Detailed information for compound 617166

Basic information

Technical information
  • TDR Targets ID: 617166
  • Name: (E)-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2- yl]-3-phenylprop-2-enamide
  • MW: 321.33 | Formula: C18H15N3O3
  • H donors: 1 H acceptors: 3 LogP: 2.98 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1nnc(o1)NC(=O)C=Cc1ccccc1
  • InChi: 1S/C18H15N3O3/c1-23-15-10-8-14(9-11-15)17-20-21-18(24-17)19-16(22)12-7-13-5-3-2-4-6-13/h2-12H,1H3,(H,19,21,22)/b12-7+
  • InChiKey: BTTIWTIBWOPJMI-KPKJPENVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-3-phenylprop-2-enamide
  • N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-3-phenyl-prop-2-enamide
  • (E)-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-3-phenyl-prop-2-enamide
  • N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-3-phenyl-acrylamide
  • (E)-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-3-phenyl-acrylamide
  • IDI1_010900
  • IFLab1_005497
  • ZINC04276071

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0031 0.0455 0.0209
Plasmodium falciparum importin beta, putative 0.0029 0.0412 0.669
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0071
Echinococcus multilocularis GPCR, family 2 0.0066 0.1188 0.182
Onchocerca volvulus 0.0074 0.1379 0.2143
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.1188 0.182
Schistosoma mansoni intermediate filament proteins 0.0027 0.0355 0.0543
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.2325 0.3562
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.1379 0.1328
Schistosoma mansoni tar DNA-binding protein 0.0136 0.2703 0.414
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0059 0.5
Schistosoma mansoni hypothetical protein 0.004 0.0645 0.0988
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.1188 0.182
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.1299 0.199
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0455 0.2995
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.1379 0.1328
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1379 0.2601
Brugia malayi Ets-domain containing protein 0.0071 0.1299 0.2896
Echinococcus multilocularis snurportin 1 0.0314 0.6528 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0207 0.4232 0.6483
Schistosoma mansoni tar DNA-binding protein 0.0136 0.2703 0.414
Plasmodium vivax hypothetical protein, conserved 0.0074 0.1379 1
Loa Loa (eye worm) TAR-binding protein 0.0136 0.2703 0.414
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0059 0.0091
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0245 0.1407
Echinococcus granulosus lamin dm0 0.0027 0.0355 0.0543
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0292 0.1765
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1379 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0057 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2808 0.4302
Onchocerca volvulus 0.0074 0.1379 0.2143
Brugia malayi Pre-SET motif family protein 0.0219 0.4485 1
Toxoplasma gondii thioredoxin reductase 0.0038 0.0586 0.3992
Leishmania major hypothetical protein, conserved 0.0074 0.1379 1
Schistosoma mansoni hypothetical protein 0.0066 0.1188 0.182
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0597 0.0914
Brugia malayi RNA binding protein 0.0136 0.2703 0.6026
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.1379 0.1328
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0071
Echinococcus multilocularis lamin dm0 0.0027 0.0355 0.0543
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0292 0.0459
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0597 0.0914
Schistosoma mansoni lamin 0.0027 0.0355 0.0543
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0059 0.5
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0412 0.2671
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1379 0.2601
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0088 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0136 0.2703 0.414
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.162 0.5391
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.1188 0.182
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0059 0.0091
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.1379 0.2113
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0412 0.0631
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0245 0.1407
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.162 0.157
Brugia malayi glutathione reductase 0.0038 0.0586 0.1307
Loa Loa (eye worm) RNA binding protein 0.0136 0.2703 0.414
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0586 0.3992
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1379 0.2601
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.2808 0.4302
Plasmodium vivax glutathione reductase, putative 0.0038 0.0586 0.3992
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.1379 1
Loa Loa (eye worm) fli-1 protein 0.0215 0.4392 0.6729
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0455 0.0696
Loa Loa (eye worm) hypothetical protein 0.0026 0.0344 0.0527
