Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.7104 | 0.7065 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0023 | 0.0582 | 0.0453 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0582 | 0.0453 |
Brugia malayi | steroid hormone receptor | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0582 | 0.0453 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.7104 | 0.7065 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0043 | 0.431 | 0.4233 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | nuclear receptor NHR-88 | 0.0043 | 0.431 | 0.4233 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0043 | 0.431 | 0.4233 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0043 | 0.431 | 0.4233 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0023 | 0.0582 | 0.0453 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0043 | 0.431 | 0.4233 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0043 | 0.431 | 0.4233 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0043 | 0.431 | 0.4233 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.7104 | 0.7065 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | nuclear receptor RXR | 0.0023 | 0.0582 | 0.0453 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1494 | 0.1378 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.431 | 0.4233 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0043 | 0.431 | 0.4233 |
Echinococcus granulosus | FTZ F1 alpha | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0043 | 0.431 | 0.4233 |
Schistosoma mansoni | nuclear hormone receptor | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1494 | 0.1378 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0043 | 0.431 | 0.4233 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.1494 | 0.1378 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0043 | 0.431 | 0.4233 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.1494 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0208 | 0.0074 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 0.0582 | 0.0453 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0028 | 0.1494 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0043 | 0.431 | 0.4233 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.1494 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.1494 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | TAR-binding protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0043 | 0.431 | 0.4233 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0043 | 0.431 | 0.4233 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0021 | 0.0208 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0043 | 0.431 | 0.4233 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.1494 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.1494 | 0.1378 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0582 | 0.0453 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0043 | 0.431 | 0.4233 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0582 | 0.0453 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0043 | 0.431 | 0.4233 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0208 | 0.139 |
Brugia malayi | nuclear hormone receptor | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0043 | 0.431 | 0.4233 |
Onchocerca volvulus | 0.0043 | 0.431 | 1 | |
Onchocerca volvulus | 0.0028 | 0.1494 | 0.3255 | |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0043 | 0.431 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.1494 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.1494 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0043 | 0.431 | 0.4233 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0043 | 0.431 | 0.4233 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.1494 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0043 | 0.431 | 0.4233 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0582 | 0.0453 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.1494 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0043 | 0.431 | 0.4233 |
Schistosoma mansoni | thyroid hormone receptor | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0582 | 0.0453 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.1494 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0043 | 0.431 | 0.4233 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0023 | 0.0582 | 0.0453 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0043 | 0.431 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0043 | 0.431 | 0.4233 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0208 | 0.0074 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 0.0582 | 0.0453 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0021 | 0.0208 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.3719 | 0.3633 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0208 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.7104 | 0.7065 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0.0208 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1494 | 0.1378 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0043 | 0.431 | 0.4233 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.1494 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.3719 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0208 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.431 | 0.4233 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.1494 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0043 | 0.431 | 0.4233 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0023 | 0.0582 | 0.0453 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0023 | 0.0582 | 0.0453 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.1494 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.1494 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.1494 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.1494 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.1494 | 0.1378 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.3719 | 0.3633 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.1494 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.1494 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0208 | 0.0074 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0043 | 0.431 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0043 | 0.431 | 0.4233 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0043 | 0.431 | 0.4233 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0582 | 0.0453 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0043 | 0.431 | 0.4233 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.