Detailed information for compound 616538

Basic information

Technical information
  • TDR Targets ID: 616538
  • Name: 1-(2,3-dimethylphenyl)-3-(4-ethylphenyl)-2,5, 6,7-tetrahydroimidazo[2,3-b][1,3]thiazin-4-iu m-3-ol
  • MW: 367.528 | Formula: C22H27N2OS+
  • H donors: 1 H acceptors: 1 LogP: 4.35 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)C1(O)C[N+](=C2N1CCCS2)c1cccc(c1C)C
  • InChi: 1S/C22H27N2OS/c1-4-18-9-11-19(12-10-18)22(25)15-23(21-24(22)13-6-14-26-21)20-8-5-7-16(2)17(20)3/h5,7-12,25H,4,6,13-15H2,1-3H3/q+1
  • InChiKey: QIDGAHMJZPRKIC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0037 0.0062 0.0183
Schistosoma mansoni coup transcription factor 0.0021 0.0005 0.0005
Brugia malayi beta-lactamase family protein 0.0037 0.0062 0.0183
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.0967 1
Echinococcus granulosus tar DNA binding protein 0.0997 0.3361 0.3361
Echinococcus multilocularis musashi 0.0171 0.0522 0.0522
Brugia malayi Latrophilin receptor protein 2 0.0145 0.0433 0.1288
Brugia malayi MH1 domain containing protein 0.0024 0.0016 0.0046
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0019 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.0967 0.3922
Schistosoma mansoni lamin 0.0171 0.0522 0.0522
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0081 0.0081
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0065 0.1293
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0009 0.0028
Echinococcus granulosus Smad4 0.0043 0.0081 0.0081
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0005 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0173 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0061 0.0213
Mycobacterium tuberculosis Conserved protein 0.0037 0.0062 0.0708
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0173 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0062 0.0183
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0201 0.0201
Brugia malayi RNA recognition motif domain containing protein 0.0997 0.3361 1
Echinococcus granulosus expressed protein 0.0026 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0145 0.0433 0.0433
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0025 0.0359
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.019 0.42
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.019 0.42
Loa Loa (eye worm) hypothetical protein 0.0056 0.0125 0.0372
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0005 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0062 0.0214
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Brugia malayi beta-lactamase 0.0037 0.0062 0.0183
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0019 0.0057
Schistosoma mansoni thyroid hormone receptor 0.0148 0.0442 0.0442
Plasmodium vivax SET domain protein, putative 0.0092 0.0252 1
Onchocerca volvulus 0.0022 0.0009 0.0038
Schistosoma mansoni hypothetical protein 0.0145 0.0433 0.0433
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0115 0.1429
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0083 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0145 0.0433 0.1288
Brugia malayi MH2 domain containing protein 0.0043 0.0081 0.0242
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0062 0.3181
Schistosoma mansoni cellular tumor antigen P53 0.026 0.083 0.083
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.019 0.2445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0005 0.0014
Schistosoma mansoni ets-related 0.0214 0.0669 0.0669
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0092 0.0252 0.0252
Brugia malayi steroid hormone receptor 0.0021 0.0005 0.0014
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0062 0.0708
Echinococcus multilocularis lamin 0.0171 0.0522 0.0522
Echinococcus multilocularis Smad4 0.0043 0.0081 0.0081
Loa Loa (eye worm) fli-1 protein 0.0214 0.0669 0.199
Echinococcus multilocularis microtubule associated protein 2 0.2927 1 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.0439 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0125 0.2697
Loa Loa (eye worm) nuclear factor I 0.0024 0.0016 0.0046
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0046
Brugia malayi ecdysteroid receptor 0.0021 0.0005 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0005 0.0014
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0081 0.0081
Echinococcus multilocularis tar DNA binding protein 0.0997 0.3361 0.3361
Brugia malayi MH1 domain containing protein 0.0024 0.0016 0.0046
Mycobacterium tuberculosis Conserved protein 0.0037 0.0062 0.0708
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0171 0.0522 0.1553
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0019 0.0554
Onchocerca volvulus 0.0022 0.0009 0.0038
Echinococcus granulosus lamin dm0 0.0171 0.0522 0.0522
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0005 0.0005
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.0967 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0125 0.0372
Brugia malayi hypothetical protein 0.0078 0.0201 0.0599
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0176 0.0524
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0025 0.0359
Echinococcus granulosus smad 0.0043 0.0081 0.0081
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0061 0.0182
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0061 0.0213
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.019 0.42
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0005 0.0005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0005 0.002
