Detailed information for compound 616456

Basic information

Technical information
  • TDR Targets ID: 616456
  • Name: 3-(4-chlorophenyl)-1-(4-methylphenyl)-2,5,6,7 -tetrahydroimidazo[2,3-b][1,3]thiazin-4-ium-3 -ol
  • MW: 359.893 | Formula: C19H20ClN2OS+
  • H donors: 1 H acceptors: 1 LogP: 3.81 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)[N+]1=C2SCCCN2C(C1)(O)c1ccc(cc1)Cl
  • InChi: 1S/C19H20ClN2OS/c1-14-3-9-17(10-4-14)21-13-19(23,15-5-7-16(20)8-6-15)22-11-2-12-24-18(21)22/h3-10,23H,2,11-13H2,1H3/q+1
  • InChiKey: HOPPIGKFNFIZEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ChemDiv1_026798
  • ChemDivAM_001251

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0057 0.0077
Loa Loa (eye worm) hypothetical protein 0.0063 0.0343 0.0338
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0093
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.1625 0.162
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0057 0.0105
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0543 0.386 1
Schistosoma mansoni tar DNA-binding protein 0.0213 0.1444 0.2894
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0636 0.0631
Loa Loa (eye worm) TAR-binding protein 0.0213 0.1444 0.144
Schistosoma mansoni hypothetical protein 0.0032 0.0123 0.0237
Brugia malayi ecdysteroid receptor 0.0023 0.0057 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.0775 0.19
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0057 0.0105
Mycobacterium tuberculosis Probable hydrolase 0.0121 0.0775 0.1313
Trichomonas vaginalis D-aminoacylase, putative 0.0121 0.0775 1
Schistosoma mansoni lamin 0.0063 0.0343 0.068
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0057 0.0052
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0051 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0213 0.1444 0.2894
Loa Loa (eye worm) hypothetical protein 0.0109 0.0683 0.0678
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0057 0.0052
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0121 0.0775 0.077
Schistosoma mansoni tar DNA-binding protein 0.0213 0.1444 0.2894
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0057 0.0077
Trypanosoma brucei unspecified product 0.0023 0.0051 0.0133
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0051 0.0092
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0051 0.0067
Loa Loa (eye worm) inositol-1 0.0043 0.0202 0.0197
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0051 0.0133
Echinococcus granulosus microtubule associated protein 2 0.0696 0.4978 1
Mycobacterium tuberculosis Probable esterase LipL 0.0121 0.0775 0.1313
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0051 0.0092
Plasmodium vivax hypothetical protein, conserved 0.0121 0.0775 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0123 0.0118
Onchocerca volvulus 0.0063 0.0343 0.2082
Trichomonas vaginalis D-aminoacylase, putative 0.0121 0.0775 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0133
Brugia malayi beta-lactamase family protein 0.0121 0.0775 0.077
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0202 0.2085
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0543 0.386 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0057 0.0105
Trypanosoma brucei hypothetical protein, conserved 0.0121 0.0775 0.2007
Schistosoma mansoni lamin 0.0063 0.0343 0.068
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0123 0.0237
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0052
Toxoplasma gondii LsmAD domain-containing protein 0.0109 0.0683 0.8392
Schistosoma mansoni intermediate filament proteins 0.0063 0.0343 0.068
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0051 0.0067
Brugia malayi hypothetical protein 0.0277 0.1909 0.1905
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.027 0.0265
Echinococcus multilocularis musashi 0.0063 0.0343 0.0496
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0107 0.0149
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0202 0.0524
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0052
Loa Loa (eye worm) hypothetical protein 0.0121 0.0775 0.077
Onchocerca volvulus 0.0121 0.0775 0.5224
Loa Loa (eye worm) hypothetical protein 0.1383 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0109 0.0683 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0109 0.0683 0.1658
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0121 0.0775 0.1313
Brugia malayi RNA recognition motif domain containing protein 0.0213 0.1444 0.144
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0121 0.0775 0.077
Echinococcus granulosus survival motor neuron protein 1 0.0277 0.1909 0.3829
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0057 0.0105
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0213 0.1444 0.144
Echinococcus multilocularis GPCR, family 2 0.0032 0.0123 0.0173
Plasmodium falciparum ataxin-2 like protein, putative 0.0109 0.0683 0.5
Schistosoma mansoni microtubule-associated protein tau 0.0696 0.4978 1
Echinococcus granulosus tar DNA binding protein 0.0213 0.1444 0.2894
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0057 0.0052
Schistosoma mansoni inositol monophosphatase 0.0043 0.0202 0.0396
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0057 0.0052
Brugia malayi steroid hormone receptor 0.0023 0.0057 0.0052
Loa Loa (eye worm) hypothetical protein 0.0121 0.0775 0.077
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0051 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0057 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0057 0.0052
Loa Loa (eye worm) hypothetical protein 0.0103 0.0636 0.0631
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0057 0.0105
Echinococcus multilocularis lamin 0.0063 0.0343 0.0496
Leishmania major hypothetical protein, conserved 0.0109 0.0683 0.1658
Schistosoma mansoni hypothetical protein 0.0056 0.0299 0.059