Loa Loa (eye worm) hypothetical protein 0.006 0.1079 0.1652
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0586 0.053
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0355 0.0543
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.2464 0.3774
Trichomonas vaginalis esterase, putative 0.0074 0.1379 0.2601
Trypanosoma brucei trypanothione reductase 0.0038 0.0586 0.3992
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0645 0.0988
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0586 0.3992
Echinococcus multilocularis tar DNA binding protein 0.0136 0.2703 0.414
Schistosoma mansoni gabp alpha 0.0071 0.1299 0.199
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0292 0.0459
Brugia malayi Importin beta-1 subunit 0.0029 0.0412 0.0918
Brugia malayi TAR-binding protein 0.0136 0.2703 0.6026
Entamoeba histolytica hypothetical protein 0.004 0.0645 1
Schistosoma mansoni thyroid hormone receptor 0.0135 0.2679 0.4105
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0088 0.0195
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0455 0.0696
Loa Loa (eye worm) hypothetical protein 0.0074 0.1379 0.2113
Brugia malayi Calcitonin receptor-like protein seb-1 0.0207 0.4232 0.9435
Loa Loa (eye worm) hypothetical protein 0.0074 0.1379 0.2113
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0245 0.0546
Trichomonas vaginalis ran, putative 0.0022 0.0245 0.0366
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.1379 0.2113
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1379 0.2601
Mycobacterium tuberculosis Probable reductase 0.0086 0.162 0.157
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.1299 0.199
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1379 0.2601
Loa Loa (eye worm) beta-lactamase 0.0074 0.1379 0.2113
Loa Loa (eye worm) hypothetical protein 0.0066 0.1188 0.182
Brugia malayi hypothetical protein 0.004 0.0645 0.1439
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0059 0.0091
Mycobacterium tuberculosis Conserved protein 0.0074 0.1379 0.1328
Brugia malayi beta-lactamase family protein 0.0074 0.1379 0.3075
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1379 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.162 0.157
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0057 0.0087
Loa Loa (eye worm) hypothetical protein 0.0027 0.0355 0.0543
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.2808 0.4302
Loa Loa (eye worm) hypothetical protein 0.0074 0.1379 0.2113
Schistosoma mansoni hypothetical protein 0.0314 0.6528 1
Echinococcus granulosus tar DNA binding protein 0.0136 0.2703 0.414
Schistosoma mansoni hypothetical protein 0.0125 0.2464 0.3774
Loa Loa (eye worm) hypothetical protein 0.0142 0.2823 0.4325
Echinococcus granulosus importin subunit beta 1 0.0029 0.0412 0.0631
Mycobacterium ulcerans hypothetical protein 0.0074 0.1379 1
Echinococcus granulosus lamin 0.0027 0.0355 0.0543
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.1825 0.1776
Brugia malayi Latrophilin receptor protein 2 0.0066 0.1188 0.265
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.1379 0.1328
Leishmania major GTP-binding protein, putative 0.0022 0.0245 0.1407
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.2464 0.3774
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0645 0.0988
Schistosoma mansoni ran 0.0022 0.0245 0.0375
Loa Loa (eye worm) hypothetical protein 0.0031 0.0455 0.0696
Schistosoma mansoni ran 0.0022 0.0245 0.0375
Leishmania major trypanothione reductase 0.0038 0.0586 0.3992
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0059 0.5
Loa Loa (eye worm) glutathione reductase 0.0038 0.0586 0.0898
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.2703 0.6026
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.162 0.157
Onchocerca volvulus 0.0249 0.5135 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0245 0.1407
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0455 0.0696
Entamoeba histolytica hypothetical protein 0.004 0.0645 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1379 0.2113
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0245 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0245 0.1407
Mycobacterium ulcerans lipase LipD 0.0074 0.1379 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1379 0.2113
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0245 0.1407
Brugia malayi RNA, U transporter 1 0.0084 0.1577 0.3517
Schistosoma mansoni thyroid hormone receptor 0.0135 0.2679 0.4105
Schistosoma mansoni lamin 0.0027 0.0355 0.0543
Brugia malayi latrophilin 2 splice variant baaae 0.0142 0.2823 0.6295
Echinococcus granulosus intermediate filament protein 0.0027 0.0355 0.0543
Echinococcus multilocularis musashi 0.0027 0.0355 0.0543
Loa Loa (eye worm) hypothetical protein 0.0029 0.0412 0.0631
Brugia malayi Fli-1 protein 0.0215 0.4392 0.9794
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.043 0.0658
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.162 0.157
Brugia malayi beta-lactamase 0.0074 0.1379 0.3075
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0245 0.0375
