Detailed information for compound 616550

Basic information

Technical information
  • TDR Targets ID: 616550
  • Name: 3-(4-ethoxyphenyl)-1-(2-methylphenyl)-2,5,6,7 -tetrahydroimidazo[2,3-b][1,3]thiazin-4-ium-3 -ol
  • MW: 369.5 | Formula: C21H25N2O2S+
  • H donors: 1 H acceptors: 1 LogP: 3.52 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)C1(O)C[N+](=C2N1CCCS2)c1ccccc1C
  • InChi: 1S/C21H25N2O2S/c1-3-25-18-11-9-17(10-12-18)21(24)15-22(19-8-5-4-7-16(19)2)20-23(21)13-6-14-26-20/h4-5,7-12,24H,3,6,13-15H2,1-2H3/q+1
  • InChiKey: YTPCSOFQSCEAIV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ChemDiv1_026858

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0741 0.2252
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.021 0.1522
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Plasmodium vivax heat shock protein 86, putative 0.0037 0.0741 0.5359
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0013 0.0013
Echinococcus granulosus geminin 0.0175 0.5417 0.5417
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0013 0.0013
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0514 0.2585
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0013 0.0013
Schistosoma mansoni glutaminase 0.0264 0.8449 0.8449
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.1383 0.3199
Echinococcus granulosus heat shock protein 90 0.0029 0.0485 0.0485
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0514 0.3714
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.165 0.5015
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0514 0.3714
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.3291 1
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Brugia malayi Importin beta-1 subunit 0.0029 0.047 0.0557
Plasmodium falciparum heat shock protein 90 0.0037 0.0741 0.5359
Echinococcus granulosus dna polymerase kappa 0.0039 0.0813 0.0813
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0514 0.1561
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.3291 0.3291
Onchocerca volvulus 0.0244 0.7777 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0813 0.0962
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0531 0.0531
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.1383 0.1383
Entamoeba histolytica hypothetical protein 0.0035 0.0665 0.2022
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0013 0.0015
Schistosoma mansoni hypothetical protein 0.0035 0.0665 0.0665
Trypanosoma brucei heat shock protein, putative 0.0037 0.0741 0.2252
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0514 0.0608
Toxoplasma gondii heat shock protein 90, putative 0.0037 0.0741 0.4491
Brugia malayi Pre-SET motif family protein 0.0031 0.0531 0.0628
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0013 0.0013
Onchocerca volvulus 0.0031 0.0531 0.0682
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0013 0.0016
Echinococcus granulosus heat shock protein 90 0.0037 0.0741 0.0741
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0013 0.0013
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.1383 0.3199
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0813 0.0813
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.3291 1
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0013 0.0013
Trypanosoma brucei heat shock protein, putative 0.0037 0.0741 0.2252
Loa Loa (eye worm) heat shock protein 90 0.0037 0.0741 0.0741
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.3291 0.3291
Echinococcus granulosus heat shock protein 0.0037 0.0741 0.0741
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.3291 0.3522
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0485 0.0574
Trypanosoma brucei unspecified product 0.0039 0.0813 0.2471
Leishmania major hypothetical protein, conserved 0.0025 0.0318 0.0967
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0013 0.0015
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0813 0.0412
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Trypanosoma brucei heat shock protein, putative 0.0037 0.0741 0.2252
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0013 0.0013
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.1383 0.1383
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.1383 0.1127
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0813 0.0813
Plasmodium falciparum endoplasmin, putative 0.0023 0.0256 0.1849
Entamoeba histolytica hypothetical protein 0.0035 0.0665 0.2022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0013 0.0013
Schistosoma mansoni endoplasmin 0.0037 0.0741 0.0741
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.3291 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0531 0.0531
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0013 0.0015
Plasmodium vivax importin-beta 2, putative 0.0029 0.047 0.3402
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.021 0.064
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0531 0.0531
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.3291 0.3894
Schistosoma mansoni ran 0.0021 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0031 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0025 0.0318 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0013 0.0015
Schistosoma mansoni hypothetical protein 0.031 1 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0514 0.3714
Schistosoma mansoni heat shock protein 0.0037 0.0741 0.0741
Trichomonas vaginalis endoplasmin, putative 0.0023 0.0256 0.0303
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.3291 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0318 0.0967
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0013 0.0013
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0813 0.2471
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0013 0.0015
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0531 0.3215
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0013 0.0013
Trypanosoma brucei heat shock protein, putative 0.0037 0.0741 0.2252
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0024 0.0284 0.0864
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0318 0.1929
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.047 0.143
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0013 0.0016
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0013 0.0013
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0813 0.0813
Loa Loa (eye worm) phosphofructokinase 0.0112 0.3291 0.3291
Trypanosoma brucei heat shock protein, putative 0.0037 0.0741 0.2252
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0013 0.0013
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0514 0.3714
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.3291 0.3291
