TDR Targets

Basic information

Technical information

TDR Targets ID: 617496
Name: 2-(2,5-dimethoxyphenyl)-9-(2-methoxyphenyl)-8 -oxo-7H-purine-6-carboxamide
MW: 421.406 | Formula: C21H19N5O5
H donors: 2 H acceptors: 5 LogP: 2.48 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1)c1nc(C(=O)N)c2c(n1)n(c(n2)O)c1ccccc1OC)OC
InChi: 1S/C21H19N5O5/c1-29-11-8-9-14(30-2)12(10-11)19-23-16(18(22)27)17-20(25-19)26(21(28)24-17)13-6-4-5-7-15(13)31-3/h4-10H,1-3H3,(H2,22,27)(H,24,28)
InChiKey: AYUZJODZPMOVJM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2,5-dimethoxyphenyl)-8-keto-9-(2-methoxyphenyl)-7H-purine-6-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	trypanothione reductase	0.004	0.0334	0.4399
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0019	0.0071	0.0071
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0092	0.0978	0.0978
Onchocerca volvulus		0.0073	0.0744	1
Mycobacterium ulcerans	hypothetical protein	0.0073	0.0744	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0019	0.0071	0.023
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0071	0.023
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0671	0.218
Schistosoma mansoni	nAChR subunit	0.0019	0.0071	0.023
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0101	0.1092	1
Echinococcus granulosus	glycine receptor subunit beta	0.0019	0.0071	0.023
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0224	0.0729
Schistosoma mansoni	hypothetical protein	0.0031	0.0224	0.0729
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0224	0.0729
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0073	0.0744	0.2419
Brugia malayi	Cation transporter family protein	0.0019	0.0071	0.023
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.0744	1
Schistosoma mansoni	jumonji domain containing protein	0.0073	0.0744	0.2419
Plasmodium vivax	thioredoxin reductase, putative	0.004	0.0334	0.4399
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0071	0.023
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0028	0.0187	0.0609
Brugia malayi	glutathione reductase	0.004	0.0334	0.1084
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0019	0.0071	0.023
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0019	0.0071	0.023
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0071	0.023
Loa Loa (eye worm)	glutathione reductase	0.004	0.0334	0.1084
Echinococcus multilocularis	jumonji domain containing protein	0.0039	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0091	0.0966	0.1703
Brugia malayi	excitatory GABA receptor EXP-1A	0.0019	0.0071	0.023
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Schistosoma mansoni	hypothetical protein	0.0031	0.0224	0.0729
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.1055	0.343
Schistosoma mansoni	nAChR subunit	0.0019	0.0071	0.023
Loa Loa (eye worm)	MH2 domain-containing protein	0.0126	0.1398	0.4544
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0014	0.0011	0.0036
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0071	0.023
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0468	0.5619	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0261	0.0847
Plasmodium vivax	glutathione reductase, putative	0.004	0.0334	0.4399
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0019	0.0071	0.023
Loa Loa (eye worm)	transcription factor SMAD2	0.0126	0.1398	0.4544
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0019	0.0071	0.023
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0091	0.0966	0.1703
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0019	0.0071	0.023
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0955	0.3103
Brugia malayi	Thioredoxin reductase	0.004	0.0334	0.1084
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0224	0.0729
Echinococcus granulosus	jumonji domain containing protein	0.0039	0.0324	0.1051
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0224	0.0729
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0014	0.0011	0.0011
Plasmodium falciparum	thioredoxin reductase	0.004	0.0334	1
Brugia malayi	PHD-finger family protein	0.0028	0.0187	0.0609
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0262	0.3077	1
Schistosoma mansoni	nAChR subunit	0.0019	0.0071	0.023
Plasmodium falciparum	phd finger protein, putative	0.0028	0.0187	0.547
Schistosoma mansoni	nAChR subunit	0.0019	0.0071	0.023
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Treponema pallidum	NADH oxidase	0.0014	0.0011	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.3077	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0073	0.0744	0.2419
Mycobacterium tuberculosis	Probable esterase LipL	0.0073	0.0744	0.1308
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0071	0.023
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0744	0.2419
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Mycobacterium tuberculosis	Probable lipase LipE	0.0073	0.0744	0.1308
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0019	0.0071	0.023
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0116	0.1272	0.4135
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Mycobacterium tuberculosis	Probable oxidoreductase	0.0101	0.1092	0.1927
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0019	0.0071	0.023
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0744	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0071	0.023
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0019	0.0071	0.023
