Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0097 | 0.0346 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0072 | 0.0517 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0072 | 0.0517 | 0.0822 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0072 | 0.0517 | 0.0517 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.0097 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0517 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0072 | 0.0517 | 0.1856 |
Echinococcus granulosus | tar DNA binding protein | 0.026 | 0.2786 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0517 | 0.1856 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.079 | 0.079 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0258 | 0.0925 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0064 | 0.0229 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0258 | 0.0925 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0075 | 0.0268 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.0517 | 0.1856 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2786 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.026 | 0.2786 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2786 | 1 |
Brugia malayi | RNA binding protein | 0.026 | 0.2786 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.026 | 0.2786 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0517 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0075 | 0.0075 |
Onchocerca volvulus | 0.0072 | 0.0517 | 1 | |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.0139 | 0.0498 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0085 | 0.0674 | 0.1129 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0096 | 0.0807 | 0.0807 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0075 | 0.0268 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.0097 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0072 | 0.0517 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.0097 | 0.1866 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.0139 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0253 | 0.0909 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0075 | 0.0268 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.0378 | 0.1355 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0075 | 0.0268 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0064 | 0.0229 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0517 | 0.0822 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.0097 | 0.0346 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.0789 | 0.1353 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.079 | 0.2836 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0461 | 0.5215 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0072 | 0.0517 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0517 | 0.1856 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0085 | 0.0674 | 0.1129 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0072 | 0.0517 | 0.1856 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.079 | 0.2836 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0085 | 0.0674 | 0.1129 |
Brugia malayi | jmjC domain containing protein | 0.0096 | 0.0807 | 0.2896 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.0789 | 0.1353 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0517 | 1 |
Brugia malayi | beta-lactamase | 0.0072 | 0.0517 | 0.1856 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.1069 | 0.3837 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0075 | 0.0268 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0072 | 0.0517 | 0.0822 |
Brugia malayi | TAR-binding protein | 0.026 | 0.2786 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0517 | 0.0822 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.0789 | 0.1353 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.0097 | 0.1866 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2786 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.079 | 0.2836 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0097 | 0.0346 |
Mycobacterium ulcerans | beta-lactamase | 0.0072 | 0.0517 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0517 | 0.5 |
Onchocerca volvulus | 0.0072 | 0.0517 | 1 | |
Mycobacterium tuberculosis | Probable hydrolase | 0.0072 | 0.0517 | 0.0822 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.1069 | 0.3837 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0517 | 0.0822 |
Leishmania major | hypothetical protein, conserved | 0.0072 | 0.0517 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.026 | 0.2786 | 0.2786 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.0789 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0517 | 0.1856 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2786 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0517 | 0.5 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0085 | 0.0674 | 0.5779 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0517 | 0.1856 |
Mycobacterium ulcerans | hypothetical protein | 0.0072 | 0.0517 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0072 | 0.0517 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.0097 | 0.0346 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0038 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.026 | 0.2786 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0072 | 0.0517 | 0.0822 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0517 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.026 | 0.2786 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.0097 | 0.1866 |
Schistosoma mansoni | jumonji domain containing protein | 0.0076 | 0.0568 | 0.2039 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0072 | 0.0517 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.079 | 0.2836 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0072 | 0.0517 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0072 | 0.0517 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0258 | 0.0925 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0517 | 0.1856 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0072 | 0.0517 | 0.0822 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0085 | 0.0674 | 0.1129 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2786 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.079 | 0.2836 |
Onchocerca volvulus | 0.0072 | 0.0517 | 1 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.1069 | 0.3837 |
Mycobacterium tuberculosis | Probable reductase | 0.0085 | 0.0674 | 0.1129 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.079 | 0.2836 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0517 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0258 | 0.0925 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.0517 | 0.1856 |
Loa Loa (eye worm) | beta-lactamase | 0.0072 | 0.0517 | 0.1856 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0096 | 0.0807 | 0.2896 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0517 | 0.1856 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0064 | 0.0229 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0085 | 0.0674 | 0.1129 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0517 | 0.1856 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.079 | 0.079 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0072 | 0.0517 | 0.1856 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0038 | 0.0103 | 0.0368 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0072 | 0.0517 | 0.0822 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.079 | 0.2836 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0072 | 0.0517 | 0.0822 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0517 | 0.1856 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.