Echinococcus multilocularis lamin dm0 0.0063 0.0343 0.0496
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0202 0.0396
Brugia malayi intermediate filament protein 0.0063 0.0343 0.0338
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0057 0.0077
Loa Loa (eye worm) hypothetical protein 0.0029 0.0098 0.0093
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0057 0.0105
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0046
Onchocerca volvulus 0.0063 0.0343 0.2082
Loa Loa (eye worm) hypothetical protein 0.0277 0.1909 0.1905
Loa Loa (eye worm) RNA binding protein 0.0213 0.1444 0.144
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0636 0.0631
Loa Loa (eye worm) hypothetical protein 0.0121 0.0775 0.077
Schistosoma mansoni tar DNA-binding protein 0.0213 0.1444 0.2894
Schistosoma mansoni coup transcription factor 0.0023 0.0057 0.0105
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0057 0.0105
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.1635 0.1631
Echinococcus granulosus intermediate filament protein 0.0063 0.0343 0.068
Onchocerca volvulus 0.0121 0.0775 0.5224
Echinococcus granulosus dna polymerase kappa 0.0023 0.0051 0.0092
Brugia malayi follicle stimulating hormone receptor 0.0238 0.1625 0.162
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0051 0.0046
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0049 0.0243 0.0479
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0202 1
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0057 0.0052
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0057 0.0052
Brugia malayi RNA binding protein 0.0213 0.1444 0.144
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0121 0.0775 1
Echinococcus multilocularis dna polymerase eta 0.0023 0.0051 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0057 0.0052
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0057 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0057 0.0052
Trichomonas vaginalis esterase, putative 0.0121 0.0775 1
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0057 0.0105
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0123 0.0118
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0057 0.0077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0057 0.0077
Mycobacterium tuberculosis Probable lipase LipD 0.0121 0.0775 0.1313
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0123 0.0237
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0121 0.0775 0.1313
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0057 0.0105
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0057 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0057 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0052
Leishmania major malonyl-coa decarboxylase-like protein 0.0543 0.386 1
Brugia malayi beta-lactamase 0.0121 0.0775 0.077
Brugia malayi Inositol-1 0.0043 0.0202 0.0197
Trypanosoma cruzi PAB1-binding protein , putative 0.0109 0.0683 0.1658
Echinococcus multilocularis survival motor neuron protein 1 0.0277 0.1909 0.2792
Loa Loa (eye worm) hypothetical protein 0.0121 0.0775 0.077
Echinococcus multilocularis microtubule associated protein 2 0.0696 0.4978 0.7293
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0057 0.0105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.027 0.0533
Loa Loa (eye worm) hypothetical protein 0.0061 0.0335 0.033
Trichomonas vaginalis D-aminoacylase, putative 0.0121 0.0775 1
Mycobacterium tuberculosis Conserved protein 0.0121 0.0775 0.1313
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0133
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.027 0.0389
Schistosoma mansoni tar DNA-binding protein 0.0213 0.1444 0.2894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0057 0.0052
Brugia malayi nuclear hormone receptor 0.0023 0.0057 0.0052
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0057 0.0105
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0123 0.0173
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0049 0.0243 0.0349
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.027 0.0533
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0131 0.0126
Schistosoma mansoni hypothetical protein 0.0032 0.0123 0.0237
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0299 0.0294
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0543 0.386 1
Brugia malayi Intermediate filament tail domain containing protein 0.0063 0.0343 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0133
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0052
Mycobacterium ulcerans esterase/lipase LipP 0.0121 0.0775 1
Brugia malayi nuclear receptor NHR-88 0.0023 0.0057 0.0052
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0399 0.0394
Loa Loa (eye worm) hypothetical protein 0.0032 0.0123 0.0118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0121 0.0775 0.1548
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0057 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0057 0.0052
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0211 0.143 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0057 0.0077
Mycobacterium ulcerans lipase LipD 0.0121 0.0775 1
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.1383 1 1
Leishmania major hypothetical protein, conserved 0.0121 0.0775 0.19
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0948 0.6823 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0123 0.0118
Trichomonas vaginalis penicillin-binding protein, putative 0.0121 0.0775 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0057 0.0052
Echinococcus granulosus lamin dm0 0.0063 0.0343 0.068
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0057 0.0052
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0776 0.5563 1
Schistosoma mansoni DNA polymerase eta 0.0023 0.0051 0.0092
Schistosoma mansoni inositol monophosphatase 0.0043 0.0202 0.0396
