Detailed information for compound 616444

Basic information

Technical information
  • TDR Targets ID: 616444
  • Name: 6-ethyl-2-[(4-piperidin-1-ylsulfonylbenzoyl)a mino]-5,7-dihydro-4H-thieno[5,4-c]pyridine-3- carboxamide
  • MW: 476.612 | Formula: C22H28N4O4S2
  • H donors: 2 H acceptors: 4 LogP: 2.46 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCc2c(C1)sc(c2C(=O)N)NC(=O)c1ccc(cc1)S(=O)(=O)N1CCCCC1
  • InChi: 1S/C22H28N4O4S2/c1-2-25-13-10-17-18(14-25)31-22(19(17)20(23)27)24-21(28)15-6-8-16(9-7-15)32(29,30)26-11-4-3-5-12-26/h6-9H,2-5,10-14H2,1H3,(H2,23,27)(H,24,28)
  • InChiKey: JVQMYZYUHNAIHW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-ethyl-2-[[4-(1-piperidylsulfonyl)benzoyl]amino]-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxamide
  • 6-ethyl-2-[[oxo-[4-(1-piperidylsulfonyl)phenyl]methyl]amino]-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxamide
  • 6-ethyl-2-[(4-piperidinosulfonylbenzoyl)amino]-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxamide
  • 6-ethyl-2-[(4-piperidin-1-ylsulfonylphenyl)carbonylamino]-5,7-dihydro-4H-thieno[5,4-c]pyridine-3-carboxamide
  • Oprea1_614673

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0042 0.0042
Mycobacterium ulcerans beta-lactamase 0.0147 0.029 0.4824
Loa Loa (eye worm) MH2 domain-containing protein 0.0074 0.0131 0.0131
Schistosoma mansoni inositol monophosphatase 0.0038 0.0051 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0107 0.0134
Mycobacterium leprae conserved hypothetical protein 0.0147 0.029 1
Brugia malayi hypothetical protein 0.0052 0.0083 0.0083
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0147 0.029 0.1253
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0147 0.029 0.1253
Schistosoma mansoni hypothetical protein 0.0039 0.0054 0.0045
Leishmania major hypothetical protein, conserved 0.0147 0.029 0.0619
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0114 0.0219 0.1661
Mycobacterium leprae Probable lipase LipE 0.0147 0.029 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0107 0.0134
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0146 1
Echinococcus multilocularis Smad4 0.0074 0.0131 0.0175
Loa Loa (eye worm) transcription factor SMAD2 0.1093 0.2352 0.2352
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0147 0.029 0.029
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0111 0.014
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.0299 0.0455
Brugia malayi beta-lactamase 0.0147 0.029 0.029
Echinococcus granulosus neuropeptide receptor A26 0.0496 0.105 0.1712
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0054 0.0045
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0048 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0383 0.0803 0.1299
Loa Loa (eye worm) hypothetical protein 0.0063 0.0107 0.0107
Echinococcus multilocularis geminin 0.0699 0.1492 0.2451
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0111 0.2493
Echinococcus granulosus mothers against decapentaplegic 2 0.0033 0.0042 0.0025
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0147 0.029 0.1253
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0232 0.0474 0.0749
Plasmodium vivax SET domain protein, putative 0.0063 0.0107 0.2243
Schistosoma mansoni hypothetical protein 0.0115 0.022 0.0323
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0066 0.0631
Brugia malayi intermediate filament protein 0.0026 0.0027 0.0027
Echinococcus granulosus tumor protein p63 0.0668 0.1424 0.2338
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0107 0.2325
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0081 0.0091
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0115 0.022 0.0323
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0054 0.0045
Loa Loa (eye worm) beta-lactamase 0.0147 0.029 0.029
Echinococcus multilocularis neuropeptide s receptor 0.0496 0.105 0.1712
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0111 0.0154
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0081 0.0078
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0081 0.0297
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0081 0.0091
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0081 0.0078
Loa Loa (eye worm) RNA binding protein 0.0383 0.0803 0.0803
Echinococcus granulosus mothers against decapentaplegic 5 0.0074 0.0131 0.0175
Schistosoma mansoni smad1 5 8 and 0.0074 0.0131 0.0175
Brugia malayi follicle stimulating hormone receptor 0.0241 0.0495 0.0495
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0114 0.0219 0.0434
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.0146 0.3975
Schistosoma mansoni smad1 5 8 and 0.0074 0.0131 0.0175
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0081 0.0078
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0027 0.0027
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.03 0.0644
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0081 0.0078
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0081 0.1431
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.029 0.2369
Schistosoma mansoni rab6-interacting 0.0039 0.0054 0.0045
Loa Loa (eye worm) hypothetical protein 0.0115 0.022 0.022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.029 0.0441
Loa Loa (eye worm) MH2 domain-containing protein 0.1093 0.2352 0.2352
