Detailed information for compound 616304

Basic information

Technical information
  • TDR Targets ID: 616304
  • Name: 1-(2,5-dimethoxyphenyl)-3-(4-nitrophenyl)-2,5 ,6,7-tetrahydroimidazo[2,3-b][1,3]thiazin-4-i um-3-ol
  • MW: 416.471 | Formula: C20H22N3O5S+
  • H donors: 1 H acceptors: 3 LogP: 2.59 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1[N+]1=C2SCCCN2C(C1)(O)c1ccc(cc1)[N+](=O)[O-])OC
  • InChi: 1S/C20H22N3O5S/c1-27-16-8-9-18(28-2)17(12-16)21-13-20(24,22-10-3-11-29-19(21)22)14-4-6-15(7-5-14)23(25)26/h4-9,12,24H,3,10-11,13H2,1-2H3/q+1
  • InChiKey: MPWUEAVKZCWXGW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ChemDiv1_026892

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0093 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0373 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0138 0.0125
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0138 0.0125
Echinococcus multilocularis tumor protein p63 0.1397 0.9781 0.978
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0238 0.0224
Schistosoma mansoni hypothetical protein 0.0048 0.0256 0.0243
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0138 0.0125
Schistosoma mansoni smad1 5 8 and 0.0025 0.0093 0.0079
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0026 0.0034
Schistosoma mansoni Smad4 0.0025 0.0093 0.0079
Schistosoma mansoni smad 0.0025 0.0093 0.0079
Brugia malayi hypothetical protein 0.0237 0.1588 0.4396
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0014 0.0546
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0238 0.0224
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0252 0.6623
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0238 0.0224
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0026 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0373 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0335 0.0322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0335 0.0322
Plasmodium vivax SET domain protein, putative 0.006 0.0335 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0012
Schistosoma mansoni hypothetical protein 0.0168 0.1103 0.1091
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0238 0.0627
Echinococcus multilocularis geminin 0.0168 0.1103 0.1091
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0252 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0035 0.1398
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0594
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0167 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0153 0.6071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0066
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.033
Loa Loa (eye worm) hypothetical protein 0.0048 0.0252 0.0666
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0252 0.0666
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.032 0.0306
Brugia malayi RNA binding protein 0.0521 0.3594 1
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0035 0.0021
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0373 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0167 0.6421
Brugia malayi MH2 domain containing protein 0.0025 0.0093 0.0222
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0491 0.1335
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0035 0.0066
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0014 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0521 0.3594 0.3585
Echinococcus granulosus smad 0.0025 0.0093 0.0079
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0014 0.0546
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0153 0.6071
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0373 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0093 0.0079
Loa Loa (eye worm) hypothetical protein 0.0237 0.1588 0.4396
Schistosoma mansoni tar DNA-binding protein 0.0521 0.3594 0.3585
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0153 0.6071
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0594
Loa Loa (eye worm) MH2 domain-containing protein 0.037 0.253 0.7029
Trichomonas vaginalis set domain proteins, putative 0.0472 0.325 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0061
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0066
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0252 0.0666
Echinococcus multilocularis microtubule associated protein 2 0.1429 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0035 0.0021
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.6534
Brugia malayi isocitrate dehydrogenase 0.0016 0.0026 0.0034
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0035 0.1398
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0252 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0014 0.0001
Loa Loa (eye worm) Smad1 0.0025 0.0093 0.0222
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0026 0.0369
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0224 0.0587
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.033
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0035 0.0594
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0035 0.0066
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0014 0.0546
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0093 0.0079
Onchocerca volvulus 0.0472 0.325 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0252 0.6623
Mycobacterium ulcerans hypothetical protein 0.0048 0.0252 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.1359 0.3757
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0238 0.0224
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0026 0.0034
Leishmania major cathepsin L-like protease 0.0065 0.0373 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0373 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0193 0.018
Schistosoma mansoni hypothetical protein 0.0032 0.0138 0.0125
Loa Loa (eye worm) oxidoreductase 0.0014 0.0014 0.0001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0252 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0066
Schistosoma mansoni hypothetical protein 0.0168 0.1103 0.1091
Echinococcus granulosus GPCR family 2 0.0032 0.0138 0.0125
Onchocerca volvulus 0.0048 0.0252 0.0736
Schistosoma mansoni smad1 5 8 and 0.0025 0.0093 0.0079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0066
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.1588 0.1576
Schistosoma mansoni smad1 5 8 and 0.0025 0.0093 0.0079