Mycobacterium tuberculosis Conserved protein 0.0121 0.0775 0.1313
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0057 0.0077
Echinococcus granulosus lamin 0.0063 0.0343 0.068
Loa Loa (eye worm) hypothetical protein 0.003 0.0107 0.0102
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0169 0.0214
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0057 0.0077
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0202 0.0396
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0052
Loa Loa (eye worm) beta-lactamase 0.0121 0.0775 0.077
Mycobacterium leprae Probable lipase LipE 0.0121 0.0775 1
Mycobacterium ulcerans hypothetical protein 0.0121 0.0775 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0057 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0133
Echinococcus granulosus dna polymerase eta 0.0023 0.0051 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0133
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0202 0.2085
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0107 0.0204
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0051 0.0133
Loa Loa (eye worm) hypothetical protein 0.0211 0.143 0.1426
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0133
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0057 0.0052
Mycobacterium leprae conserved hypothetical protein 0.0121 0.0775 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0399 0.0394
Echinococcus granulosus GPCR family 2 0.0032 0.0123 0.0237
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0057 0.0105
Echinococcus multilocularis beta LACTamase domain containing family member 0.0121 0.0775 0.1129
Echinococcus multilocularis tar DNA binding protein 0.0213 0.1444 0.2111
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0121 0.0775 0.1313
Schistosoma mansoni hypothetical protein 0.0032 0.0123 0.0237
Onchocerca volvulus 0.0056 0.0299 0.1757
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0133
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0057 0.0105
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0202 0.0396
Schistosoma mansoni hypothetical protein 0.007 0.0399 0.0791
Brugia malayi beta-lactamase family protein 0.0121 0.0775 0.077
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0052
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0202 0.0396
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0202 0.0289
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0057 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0057 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0636 0.0631
Brugia malayi hypothetical protein 0.0109 0.0683 0.0678
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0202 0.2085
Brugia malayi hypothetical protein 0.007 0.04 0.0395
Trypanosoma brucei PAB1-binding protein , putative 0.0109 0.0683 0.1769
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.027 0.0533
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0051 0.0133
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0052
Mycobacterium ulcerans beta-lactamase 0.0121 0.0775 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.1635 0.1631
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0057 0.0052
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0057 0.0052
Brugia malayi N-terminal motif family protein 0.0211 0.143 0.1426
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0057 0.0105
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0051 0.0092
Trichomonas vaginalis penicillin-binding protein, putative 0.0121 0.0775 1
Mycobacterium tuberculosis Probable lipase LipE 0.0121 0.0775 0.1313
Toxoplasma gondii ABC1 family protein 0.0121 0.0775 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0121 0.0775 0.1548
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.027 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0057 0.0052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0057 0.0105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.027 0.0533
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.027 0.0389
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0121 0.0775 0.1548
Schistosoma mansoni hypothetical protein 0.0032 0.0123 0.0237
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0133
Brugia malayi MH2 domain containing protein 0.0239 0.1635 0.1631
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.027 0.0533
Onchocerca volvulus 0.0121 0.0775 0.5224
Schistosoma mansoni survival motor neuron protein 0.0056 0.0299 0.059
Brugia malayi TAR-binding protein 0.0213 0.1444 0.144
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0131 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0057 0.0052
Mycobacterium tuberculosis Conserved protein 0.0121 0.0775 0.1313
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0057 0.0105
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0063 0.0343 0.0338
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.0775 0.19
Loa Loa (eye worm) intermediate filament protein 0.0063 0.0343 0.0338
Loa Loa (eye worm) hypothetical protein 0.0023 0.0057 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0133
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0057 0.0105
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0202 0.2085
Giardia lamblia DINP protein human, muc B family 0.0023 0.0051 0.5
Schistosoma mansoni hypothetical protein 0.0049 0.0243 0.0479
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0123 0.0173
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0051 0.0133
Loa Loa (eye worm) hypothetical protein 0.0121 0.0775 0.077
Loa Loa (eye worm) hypothetical protein 0.0121 0.0775 0.077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0057 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0057 0.0052
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0057 0.0077

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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