Detailed information for compound 616300

Basic information

Technical information
  • TDR Targets ID: 616300
  • Name: 3-(4-chlorophenyl)-1-(2,3-dimethylphenyl)-2,5 ,6,7-tetrahydroimidazo[2,3-b][1,3]thiazin-4-i um-3-ol
  • MW: 373.919 | Formula: C20H22ClN2OS+
  • H donors: 1 H acceptors: 1 LogP: 4.18 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C1(O)C[N+](=C2N1CCCS2)c1cccc(c1C)C
  • InChi: 1S/C20H22ClN2OS/c1-14-5-3-6-18(15(14)2)22-13-20(24,16-7-9-17(21)10-8-16)23-11-4-12-25-19(22)23/h3,5-10,24H,4,11-13H2,1-2H3/q+1
  • InChiKey: KBSPULRGLZKGJU-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0066 0.1038
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0018 0.0018
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0019 0.021
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.1025 1
Loa Loa (eye worm) ctsf protein 0.0017 0.0006 0.0008
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0019 0.0038
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0009 0.0016
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0032 0.0032
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0019 0.0414
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0893 0.3158 0.8383
Brugia malayi AMP-binding enzyme family protein 0.0071 0.02 0.0525
Brugia malayi MH1 domain containing protein 0.0023 0.0026 0.0063
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0006 0.0008
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.002 0.0045
Schistosoma mansoni Smad4 0.0018 0.0011 0.0011
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0032 0.0077
Loa Loa (eye worm) Smad1 0.0041 0.0093 0.024
Schistosoma mansoni hypothetical protein 0.008 0.0233 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0179 1
Schistosoma mansoni ferritin 0.0026 0.0039 0.0039
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0003 0.0148
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1025 0.2835
Echinococcus multilocularis importin subunit beta 1 0.0029 0.005 0.0047
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0006 0.0003
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.02 0.191
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0018 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0018 0.0042
Echinococcus granulosus expressed protein 0.0026 0.0039 0.0036
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0076 0.0073
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0018 0.0016
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.0795 1
Loa Loa (eye worm) RNA binding protein 0.1062 0.3767 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0081 0.4502
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0018 0.0018
Schistosoma mansoni ran 0.0022 0.0022 0.0022
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0032 0.0718
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0018 0.0042
Echinococcus multilocularis tumor protein p63 0.1717 0.6125 0.6124
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0148
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0042
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0459 0.1597 0.4234
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0027 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1025 0.2835
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0018 0.0016
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0077 0.0941
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0081 0.0078
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0019 0.1077
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.02 0.4
Trichomonas vaginalis chaperonin, putative 0.0024 0.0032 0.0072
Loa Loa (eye worm) hypothetical protein 0.0071 0.02 0.0525
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0018 0.0016
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0019 0.1252
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.02 1
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.008 0.0232 0.061
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0145 0.0467 0.1233
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0075 0.4174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0018 0.0016
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0018 0.0018
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0081 0.4502
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0019 0.1077
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0032 0.2174
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0081 0.1938
Brugia malayi latrophilin 2 splice variant baaae 0.0314 0.1074 0.2845
Entamoeba histolytica hypothetical protein 0.008 0.0233 0.2231
Schistosoma mansoni hypothetical protein 0.0352 0.1212 0.1212
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0075 0.0192
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0063
Echinococcus multilocularis cysteine protease 0.0017 0.0006 0.0003
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0075 0.0677
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0159 0.8861
Loa Loa (eye worm) hypothetical protein 0.0083 0.0244 0.064
Schistosoma mansoni smad 0.0041 0.0093 0.0093
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0022 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0018 0.0042
Echinococcus multilocularis smad 0.0041 0.0093 0.009
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0003 0.0148
Brugia malayi MH2 domain containing protein 0.0607 0.213 0.5652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0179 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0077 0.0941
Loa Loa (eye worm) hypothetical protein 0.008 0.0232 0.061
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0075 0.0192
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.0472 0.5926
Schistosoma mansoni hypothetical protein 0.0145 0.0467 0.0467
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0019 0.1077
Mycobacterium ulcerans beta-lactamase 0.0037 0.0077 0.1279
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0019 0.021
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0077 0.0941
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0128 0.0405 0.0403