Brugia malayi beta-lactamase family protein 0.0074 0.1379 0.3075
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.1379 0.1328
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0412 0.2671
Schistosoma mansoni hypothetical protein 0.0066 0.1188 0.182
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0455 0.0696
Schistosoma mansoni tar DNA-binding protein 0.0136 0.2703 0.414
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.1379 0.2113
Loa Loa (eye worm) hypothetical protein 0.0074 0.1379 0.2113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0455 0.0696
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.4485 0.6871
Brugia malayi Pre-SET motif family protein 0.0031 0.0455 0.1013
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0245 0.0375
Loa Loa (eye worm) hypothetical protein 0.0207 0.4232 0.6483
Plasmodium vivax SET domain protein, putative 0.0031 0.0455 0.2995
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0059 0.0132
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0245 0.0375
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.2808 0.4302
Mycobacterium tuberculosis Conserved protein 0.0074 0.1379 0.1328
Entamoeba histolytica hypothetical protein 0.004 0.0645 1
Toxoplasma gondii ABC1 family protein 0.0074 0.1379 1
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0586 0.0898
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2808 0.4302
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.1379 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1379 0.2113
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.1299 0.199
Entamoeba histolytica hypothetical protein 0.0024 0.0292 0.1182
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.1379 0.1328
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.2679 0.4105
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.1825 0.1776
Schistosoma mansoni hypothetical protein 0.0142 0.2823 0.4325
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.2325 0.3562
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.1188 0.182
Plasmodium vivax importin-beta 2, putative 0.0029 0.0412 0.2671
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.1188 0.182
Mycobacterium ulcerans beta-lactamase 0.0074 0.1379 1
Schistosoma mansoni hypothetical protein 0.0066 0.1188 0.182
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2808 0.4302
Schistosoma mansoni ets-related 0.0215 0.4392 0.6729
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.2808 0.4302
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0455 0.0696
Echinococcus granulosus snurportin 1 0.0314 0.6528 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0245 0.3524
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.2808 0.4302
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.1188 0.265
Echinococcus granulosus GPCR family 2 0.0066 0.1188 0.182
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1379 0.2113
Brugia malayi MH2 domain containing protein 0.0118 0.2325 0.5184
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.1825 1
Onchocerca volvulus 0.0074 0.1379 0.2143
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.1379 0.3075
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0645 0.0988
Loa Loa (eye worm) hypothetical protein 0.0013 0.0057 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0136 0.2703 0.414
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0412 0.2671
Brugia malayi Ets-domain containing protein 0.0071 0.1299 0.2896
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0355 0.0791
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0207 0.4232 0.9435
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0292 0.0459
Leishmania major importin beta-1 subunit, putative 0.0024 0.0292 0.1765
Plasmodium falciparum thioredoxin reductase 0.0038 0.0586 1
Echinococcus multilocularis lamin 0.0027 0.0355 0.0543
Entamoeba histolytica hypothetical protein 0.004 0.0645 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.1825 0.1776
Schistosoma mansoni importin beta-1 0.0029 0.0412 0.0631
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.1379 0.1328
Mycobacterium tuberculosis Conserved protein 0.0074 0.1379 0.1328
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.1379 1
Trichomonas vaginalis set domain proteins, putative 0.0249 0.5135 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.162 0.157
Treponema pallidum NADH oxidase 0.0013 0.0059 0.5
Brugia malayi intermediate filament protein 0.0027 0.0355 0.0791
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0314 0.6528 1
Plasmodium falciparum glutathione reductase 0.0038 0.0586 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0355 0.0543
Schistosoma mansoni hypothetical protein 0.0066 0.1188 0.182
Brugia malayi Thioredoxin reductase 0.0038 0.0586 0.1307
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.2808 0.6261
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.2703 0.414
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0455 0.0696

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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