Detailed information for compound 616497

Basic information

Technical information
  • TDR Targets ID: 616497
  • Name: 3-(4-ethoxyphenyl)-1-phenyl-2,5,6,7,8,9-hexah ydroimidazo[3,2-a]azepin-4-ium-3-ol
  • MW: 351.462 | Formula: C22H27N2O2+
  • H donors: 1 H acceptors: 1 LogP: 2.86 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)C1(O)C[N+](=C2N1CCCCC2)c1ccccc1
  • InChi: 1S/C22H27N2O2/c1-2-26-20-14-12-18(13-15-20)22(25)17-23(19-9-5-3-6-10-19)21-11-7-4-8-16-24(21)22/h3,5-6,9-10,12-15,25H,2,4,7-8,11,16-17H2,1H3/q+1
  • InChiKey: MPEBCBPXJWNSLX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0193 0.4181
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0108
Onchocerca volvulus 0.0071 0.0193 0.1098
Schistosoma mansoni hypothetical protein 0.034 0.1131 0.1131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0104 0.0629
Trichomonas vaginalis ferritin, putative 0.0027 0.0042 0.0252
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0193 0.1997
Schistosoma mansoni smad 0.0042 0.0094 0.0094
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0094 0.0299
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0201 0.2081
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0034 0.0352
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0072 0.0439
Echinococcus granulosus lamin dm0 0.0168 0.0531 0.0531
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0034 0.1559
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0022 0.092
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0104 0.0104
Brugia malayi beta-lactamase family protein 0.0071 0.0193 0.0616
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0936 0.5668
Mycobacterium ulcerans beta-lactamase 0.0071 0.0193 0.4181
Brugia malayi MH2 domain containing protein 0.0616 0.2091 0.668
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0054 0.0137 0.0437
Loa Loa (eye worm) hypothetical protein 0.0099 0.0292 0.0931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0041 0.0248
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0034 0.0352
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0099 0.0292 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0032 0.0194
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.0936 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0072 0.0197 0.1916
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0126 0.0807
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0072 0.0072
Brugia malayi latrophilin 2 splice variant baaae 0.0214 0.0691 0.2207
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0022 0.0133
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0313 0.1035 0.3306
Brugia malayi Smad1 0.0042 0.0094 0.0299
Schistosoma mansoni tar DNA-binding protein 0.0915 0.313 0.313
Brugia malayi Ets-domain containing protein 0.0071 0.0194 0.062
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0094 0.0094
Echinococcus granulosus Smad4 0.0042 0.0094 0.0094
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.0936 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0698
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0201 0.2081
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0915 0.313 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1622 0.5585 0.5585
Echinococcus granulosus mitogen activated protein kinase 14 0.0293 0.0965 0.0965
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0193 1
Brugia malayi RNA binding protein 0.0915 0.313 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0197 0.0197
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0193 0.1246
Brugia malayi Inositol-1 0.0036 0.0072 0.0232
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0034 0.2218
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0022 0.0227
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0005 0.0048
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0193 0.0616
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0201 0.438
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0005 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0126 0.0807
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0201 0.438
Onchocerca volvulus 0.0021 0.0022 0.0056
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0193 0.1246
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.0936 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0064 0.0387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0032 0.0194
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0022 0.0115
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0137 0.2813
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0193 0.0193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0267 0.0267
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0201 0.2081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0072 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.004 0.0243
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0034 0.0352
Schistosoma mansoni ferritin 0.0027 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0064 0.0387
Loa Loa (eye worm) hypothetical protein 0.0214 0.0691 0.2207
Loa Loa (eye worm) hypothetical protein 0.0168 0.0531 0.1696
Schistosoma mansoni hypothetical protein 0.0099 0.0292 0.0292
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0137 0.5
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0072 0.3607
Brugia malayi cytoplasmic intermediate filament protein 0.009 0.026 0.0831
Schistosoma mansoni inositol monophosphatase 0.0036 0.0072 0.0072