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0006 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0283 0.028
Mycobacterium leprae Probable lipase LipE 0.0037 0.0077 0.1279
Loa Loa (eye worm) MH2 domain-containing protein 0.0607 0.213 0.5652
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.005 0.2766
Brugia malayi MH1 domain containing protein 0.0041 0.0093 0.024
Echinococcus multilocularis GPCR, family 2 0.0145 0.0467 0.0464
Onchocerca volvulus 0.0095 0.0285 0.0776
Brugia malayi Calcitonin receptor-like protein seb-1 0.0459 0.1597 0.4234
Echinococcus granulosus geminin 0.0352 0.1212 0.121
Schistosoma mansoni ferritin light chain 0.0026 0.0039 0.0039
Mycobacterium tuberculosis Conserved protein 0.0037 0.0077 0.0941
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.0533 0.141
Brugia malayi Importin beta-1 subunit 0.0029 0.005 0.0125
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0019 0.021
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0019 0.021
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0283 0.0744
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.003 0.1652
Loa Loa (eye worm) intermediate filament protein 0.0172 0.0565 0.1493
Loa Loa (eye worm) hypothetical protein 0.0071 0.02 0.0525
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0179 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.02 0.4
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.02 0.4
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0018 0.0042
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0077 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0179 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0018 0.0035
Echinococcus granulosus zinc finger protein 0.002 0.0016 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0018 0.0042
Echinococcus granulosus lamin 0.0172 0.0565 0.0562
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0077 0.0077
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0081 0.0208
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0019 0.021
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0077 0.0941
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0019 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.02 0.4
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0019 0.021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0125 0.1546
Onchocerca volvulus 0.0037 0.0077 0.0199
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0006 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0283 0.028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0018 0.0042
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0018 0.0011 0.0014
Onchocerca volvulus 0.1016 0.3603 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0179 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0027 0.0024
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0022 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0018 0.0042
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0003 0.0003
Onchocerca volvulus 0.0021 0.0018 0.0035
Leishmania major importin beta-1 subunit, putative 0.0024 0.003 0.1476
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0081 0.0208
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0006 0.023
Trichomonas vaginalis set domain proteins, putative 0.1016 0.3603 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0018 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0283 0.028
Schistosoma mansoni hypothetical protein 0.0145 0.0467 0.0467
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0042
Echinococcus multilocularis Smad4 0.0041 0.0093 0.009
Schistosoma mansoni cellular tumor antigen P53 0.0251 0.0849 0.0849
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0006 0.0008
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0032 0.0718
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0018 0.0016
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0093 0.024
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0077 0.431
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0019 0.0044
Entamoeba histolytica hypothetical protein 0.008 0.0233 0.2231
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0136 1
Leishmania major cathepsin L-like protease 0.0065 0.0179 0.8936
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0008
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0022 0.0473
Schistosoma mansoni alpha glucosidase 0.0036 0.0075 0.0075
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0081 0.1355
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0077 0.0941
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.0532
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0129 0.7191
Trichomonas vaginalis importin beta-1, putative 0.0024 0.003 0.0066
Schistosoma mansoni importin beta-1 0.0029 0.005 0.005
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0019 0.0038
Brugia malayi hypothetical protein 0.0778 0.2744 0.7281
Schistosoma mansoni Smad4 0.0041 0.0093 0.0093
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0075 0.0072
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0314 0.1074 0.2845
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0198
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0285
Schistosoma mansoni hypothetical protein 0.0145 0.0467 0.0467
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0006 0.0006
Mycobacterium ulcerans hypothetical protein 0.0037 0.0077 0.1279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0018 0.0042
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0018 0.0016
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0019 0.1077
Brugia malayi cytoplasmic intermediate filament protein 0.0092 0.0277 0.0728
Schistosoma mansoni tar DNA-binding protein 0.1062 0.3767 0.3767
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0077 0.0941
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0077 0.1279
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1025 0.2835
Schistosoma mansoni ferritin light chain 0.0026 0.0039 0.0039
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.1071 0.2838
