Detailed information for compound 616369

Basic information

Technical information
  • TDR Targets ID: 616369
  • Name: 2-[[2-(4-chlorophenoxy)acetyl]amino]-6-ethyl- 5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carbox amide
  • MW: 393.888 | Formula: C18H20ClN3O3S
  • H donors: 2 H acceptors: 2 LogP: 3.14 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCc2c(C1)sc(c2C(=O)N)NC(=O)COc1ccc(cc1)Cl
  • InChi: 1S/C18H20ClN3O3S/c1-2-22-8-7-13-14(9-22)26-18(16(13)17(20)24)21-15(23)10-25-12-5-3-11(19)4-6-12/h3-6H,2,7-10H2,1H3,(H2,20,24)(H,21,23)
  • InChiKey: SOUNOXYZPHBXPB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[2-(4-chlorophenoxy)-1-oxoethyl]amino]-6-ethyl-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxamide
  • 2-[2-(4-chlorophenoxy)ethanoylamino]-6-ethyl-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxamide
  • Oprea1_090398

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0108 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.003 0.003
Trypanosoma brucei Aminopeptidase M1, putative 0.0206 0.1116 0.2851
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0958 0.631
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.003 0.0149
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0072 0.0332 0.1656
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0206 0.1116 0.5568
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0134 0.0691 0.3447
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.003 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.003 0.003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.003 0.0149
Plasmodium falciparum glutathione reductase 0.0054 0.0222 0.6525
Brugia malayi follicle stimulating hormone receptor 0.0496 0.2814 0.2814
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0123 0.0626 0.8837
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Trypanosoma brucei Aminopeptidase M1, putative 0.0206 0.1116 0.2851
Brugia malayi hypothetical protein 0.0206 0.1116 0.1116
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.003 0.0149
Brugia malayi hypothetical protein 0.0072 0.0332 0.0332
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0016 0.008
Brugia malayi Peptidase family M1 containing protein 0.0206 0.1116 0.1116
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0958 0.631
Onchocerca volvulus 0.0206 0.1116 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0206 0.1116 0.7368
Onchocerca volvulus 0.0088 0.0422 0.3615
Loa Loa (eye worm) hypothetical protein 0.0034 0.0108 0.0108
Onchocerca volvulus Huntingtin homolog 0.013 0.0667 0.5864
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0052 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.003 0.003
Echinococcus granulosus geminin 0.0358 0.2003 1
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0206 0.1116 0.5568
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0072 0.0332 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.003 0.0149
Schistosoma mansoni lamin 0.0027 0.0066 0.033
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.1508 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0206 0.1116 0.2851
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0676 0.3873 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0201 0.0201
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.003 0.003
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0206 0.1116 0.5568
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.003 0.0149
Brugia malayi nuclear receptor NHR-88 0.0021 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1254 0.626
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.1508 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0206 0.1116 0.2851
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0206 0.1116 0.5568
Brugia malayi hypothetical protein 0.013 0.0667 0.0667
Onchocerca volvulus 0.0027 0.0066 0.0333
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0123 0.0626 0.8837
Loa Loa (eye worm) hypothetical protein 0.0134 0.0691 0.0691
Loa Loa (eye worm) hypothetical protein 0.0134 0.0691 0.0691
Loa Loa (eye worm) hypothetical protein 0.1721 1 1
Brugia malayi MH2 domain containing protein 0.0116 0.0587 0.0587
Mycobacterium tuberculosis Probable dehydrogenase 0.0123 0.0626 0.8837
Loa Loa (eye worm) peptidase family M1 containing protein 0.0072 0.0332 0.0332
Echinococcus granulosus intermediate filament protein 0.0027 0.0066 0.033
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0201 0.0201
Schistosoma mansoni lamin 0.0027 0.0066 0.033
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0072 0.0332 0.1656
Brugia malayi nuclear hormone receptor 0.0021 0.003 0.003
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0587 0.0587
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.003 0.0149
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0072 0.0332 1
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.1508 1
Toxoplasma gondii aminopeptidase N protein 0.0072 0.0332 1
Loa Loa (eye worm) glutathione reductase 0.0054 0.0222 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.003 0.003
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0496 0.2814 0.2814
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0958 0.631
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0016 0.008
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.1508 1
Toxoplasma gondii thioredoxin reductase 0.0054 0.0222 0.6525
Trypanosoma brucei trypanothione reductase 0.0054 0.0222 0.0534
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.003 0.0149
Onchocerca volvulus Glucosylceramidase homolog 0.0179 0.0958 0.8545