Mycobacterium ulcerans glutaminase 0.0265 0.0547 1
Echinococcus granulosus geminin 0.0699 0.1492 0.2451
Loa Loa (eye worm) hypothetical protein 0.0039 0.0054 0.0054
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1808 0.391 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0107 0.0134
Mycobacterium tuberculosis Probable lipase LipE 0.0147 0.029 0.1253
Loa Loa (eye worm) hypothetical protein 0.0129 0.0251 0.0251
Echinococcus granulosus tar DNA binding protein 0.0383 0.0803 0.1299
Schistosoma mansoni lipoxygenase 0.0162 0.0322 0.0494
Onchocerca volvulus 0.05 0.106 1
Brugia malayi hypothetical protein 0.0039 0.0054 0.0054
Onchocerca volvulus Huntingtin homolog 0.0129 0.0251 0.2168
Schistosoma mansoni Smad4 0.0074 0.0131 0.0175
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0146 1
Mycobacterium tuberculosis Probable hydrolase 0.0147 0.029 0.1253
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0111 0.014
Echinococcus multilocularis tumor protein p63 0.0668 0.1424 0.2338
Brugia malayi Pre-SET motif family protein 0.044 0.0928 0.0928
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1808 0.391 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0042 0.0042
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0081 0.1255
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0054 0.0045
Echinococcus multilocularis neuropeptide receptor A26 0.0496 0.105 0.1712
Mycobacterium ulcerans hypothetical protein 0.0147 0.029 0.4824
Schistosoma mansoni polycystin 1-related 0.0039 0.0054 0.0045
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0081 0.0078
Brugia malayi MH2 domain containing protein 0.0074 0.0131 0.0131
Trichomonas vaginalis esterase, putative 0.0147 0.029 0.2369
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0114 0.0219 0.0321
Brugia malayi glutaminase DH11.1 0.0265 0.0547 0.0547
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.0495 0.0495
Mycobacterium tuberculosis Probable lipase LipD 0.0147 0.029 0.1253
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.044 0.0928 0.0928
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0067 0.0042
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0078 0.0086
Loa Loa (eye worm) hypothetical protein 0.0147 0.029 0.029
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0054 0.0045
Echinococcus granulosus TGF beta signal transducer SmadC 0.0074 0.0131 0.0175
Brugia malayi RNA binding protein 0.0383 0.0803 0.0803
Leishmania major mitochondrial DNA polymerase beta 0.032 0.0667 0.1597
Echinococcus granulosus smad 0.0074 0.0131 0.0175
Brugia malayi Latrophilin receptor protein 2 0.0115 0.022 0.022
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0111 0.014
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0066 0.053
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0081 0.0297
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1808 0.391 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0114 0.0219 0.0434
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0111 0.0345
Trypanosoma brucei mitochondrial DNA polymerase beta 0.032 0.0667 0.1597
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0232 0.0474 0.0749
Loa Loa (eye worm) acetyltransferase 0.0151 0.0299 0.0299
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0111 0.1203
Loa Loa (eye worm) glutaminase 2 0.0265 0.0547 0.0547
Mycobacterium ulcerans lipase LipD 0.0147 0.029 0.4824
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0026
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0114 0.0219 0.0321
Mycobacterium ulcerans hypothetical protein 0.0169 0.0337 0.5769
Leishmania major malonyl-coa decarboxylase-like protein 0.1808 0.391 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0067 0.0042
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0067 0.0042
Brugia malayi hypothetical protein 0.0081 0.0146 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.029 0.0619
Echinococcus granulosus Smad4 0.0074 0.0131 0.0175
Echinococcus granulosus GPCR family 2 0.0115 0.022 0.0323
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0846 0.1814 0.299
Loa Loa (eye worm) hypothetical protein 0.0147 0.029 0.029
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.029 0.044
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0114 0.0219 0.0321
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.0146 0.391
Brugia malayi hypothetical protein 0.0039 0.0054 0.0054
Brugia malayi beta-lactamase family protein 0.0147 0.029 0.029
Loa Loa (eye worm) nuclear factor I 0.0041 0.0059 0.0059
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0027 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.029 0.2369
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.0299 0.0455
Onchocerca volvulus 0.0147 0.029 0.2549
Loa Loa (eye worm) hypothetical protein 0.0147 0.029 0.029
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.4602 1 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0081 0.0078
Trichomonas vaginalis set domain proteins, putative 0.05 0.106 1
Schistosoma mansoni hypothetical protein 0.0248 0.0511 0.0809
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0941 0.2019 1
Schistosoma mansoni tar DNA-binding protein 0.0383 0.0803 0.1299
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0027 0.0027