Echinococcus granulosus Smad4 0.0041 0.0093 0.009
Echinococcus multilocularis lamin 0.0172 0.0565 0.0562
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0145 0.0467 0.0465
Schistosoma mansoni smad1 5 8 and 0.0041 0.0093 0.0093
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0081 0.4502
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0042
Toxoplasma gondii ABC1 family protein 0.0037 0.0077 0.1853
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0179 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.0233 0.0231
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0075 0.1792
Brugia malayi Bromodomain containing protein 0.0076 0.0219 0.0574
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.02 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0039 0.046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0021
Echinococcus multilocularis tar DNA binding protein 0.1062 0.3767 0.3765
Brugia malayi Latrophilin receptor protein 2 0.0145 0.0467 0.1233
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0019 0.1077
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0075 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0018 0.0042
Brugia malayi nuclear hormone receptor 0.0021 0.0018 0.0042
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0081 0.0078
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0039 0.0437
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0132
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0032 0.1575
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0006 0.0004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0145 0.0467 0.0464
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0075 0.0192
Brugia malayi RNA, U transporter 1 0.0083 0.0244 0.0642
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0019 0.0044
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0018 0.0018
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0011 0.0008
Brugia malayi ecdysteroid receptor 0.0021 0.0018 0.0042
Loa Loa (eye worm) hypothetical protein 0.0251 0.0849 0.2248
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0018 0.0016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.0233 0.0231
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1025 0.2835
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0125 0.1546
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0006 0.0006
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0011 0.0021
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0039 0.046
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0778 0.2744 0.7281
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0179 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0006 0.023
Schistosoma mansoni ferritin 0.0026 0.0039 0.0039
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0145 0.0467 0.0464
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0179 1
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0179 1
Loa Loa (eye worm) hypothetical protein 0.0459 0.1597 0.4234
Echinococcus granulosus importin subunit beta 1 0.0029 0.005 0.0047
Brugia malayi beta-lactamase 0.0037 0.0077 0.0198
Onchocerca volvulus 0.0021 0.0019 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.02 0.2496
Brugia malayi beta-lactamase family protein 0.0037 0.0077 0.0198
Onchocerca volvulus 0.0251 0.0849 0.2344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0283 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0018 0.0042
Toxoplasma gondii cathepsin CPL 0.0017 0.0006 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0042
Schistosoma mansoni bromodomain containing protein 0.0064 0.0176 0.0176
Echinococcus granulosus snurportin 1 0.0313 0.1071 0.1068
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.02 0.4
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1691 0.6032 0.6031
Loa Loa (eye worm) hypothetical protein 0.0043 0.01 0.0259
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0032 0.0072
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0008
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0076 0.0073
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0039 0.0437
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1025 0.2835
Trichomonas vaginalis esterase, putative 0.0037 0.0077 0.0199
Loa Loa (eye worm) cysteine protease 0.0017 0.0006 0.0008
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0077 0.0941
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0006 0.0006
Onchocerca volvulus 0.0037 0.0077 0.0199
Brugia malayi MH2 domain containing protein 0.0018 0.0011 0.0021
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0285
Plasmodium vivax importin-beta 2, putative 0.0029 0.005 0.1166
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0075 0.0192
Loa Loa (eye worm) beta-lactamase 0.0037 0.0077 0.0198
Loa Loa (eye worm) hypothetical protein 0.0041 0.0093 0.024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0145 0.0467 0.0464
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0283 0.0283
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0019 0.0017
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0092 0.0277 0.0728
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0093 0.024
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0032 0.0029
Echinococcus multilocularis expressed protein 0.0026 0.0039 0.0036
Plasmodium vivax vivapain-2 0.0017 0.0006 0.0076
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0075 0.0192
Onchocerca volvulus 0.0037 0.0077 0.0199
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0011 0.0008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.02 0.191
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0075 0.0192
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0006 0.0003
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0285
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0128 0.0405 0.0405
Brugia malayi MH2 domain containing protein 0.0041 0.0093 0.024
Brugia malayi MH2 domain containing protein 0.0041 0.0093 0.024
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.1025 1