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.004	0.0334	0.0575
Brugia malayi	RNA binding protein	0.0262	0.3077	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1055	0.343
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0019	0.0071	0.023
Echinococcus multilocularis	nAChR subunit	0.0019	0.0071	0.0071
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.0187	0.2406
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0071	0.023
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0092	0.0978	0.3179
Trypanosoma brucei	trypanothione reductase	0.004	0.0334	0.4399
Mycobacterium ulcerans	esterase/lipase LipP	0.0073	0.0744	1
Onchocerca volvulus		0.0073	0.0744	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0744	0.2419
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0224	0.0729
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0073	0.0744	0.2419
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0744	1
Brugia malayi	beta-lactamase family protein	0.0073	0.0744	0.2419
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.1055	0.343
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0224	0.0224
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0028	0.0187	0.0187
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0261	0.0261
Echinococcus granulosus	GPCR family 2	0.0031	0.0224	0.0729
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0071	0.023
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.0261	0.0847
Brugia malayi	jmjC domain containing protein	0.0092	0.0978	0.3179
Echinococcus granulosus	tar DNA binding protein	0.0262	0.3077	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0955	0.3103
Echinococcus granulosus	geminin	0.017	0.1933	0.6281
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.3077	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0091	0.0966	0.6382
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0019	0.0071	0.023
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0019	0.0071	0.023
Trypanosoma cruzi	trypanothione reductase, putative	0.004	0.0334	0.4399
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0073	0.0744	0.0744
Loa Loa (eye worm)	ACC-1 protein	0.0019	0.0071	0.023
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0744	0.2419
Brugia malayi	beta-lactamase	0.0073	0.0744	0.2419
Echinococcus granulosus	thioredoxin glutathione reductase	0.0041	0.034	0.1106
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0019	0.0071	0.023
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0071	0.0071
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0073	0.0744	1
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0019	0.0071	0.0071
Schistosoma mansoni	hypothetical protein	0.0031	0.0224	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.3077	1
Mycobacterium ulcerans	beta-lactamase	0.0073	0.0744	1
Schistosoma mansoni	nAChR subunit	0.0019	0.0071	0.023
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0091	0.0966	0.1703
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0019	0.0071	0.0071
Echinococcus multilocularis	glycine receptor subunit beta	0.0019	0.0071	0.0071
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0071	0.0071
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0071	0.0071
Schistosoma mansoni	hypothetical protein	0.017	0.1933	0.6281
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.3077	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0955	0.3103
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.3077	1
Echinococcus granulosus	glycine receptor subunit beta	0.0019	0.0071	0.023
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0744	0.2419
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0071	0.023
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0744	0.2419
Onchocerca volvulus		0.0073	0.0744	1
Schistosoma mansoni	hypothetical protein	0.0067	0.0671	0.218
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0955	0.0955
Loa Loa (eye worm)	ACC-1 protein	0.0019	0.0071	0.023
Mycobacterium ulcerans	lipase LipD	0.0073	0.0744	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0011	0.5
Toxoplasma gondii	ABC1 family protein	0.0073	0.0744	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0744	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0955	0.3103
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0071	0.023
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0019	0.0071	0.023
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.0187	0.2406
Echinococcus multilocularis	tar DNA binding protein	0.0262	0.3077	0.3077
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0744	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.1055	0.343
Brugia malayi	Bromodomain containing protein	0.0028	0.0187	0.0609
Echinococcus granulosus	PHD finger protein rhinoceros	0.0028	0.0187	0.0609
Brugia malayi	jmjC domain containing protein	0.0034	0.0261	0.0847
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0019	0.0071	0.023
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0955	0.0955
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0019	0.0071	0.0071
Toxoplasma gondii	thioredoxin reductase	0.004	0.0334	0.4399
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0014	0.0011	0.0036
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.0744	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0019	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0744	0.2419