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.003 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.003 0.003
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0273 0.1508 0.1508
Schistosoma mansoni nuclear hormone receptor 0.0021 0.003 0.0149
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0072 0.0332 0.0332
Brugia malayi hypothetical protein 0.023 0.1254 0.1254
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0134 0.0691 0.3447
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0422 0.2109
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0206 0.1116 0.5568
Schistosoma mansoni thyroid hormone receptor 0.0021 0.003 0.0149
Schistosoma mansoni thyroid hormone receptor 0.0021 0.003 0.0149
Echinococcus granulosus lamin dm0 0.0027 0.0066 0.033
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0358 0.2003 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0332 0.0332
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0422 0.2109
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0072 0.0332 0.0819
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0222 0.2985
Toxoplasma gondii aminopeptidase n, putative 0.0072 0.0332 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0072 0.0332 0.1656
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.003 0.003
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0072 0.0332 0.0819
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0052 1
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.003 0.0149
Loa Loa (eye worm) hypothetical protein 0.0088 0.0422 0.0422
Trypanosoma cruzi aminopeptidase, putative 0.0206 0.1116 0.2851
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0958 0.631
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0052 0.0518
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0072 0.0332 1
Loa Loa (eye worm) hypothetical protein 0.023 0.1254 0.1254
Onchocerca volvulus 0.0072 0.0332 0.278
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0072 0.0332 0.2116
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0206 0.1116 0.5568
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.1508 1
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0676 0.3873 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.003 0.0149
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Echinococcus multilocularis geminin 0.0358 0.2003 1
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0222 0.0534
Mycobacterium tuberculosis Probable reductase 0.0123 0.0626 0.8837
Loa Loa (eye worm) hypothetical protein 0.0134 0.0691 0.0691
Echinococcus multilocularis lamin 0.0027 0.0066 0.033
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.0706 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.003 0.003
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0052 0.0093
Brugia malayi ecdysteroid receptor 0.0021 0.003 0.003
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0206 0.1116 0.2851
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0066 0.0066
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.003 0.0149
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0052 0.1133
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0958 0.631
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.003 0.003
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0123 0.0626 0.8837
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1254 0.626
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.003 0.0149
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0206 0.1116 0.5568
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0052 0.1133
Loa Loa (eye worm) hypothetical protein 0.013 0.0667 0.0667
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.0706 1
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.1721 1 1
Schistosoma mansoni coup transcription factor 0.0021 0.003 0.0149
Mycobacterium ulcerans aminopeptidase N PepN 0.0072 0.0332 0.2872
Onchocerca volvulus 0.0047 0.0182 0.1397
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.003 0.0149
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0206 0.1116 0.5568
Loa Loa (eye worm) hypothetical protein 0.013 0.0667 0.0667
Schistosoma mansoni hypothetical protein 0.0358 0.2003 1
Brugia malayi TATA binding protein associated factor 0.0072 0.0332 0.0332
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0052 0.1133
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0182 0.0182
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0072 0.0332 0.1656
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0222 0.1109
Trypanosoma cruzi aminopeptidase, putative 0.0072 0.0332 0.0819
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0066 0.0066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.003 0.0149
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.003 0.0149
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.003 0.0149
Echinococcus multilocularis musashi 0.0027 0.0066 0.033
Entamoeba histolytica aminopeptidase, putative 0.0206 0.1116 1
Echinococcus multilocularis aminopeptidase N 0.0206 0.1116 0.5568
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0016 0.5
Toxoplasma gondii aminopeptidase N, putative 0.0072 0.0332 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0066 0.0066
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0222 0.6525
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.003 0.0149
Brugia malayi steroid hormone receptor 0.0021 0.003 0.003
Echinococcus multilocularis lamin dm0 0.0027 0.0066 0.033
Onchocerca volvulus 0.0206 0.1116 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0206 0.1116 0.5568