Schistosoma mansoni alpha-glucosidase 0.0141 0.0451 0.0451
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0018 0.0042
Loa Loa (eye worm) hypothetical protein 0.0053 0.0136 0.0353
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0077 0.1853
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.02 0.4
Entamoeba histolytica hypothetical protein 0.008 0.0233 0.2231
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1025 0.2835
Brugia malayi beta-lactamase family protein 0.0037 0.0077 0.0198
Brugia malayi RNA binding protein 0.1062 0.3767 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0053 0.0136 0.0353
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0077 0.0198
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0019 0.021
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.0472 1
Schistosoma mansoni ran 0.0022 0.0022 0.0022
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0032 0.1762
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0019 0.0414
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0083 0.0244 0.0241
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.1062 0.3767 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0145 0.0467 0.1233
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0019 0.0962
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0006 0.0003
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0093 0.009
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0019 0.0962
Loa Loa (eye worm) hypothetical protein 0.0053 0.0136 0.0353
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1025 0.2835
Onchocerca volvulus 0.0128 0.0405 0.111
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0198
Plasmodium falciparum importin beta, putative 0.0029 0.005 0.3528
Echinococcus granulosus survival motor neuron protein 1 0.0778 0.2744 0.2742
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0136 0.3304
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0148
Loa Loa (eye worm) nuclear factor I 0.0023 0.0026 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0018 0.0042
Echinococcus granulosus lamin dm0 0.0172 0.0565 0.0562
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0011 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0179 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.005 0.1166
Schistosoma mansoni survival motor neuron protein 0.0159 0.0515 0.0515
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.02 0.191
Plasmodium vivax vivapain-2 0.0017 0.0006 0.0076
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0019 0.1077
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0018 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0198
Schistosoma mansoni thyroid hormone receptor 0.0152 0.049 0.049
Schistosoma mansoni smad1 5 8 and 0.0041 0.0093 0.0093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0125 0.1546
Schistosoma mansoni hypothetical protein 0.0159 0.0515 0.0515
Brugia malayi Inositol-1 0.0038 0.0081 0.0207
Onchocerca volvulus 0.0172 0.0565 0.1554
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0032 0.0029
Schistosoma mansoni hypothetical protein 0.0313 0.1071 0.1071
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0077 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0145 0.0467 0.0467
Loa Loa (eye worm) fibroinase 0.0017 0.0006 0.0008
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0081 0.0208
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0019 0.021
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0018 0.0042
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0123 0.0388 0.0386
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0075 0.4174
Brugia malayi PHD-finger family protein 0.0025 0.0035 0.0086
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0075 0.0192
Leishmania major GTP-binding protein, putative 0.0022 0.0022 0.1082
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0198
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0044
Onchocerca volvulus 0.0172 0.0565 0.1554
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0075 0.0072
Loa Loa (eye worm) hypothetical protein 0.0169 0.0553 0.1463
Schistosoma mansoni smad 0.0018 0.0011 0.0011
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0032 0.0254
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0159 0.0515 0.1361
Brugia malayi hypothetical protein 0.008 0.0233 0.0613
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0163 0.016
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0093 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0042
Loa Loa (eye worm) hypothetical protein 0.0145 0.0467 0.1235
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0018 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0077 0.0199
Leishmania major cathepsin L-like protease 0.0065 0.0179 0.8936
Schistosoma mansoni tar DNA-binding protein 0.1062 0.3767 0.3767
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.1025 1
Leishmania major cathepsin L-like protease 0.0065 0.0179 0.8936
Loa Loa (eye worm) TAR-binding protein 0.1062 0.3767 1
Echinococcus granulosus intermediate filament protein 0.0172 0.0565 0.0562
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0019 0.0414
Mycobacterium ulcerans hypothetical protein 0.0071 0.02 0.4
Echinococcus multilocularis survival motor neuron protein 1 0.0778 0.2744 0.2742
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0018 0.0042
Onchocerca volvulus 0.0021 0.0019 0.0038
Brugia malayi RNA recognition motif domain containing protein 0.1062 0.3767 1
Schistosoma mansoni lamin 0.0172 0.0565 0.0565
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.02 0.4
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0019 0.021
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.02 0.4
Echinococcus granulosus GPCR family 2 0.0145 0.0467 0.0464
Brugia malayi nuclear receptor NHR-88 0.0021 0.0018 0.0042
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0533 0.0531
Mycobacterium tuberculosis Conserved protein 0.0037 0.0077 0.0941
Echinococcus multilocularis lamin dm0 0.0172 0.0565 0.0562