Plasmodium falciparum importin beta, putative 0.0029 0.047 0.3402
Entamoeba histolytica hypothetical protein 0.0035 0.0665 0.2022
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0813 0.2471
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0013 0.0013
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Brugia malayi hypothetical protein 0.0025 0.0318 0.0377
Echinococcus multilocularis geminin 0.0175 0.5417 0.5417
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Plasmodium vivax SET domain protein, putative 0.0031 0.0531 0.3837
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0013 0.0013
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.047 0.143
Trypanosoma brucei DNA polymerase eta, putative 0.0091 0.2566 0.7797
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Trypanosoma cruzi Heat shock protein 83, putative 0.0037 0.0741 0.2252
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0013 0.0013
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.021 0.021
Toxoplasma gondii exonuclease III APE 0.0056 0.1383 0.838
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.3291 0.3894
Loa Loa (eye worm) glutaminase 0.0264 0.8449 0.8449
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.1383 0.1637
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0485 0.0574
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0531 0.0531
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.1383 0.1637
Mycobacterium ulcerans glutaminase 0.0264 0.8449 1
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0813 0.2471
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0284 0.0336
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Leishmania major DNA polymerase eta, putative 0.0064 0.165 0.5015
Trypanosoma cruzi heat shock protein 85, putative 0.0029 0.0485 0.1475
Leishmania major GTP-binding protein, putative 0.0021 0.021 0.064
Trypanosoma brucei heat shock protein, putative 0.0037 0.0741 0.2252
Brugia malayi ImpB/MucB/SamB family protein 0.0091 0.2566 0.3037
Loa Loa (eye worm) hypothetical protein 0.0029 0.047 0.047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0013 0.0013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0665 0.0665
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0013 0.0016
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.3291 0.3291
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0741 0.2252
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.3291 1
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0013 0.0013
Brugia malayi RNA, U transporter 1 0.0083 0.2286 0.2706
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0013 0.0013
Giardia lamblia Grp94/Hsp90 0.0029 0.0485 0.2345
Loa Loa (eye worm) glutaminase 2 0.0264 0.8449 0.8449
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0318 0.0967
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.021 0.064
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.021 0.1522
Trypanosoma cruzi DNA polymerase eta, putative 0.0091 0.2566 0.7797
Schistosoma mansoni ap endonuclease 0.0056 0.1383 0.1383
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0013 0.0013
Leishmania major DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0514 0.5
Trichomonas vaginalis heat shock protein, putative 0.0023 0.0256 0.0303
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.3291 0.3291
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0284 0.0336
Toxoplasma gondii heat shock protein HSP90 0.0037 0.0741 0.4491
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0013 0.0013
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.3291 1
Echinococcus granulosus endoplasmin 0.0029 0.0485 0.0485
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.0741 0.2252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0013 0.0013
Schistosoma mansoni ran 0.0021 0.021 0.021
Brugia malayi steroid hormone receptor 0.0016 0.0013 0.0015
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.1383 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0665 0.0665
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0531 0.0531
Trypanosoma brucei Heat shock protein 83, putative 0.0037 0.0741 0.2252
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0514 0.3112
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0514 0.01
Brugia malayi phosphofructokinase 0.0112 0.3291 0.3894
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0013 0.0015
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0227 0.0689
Entamoeba histolytica hypothetical protein 0.0035 0.0665 0.2022
Entamoeba histolytica Ran family GTPase 0.0021 0.021 0.064
Trichomonas vaginalis ran, putative 0.0021 0.021 0.0249
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0013 0.0013
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0284 0.0336
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0813 0.0813
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0485 0.0574
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.1383 0.1637
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.3291 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0514 0.0608
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0318 0.2302
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0813 0.2471
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0013 0.0013
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0813 0.0962
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.1383 0.4202
Brugia malayi heat shock protein 90 0.0037 0.0741 0.0877
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0013 0.0013
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0318 0.2302
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.1383 0.4202
Brugia malayi 6-phosphofructokinase 0.0112 0.3291 0.3894
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0013 0.0015
Schistosoma mansoni hypothetical protein 0.0175 0.5417 0.5417
Brugia malayi hypothetical protein 0.0035 0.0665 0.0787
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0013 0.0015
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.1383 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.021 0.064
Trypanosoma brucei heat shock protein, putative 0.0037 0.0741 0.2252
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.3291 1
Trichomonas vaginalis glutaminase, putative 0.0264 0.8449 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.2566 0.2566
Brugia malayi Pre-SET motif family protein 0.0215 0.6771 0.8013
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0514 0.5
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0741 0.2252
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0514 0.0608
Brugia malayi nuclear receptor NHR-88 0.0016 0.0013 0.0015