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0052 0.0093
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0222 0.0222
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.0706 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.003 0.003
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0052 0.0325
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0072 0.0332 0.0819
Loa Loa (eye worm) hypothetical protein 0.005 0.0201 0.0201
Brugia malayi intermediate filament protein 0.0027 0.0066 0.0066
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.003 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.003 0.003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0201 0.0201
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.0706 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0066 0.033
Leishmania major malonyl-coa decarboxylase-like protein 0.0676 0.3873 1
Echinococcus granulosus leukotriene A 4 hydrolase 0.0072 0.0332 0.1656
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.003 0.003
Loa Loa (eye worm) aminopeptidase N 0.0206 0.1116 0.1116
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0016 0.008
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0676 0.3873 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0206 0.1116 0.5568
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0206 0.1116 0.5568
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0072 0.0332 0.0819
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.003 0.003
Brugia malayi Peptidase family M1 containing protein 0.0206 0.1116 0.1116
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0273 0.1508 0.1508
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.003 0.003
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.003 0.0149
Onchocerca volvulus Huntingtin homolog 0.013 0.0667 0.5864
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0206 0.1116 0.2851
Echinococcus granulosus lamin 0.0027 0.0066 0.033
Echinococcus granulosus FTZ F1 alpha 0.0021 0.003 0.0149
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0123 0.0626 0.8837
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0422 0.2109
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0072 0.0332 0.0819
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0222 0.1109
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0072 0.0332 0.0819
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0587 0.0587
Plasmodium vivax glutathione reductase, putative 0.0054 0.0222 0.6525
Brugia malayi glutathione reductase 0.0054 0.0222 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.003 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.003 0.003
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0422 0.0422
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.003 0.0149
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0072 0.0332 1
Brugia malayi Peptidase family M1 containing protein 0.0072 0.0332 0.0332
Plasmodium falciparum thioredoxin reductase 0.0054 0.0222 0.6525
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.003 0.0149
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.003 0.0149
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0206 0.1116 0.5568
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1014 0.6689
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.003 0.003
Echinococcus granulosus aminopeptidase N 0.0206 0.1116 0.5568
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0123 0.0626 0.8774
Schistosoma mansoni hypothetical protein 0.0034 0.0108 0.054
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0134 0.0691 0.1749
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0206 0.1116 0.2851
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.003 0.003
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0047 0.0182 0.0907
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0052 0.0325
Leishmania major trypanothione reductase 0.0054 0.0222 0.0534
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0016 0.0016
Brugia malayi Thioredoxin reductase 0.0054 0.0222 0.0222
Trypanosoma brucei aminopeptidase, putative 0.0072 0.0332 0.0819
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0052 0.1133
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0052 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.003 0.003
Schistosoma mansoni survival motor neuron protein 0.0047 0.0182 0.0907
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.003 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0958 0.631
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.003 0.0149
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1014 0.6689
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0072 0.0332 0.1656
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.003 0.0149
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.1508 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0332 0.0332
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0958 0.631
Schistosoma mansoni aminopeptidase A (M01 family) 0.0072 0.0332 0.1656
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0206 0.1116 0.7368
Loa Loa (eye worm) TATA binding protein associated factor 0.0072 0.0332 0.0332
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0066 0.0066
Mycobacterium ulcerans aminopeptidase N PepN 0.0206 0.1116 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0332 0.0332
Onchocerca volvulus 0.0027 0.0066 0.0333
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.003 0.0149

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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