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0533 0.0531
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0283 0.0283
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0018 0.0042
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0093 0.0093
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0011 0.0021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0145 0.0467 0.1233
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0022 0.0473
Echinococcus granulosus tumor protein p63 0.1717 0.6125 0.6124
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.02 1
Trypanosoma brucei glucosidase, putative 0.0036 0.0075 0.4174
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0018 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0071 0.02 0.0525
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0018 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0018 0.0042
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0022 0.0019
Echinococcus multilocularis zinc finger protein 0.002 0.0016 0.0013
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.02 0.2496
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0077 0.1279
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0011 0.0008
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.0416 0.0413
Loa Loa (eye worm) hypothetical protein 0.0071 0.02 0.0525
Echinococcus multilocularis geminin 0.0352 0.1212 0.121
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0018 0.0016
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0077 0.1279
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0093 0.009
Loa Loa (eye worm) transcription factor SMAD2 0.0607 0.213 0.5652
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0032 0.0032
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0081 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0019 0.0414
Schistosoma mansoni hypothetical protein 0.0021 0.002 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0179 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0283 0.0744
Echinococcus multilocularis musashi 0.0172 0.0565 0.0562
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0027 0.0027
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0032 0.0077
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0006 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0145 0.0467 0.0467
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0019 0.021
Brugia malayi MH1 domain containing protein 0.0041 0.0093 0.024
Loa Loa (eye worm) hypothetical protein 0.0029 0.005 0.0125
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0018 0.0016
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0019 0.0017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0459 0.1597 0.4234
Schistosoma mansoni hypothetical protein 0.0145 0.0467 0.0467
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0405 0.0405
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0077 0.0199
Trichomonas vaginalis ran, putative 0.0022 0.0022 0.0044
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0136 0.5
Schistosoma mansoni microtubule-associated protein tau 0.2793 1 1
Schistosoma mansoni hypothetical protein 0.0131 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.0039 0.0084 0.0217
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0008
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0075 0.373
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0081 0.0735
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0075 0.0677
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0077 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0179 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0075 0.0192
Loa Loa (eye worm) inositol-1 0.0038 0.0081 0.0207
Leishmania major hypothetical protein, conserved 0.0037 0.0077 0.3851
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0083 0.0244 0.0241
Echinococcus multilocularis microtubule associated protein 2 0.2793 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0018 0.0042
Loa Loa (eye worm) hypothetical protein 0.0053 0.0136 0.0353
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.0472 1
Entamoeba histolytica Ran family GTPase 0.0022 0.0022 0.0157
Schistosoma mansoni zinc finger protein 0.002 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0018 0.0042
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0018 0.0016
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.003 0.0066
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0019 0.0133
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0018 0.0042
Schistosoma mansoni tar DNA-binding protein 0.1062 0.3767 0.3767
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.003 0.0066
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.0533 0.141
Schistosoma mansoni ferritin 0.0026 0.0039 0.0039
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0032 0.0077
Brugia malayi intermediate filament protein 0.0172 0.0565 0.1493
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.1025 1
Echinococcus multilocularis cysteine protease 0.0017 0.0006 0.0003
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0022 0.1431
Brugia malayi steroid hormone receptor 0.0021 0.0018 0.0042
Echinococcus granulosus smad 0.0041 0.0093 0.009
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0022 0.1211
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0198
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0008
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0006 0.023
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0019 0.0044
Brugia malayi MH1 domain containing protein 0.0023 0.0026 0.0063
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0006 0.0003
Schistosoma mansoni ferritin 0.0026 0.0039 0.0039
Brugia malayi Intermediate filament tail domain containing protein 0.0172 0.0565 0.1493
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0077 0.0199
Schistosoma mansoni coup transcription factor 0.0021 0.0018 0.0018
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0019 0.0044
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0128 0.0405 1