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0122 0.6882
Brugia malayi beta-lactamase family protein 0.0037 0.0062 0.0183
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0009 0.0009
Schistosoma mansoni ferritin 0.0026 0.0025 0.0025
Brugia malayi Smad1 0.0043 0.0081 0.0242
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0019 0.0057
Onchocerca volvulus 0.0732 0.2452 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0005 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.0313 0.1012 0.301
Trypanosoma brucei glucosidase, putative 0.0037 0.0061 0.3163
Schistosoma mansoni lamin 0.0171 0.0522 0.0522
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0005 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0062 0.0062
Onchocerca volvulus 0.0037 0.0062 0.0251
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0062 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0266 0.0266
Echinococcus multilocularis survival motor neuron protein 1 0.096 0.3235 0.3235
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0005 0.0014
Schistosoma mansoni alpha-glucosidase 0.0143 0.0427 0.0427
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.024 0.024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0005 0.0014
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0153 0.8736
Schistosoma mansoni tar DNA-binding protein 0.0997 0.3361 0.3361
Schistosoma mansoni alpha glucosidase 0.0037 0.0061 0.0061
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0019 0.0863
Echinococcus granulosus ferritin 0.0026 0.0025 0.0025
Schistosoma mansoni apoferritin-2 0.0026 0.0025 0.0025
Schistosoma mansoni thyroid hormone receptor 0.0148 0.0442 0.0442
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0062 0.0214
Echinococcus granulosus lamin 0.0171 0.0522 0.0522
Loa Loa (eye worm) Smad1 0.0043 0.0081 0.0242
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0145 0.0433 0.0433
Mycobacterium leprae Probable lipase LipE 0.0037 0.0062 0.1216
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0028
Brugia malayi cytoplasmic intermediate filament protein 0.0092 0.0249 0.0741
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0065 0.0227
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0083 0.0218 0.0218
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0125 1
Schistosoma mansoni survival motor neuron protein 0.0196 0.0607 0.0607
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0062 0.0214
Schistosoma mansoni smad1 5 8 and 0.0043 0.0081 0.0081
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0009 0.0028
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0019 0.0413
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0173 1
Entamoeba histolytica hypothetical protein 0.0078 0.0201 0.2004
Onchocerca volvulus 0.0096 0.0265 0.1082
Mycobacterium ulcerans lipase LipD 0.0037 0.0062 0.1216
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0061 0.0061
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0062 0.0183
Brugia malayi MH2 domain containing protein 0.0043 0.0081 0.0242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0173 1
Loa Loa (eye worm) hypothetical protein 0.0313 0.1012 0.301
Loa Loa (eye worm) hypothetical protein 0.0074 0.019 0.0564
Onchocerca volvulus 0.0092 0.0252 0.1026
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0062 0.0708
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0019 0.0057
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0019 0.0019
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0081 0.0242
Echinococcus multilocularis geminin 0.0339 0.1099 0.1099
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0081 0.0081
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.0967 0.3922
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0266 0.0266
Schistosoma mansoni apoferritin-2 0.0026 0.0025 0.0025
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0005 0.0005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0266 0.0266
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0009 0.0028
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.019 0.42
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0019 0.0609
Mycobacterium tuberculosis Conserved protein 0.0037 0.0062 0.0708
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.0442 0.0442
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0005 0.0005
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0019 0.0019
Loa Loa (eye worm) inositol-1 0.0038 0.0065 0.0193
Loa Loa (eye worm) hypothetical protein 0.026 0.083 0.2469
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0115 0.1429
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0005 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0173 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0643 0.2146 0.6384
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0061 0.0213
Schistosoma mansoni Smad4 0.0043 0.0081 0.0081
Echinococcus multilocularis GPCR, family 2 0.0145 0.0433 0.0433
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0019 0.0104
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.0019 0.0041
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0173 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0173 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0458 0.1511 0.4494
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0065 1
Schistosoma mansoni ferritin light chain 0.0026 0.0025 0.0025