Toxoplasma gondii ABC1 family protein 0.0147 0.029 1
Plasmodium vivax hypothetical protein, conserved 0.0147 0.029 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0182 0.0182
Echinococcus multilocularis ubiquitin specific protease 41 0.0114 0.0219 0.0321
Brugia malayi Pre-SET motif family protein 0.0063 0.0107 0.0107
Schistosoma mansoni tar DNA-binding protein 0.0383 0.0803 0.1299
Echinococcus multilocularis microtubule associated protein 2 0.2769 0.6004 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0107 0.0134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0078 0.0086
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0054 0.0054
Brugia malayi Inositol-1 0.0038 0.0051 0.0051
Loa Loa (eye worm) TAR-binding protein 0.0383 0.0803 0.0803
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0081 0.0091
Brugia malayi mothers against decapentaplegic homolog 3 0.0033 0.0042 0.0042
Loa Loa (eye worm) inositol-1 0.0038 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0248 0.0511 0.0511
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0081 0.0297
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.029 0.0441
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0114 0.0219 0.0321
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0383 0.0803 0.0803
Onchocerca volvulus 0.0147 0.029 0.2549
Loa Loa (eye worm) glutaminase 0.0265 0.0547 0.0547
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.029 0.0619
Schistosoma mansoni smad1 5 8 and 0.0074 0.0131 0.0175
Schistosoma mansoni hypothetical protein 0.0115 0.022 0.0323
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0111 0.014
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0054 0.0045
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0048 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0078 0.0086
Loa Loa (eye worm) hypothetical protein 0.0114 0.0219 0.0219
Echinococcus multilocularis GPCR, family 2 0.0115 0.022 0.0323
Mycobacterium tuberculosis Conserved protein 0.0147 0.029 0.1253
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0081 0.0081
Echinococcus multilocularis mothers against decapentaplegic 2 0.0033 0.0042 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0078 0.0086
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0147 0.029 0.4824
Brugia malayi hypothetical protein 0.0129 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0147 0.029 0.029
Mycobacterium tuberculosis Conserved protein 0.0147 0.029 0.1253
Echinococcus granulosus ubiquitin specific protease 41 0.0114 0.0219 0.0321
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0111 0.1203
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0146 0.0246
Echinococcus granulosus beta LACTamase domain containing family member 0.0147 0.029 0.0441
Schistosoma mansoni hypothetical protein 0.0036 0.0048 0.0036
Brugia malayi TAR-binding protein 0.0383 0.0803 0.0803
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0058 0.0419
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0078 0.0086
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0699 0.1492 0.2451
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.029 0.2369
Loa Loa (eye worm) hypothetical protein 0.0363 0.0761 0.0761
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0081 0.0297
Toxoplasma gondii hypothetical protein 0.0052 0.0082 0.1286
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.0667 0.1597
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0033 0.0042 0.0145
Schistosoma mansoni glutaminase 0.0265 0.0547 0.087
Brugia malayi MH1 domain containing protein 0.0041 0.0059 0.0059
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0115 0.022 0.0323
Schistosoma mansoni loxhd1 0.0039 0.0054 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0107 0.0134
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0115 0.022 0.0323
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0051 0.0041
Loa Loa (eye worm) hypothetical protein 0.0081 0.0146 0.0146
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0114 0.0219 0.0219
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0363 0.0761 0.0761
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0129 0.0251 0.0251
Mycobacterium ulcerans esterase/lipase LipP 0.0147 0.029 0.4824
Schistosoma mansoni hypothetical protein 0.0115 0.022 0.0323
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.0337 0.1489
Schistosoma mansoni hypothetical protein 0.0699 0.1492 0.2451
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0074 0.0131 0.0175
Echinococcus granulosus neuropeptide s receptor 0.0496 0.105 0.1712
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0054 0.0045
Schistosoma mansoni lipoxygenase 0.0232 0.0474 0.0749
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0102 0.0125
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0114 0.0219 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0078 0.0078
Brugia malayi latrophilin 2 splice variant baaae 0.0248 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0147 0.029 0.029
Loa Loa (eye worm) Smad1 0.0074 0.0131 0.0131
Mycobacterium tuberculosis Conserved protein 0.0147 0.029 0.1253
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0107 0.0134
Brugia malayi MH1 domain containing protein 0.0074 0.0131 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0219 0.1661