Brugia malayi Pre-SET motif family protein 0.0893 0.3158 0.8383
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0163 0.016
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0022 0.0051
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0009 0.0078
Schistosoma mansoni tar DNA-binding protein 0.1062 0.3767 0.3767
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0032 0.0032
Schistosoma mansoni intermediate filament proteins 0.0172 0.0565 0.0565
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0006 0.0008
Entamoeba histolytica hypothetical protein 0.0024 0.003 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0077 0.0199
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0018 0.0016
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0077 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0179 1
Onchocerca volvulus 0.0021 0.0019 0.0038
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0136 0.2568
Schistosoma mansoni alpha-glucosidase 0.0141 0.0451 0.0451
Schistosoma mansoni thyroid hormone receptor 0.0152 0.049 0.049
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0019 0.0044
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0077 0.0941
Echinococcus granulosus histone lysine methyltransferase setb 0.0145 0.0467 0.0465
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0285
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0125 0.1546
Plasmodium vivax SET domain protein, putative 0.0128 0.0405 1
Schistosoma mansoni smad1 5 8 and 0.0041 0.0093 0.0093
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0006 0.0319
Onchocerca volvulus 0.0071 0.02 0.0541
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.1025 0.2835
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0019 0.021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0198
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0018 0.0018
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.0533 0.0531
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0283 0.028
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0019 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0077 0.0199
Echinococcus multilocularis ferritin 0.0026 0.0039 0.0036
Onchocerca volvulus 0.0159 0.0515 0.1416
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0022 0.1211
Schistosoma mansoni inositol monophosphatase 0.0038 0.0081 0.0081
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0075 0.0192
Brugia malayi Smad1 0.0041 0.0093 0.024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0044
Echinococcus granulosus ferritin 0.0026 0.0039 0.0036
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0285
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0081 0.4023
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0006 0.0285
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0077 0.431
Entamoeba histolytica hypothetical protein 0.008 0.0233 0.2231
Onchocerca volvulus 0.0021 0.0019 0.0038
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0136 0.1678
Brugia malayi TAR-binding protein 0.1062 0.3767 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0011 0.0021
Schistosoma mansoni tar DNA-binding protein 0.1062 0.3767 0.3767
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0018 0.0016
Schistosoma mansoni apoferritin-2 0.0026 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0018 0.0042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0145 0.0467 0.0464
Loa Loa (eye worm) oxidoreductase 0.0021 0.0019 0.0044
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0172 0.0565 0.1493
Schistosoma mansoni inositol monophosphatase 0.0038 0.0081 0.0081
Brugia malayi AMP-binding enzyme family protein 0.0071 0.02 0.0525
Echinococcus multilocularis snurportin 1 0.0313 0.1071 0.1068
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0022 0.1211
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0008
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.02 0.4
Echinococcus granulosus tar DNA binding protein 0.1062 0.3767 0.3765
Schistosoma mansoni apoferritin-2 0.0026 0.0039 0.0039
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0019 0.0962
Mycobacterium ulcerans lipase LipD 0.0037 0.0077 0.1279
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.049 0.0488
Loa Loa (eye worm) hypothetical protein 0.0172 0.0565 0.1493
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0018 0.0042
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.005 0.2766
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0018 0.0016
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0032 0.1762
Brugia malayi Bromodomain containing protein 0.0039 0.0084 0.0217
Schistosoma mansoni lamin 0.0172 0.0565 0.0565
Schistosoma mansoni Smad4 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0053 0.0136 0.0353
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0019 0.0044
Schistosoma mansoni transcription factor LCR-F1 0.008 0.0233 0.0233
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.0416 0.0413
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0179 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0075 0.0192
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0018 0.0035
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0314 0.1074 0.1074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0179 1
Echinococcus granulosus cathepsin l1 0.0017 0.0006 0.0003
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0093 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0077 0.431
Schistosoma mansoni hypothetical protein 0.0352 0.1212 0.1212
Trichomonas vaginalis ferritin, putative 0.0026 0.0039 0.0093
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0039 0.0437
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0018 0.0018
Brugia malayi Pre-SET motif family protein 0.0128 0.0405 0.1069
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0006 0.0004
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0032 0.0098
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0066 0.0804

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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