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.019 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0061 0.3163
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0062 0.1216
Brugia malayi Fli-1 protein 0.0214 0.0669 0.199
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0062 0.3181
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0078 0.0201 0.0201
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.0252 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0997 0.3361 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.019 0.0564
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.0967 0.3922
Leishmania major cathepsin L-like protease 0.007 0.0173 0.9101
Loa Loa (eye worm) TAR-binding protein 0.0997 0.3361 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1629 0.5534 0.5534
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0125 0.157
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0019 0.0609
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0062 0.0708
Schistosoma mansoni smad1 5 8 and 0.0043 0.0081 0.0081
Brugia malayi nuclear receptor NHR-88 0.0021 0.0005 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0009 0.0028
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0019 0.0019
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0005 0.0014
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.0747 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0145 0.0433 0.0433
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0062 0.0062
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0065 0.0227
Onchocerca volvulus 0.0074 0.019 0.0774
Echinococcus granulosus intermediate filament protein 0.0171 0.0522 0.0522
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0005 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.0967 0.3922
Mycobacterium ulcerans hypothetical protein 0.0037 0.0062 0.1216
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.019 0.42
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0061 0.2879
Brugia malayi RNA binding protein 0.0997 0.3361 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0005 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0005 0.0014
Echinococcus granulosus tumor protein p63 0.178 0.6054 0.6054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0115 0.1429
Onchocerca volvulus 0.0022 0.0009 0.0038
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0061 0.0213
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.0439 0.5821
Schistosoma mansoni smad 0.0043 0.0081 0.0081
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0037 0.0062 0.0183
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0061 0.0213
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0145 0.0433 0.0433
Brugia malayi Intermediate filament tail domain containing protein 0.0171 0.0522 0.1553
Loa Loa (eye worm) oxidoreductase 0.0022 0.0009 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.0967 0.3922
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0062 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0005 0.0014
Trichomonas vaginalis chaperonin, putative 0.0025 0.0019 0.0041
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0051 0.0974
Brugia malayi Calcitonin receptor-like protein seb-1 0.0458 0.1511 0.4494
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.0252 0.0252
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0005 0.0005
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0062 0.0062
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0005 0.0005
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0061 0.0213
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.0967 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.019 0.42
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0062 0.3181
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0009 0.0028
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0065 0.3382
Schistosoma mansoni hypothetical protein 0.0196 0.0607 0.0607
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0061 0.0542
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.019 0.2445
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0005 0.0005
Leishmania major cathepsin L-like protease 0.007 0.0173 0.9101
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0201 0.0201
Onchocerca volvulus 0.0022 0.0009 0.0038
Onchocerca volvulus 0.0171 0.0522 0.213
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0005 0.0014
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.019 0.42
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0145 0.0433 0.1288
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0506 0.1506
Schistosoma mansoni ferritin light chain 0.0026 0.0025 0.0025
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0065 0.3078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0173 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0005 0.0014
Schistosoma mansoni hypothetical protein 0.0313 0.1012 0.1012
Entamoeba histolytica hypothetical protein 0.0078 0.0201 0.2004
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0065 0.2293
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0009 0.0028
Onchocerca volvulus 0.0037 0.0062 0.0251
Schistosoma mansoni hypothetical protein 0.0145 0.0433 0.0433
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0081 0.0242
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0339 0.1099 0.1099
Schistosoma mansoni ferritin 0.0026 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0056 0.0125 0.0372