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0154 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0032 0.0194
Brugia malayi hypothetical protein 0.0025 0.0034 0.0108
Schistosoma mansoni cellular tumor antigen P53 0.0319 0.1058 0.1058
Echinococcus multilocularis mitogen activated protein kinase 14 0.0293 0.0965 0.0965
Loa Loa (eye worm) hypothetical protein 0.0061 0.0158 0.0506
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0267 0.0267
Onchocerca volvulus 0.0021 0.0022 0.0056
Mycobacterium ulcerans bacterioferritin BfrB 0.0027 0.0042 0.0483
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0022 0.0115
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.0292 0.0931
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0094 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0064 0.0387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0064 0.0387
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0197 0.0197
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0193 0.4181
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0313 0.1035 0.3306
Loa Loa (eye worm) hypothetical protein 0.0054 0.0137 0.0437
Loa Loa (eye worm) TAR-binding protein 0.0915 0.313 1
Brugia malayi MH1 domain containing protein 0.0023 0.0028 0.009
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0072 0.0439
Leishmania major hypothetical protein, conserved 0.0025 0.0034 0.0352
Onchocerca volvulus 0.0168 0.0531 0.3161
Echinococcus multilocularis mitogen activated protein kinase 11 0.0293 0.0965 0.0965
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0022 0.007
Loa Loa (eye worm) fli-1 protein 0.0215 0.0696 0.2224
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0022 0.1309
Mycobacterium tuberculosis Conserved protein 0.0071 0.0193 0.1246
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0193 0.4181
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0201 0.438
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0162 0.0162
Echinococcus multilocularis microtubule associated protein 2 0.2892 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0936 0.5668
Echinococcus multilocularis musashi 0.0168 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0071 0.0193 0.0616
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.009
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0022 0.092
Brugia malayi MH1 domain containing protein 0.0023 0.0028 0.009
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0013 0.0041
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0012 0.0046
Brugia malayi Calcitonin receptor-like protein seb-1 0.0313 0.1035 0.3306
Schistosoma mansoni hypothetical protein 0.0214 0.0691 0.0691
Schistosoma mansoni apoferritin-2 0.0027 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0072 0.0436
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0022 0.007
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0072 0.0751
Loa Loa (eye worm) hypothetical protein 0.0702 0.2387 0.7627
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0267 0.0267
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0072 1
Schistosoma mansoni hypothetical protein 0.0099 0.0292 0.0292
Onchocerca volvulus 0.0071 0.0193 0.1098
Brugia malayi TAR-binding protein 0.0915 0.313 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0201 0.438
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.007
Schistosoma mansoni smad1 5 8 and 0.0042 0.0094 0.0094
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0104 0.1077
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0201 0.13
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0041 0.0248
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0022 0.0022
Mycobacterium ulcerans lipase LipD 0.0071 0.0193 0.4181
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0072 0.0439
Echinococcus multilocularis expressed protein 0.0027 0.0042 0.0042
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0022 0.0227
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0034 0.2218
Loa Loa (eye worm) hypothetical protein 0.0054 0.0137 0.0437
Loa Loa (eye worm) MH2 domain-containing protein 0.0616 0.2091 0.668
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0022 0.007
Schistosoma mansoni inositol monophosphatase 0.0036 0.0072 0.0072
Leishmania major hypothetical protein, conserved 0.0071 0.0193 0.1997
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0013 0.013
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0048
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0072 0.0747
Onchocerca volvulus 0.0073 0.0201 0.1148
Loa Loa (eye worm) hypothetical protein 0.0071 0.0193 0.0616
Brugia malayi MH1 domain containing protein 0.0042 0.0094 0.0299
Schistosoma mansoni hypothetical protein 0.0143 0.0445 0.0445
Schistosoma mansoni tar DNA-binding protein 0.0915 0.313 0.313
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0027 0.0042 0.0483
Schistosoma mansoni hypothetical protein 0.0072 0.0197 0.0197
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0201 0.438
Schistosoma mansoni ferritin light chain 0.0027 0.0042 0.0042
Mycobacterium leprae Probable lipase LipE 0.0071 0.0193 0.4181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0064 0.0387
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0022 0.007
Loa Loa (eye worm) Smad1 0.0042 0.0094 0.0299
Echinococcus multilocularis smad 0.0042 0.0094 0.0094
Loa Loa (eye worm) RNA binding protein 0.0915 0.313 1
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0293 0.0965 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.043 1
