Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0123 | 0.1216 | 0.3068 |
Brugia malayi | glutathione reductase | 0.0044 | 0.0172 | 0.0435 |
Echinococcus granulosus | peregrin | 0.006 | 0.0379 | 0.0957 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0941 | 0.2374 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0089 | 0.0224 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0072 | 0.0545 | 0.1374 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0083 | 0.0687 | 0.0687 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0139 | 0.1723 |
Plasmodium falciparum | phd finger protein, putative | 0.006 | 0.0379 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0044 | 0.0172 | 0.2882 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.006 | 0.0379 | 0.0379 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0139 | 0.1224 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.0089 | 0.5 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.006 | 0.0379 | 0.0957 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.0498 | 0.1256 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.01 | 0.0283 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.0878 | 0.2216 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0138 | 0.141 | 0.3557 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0089 | 0.0224 |
Schistosoma mansoni | tar DNA-binding protein | 0.0331 | 0.3963 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0044 | 0.0172 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.0498 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.01 | 0.0914 | 0.3093 |
Toxoplasma gondii | thioredoxin reductase | 0.0044 | 0.0172 | 0.2882 |
Mycobacterium tuberculosis | Probable reductase | 0.01 | 0.0914 | 0.3093 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.0498 | 0.1256 |
Onchocerca volvulus | Alhambra homolog | 0.006 | 0.0379 | 1 |
Brugia malayi | PHD-finger family protein | 0.006 | 0.0379 | 0.0957 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0044 | 0.018 | 0.018 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0044 | 0.0172 | 0.2882 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0331 | 0.3963 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.01 | 0.0914 | 0.3093 |
Schistosoma mansoni | tar DNA-binding protein | 0.0331 | 0.3963 | 1 |
Brugia malayi | TAR-binding protein | 0.0331 | 0.3963 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0089 | 0.0224 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.006 | 0.0379 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.0089 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0155 | 0.1638 | 0.4134 |
Schistosoma mansoni | tar DNA-binding protein | 0.0331 | 0.3963 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.006 | 0.0379 | 0.0957 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.0472 | 0.1191 |
Brugia malayi | Heterochromatin protein 1 | 0.0068 | 0.0498 | 0.1256 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0111 | 0.1062 | 0.3645 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0138 | 0.141 | 0.3557 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0138 | 0.141 | 0.3557 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.01 | 0.0914 | 0.3093 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0089 | 0.0224 |
Echinococcus granulosus | jumonji domain containing protein | 0.0083 | 0.0687 | 0.1734 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0195 | 0.2167 | 0.5468 |
Brugia malayi | Thioredoxin reductase | 0.0044 | 0.0172 | 0.0435 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0068 | 0.0498 | 0.1256 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.01 | 0.0914 | 0.8485 |
Plasmodium vivax | hypothetical protein, conserved | 0.006 | 0.0379 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0044 | 0.0172 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0195 | 0.2167 | 0.5468 |
Loa Loa (eye worm) | RNA binding protein | 0.0331 | 0.3963 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1762 | 0.4446 |
Brugia malayi | jmjC domain containing protein | 0.0072 | 0.0545 | 0.1374 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0044 | 0.0172 | 0.0314 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.0878 | 0.2216 |
Brugia malayi | RNA binding protein | 0.0331 | 0.3963 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0072 | 0.0545 | 0.1374 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0089 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0089 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0089 | 0.0224 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.0878 | 0.2216 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0111 | 0.1062 | 0.3645 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1762 | 0.4446 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0089 | 0.0224 |
Echinococcus multilocularis | tar DNA binding protein | 0.0331 | 0.3963 | 0.3963 |
Echinococcus multilocularis | geminin | 0.0164 | 0.1762 | 0.1762 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0111 | 0.1062 | 0.3645 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0138 | 0.141 | 0.3557 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.01 | 0.0253 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.0089 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.01 | 0.0398 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0089 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0472 | 0.1191 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.0498 | 0.0498 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.0498 | 0.0498 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0138 | 0.141 | 0.141 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0044 | 0.018 | 0.0455 |
Brugia malayi | Bromodomain containing protein | 0.006 | 0.0379 | 0.0957 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0472 | 0.1191 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0138 | 0.141 | 0.3557 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.01 | 0.0283 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0195 | 0.2167 | 0.2167 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.01 | 0.0914 | 0.3093 |
Schistosoma mansoni | tar DNA-binding protein | 0.0331 | 0.3963 | 1 |
Brugia malayi | beta-lactamase | 0.0038 | 0.0089 | 0.0224 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.0498 | 1 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.0498 | 0.1256 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0072 | 0.0545 | 0.0545 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0044 | 0.0172 | 0.0435 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0139 | 0.1224 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.006 | 0.0379 | 0.0957 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0089 | 0.0089 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.01 | 0.0914 | 0.3093 |
Loa Loa (eye worm) | TAR-binding protein | 0.0331 | 0.3963 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0089 | 0.0224 |
Brugia malayi | MH2 domain containing protein | 0.0138 | 0.1421 | 0.3585 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0111 | 0.1062 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.1762 | 0.4446 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0331 | 0.3963 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0089 | 0.0224 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.0089 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0089 | 0.0224 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 0.1421 | 0.3585 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.0379 | 0.0957 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.0498 | 0.1256 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.006 | 0.0379 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0089 | 0.0224 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0072 | 0.0545 | 0.1374 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.01 | 0.0253 |
Leishmania major | trypanothione reductase | 0.0044 | 0.0172 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0044 | 0.0172 | 0.0435 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0138 | 0.141 | 0.3557 |
Schistosoma mansoni | tar DNA-binding protein | 0.0331 | 0.3963 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0138 | 0.141 | 0.3557 |
Echinococcus multilocularis | peregrin | 0.006 | 0.0379 | 0.0379 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0089 | 0.0224 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0138 | 0.141 | 0.141 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 0.1421 | 0.3585 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0072 | 0.0545 | 0.1374 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0878 | 0.2216 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0379 | 0.0957 |
Echinococcus granulosus | tar DNA binding protein | 0.0331 | 0.3963 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.006 | 0.0379 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.024 | 0.2758 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.