Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0239 | 0.5701 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0239 | 0.5701 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Plasmodium vivax | vivapain-2 | 0.0239 | 0.5701 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0239 | 0.5701 | 0.5701 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0239 | 0.5701 | 0.5701 |
Onchocerca volvulus | Cathepsin F homolog | 0.0239 | 0.5701 | 1 |
Leishmania major | cathepsin L-like protease | 0.0239 | 0.5701 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0239 | 0.5701 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0239 | 0.5701 | 0.5701 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0239 | 0.5701 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0239 | 0.5701 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0239 | 0.5701 | 0.5701 |
Plasmodium vivax | vivapain-2 | 0.0239 | 0.5701 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0324 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0239 | 0.5701 | 0.5701 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0324 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1814 | 0.1466 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.1814 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0239 | 0.5701 | 0.5701 |
Echinococcus granulosus | cathepsin b | 0.0324 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0163 | 0.1814 | 0.1814 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0239 | 0.5701 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0239 | 0.5701 | 0.5701 |
Leishmania major | cathepsin L-like protease | 0.0239 | 0.5701 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0239 | 0.5701 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0239 | 0.5701 | 0.5701 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Onchocerca volvulus | 0.0239 | 0.5701 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0239 | 0.5701 | 0.5701 |
Giardia lamblia | Cathepsin B precursor | 0.0135 | 0.0408 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0135 | 0.0408 | 0.0408 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0163 | 0.1814 | 0.1814 |
Brugia malayi | Cathepsin L-like precursor | 0.0239 | 0.5701 | 0.5701 |
Leishmania major | cysteine peptidase A (CPA) | 0.0239 | 0.5701 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0163 | 0.1814 | 0.1814 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1814 | 0.1466 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0239 | 0.5701 | 0.5701 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0239 | 0.5701 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0135 | 0.0408 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0239 | 0.5701 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0239 | 0.5701 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.1814 | 0.3182 |
Loa Loa (eye worm) | ctsf protein | 0.0239 | 0.5701 | 0.5518 |
Onchocerca volvulus | 0.0239 | 0.5701 | 1 | |
Loa Loa (eye worm) | cysteine protease | 0.0239 | 0.5701 | 0.5518 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Leishmania major | cathepsin L-like protease | 0.0239 | 0.5701 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0239 | 0.5701 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0324 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0135 | 0.0408 | 0.0716 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0163 | 0.1814 | 0.1814 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0163 | 0.1814 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0324 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0239 | 0.5701 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.5701 | 0.5518 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0239 | 0.5701 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0239 | 0.5701 | 0.5518 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0239 | 0.5701 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0239 | 0.5701 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0239 | 0.5701 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0239 | 0.5701 | 0.5701 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0324 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0239 | 0.5701 | 0.5701 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0239 | 0.5701 | 0.5701 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0239 | 0.5701 | 0.5701 |
Leishmania major | cathepsin L-like protease | 0.0239 | 0.5701 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0239 | 0.5701 | 0.5701 |
Brugia malayi | Cathepsin L-like precursor | 0.0163 | 0.1814 | 0.1814 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0239 | 0.5701 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0239 | 0.5701 | 0.5701 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0239 | 0.5701 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1814 | 0.1466 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Onchocerca volvulus | 0.0239 | 0.5701 | 1 | |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0324 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0239 | 0.5701 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0135 | 0.0408 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0135 | 0.0408 | 0.0408 |
Echinococcus multilocularis | cysteine protease | 0.0239 | 0.5701 | 0.5701 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0239 | 0.5701 | 1 |
Leishmania major | cathepsin L-like protease | 0.0239 | 0.5701 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0239 | 0.5701 | 1 |
Onchocerca volvulus | 0.0239 | 0.5701 | 1 | |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0239 | 0.5701 | 0.5518 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0239 | 0.5701 | 1 |
Onchocerca volvulus | 0.0239 | 0.5701 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0163 | 0.1814 | 0.1814 |
Entamoeba histolytica | cysteine protease, putative | 0.0239 | 0.5701 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0135 | 0.0408 | 0.0716 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0239 | 0.5701 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0239 | 0.5701 | 0.5701 |
Leishmania major | cathepsin L-like protease | 0.0239 | 0.5701 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0324 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0324 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0239 | 0.5701 | 0.5701 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0239 | 0.5701 | 0.5701 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0239 | 0.5701 | 0.5701 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0163 | 0.1814 | 0.1814 |
Loa Loa (eye worm) | fibroinase | 0.0239 | 0.5701 | 0.5518 |
Onchocerca volvulus | 0.0239 | 0.5701 | 1 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0239 | 0.5701 | 0.5701 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MED (functional) | = 25 mg kg-1 | Minimum effective dose against herpes simplex virus-2 (HSV-2) by oral administration in female mice. | ChEMBL. | 8388470 |
MIC (functional) | = 0.78 ug ml-1 | In vitro minimum inhibitory concentration against herpes simplex virus-2 (HSV-2) by plaque-reduction assay in vero cells | ChEMBL. | 8388470 |
MTD (functional) | = 50 mg kg-1 | In vivo maximum tolerated dose against herpes simplex virus-2 (HSV-2) by oral administration in female mice | ChEMBL. | 8388470 |
MTL (functional) | = 6.25 ug ml-1 | In vitro maximum tolerated level against herpes simplex virus-2 (HSV-2) by plaque-reduction assay in vero cells | ChEMBL. | 8388470 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.