Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2868 | 0.2868 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0049 | 0.0422 | 0.5 |
Echinococcus multilocularis | geminin | 0.0346 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2868 | 0.2868 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.2868 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0027 | 0.0093 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.2868 | 0.2868 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.2868 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0049 | 0.0422 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.2868 | 0.2868 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2868 | 0.2868 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2868 | 0.2868 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.6222 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.2868 | 0.2868 |
Schistosoma mansoni | hypothetical protein | 0.0346 | 1 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.2868 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0573 | 0.1999 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0049 | 0.0422 | 0.5 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0049 | 0.0422 | 1 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0422 | 0.1472 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.2868 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0049 | 0.0422 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0027 | 0.0093 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.2868 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0346 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0573 | 0.1999 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0049 | 0.0422 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0049 | 0.0422 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0573 | 0.1999 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0573 | 0.1999 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0422 | 0.1472 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0049 | 0.0422 | 1 |
Brugia malayi | RNA binding protein | 0.0125 | 0.2868 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.