Onchocerca volvulus 0.0168 0.0531 0.3161
Brugia malayi Fli-1 protein 0.0215 0.0696 0.2224
Brugia malayi Pre-SET motif family protein 0.0062 0.0162 0.0518
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0293 0.0965 1
Loa Loa (eye worm) nuclear factor I 0.0023 0.0028 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0032 0.0194
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0126 0.0807
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0162 0.0162
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0022 0.0227
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0293 0.0965 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0936 0.5668
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0194 0.0194
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0081 0.0229 0.0732
Schistosoma mansoni smad 0.0019 0.0013 0.0013
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0072 0.0751
Echinococcus multilocularis lamin dm0 0.0168 0.0531 0.0531
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0048
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0267 0.0854
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0104 0.0629
Brugia malayi MH2 domain containing protein 0.0019 0.0013 0.0041
Schistosoma mansoni smad1 5 8 and 0.0042 0.0094 0.0094
Schistosoma mansoni Smad4 0.0019 0.0013 0.0013
Loa Loa (eye worm) intermediate filament protein 0.0168 0.0531 0.1696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0032 0.0193
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.009 0.026 0.0831
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0193 0.0193
Schistosoma mansoni hypothetical protein 0.0099 0.0292 0.0292
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0022 0.0227
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0201 0.438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0049 0.0297
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0099 0.0292 0.0292
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0162 0.0162
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0201 0.438
Entamoeba histolytica hypothetical protein 0.0072 0.0197 0.1916
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0104 0.1077
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.043 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.0292 0.0931
Onchocerca volvulus 0.0143 0.0445 0.2638
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0052 0.0318
Brugia malayi isocitrate dehydrogenase 0.0016 0.0005 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0081 0.0491
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0005
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0064 0.315
Brugia malayi RNA recognition motif domain containing protein 0.0915 0.313 1
Loa Loa (eye worm) beta-lactamase 0.0071 0.0193 0.0616
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0022 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0064 0.0387
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0162 0.8381
Loa Loa (eye worm) hypothetical protein 0.0175 0.0555 0.1775
Schistosoma mansoni tar DNA-binding protein 0.0915 0.313 0.313
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0201 0.1957
Toxoplasma gondii ABC1 family protein 0.0071 0.0193 1
Echinococcus granulosus mitogen activated protein kinase 11 0.0293 0.0965 0.0965
Mycobacterium ulcerans hypothetical protein 0.0071 0.0193 0.4181
Loa Loa (eye worm) transcription factor SMAD2 0.0616 0.2091 0.668
Plasmodium vivax SET domain protein, putative 0.0062 0.0162 0.8381
Entamoeba histolytica hypothetical protein 0.0072 0.0197 0.1916
Schistosoma mansoni Smad4 0.0019 0.0013 0.0013
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0022 0.092
Brugia malayi hypothetical protein 0.0072 0.0197 0.063
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0168 0.0531 0.1696
Loa Loa (eye worm) hypothetical protein 0.0071 0.0193 0.0616
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0451 0.1514 1
Echinococcus granulosus tar DNA binding protein 0.0915 0.313 0.313
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0022 0.007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0143 0.0445 0.1422
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0005 0.0048
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0193 0.0193
Schistosoma mansoni ets-related 0.0215 0.0696 0.0696
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0193 0.1167
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0022 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0041 0.0248
Echinococcus multilocularis tumor protein p63 0.2182 0.7532 0.7532
Loa Loa (eye worm) hypothetical protein 0.0073 0.0201 0.0642
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0193 0.1246
Loa Loa (eye worm) hypothetical protein 0.0071 0.0193 0.0616
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0193 0.1167
Brugia malayi beta-lactamase 0.0071 0.0193 0.0616
Loa Loa (eye worm) inositol-1 0.0036 0.0072 0.0232
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0022 0.0133
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0193 0.1246
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.0698
Schistosoma mansoni Smad4 0.0042 0.0094 0.0094
Brugia malayi Intermediate filament tail domain containing protein 0.0168 0.0531 0.1696
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0094 0.0094
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0936 0.5668
Echinococcus multilocularis lamin 0.0168 0.0531 0.0531