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0019	0.0071	0.0071
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0261	0.0847
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0041	0.034	0.034
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0019	0.0071	0.023
Giardia lamblia	PHD finger protein 15	0.0028	0.0187	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0224	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.0558	0.1812
Leishmania major	hypothetical protein, conserved	0.0073	0.0744	1
Onchocerca volvulus	Alhambra homolog	0.0028	0.0187	0.1733
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0436	0.1416
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0744	0.1308
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0744	0.1308
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0011	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0071	0.023
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0071	0.023
Trypanosoma brucei	hypothetical protein, conserved	0.0073	0.0744	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0224	0.0729
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0091	0.0966	0.1703
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0187	0.0609
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0014	0.0011	0.0036
Mycobacterium tuberculosis	Probable hydrolase	0.0073	0.0744	0.1308
Brugia malayi	beta-lactamase family protein	0.0073	0.0744	0.2419
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0019	0.0071	0.023
Mycobacterium tuberculosis	Probable dehydrogenase	0.0091	0.0966	0.1703
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0744	0.1308
Loa Loa (eye worm)	RNA binding protein	0.0262	0.3077	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0019	0.0071	0.023
Brugia malayi	Cation transporter family protein	0.0019	0.0071	0.023
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.0187	0.2406
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.0955	0.3103
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0071	0.023
Plasmodium vivax	hypothetical protein, conserved	0.0073	0.0744	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Loa Loa (eye worm)	beta-lactamase	0.0073	0.0744	0.2419
Brugia malayi	TAR-binding protein	0.0262	0.3077	1
Brugia malayi	MH2 domain containing protein	0.0126	0.1398	0.4544
Echinococcus granulosus	nAChR subunit	0.0019	0.0071	0.023
Schistosoma mansoni	hypothetical protein	0.017	0.1933	0.6281
Echinococcus multilocularis	glycine receptor subunit beta	0.0019	0.0071	0.0071
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0019	0.0071	0.023
Mycobacterium tuberculosis	Probable lipase LipD	0.0073	0.0744	0.1308
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0744	1
Trichomonas vaginalis	esterase, putative	0.0073	0.0744	1
Schistosoma mansoni	hypothetical protein	0.0028	0.0187	0.0609
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0955	0.3103
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0019	0.0071	0.023
Loa Loa (eye worm)	PHD-finger family protein	0.0028	0.0187	0.0609
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0019	0.0071	0.023
Schistosoma mansoni	nAChR subunit	0.0019	0.0071	0.023
Echinococcus multilocularis	geminin	0.017	0.1933	0.1933
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0071	0.023
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0671	0.218
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0224	0.0224
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0019	0.0071	0.023
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.023
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0744	0.2419
Echinococcus multilocularis	peregrin	0.0028	0.0187	0.0187
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.0955	0.3103
Plasmodium falciparum	glutathione reductase	0.004	0.0334	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0071	0.023
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0019	0.0071	0.023
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0019	0.0071	0.0071
Loa Loa (eye worm)	LGC-31 protein	0.0019	0.0071	0.023
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0101	0.1092	0.1927
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0101	0.1092	0.1927
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0073	0.0744	0.1308
Mycobacterium tuberculosis	Probable reductase	0.0091	0.0966	0.1703
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0019	0.0071	0.023
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0073	0.0744	0.1308
Schistosoma mansoni	nAChR subunit	0.0019	0.0071	0.023
Brugia malayi	RNA recognition motif domain containing protein	0.0262	0.3077	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0073	0.0744	0.1308
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0261	0.0847
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0744	0.2419
Brugia malayi	Receptor family ligand binding region containing protein	0.0116	0.1272	0.4135
Loa Loa (eye worm)	thioredoxin reductase	0.004	0.0334	0.1084
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0014	0.0011	0.5
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0224	0.0224
Brugia malayi	Cation transporter family protein	0.0019	0.0071	0.023
Loa Loa (eye worm)	TAR-binding protein	0.0262	0.3077	1
Echinococcus granulosus	peregrin	0.0028	0.0187	0.0609

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 617496