Echinococcus multilocularis endoplasmin 0.0029 0.0485 0.0485
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0318 0.2302
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0741 0.2252
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0029 0.0485 0.1475
Schistosoma mansoni ap endonuclease 0.0056 0.1383 0.1383
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0401 0.1219
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0492 0.0492
Echinococcus multilocularis heat shock protein 0.0037 0.0741 0.0741
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Brugia malayi ecdysteroid receptor 0.0016 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.1383 0.1383
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0013 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Giardia lamblia DINP protein human, muc B family 0.0039 0.0813 0.5142
Trypanosoma brucei unspecified product 0.0027 0.0401 0.1219
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0013 0.0013
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0741 0.2252
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0013 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0401 0.1219
Brugia malayi 6-phosphofructokinase 0.0112 0.3291 0.3894
Leishmania major DNA polymerase eta, putative 0.0091 0.2566 0.7797
Trypanosoma brucei unspecified product 0.0027 0.0401 0.1219
Schistosoma mansoni heat shock protein 0.0037 0.0741 0.0741
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0013 0.0015
Echinococcus multilocularis heat shock protein 90 0.0037 0.0741 0.0741
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0013 0.0015
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.021 0.021
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.047 0.2851
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0013 0.0015
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0741 0.2252
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0531 0.0531
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.3291 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0318 0.0967
Schistosoma mansoni hypothetical protein 0.0175 0.5417 0.5417
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Echinococcus multilocularis dna polymerase eta 0.0091 0.2566 0.2566
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.1383 0.4202
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0514 0.0608
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0514 0.0608
Echinococcus multilocularis snurportin 1 0.031 1 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0029 0.0485 0.2345
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.1383 1
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0813 0.0962
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0514 0.0608
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.3291 0.3291
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.1383 1
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0013 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0013 0.0013
Brugia malayi nuclear hormone receptor 0.0016 0.0013 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.3291 0.3894
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0013 0.0013
Giardia lamblia Heat shock protein HSP 90-alpha 0.0037 0.0741 0.4526
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0813 0.0813
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0514 0.0608
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.6771 0.6771
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0741 0.0877
Onchocerca volvulus 0.0016 0.0013 0.0016
Plasmodium vivax endoplasmin, putative 0.0037 0.0741 0.5359
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.021 0.1275
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0029 0.0485 0.0485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0013 0.0013
Trypanosoma cruzi heat shock protein 90, putative 0.0029 0.0485 0.1475
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0013 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0401 0.1219
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.3291 0.3894
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0531 0.0531
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0013 0.0015
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0013 0.0013
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0013 0.0013
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0514 0.3112
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0813 0.0412
Brugia malayi glutaminase DH11.1 0.0264 0.8449 1
Brugia malayi Endoplasmin precursor 0.0037 0.0741 0.0877
Leishmania major heat shock protein 83-1 0.0037 0.0741 0.2252
Schistosoma mansoni coup transcription factor 0.0016 0.0013 0.0013
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0514 0.3112
Brugia malayi hypothetical protein 0.0016 0.0023 0.0027
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.021 0.0249
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0013 0.0013
Trichomonas vaginalis set domain proteins, putative 0.0244 0.7777 0.9205
Schistosoma mansoni DNA polymerase eta 0.0091 0.2566 0.2566
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0813 0.2471
Schistosoma mansoni importin beta-1 0.0029 0.047 0.047
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.1383 0.4202
Echinococcus granulosus dna polymerase eta 0.0091 0.2566 0.2566
Leishmania major importin beta-1 subunit, putative 0.0024 0.0284 0.0864
Echinococcus granulosus importin subunit beta 1 0.0029 0.047 0.047
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0064 0.165 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.1383 0.4202
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0665 0.0665
Trypanosoma brucei heat shock protein, putative 0.0037 0.0741 0.2252
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0813 0.1169
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0013 0.0013
Schistosoma mansoni endoplasmin 0.0037 0.0741 0.0741
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0284 0.0864
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0013
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0813 0.0813
Loa Loa (eye worm) endoplasmin 0.0037 0.0741 0.0741
Echinococcus multilocularis importin subunit beta 1 0.0029 0.047 0.047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0813 0.1169
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0741 0.2252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0013 0.0013
Echinococcus multilocularis heat shock protein 90 0.0029 0.0485 0.0485
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0813 0.2471

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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