Echinococcus granulosus expressed protein 0.0027 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0072 0.0436
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0431 0.1444 0.4615
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0201 0.438
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0319 0.1058 0.338
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0081 0.0229 0.0229
Echinococcus granulosus geminin 0.034 0.1131 0.1131
Echinococcus granulosus GPCR family 2 0.0099 0.0292 0.0292
Onchocerca volvulus 0.0062 0.0162 0.0912
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0137 0.0876
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0013 0.0041
Schistosoma mansoni intermediate filament proteins 0.0168 0.0531 0.0531
Schistosoma mansoni ferritin light chain 0.0027 0.0042 0.0042
Echinococcus granulosus smad 0.0042 0.0094 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.004 0.0243
Loa Loa (eye worm) hypothetical protein 0.0073 0.0201 0.0642
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0072 0.0751
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0022 0.0227
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0936 0.5668
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0022 0.0227
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0175 0.0555 0.1775
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.0292 0.0292
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0104 0.0629
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0005 0.0048
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0193 0.1167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0072 0.0436
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0267 0.0267
Echinococcus multilocularis geminin 0.034 0.1131 0.1131
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0194 0.0194
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0072 0.0747
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0162 0.0162
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0094 0.0094
Brugia malayi beta-lactamase family protein 0.0071 0.0193 0.0616
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0193 0.1997
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0104 0.0104
Trichomonas vaginalis set domain proteins, putative 0.049 0.1651 1
Onchocerca volvulus 0.0021 0.0022 0.0056
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0137 1
Schistosoma mansoni ferritin 0.0027 0.0042 0.0042
Schistosoma mansoni microtubule-associated protein tau 0.2892 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0267 0.0267
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0104 0.1077
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0193 0.1246
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0022 0.0227
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0022 0.092
Echinococcus granulosus survival motor neuron protein 1 0.0702 0.2387 0.2387
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0126 0.0807
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0059 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0064 0.0387
Brugia malayi Latrophilin receptor protein 2 0.0099 0.0292 0.0931
Loa Loa (eye worm) hypothetical protein 0.0071 0.0193 0.0616
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0072 0.0553
Mycobacterium ulcerans hypothetical protein 0.0073 0.0201 0.438
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0201 0.1957
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0072 0.1237
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0104 0.0332
Loa Loa (eye worm) hypothetical protein 0.0054 0.0137 0.0437
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0193 0.1246
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0094 0.0094
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0027 0.0042 0.0246
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0267 0.0854
Echinococcus multilocularis GPCR, family 2 0.0099 0.0292 0.0292
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0201 0.438
Schistosoma mansoni hypothetical protein 0.034 0.1131 0.1131
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.007
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0022 0.0115
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0072 0.0072
Echinococcus multilocularis survival motor neuron protein 1 0.0702 0.2387 0.2387
Loa Loa (eye worm) hypothetical protein 0.0071 0.0193 0.0616
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0022 0.0115
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0194 0.062
Trichomonas vaginalis esterase, putative 0.0071 0.0193 0.1167
Loa Loa (eye worm) hypothetical protein 0.0165 0.052 0.1662
Loa Loa (eye worm) oxidoreductase 0.0021 0.0022 0.007
Brugia malayi MH1 domain containing protein 0.0042 0.0094 0.0299
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0201 0.0642
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0022 0.0227
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0022 0.0115
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0137 0.7029
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.0292 0.0292
Schistosoma mansoni tar DNA-binding protein 0.0915 0.313 0.313
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0193 0.0616
Loa Loa (eye worm) hypothetical protein 0.0073 0.0201 0.0642
Schistosoma mansoni apoferritin-2 0.0027 0.0042 0.0042
Mycobacterium tuberculosis Conserved protein 0.0071 0.0193 0.1246
Brugia malayi P38 map kinase family protein 2 0.0293 0.0965 0.3083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0201 0.13
Entamoeba histolytica hypothetical protein 0.0072 0.0197 0.1916