Schistosoma mansoni hypothetical protein 0.0115 0.022 0.0323
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0067 0.0042
Echinococcus multilocularis RUN 0.0039 0.0054 0.0045
Onchocerca volvulus 0.0039 0.0054 0.026
Echinococcus multilocularis smad 0.0074 0.0131 0.0175
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0114 0.0219 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.029 0.029
Brugia malayi MH2 domain containing protein 0.0074 0.0131 0.0131
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0081 0.0091
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0058 0.0482
Echinococcus multilocularis tar DNA binding protein 0.0383 0.0803 0.1299
Brugia malayi MAP kinase sur-1 0.0051 0.0081 0.0081
Echinococcus multilocularis mothers against decapentaplegic 6 0.0033 0.0042 0.0025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0078 0.0086
Schistosoma mansoni inositol monophosphatase 0.0038 0.0051 0.0041
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0182 0.026
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0089 0.0098
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0114 0.0219 0.1661
Onchocerca volvulus Huntingtin homolog 0.0129 0.0251 0.2168
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0115 0.022 0.022
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0147 0.029 0.029
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0114 0.0219 0.0434
Brugia malayi MH2 domain containing protein 0.0033 0.0042 0.0042
Brugia malayi beta-lactamase family protein 0.0147 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0039 0.0054 0.0054
Schistosoma mansoni rab6-interacting 0.0039 0.0054 0.0045
Brugia malayi MH2 domain containing protein 0.1093 0.2352 0.2352
Loa Loa (eye worm) MH1 domain-containing protein 0.0074 0.0131 0.0131
Echinococcus granulosus mothers against decapentaplegic 6 0.0033 0.0042 0.0025
Brugia malayi MH1 domain containing protein 0.0041 0.0059 0.0059
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.029 0.2369
Trypanosoma brucei hypothetical protein, conserved 0.0147 0.029 0.0619
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0114 0.0219 0.0434
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0078 0.0086
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0107 0.0134
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.032 0.0667 0.1597
Echinococcus granulosus RUN 0.0039 0.0054 0.0045
Echinococcus multilocularis mothers against decapentaplegic 5 0.0074 0.0131 0.0175
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0051 0.0041
Brugia malayi RNA recognition motif domain containing protein 0.0383 0.0803 0.0803
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0078 0.0078
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.4602 1 1
Schistosoma mansoni Smad4 0.0033 0.0042 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.029 0.2369
Onchocerca volvulus 0.0039 0.0054 0.026
Echinococcus multilocularis beta LACTamase domain containing family member 0.0147 0.029 0.0441
Trichomonas vaginalis glutaminase, putative 0.0265 0.0547 0.4912
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0081 0.0091
Onchocerca volvulus 0.0098 0.0182 0.1504
Echinococcus granulosus microtubule associated protein 2 0.2769 0.6004 1
Schistosoma mansoni microtubule-associated protein tau 0.2769 0.6004 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0066 0.0066
Trypanosoma brucei protein kinase, putative 0.0051 0.0081 0.0078
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0114 0.0219 0.0321
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.03 0.0644
Mycobacterium tuberculosis Probable esterase LipL 0.0147 0.029 0.1253
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0074 0.0131 0.0175
Schistosoma mansoni smad 0.0074 0.0131 0.0175
Schistosoma mansoni Smad4 0.0033 0.0042 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0146 0.0246
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0114 0.0219 0.0321
Schistosoma mansoni tar DNA-binding protein 0.0383 0.0803 0.1299
Brugia malayi Calcitonin receptor-like protein seb-1 0.0363 0.0761 0.0761
Brugia malayi MH1 domain containing protein 0.0074 0.0131 0.0131
Loa Loa (eye worm) latrophilin receptor protein 2 0.0115 0.022 0.022
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0081 0.0078
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.03 0.0644
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0111 0.1203
Onchocerca volvulus 0.0063 0.0107 0.0773
Brugia malayi Smad1 0.0074 0.0131 0.0131
Leishmania major hypothetical protein, conserved 0.0081 0.0146 0.0246
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0115 0.022 0.0323
Schistosoma mansoni smad 0.0033 0.0042 0.0025
Brugia malayi Doublecortin family protein 0.0039 0.0054 0.0054
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0066 0.015
Schistosoma mansoni tar DNA-binding protein 0.0383 0.0803 0.1299
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0066 0.0631
Onchocerca volvulus 0.0147 0.029 0.2549
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0066 0.015
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0363 0.0761 0.0761
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.0146 0.0246

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.