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0014 0.0546
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0035 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0066
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0093 0.0222
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0373 1
Echinococcus granulosus tar DNA binding protein 0.0521 0.3594 0.3585
Loa Loa (eye worm) hypothetical protein 0.0068 0.0398 0.1073
Loa Loa (eye worm) fibroinase 0.0017 0.0035 0.0061
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0167 0.4758
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0335 0.0322
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0066
Echinococcus granulosus intermediate filament protein 0.0082 0.0491 0.0478
Onchocerca volvulus 0.0048 0.0256 0.0749
Onchocerca volvulus 0.0017 0.0035 0.0066
Echinococcus granulosus lamin dm0 0.0082 0.0491 0.0478
Loa Loa (eye worm) cysteine protease 0.0017 0.0035 0.0061
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.1588 0.1576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0066
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0138 0.0349
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0333 0.8893
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0026 0.0776
Loa Loa (eye worm) hypothetical protein 0.0032 0.0138 0.0349
Echinococcus multilocularis cysteine protease 0.0017 0.0035 0.0021
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0252 1
Echinococcus multilocularis smad 0.0025 0.0093 0.0079
Brugia malayi RNA recognition motif domain containing protein 0.0521 0.3594 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0472
Loa Loa (eye worm) hypothetical protein 0.0036 0.0167 0.0428
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0594
Schistosoma mansoni intermediate filament proteins 0.0082 0.0491 0.0478
Loa Loa (eye worm) hypothetical protein 0.0036 0.0167 0.0428
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0138 0.0349
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0012
Onchocerca volvulus 0.0017 0.0035 0.0066
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0415 0.2845 0.7907
Schistosoma mansoni tar DNA-binding protein 0.0521 0.3594 0.3585
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0066
Brugia malayi intermediate filament protein 0.0082 0.0491 0.1335
Onchocerca volvulus 0.0017 0.0035 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0066
Loa Loa (eye worm) hypothetical protein 0.0036 0.0167 0.0428
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0252 1
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0335 0.0322
Loa Loa (eye worm) hypothetical protein 0.0048 0.0252 0.0666
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0014 0.0546
Echinococcus granulosus geminin 0.0168 0.1103 0.1091
Plasmodium vivax vivapain-2 0.0017 0.0035 0.0665
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.6534
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0621 0.1697
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0373 1
Schistosoma mansoni hypothetical protein 0.0032 0.0138 0.0125
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0138 0.0349
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0026 0.033
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0035 0.0066
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.6534
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0373 1
Schistosoma mansoni hypothetical protein 0.0032 0.0138 0.0125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0066
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0026 0.033
Schistosoma mansoni lamin 0.0082 0.0491 0.0478
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0238 0.0224
Onchocerca volvulus 0.0205 0.1359 0.4157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0061
Echinococcus granulosus tumor protein p63 0.1397 0.9781 0.978
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0035 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0014 0.0001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0335 0.0322
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0252 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0066
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0491 0.1335
Leishmania major cathepsin L-like protease 0.0065 0.0373 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0335 0.0322
Loa Loa (eye worm) hypothetical protein 0.0036 0.0167 0.0428
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0061
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0014 0.0546
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0373 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0256 0.0243
Echinococcus multilocularis musashi 0.0082 0.0491 0.0478
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0026 0.0012
Brugia malayi TAR-binding protein 0.0521 0.3594 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0026 0.0012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0138 0.0125
Onchocerca volvulus 0.0082 0.0491 0.1476
Entamoeba histolytica hypothetical protein 0.0036 0.0169 0.6534
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0238 0.0224
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0398 0.1073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0066
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0014 0.0546
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0035 0.0021
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0811 0.5643 0.5637
Echinococcus multilocularis tar DNA binding protein 0.0521 0.3594 0.3585
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0153 0.6071
Echinococcus granulosus lamin 0.0082 0.0491 0.0478
Loa Loa (eye worm) TAR-binding protein 0.0521 0.3594 1
Brugia malayi MH2 domain containing protein 0.0025 0.0093 0.0222
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0035 0.0021
Schistosoma mansoni cellular tumor antigen P53 0.0205 0.1359 0.1347
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0093 0.0079
Brugia malayi MH1 domain containing protein 0.0025 0.0093 0.0222
Schistosoma mansoni hypothetical protein 0.0032 0.0138 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0066
Brugia malayi Pre-SET motif family protein 0.006 0.0335 0.0898
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0035 0.0061
Echinococcus multilocularis lamin 0.0082 0.0491 0.0478
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0167 0.5
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0014 0.0001