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0072 0.0747
Brugia malayi MH2 domain containing protein 0.0042 0.0094 0.0299
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.0936 1
Brugia malayi hypothetical protein 0.0702 0.2387 0.7627
Schistosoma mansoni tar DNA-binding protein 0.0915 0.313 0.313
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0005
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0022 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0936 0.5668
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0022 0.0115
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0013 0.0013
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0193 0.1246
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0193 0.1167
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0539 0.3263
Echinococcus multilocularis tar DNA binding protein 0.0915 0.313 0.313
Schistosoma mansoni lamin 0.0168 0.0531 0.0531
Echinococcus granulosus ferritin 0.0027 0.0042 0.0042
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0104 0.0332
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0022 0.007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0197 0.0197
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0293 0.0965 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0162 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0032 0.0193
Echinococcus multilocularis ferritin 0.0027 0.0042 0.0042
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0104 0.1077
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0293 0.0965 0.3083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0267 0.0267
Brugia malayi Ets-domain containing protein 0.0071 0.0194 0.062
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0027 0.0042 0.0246
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0193 0.0193
Echinococcus multilocularis Smad4 0.0042 0.0094 0.0094
Onchocerca volvulus 0.049 0.1651 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0034 0.1559
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0005 0.0005
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0104 0.0897
Mycobacterium ulcerans bacterioferritin BfrA 0.0027 0.0042 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0032 0.0193
Onchocerca volvulus 0.0021 0.0022 0.0056
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0081 0.0229 0.0229
Brugia malayi Pre-SET motif family protein 0.0431 0.1444 0.4615
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0094 0.0094
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0022 0.0022
Echinococcus multilocularis mitogen activated protein kinase 14 0.0293 0.0965 0.0965
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0059 0.0917
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0013 0.0041
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0022 0.0022
Schistosoma mansoni gabp alpha 0.0071 0.0194 0.0194
Echinococcus granulosus tumor protein p63 0.2182 0.7532 0.7532
Loa Loa (eye worm) hypothetical protein 0.0054 0.0137 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0072 0.0436
Schistosoma mansoni lamin 0.0168 0.0531 0.0531
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0022 0.0227
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0104 0.0104
Echinococcus granulosus lamin 0.0168 0.0531 0.0531
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.043 0.2821
Schistosoma mansoni smad1 5 8 and 0.0042 0.0094 0.0094
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0022 0.007
Echinococcus multilocularis mitogen activated protein kinase 11 0.0293 0.0965 0.0965
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0936 0.5668
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0013 0.0013
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0201 0.0642
Schistosoma mansoni ferritin 0.0027 0.0042 0.0042
Echinococcus granulosus intermediate filament protein 0.0168 0.0531 0.0531
Schistosoma mansoni hypothetical protein 0.0099 0.0292 0.0292
Onchocerca volvulus 0.0071 0.0193 0.1098
Brugia malayi hypothetical protein 0.0016 0.0003 0.0011
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0104 0.1077
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0104 0.1077
Loa Loa (eye worm) hypothetical protein 0.0313 0.1035 0.3306
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0201 0.1957
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0022 0.0115
Schistosoma mansoni survival motor neuron protein 0.0143 0.0445 0.0445
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0072 0.0751
Onchocerca volvulus 0.0319 0.1058 0.6377
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0162 0.0162
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0022 0.0223
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0022 0.0115
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0193 0.1167
Brugia malayi MH2 domain containing protein 0.0042 0.0094 0.0299
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0104 0.0897
Schistosoma mansoni ferritin 0.0027 0.0042 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0936 0.5668
Mycobacterium tuberculosis Conserved protein 0.0071 0.0193 0.1246
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0193 0.1997
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0201 0.0642
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0022 0.0115
Brugia malayi intermediate filament protein 0.0168 0.0531 0.1696

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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