Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | jmjC domain containing protein | 0.007 | 0.0483 | 0.1348 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.0453 | 0.1261 |
Mycobacterium tuberculosis | Probable reductase | 0.0084 | 0.0646 | 0.1129 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0084 | 0.0646 | 0.1129 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0071 | 0.0493 | 0.0822 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.132 | 0.1305 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.0098 | 0.1985 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0071 | 0.0493 | 0.0822 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0084 | 0.0646 | 0.1129 |
Trichomonas vaginalis | esterase, putative | 0.0071 | 0.0493 | 1 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.0453 | 0.1261 |
Echinococcus granulosus | peregrin | 0.0058 | 0.0337 | 0.0928 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.0483 | 0.1389 |
Loa Loa (eye worm) | TAR-binding protein | 0.0321 | 0.3477 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0493 | 0.1418 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0071 | 0.0493 | 0.0822 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.0453 | 0.0437 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0058 | 0.0337 | 0.0322 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.132 | 0.3766 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0071 | 0.0493 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.0819 | 0.2355 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0016 | 0.0047 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.103 | 0.2962 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.009 | 0.0212 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.019 | 0.1913 | 0.5479 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.0084 | 0.0241 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0071 | 0.0493 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0058 | 0.0337 | 0.6198 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.0098 | 0.0235 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0132 | 0.087 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0071 | 0.0493 | 0.0477 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0819 | 0.2355 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0071 | 0.0493 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.0493 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.132 | 0.3766 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.007 | 0.0483 | 0.0467 |
Plasmodium vivax | hypothetical protein, conserved | 0.0058 | 0.0337 | 0.6198 |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.0493 | 0.0822 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.007 | 0.0483 | 0.1348 |
Mycobacterium ulcerans | lipase LipD | 0.0071 | 0.0493 | 0.5 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0084 | 0.0195 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0084 | 0.0646 | 0.5779 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0832 | 0.2393 |
Plasmodium vivax | hypothetical protein, conserved | 0.0071 | 0.0493 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0447 | 0.1245 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.0084 | 0.0241 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0084 | 0.0195 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0068 | 0.0453 | 0.1302 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0058 | 0.0337 | 0.0928 |
Brugia malayi | TAR-binding protein | 0.0321 | 0.3477 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0058 | 0.0337 | 0.0928 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.0493 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0093 | 0.0758 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.0453 | 0.0437 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.007 | 0.0483 | 0.1348 |
Brugia malayi | beta-lactamase family protein | 0.0071 | 0.0493 | 0.1377 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.0453 | 0.1261 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0071 | 0.0493 | 0.1377 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0071 | 0.0493 | 0.0822 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0447 | 0.1287 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.0453 | 0.1261 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0016 | 0.0047 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0454 | 0.5063 | 1 |
Onchocerca volvulus | 0.0071 | 0.0493 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0337 | 0.097 |
Leishmania major | hypothetical protein, conserved | 0.0071 | 0.0493 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.0819 | 0.2319 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0132 | 0.087 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0084 | 0.0646 | 0.1129 |
Schistosoma mansoni | jumonji domain containing protein | 0.0151 | 0.1447 | 0.4133 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0493 | 0.1418 |
Brugia malayi | jmjC domain containing protein | 0.019 | 0.1913 | 0.5479 |
Brugia malayi | beta-lactamase family protein | 0.0071 | 0.0493 | 0.1377 |
Schistosoma mansoni | tar DNA-binding protein | 0.0321 | 0.3477 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0071 | 0.0493 | 0.1377 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.012 | 0.1075 | 0.3091 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0321 | 0.3477 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.0819 | 0.2319 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0493 | 0.1418 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0071 | 0.0493 | 0.0822 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.019 | 0.1913 | 0.1899 |
Mycobacterium ulcerans | beta-lactamase | 0.0071 | 0.0493 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0058 | 0.0337 | 0.097 |
Schistosoma mansoni | tar DNA-binding protein | 0.0321 | 0.3477 | 1 |
Brugia malayi | PHD-finger family protein | 0.0058 | 0.0337 | 0.0928 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0337 | 0.0928 |
Loa Loa (eye worm) | RNA binding protein | 0.0321 | 0.3477 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0493 | 0.1418 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0093 | 0.0758 | 0.1353 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0071 | 0.0493 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0321 | 0.3477 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0084 | 0.0646 | 0.1129 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0058 | 0.0337 | 0.0928 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0493 | 0.1418 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0081 | 0.0609 | 0.0593 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0084 | 0.0646 | 0.1129 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0071 | 0.0493 | 0.1377 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0071 | 0.0493 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0058 | 0.0337 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0321 | 0.3477 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0071 | 0.0493 | 0.1418 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0093 | 0.0758 | 0.1353 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.132 | 0.1305 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0071 | 0.0493 | 1 |
Onchocerca volvulus | Alhambra homolog | 0.0058 | 0.0337 | 0.6844 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.014 | 0.132 | 0.3766 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0071 | 0.0493 | 0.0822 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.103 | 0.2928 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0071 | 0.0493 | 0.1377 |
Brugia malayi | beta-lactamase | 0.0071 | 0.0493 | 0.1377 |
Onchocerca volvulus | 0.0071 | 0.0493 | 1 | |
Echinococcus granulosus | jumonji domain containing protein | 0.0081 | 0.0609 | 0.1711 |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.0493 | 0.0822 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0071 | 0.0493 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.007 | 0.0483 | 0.1348 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0071 | 0.0493 | 0.1418 |
Schistosoma mansoni | tar DNA-binding protein | 0.0321 | 0.3477 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0071 | 0.0493 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0071 | 0.0493 | 0.0822 |
Brugia malayi | RNA binding protein | 0.0321 | 0.3477 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0321 | 0.3477 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0321 | 0.3477 | 0.3467 |
Schistosoma mansoni | tar DNA-binding protein | 0.0321 | 0.3477 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.0453 | 0.8985 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0071 | 0.0493 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0071 | 0.0493 | 0.0822 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0132 | 0.2682 |
Echinococcus multilocularis | peregrin | 0.0058 | 0.0337 | 0.0322 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.132 | 0.3766 |
Brugia malayi | Heterochromatin protein 1 | 0.0068 | 0.0453 | 0.1261 |
Onchocerca volvulus | 0.0071 | 0.0493 | 1 | |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.0453 | 0.8985 |
Mycobacterium ulcerans | hypothetical protein | 0.0071 | 0.0493 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.132 | 0.3766 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0098 | 0.0281 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.103 | 0.2962 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0058 | 0.0337 | 0.6198 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0093 | 0.0758 | 0.1353 |
Plasmodium falciparum | phd finger protein, putative | 0.0058 | 0.0337 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.014 | 0.132 | 0.3795 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.132 | 0.3766 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0493 | 0.1418 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.0447 | 0.1245 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.009 | 0.0073 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.