Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0036 | 0.0316 | 1 | |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0316 | 0.5109 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0097 | 0.3308 | 0.309 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0312 | 0.0368 |
Echinococcus granulosus | tar DNA binding protein | 0.0201 | 0.8462 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0843 | 0.0996 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0316 | 0.0373 |
Brugia malayi | Thioredoxin reductase | 0.0042 | 0.0619 | 0.0731 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0316 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0042 | 0.0619 | 0.0731 |
Leishmania major | trypanothione reductase | 0.0042 | 0.0619 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0042 | 0.0619 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0312 | 0.0368 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0097 | 0.3308 | 0.309 |
Loa Loa (eye worm) | RNA binding protein | 0.0201 | 0.8462 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0312 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0316 | 0.0373 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0843 | 0.0996 |
Brugia malayi | glutathione reductase | 0.0042 | 0.0619 | 0.0731 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.5145 | 0.608 |
Schistosoma mansoni | jumonji domain containing protein | 0.0078 | 0.2373 | 0.2804 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0316 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.8462 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0312 | 0.0368 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0316 | 0.0373 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0108 | 0.3843 | 1 |
Brugia malayi | TAR-binding protein | 0.0201 | 0.8462 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0042 | 0.0619 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0312 | 0.0368 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0316 | 0.5109 |
Brugia malayi | jmjC domain containing protein | 0.0098 | 0.337 | 0.3982 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.1577 | 0.1864 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0316 | 0.0373 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0316 | 0.0373 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0843 | 0.0996 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0316 | 0.0373 |
Toxoplasma gondii | thioredoxin reductase | 0.0042 | 0.0619 | 1 |
Onchocerca volvulus | 0.0036 | 0.0316 | 1 | |
Plasmodium falciparum | glutathione reductase | 0.0042 | 0.0619 | 1 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0316 | 0.0373 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0316 | 0.5 |
Brugia malayi | RNA binding protein | 0.0201 | 0.8462 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0316 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0843 | 0.0996 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1058 | 0.125 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0108 | 0.3843 | 0.3642 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0042 | 0.058 | 0.0685 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0316 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0316 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0042 | 0.0619 | 0.0731 |
Echinococcus multilocularis | tar DNA binding protein | 0.0201 | 0.8462 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0316 | 0.0373 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0042 | 0.0619 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0316 | 0.0373 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0108 | 0.3843 | 0.3642 |
Echinococcus granulosus | jumonji domain containing protein | 0.0042 | 0.058 | 0.0685 |
Mycobacterium tuberculosis | Probable reductase | 0.0097 | 0.3308 | 0.309 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0097 | 0.3308 | 0.309 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0843 | 0.0996 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.5145 | 0.608 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0843 | 0.0996 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0201 | 0.8462 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0316 | 0.0373 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0843 | 0.0996 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0316 | 0.0373 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.8462 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0098 | 0.337 | 0.3982 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0042 | 0.0619 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0316 | 0.0373 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0097 | 0.3308 | 0.309 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0316 | 0.5 |
Onchocerca volvulus | 0.0036 | 0.0316 | 1 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0201 | 0.8462 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0097 | 0.3308 | 0.8485 |
Giardia lamblia | PHD finger protein 15 | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0312 | 0.0368 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0098 | 0.337 | 0.3982 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0097 | 0.3308 | 0.309 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0201 | 0.8462 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.8462 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0316 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0042 | 0.0619 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.8462 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0316 | 0.0373 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0316 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0316 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0316 | 0.0373 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0043 | 0.0647 | 0.0764 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0843 | 0.0996 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0316 | 0.0373 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0316 | 0.0373 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.5145 | 0.608 |
Schistosoma mansoni | tar DNA-binding protein | 0.0201 | 0.8462 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0108 | 0.3843 | 0.3642 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0316 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0043 | 0.0647 | 0.0764 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0843 | 0.0996 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0042 | 0.0619 | 0.0312 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.