Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hypothetical protein, conserved | 0.0071 | 0.0449 | 1 |
Brugia malayi | beta-lactamase | 0.0071 | 0.0449 | 0.1314 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.0067 | 0.006 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0074 | 0.0483 | 0.0476 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0083 | 0.0594 | 0.578 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.0426 | 0.1245 |
Plasmodium vivax | hypothetical protein, conserved | 0.0071 | 0.0449 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.0062 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0831 | 0.2462 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0071 | 0.0449 | 0.0822 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0062 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0337 | 0.0999 |
Schistosoma mansoni | tar DNA-binding protein | 0.0328 | 0.3376 | 1 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0061 | 0.0337 | 0.033 |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.0449 | 0.0822 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0093 | 0.07 | 0.1353 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.0449 | 0.9926 |
Brugia malayi | beta-lactamase family protein | 0.0071 | 0.0449 | 0.1314 |
Schistosoma mansoni | chromobox protein | 0.0071 | 0.0452 | 0.1321 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0071 | 0.0449 | 0.1314 |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.0449 | 0.0822 |
Toxoplasma gondii | ABC1 family protein | 0.0071 | 0.0449 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.0426 | 0.1245 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0007 | 0.002 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.0449 | 0.9926 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0451 | 0.4781 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0071 | 0.0449 | 0.0443 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0061 | 0.0337 | 0.098 |
Echinococcus granulosus | chromobox protein 1 | 0.0071 | 0.0452 | 0.1321 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.0787 | 0.2333 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0083 | 0.0594 | 0.1129 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.0132 | 0.0969 |
Schistosoma mansoni | jumonji domain containing protein | 0.0158 | 0.1445 | 0.4268 |
Echinococcus multilocularis | chromobox protein 1 | 0.0071 | 0.0452 | 0.0445 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0199 | 0.191 | 0.1905 |
Mycobacterium ulcerans | lipase LipD | 0.0071 | 0.0449 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.0449 | 0.9926 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0083 | 0.0594 | 0.1129 |
Trichomonas vaginalis | chromobox protein, putative | 0.0071 | 0.0452 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0083 | 0.0594 | 0.1129 |
Mycobacterium ulcerans | hypothetical protein | 0.0071 | 0.0449 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0449 | 0.1331 |
Brugia malayi | chromobox protein homolog 3 | 0.004 | 0.0098 | 0.0269 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0146 | 0.1311 | 0.1305 |
Plasmodium vivax | hypothetical protein, conserved | 0.0061 | 0.0337 | 0.7104 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0071 | 0.0449 | 0.0822 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0083 | 0.0594 | 0.1129 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0449 | 0.1331 |
Schistosoma mansoni | tar DNA-binding protein | 0.0328 | 0.3376 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0071 | 0.0449 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0071 | 0.0449 | 0.9926 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0071 | 0.0449 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0071 | 0.0449 | 0.9926 |
Plasmodium falciparum | phd finger protein, putative | 0.0061 | 0.0337 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0146 | 0.1311 | 0.3871 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0074 | 0.0483 | 0.1412 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0007 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0787 | 0.2333 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.0958 | 0.2824 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.0062 | 0.0182 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0199 | 0.191 | 0.565 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0062 | 0.0162 |
Onchocerca volvulus | 0.0071 | 0.0449 | 1 | |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.0132 | 0.0969 |
Brugia malayi | beta-lactamase family protein | 0.0071 | 0.0449 | 0.1314 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.0337 | 0.098 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.004 | 0.0098 | 0.2173 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.0787 | 0.2317 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0074 | 0.0483 | 0.1412 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0071 | 0.0452 | 0.1339 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0146 | 0.1311 | 0.3871 |
