 0.2727 0.4234
Echinococcus granulosus Smad4 0.0025 0.0078 0.0078
Loa Loa (eye worm) TAR-binding protein 0.0131 0.1154 0.1791
Mycobacterium tuberculosis Probable oxidoreductase 0.0728 0.718 1
Loa Loa (eye worm) hypothetical protein 0.03 0.2858 0.4437
Schistosoma mansoni glutamate synthase 0.0026 0.0094 0.0103
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0375 0.0582
Echinococcus granulosus tar DNA binding protein 0.0131 0.1154 0.1154
Loa Loa (eye worm) hypothetical protein 0.0053 0.0365 0.0566
Echinococcus granulosus intermediate filament protein 0.0054 0.0375 0.0375
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0026 0.0094 1
Schistosoma mansoni hypothetical protein 0.0095 0.0786 0.0864
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0655 0.6442 0.8958
Trichomonas vaginalis glutamate synthase, putative 0.0026 0.0094 0.0128
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0486 0.1782
Schistosoma mansoni disulfide oxidoreductase 0.0026 0.0094 0.0103
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0094 0.0344
Brugia malayi Smad1 0.0025 0.0078 0.0121
Trichomonas vaginalis mercuric reductase, putative 0.0099 0.0832 0.1131
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.012 0.0187
Loa Loa (eye worm) thioredoxin reductase 0.0287 0.2727 0.4234
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0078 0.0121
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0026 0.0094 0.0146
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1154 0.1268
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0776 0.0852
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1154 0.1268
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0082 0.0301
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0026 0.0094 0.0146
Treponema pallidum NADH oxidase 0.0099 0.0832 1
Leishmania major hypothetical protein, conserved 0.0026 0.0094 0.0344
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0375 0.0582
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0099 0.0832 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0026 0.0094 0.0094
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0026 0.0094 0.0344
Brugia malayi Pre-SET motif family protein 0.0655 0.6441 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0099 0.0832 0.1042
Trichomonas vaginalis glutathione reductase, putative 0.0099 0.0832 0.1131
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0082 0.0301
Brugia malayi MH1 domain containing protein 0.0025 0.0078 0.0121
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0099 0.0832 0.3051
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0099 0.0832 1
Schistosoma mansoni cellular tumor antigen P53 0.0147 0.1316 0.1446
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0728 0.718 1
Schistosoma mansoni sulfide quinone reductase 0.0026 0.0094 0.0103
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0099 0.0832 0.3051
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0026 0.0094 1
Plasmodium falciparum glutathione reductase 0.0287 0.2727 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.0741 0.0741
Echinococcus granulosus smad 0.0025 0.0078 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1154 0.1268
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0082 0.0301
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0026 0.0094 0.0128
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0486 0.1782
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0099 0.0832 0.0832
Leishmania major hypothetical protein, conserved 0.0025 0.0082 0.0301
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0345 0.1265
Schistosoma mansoni Smad4 0.0025 0.0078 0.0086
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0099 0.0832 0.0914
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0026 0.0094 0.0128
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0094 0.0128
Leishmania major cathepsin L-like protease 0.0065 0.0486 0.1782
Brugia malayi latrophilin 2 splice variant baaae 0.0205 0.1899 0.2948
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0099 0.0832 0.3051
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0026 0.0094 0.0344
Plasmodium vivax thioredoxin reductase, putative 0.0287 0.2727 1
Echinococcus granulosus lamin 0.0054 0.0375 0.0375
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0099 0.0832 0.0832
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.0786 0.122
Schistosoma mansoni smad1 5 8 and 0.0025 0.0078 0.0086
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0026 0.0094 0.0344
Brugia malayi intermediate filament protein 0.0054 0.0375 0.0582
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0026 0.0094 0.0344
Brugia malayi Calcitonin receptor-like protein seb-1 0.03 0.2858 0.4437
Trypanosoma brucei NADH dehydrogenase 0.0026 0.0094 0.0044
Toxoplasma gondii NADPH-glutathione reductase 0.0099 0.0832 0.3051
Onchocerca volvulus 0.0054 0.0375 0.0509
Mycobacterium tuberculosis Probable reductase 0.0655 0.6442 0.8958
Loa Loa (eye worm) glutathione reductase 0.0287 0.2727 0.4234
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0655 0.6442 0.8958
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0026 0.0094 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0486 0.1526