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0035 0.1398
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0252 1
Brugia malayi Smad1 0.0025 0.0093 0.0222
Loa Loa (eye worm) transcription factor SMAD2 0.037 0.253 0.7029
Entamoeba histolytica cysteine protease, putative 0.0017 0.0035 0.0898
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0621 0.1697
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0238 0.0224
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0014 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0252 1
Onchocerca volvulus 0.0082 0.0491 0.1476
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0035 0.0898
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0252 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0014 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0035 0.0066
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0061
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0169 0.0156
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0093 0.0079
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0621 0.1697
Onchocerca volvulus 0.0017 0.0035 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0373 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0193 0.018
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0224 0.0587
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0035 0.0594
Brugia malayi MH1 domain containing protein 0.0025 0.0093 0.0222
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0252 0.0666
Loa Loa (eye worm) hypothetical protein 0.0036 0.0167 0.0428
Toxoplasma gondii cathepsin CPL 0.0017 0.0035 0.0665
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0014 0.0546
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0252 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0061
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0026 0.0369
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0373 1
Onchocerca volvulus 0.006 0.0335 0.0993
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0014 0.0546
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0014 0.0546
Loa Loa (eye worm) hypothetical protein 0.01 0.0621 0.1697
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0373 1
Echinococcus multilocularis cysteine protease 0.0017 0.0035 0.0021
Loa Loa (eye worm) RNA binding protein 0.0521 0.3594 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0193 0.0502
Brugia malayi Pre-SET motif family protein 0.0415 0.2845 0.7907
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0252 0.6623
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0012
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0252 1
Onchocerca volvulus 0.0017 0.0035 0.0066
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0014 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0066
Schistosoma mansoni hypothetical protein 0.0036 0.0169 0.0156
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0066
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0035 0.0021
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0035 0.0898
Brugia malayi MH2 domain containing protein 0.037 0.253 0.7029
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0014 0.0546
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0335 1
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0594
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0521 0.3594 1
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0491 0.1335
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0373 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0093 0.0222
Brugia malayi hypothetical protein 0.0036 0.0169 0.0436
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0035 0.0021
Onchocerca volvulus 0.0017 0.0035 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0335 0.0322
Schistosoma mansoni hypothetical protein 0.0068 0.0398 0.0384
Schistosoma mansoni microtubule-associated protein tau 0.1429 1 1
Plasmodium vivax vivapain-2 0.0017 0.0035 0.0665
Schistosoma mansoni lamin 0.0082 0.0491 0.0478
Loa Loa (eye worm) hypothetical protein 0.008 0.0481 0.1305
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0138 0.0125
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0238 0.0627
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0026 0.0369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0373 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0026 0.1017
Loa Loa (eye worm) hypothetical protein 0.006 0.0335 0.0898
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0252 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0035 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0182 0.0472
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0252 1
Onchocerca volvulus 0.0017 0.0035 0.0066
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0256 0.0678
Loa Loa (eye worm) ctsf protein 0.0017 0.0035 0.0061
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0252 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0169 0.0156
Echinococcus granulosus Smad4 0.0025 0.0093 0.0079
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0026 0.033
Echinococcus multilocularis Smad4 0.0025 0.0093 0.0079
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0014 0.0001
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0026 0.0012
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0035 0.0066
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0001
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0275 0.7271
Schistosoma mansoni tar DNA-binding protein 0.0521 0.3594 0.3585
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0169 0.0156
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0167 0.6617
Schistosoma mansoni tar DNA-binding protein 0.0521 0.3594 0.3585
Echinococcus multilocularis lamin dm0 0.0082 0.0491 0.0478
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0066
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0061
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0035 0.0021
Loa Loa (eye worm) hypothetical protein 0.0048 0.0252 0.0666
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0373 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0491 0.1335
Echinococcus granulosus cathepsin l1 0.0017 0.0035 0.0021
Leishmania major cathepsin L-like protease 0.0065 0.0373 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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