Brugia malayi | Bromodomain containing protein | 0.0061 | 0.0337 | 0.098 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0071 | 0.0449 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0071 | 0.0449 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0071 | 0.0449 | 0.1331 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0071 | 0.0449 | 0.9926 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0449 | 0.1331 |
Loa Loa (eye worm) | TAR-binding protein | 0.0328 | 0.3376 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0071 | 0.0449 | 0.1314 |
Echinococcus multilocularis | chromobox protein 1 | 0.0071 | 0.0452 | 0.0445 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0328 | 0.3376 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0328 | 0.3376 | 1 |
Brugia malayi | RNA binding protein | 0.0328 | 0.3376 | 1 |
Brugia malayi | TAR-binding protein | 0.0328 | 0.3376 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0071 | 0.0449 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0071 | 0.0449 | 0.1314 |
Brugia malayi | Heterochromatin protein 1 | 0.0071 | 0.0452 | 0.1321 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0146 | 0.1311 | 0.3883 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0071 | 0.0449 | 0.0822 |
Echinococcus multilocularis | peregrin | 0.0061 | 0.0337 | 0.033 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.0132 | 0.2937 |
Trichomonas vaginalis | chromobox protein, putative | 0.0071 | 0.0452 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0071 | 0.0449 | 0.0822 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0449 | 0.1331 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0098 | 0.0289 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0146 | 0.1311 | 0.3871 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.0958 | 0.2839 |
Onchocerca volvulus | Alhambra homolog | 0.0061 | 0.0337 | 0.75 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0146 | 0.1311 | 0.1305 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0093 | 0.07 | 0.1353 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0061 | 0.0337 | 0.098 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0146 | 0.1311 | 0.3871 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0426 | 0.1262 |
Loa Loa (eye worm) | beta-lactamase | 0.0071 | 0.0449 | 0.1331 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.0067 | 0.0179 |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.0449 | 0.0822 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0125 | 0.1073 | 0.318 |
Echinococcus multilocularis | tar DNA binding protein | 0.0328 | 0.3376 | 0.3371 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0328 | 0.3376 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0449 | 0.1331 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.0787 | 0.2317 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0071 | 0.0449 | 0.1314 |
Brugia malayi | jmjC domain containing protein | 0.0199 | 0.191 | 0.565 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0071 | 0.0449 | 0.0822 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0061 | 0.0337 | 0.7104 |
Echinococcus granulosus | peregrin | 0.0061 | 0.0337 | 0.098 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0061 | 0.0337 | 0.0999 |
Echinococcus granulosus | tar DNA binding protein | 0.0328 | 0.3376 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0328 | 0.3376 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0074 | 0.0483 | 0.1412 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0093 | 0.07 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0074 | 0.0483 | 0.1412 |
Schistosoma mansoni | tar DNA-binding protein | 0.0328 | 0.3376 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0085 | 0.0608 | 0.0601 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0074 | 0.0483 | 0.143 |
Giardia lamblia | PHD finger protein 15 | 0.0061 | 0.0337 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0083 | 0.0594 | 0.1129 |
Schistosoma mansoni | chromobox protein | 0.0071 | 0.0452 | 0.1321 |
Echinococcus granulosus | jumonji domain containing protein | 0.0085 | 0.0608 | 0.1784 |
Brugia malayi | PHD-finger family protein | 0.0061 | 0.0337 | 0.098 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0071 | 0.0449 | 0.0822 |
Loa Loa (eye worm) | RNA binding protein | 0.0328 | 0.3376 | 1 |
Onchocerca volvulus | 0.0071 | 0.0449 | 1 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0093 | 0.07 | 0.1353 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0146 | 0.1311 | 0.3871 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0061 | 0.0337 | 0.7104 |
Onchocerca volvulus | 0.0071 | 0.0449 | 1 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0146 | 0.1311 | 0.3871 |
Mycobacterium ulcerans | beta-lactamase | 0.0071 | 0.0449 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.0958 | 0.2839 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0071 | 0.0449 | 0.0822 |
Echinococcus granulosus | chromobox protein 1 | 0.0071 | 0.0452 | 0.1321 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0083 | 0.0594 | 0.1129 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0449 | 0.1331 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.