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0026 0.0094 0.0044
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0728 0.718 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0099 0.0832 0.2835
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0026 0.0094 0.0344
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0026 0.0094 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0131 0.1154 0.1268
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.0786 0.0786
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0099 0.0832 0.3051
Giardia lamblia NADH oxidase lateral transfer candidate 0.0099 0.0832 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0081 0.0126
Loa Loa (eye worm) Smad1 0.0025 0.0078 0.0121
Schistosoma mansoni lamin 0.0054 0.0375 0.0412
Loa Loa (eye worm) hypothetical protein 0.0054 0.0375 0.0582
Toxoplasma gondii thioredoxin reductase 0.0287 0.2727 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0073 0.0565 0.0878
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0287 0.2727 0.3716
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0026 0.0094 1
Schistosoma mansoni sulfide quinone reductase 0.0026 0.0094 0.0103
Loa Loa (eye worm) hypothetical protein 0.0095 0.0786 0.122
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0099 0.0832 0.3051
Schistosoma mansoni smad 0.0025 0.0078 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0486 0.1526
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0078 0.0078
Plasmodium falciparum thioredoxin reductase 0.0099 0.0832 0.3051
Plasmodium falciparum glutathione reductase 0.0099 0.0832 0.3051
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.0128
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0099 0.0832 0.3051
Trypanosoma cruzi trypanothione reductase, putative 0.0287 0.2727 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0776 0.0852
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0486 0.1526
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0094 0.0128
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.012 0.0187
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.0094 0.0344
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0094 0.0128
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0099 0.0832 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0142
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0099 0.0832 0.1292
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0026 0.0094 0.0128
Trichomonas vaginalis set domain proteins, putative 0.0745 0.7355 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0486 0.1526
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0094 0.0128
Brugia malayi hypothetical protein 0.0025 0.0082 0.0128
Plasmodium vivax ferrodoxin reductase, putative 0.0026 0.0094 0.0344
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0026 0.0094 0.0344
Leishmania major trypanothione reductase 0.0287 0.2727 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0082 0.0301
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0026 0.0094 0.0344
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0776 0.0852
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0026 0.0094 0.0128
Trypanosoma brucei trypanothione reductase 0.0287 0.2727 1
Echinococcus granulosus GPCR family 2 0.0095 0.0786 0.0786
Brugia malayi MH2 domain containing protein 0.0025 0.0078 0.0121
Plasmodium falciparum ferrodoxin reductase-like protein 0.0026 0.0094 0.0344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0486 0.1526
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0099 0.0832 0.3051
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0099 0.0832 0.3051
Brugia malayi Latrophilin receptor protein 2 0.0095 0.0786 0.122
Loa Loa (eye worm) hypothetical protein 0.0094 0.0776 0.1204
Plasmodium vivax glutathione reductase, putative 0.0287 0.2727 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0486 0.1526
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0091 0.0091
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.03 0.2858 0.4437
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0026 0.0094 0.0094
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0026 0.0094 0.0344
Schistosoma mansoni smad1 5 8 and 0.0025 0.0078 0.0086
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0026 0.0094 0.0044
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.0786 0.0786
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0486 0.1526
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0486 0.1782
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0026 0.0094 0.0344
Leishmania major hypothetical protein, conserved 0.0026 0.0094 0.0344
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0094 0.0128
Echinococcus multilocularis tumor protein p63 0.1007 1 1
Plasmodium vivax SET domain protein, putative 0.0094 0.0776 0.2845
Entamoeba histolytica thioredoxin reductase, putative 0.0026 0.0094 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0364 0.351 0.545
Echinococcus granulosus glutamate synthase 0.0026 0.0094 0.0094

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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