Entamoeba histolytica hypothetical protein 0.0078 0.0201 0.2004
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.0967 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0061 0.2144
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.019 0.1884
Mycobacterium ulcerans beta-lactamase 0.0037 0.0062 0.1216
Onchocerca volvulus 0.026 0.083 0.3386
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0005 0.0014
Brugia malayi TAR-binding protein 0.0997 0.3361 1
Brugia malayi hypothetical protein 0.096 0.3235 0.9623
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0005 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.019 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0125 0.0372
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0005 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0005 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0061 0.3163
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.0439 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0005 0.0005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0201 0.0201
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0028
Brugia malayi Inositol-1 0.0038 0.0065 0.0193
Loa Loa (eye worm) latrophilin receptor protein 2 0.0145 0.0433 0.1288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0173 1
Schistosoma mansoni tar DNA-binding protein 0.0997 0.3361 0.3361
Loa Loa (eye worm) hypothetical protein 0.0083 0.0218 0.0648
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.0967 0.3922
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0081 0.0081
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0019 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0266 0.0266
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.0967 0.3922
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0061 0.0182
Schistosoma mansoni ferritin 0.0026 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0056 0.0125 0.0372
Echinococcus multilocularis ferritin 0.0026 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0074 0.019 0.0564
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0019 0.0413
Loa Loa (eye worm) hypothetical protein 0.0037 0.0062 0.0183
Brugia malayi Pre-SET motif family protein 0.0643 0.2146 0.6384
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0196 0.0607 0.1807
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0005 0.0005
Brugia malayi nuclear hormone receptor 0.0021 0.0005 0.0014
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0125 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0173 1
Schistosoma mansoni tar DNA-binding protein 0.0997 0.3361 0.3361
Echinococcus multilocularis lamin dm0 0.0171 0.0522 0.0522
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0506 0.1506
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0065 0.0065
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0025 0.0209
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0005 0.002
Brugia malayi AMP-binding enzyme family protein 0.0074 0.019 0.0564
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0266 0.079
Brugia malayi AMP-binding enzyme family protein 0.0074 0.019 0.0564
Echinococcus granulosus geminin 0.0339 0.1099 0.1099
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0061 0.0213
Leishmania major hypothetical protein, conserved 0.0037 0.0062 0.2895
Brugia malayi MH1 domain containing protein 0.0043 0.0081 0.0242
Brugia malayi Ets-domain containing protein 0.007 0.0176 0.0524
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0005 0.0014
Brugia malayi MH2 domain containing protein 0.0628 0.2093 0.6226
Loa Loa (eye worm) hypothetical protein 0.0037 0.0062 0.0183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0173 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0005 0.0005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0092 0.0252 0.0252
Schistosoma mansoni intermediate filament proteins 0.0171 0.0522 0.0522
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0009 0.0009
Toxoplasma gondii ABC1 family protein 0.0037 0.0062 0.2157
Loa Loa (eye worm) intermediate filament protein 0.0171 0.0522 0.1553
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0005 0.0005
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.0372 0.0372
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0065 0.0227
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0005 0.0014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0005 0.0014
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0062 0.0708
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.019 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0115 0.1429
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0065 0.058
Trichomonas vaginalis ferritin, putative 0.0026 0.0025 0.0063
Onchocerca volvulus 0.0037 0.0062 0.0251
Schistosoma mansoni hypothetical protein 0.0127 0.0372 0.0372
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0458 0.1511 0.4494
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0252 0.0252
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0062 0.2157
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0005 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.096 0.3235 0.9623
Schistosoma mansoni gabp alpha 0.007 0.0176 0.0176
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0065 0.3382
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0266 0.0266
Schistosoma mansoni microtubule-associated protein tau 0.2927 1 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0125 0.4783
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0051 0.0567
Schistosoma mansoni inositol monophosphatase 0.0038 0.0065 0.0065
Onchocerca volvulus 0.0021 0.0005 0.002
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0009 0.0009
Echinococcus granulosus survival motor neuron protein 1 0.096 0.3235 0.3235
Schistosoma mansoni inositol monophosphatase 0.0038 0.0065 0.0065
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0062 0.0214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0173 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0061 0.0213
Schistosoma mansoni alpha-glucosidase 0.0143 0.0427 0.0427
Brugia malayi Pre-SET motif family protein 0.0092 0.0252 0.0748
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0062 0.0708
Loa Loa (eye worm) hypothetical protein 0.0079 0.0207 0.0616
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0005 0.0014
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0065 0.3382
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0062 0.1216
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0062 0.0214
Schistosoma mansoni tar DNA-binding protein 0.0997 0.3361 0.3361
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0061 0.0213
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0173 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0207 0.0616
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0173 1
Loa Loa (eye worm) hypothetical protein 0.0171 0.0522 0.1553
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0081 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0997 0.3361 0.3361
Loa Loa (eye worm) hypothetical protein 0.006 0.0141 0.042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.0967 0.3922
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Echinococcus multilocularis smad 0.0043 0.0081 0.0081
Trichomonas vaginalis set domain proteins, putative 0.0732 0.2452 1
Mycobacterium ulcerans hypothetical protein 0.0074 0.019 0.42
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0005 0.0005
Onchocerca volvulus 0.0171 0.0522 0.213
Brugia malayi Ets-domain containing protein 0.007 0.0176 0.0524
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.019 0.1884
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Loa Loa (eye worm) RNA binding protein 0.0997 0.3361 1
Loa Loa (eye worm) transcription factor SMAD2 0.0628 0.2093 0.6226
Trichomonas vaginalis esterase, putative 0.0037 0.0062 0.0214
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.019 0.1884
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0005 0.0014
Entamoeba histolytica hypothetical protein 0.0078 0.0201 0.2004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0266 0.079
Echinococcus granulosus GPCR family 2 0.0145 0.0433 0.0433
Schistosoma mansoni hypothetical protein 0.0145 0.0433 0.0433
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0061 0.0542
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0062 0.0708
Loa Loa (eye worm) hypothetical protein 0.0037 0.0062 0.0183
Echinococcus granulosus histone lysine methyltransferase setb 0.0092 0.0252 0.0252
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0506 0.0506
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0062 0.1216
Onchocerca volvulus 0.0196 0.0607 0.2478
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0506 0.0506
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0062 0.0708
Loa Loa (eye worm) MH2 domain-containing protein 0.0628 0.2093 0.6226
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0025 0.0359
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0252 0.0252
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0092 0.0249 0.0741
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0458 0.1511 0.4494
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0252 0.0252
Schistosoma mansoni hypothetical protein 0.0339 0.1099 0.1099
Schistosoma mansoni smad1 5 8 and 0.0043 0.0081 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0005 0.0014
Brugia malayi MH1 domain containing protein 0.0043 0.0081 0.0242
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0168 0.0511 0.1521
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0025 0.0209
Echinococcus multilocularis expressed protein 0.0026 0.0025 0.0025
Loa Loa (eye worm) beta-lactamase 0.0037 0.0062 0.0183
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0005 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0005 0.0005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0145 0.0433 0.0433
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.019 0.42
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0009 0.0028
Brugia malayi intermediate filament protein 0.0171 0.0522 0.1553
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0176 0.0176
Echinococcus multilocularis tumor protein p63 0.178 0.6054 0.6054
Loa Loa (eye worm) hypothetical protein 0.0092 0.0252 0.0748
Brugia malayi AMP-binding enzyme family protein 0.0074 0.019 0.0564
Schistosoma mansoni ferritin 0.0026 0.0025 0.0025
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0176 0.0176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0173 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0061 0.0061
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.019 0.42
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0005 0.0005
Leishmania major cathepsin L-like protease 0.007 0.0173 0.9101

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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