Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.0137 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0093 | 0.0818 | 0.2828 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0101 | 0.0348 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.0137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0101 | 0.0348 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.0383 | 0.1324 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.0777 | 0.0777 |
Loa Loa (eye worm) | RNA binding protein | 0.0257 | 0.2891 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.0777 | 0.2688 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.1207 | 0.4174 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0101 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0101 | 0.0348 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0039 | 0.0137 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.0777 | 0.2688 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.009 | 0.0773 | 0.2711 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0777 | 0.2688 |
Brugia malayi | glutathione reductase | 0.0039 | 0.0137 | 0.0473 |
Brugia malayi | Thioredoxin reductase | 0.0039 | 0.0137 | 0.0473 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0101 | 0.0348 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.0137 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0099 | 0.0899 | 0.322 |
Mycobacterium tuberculosis | Probable reductase | 0.009 | 0.0773 | 0.2711 |
Trypanosoma brucei | trypanothione reductase | 0.0039 | 0.0137 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0101 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0777 | 0.2688 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0101 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0076 | 0.0262 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0101 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0257 | 0.2891 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0101 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.0777 | 0.0777 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2891 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0101 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0257 | 0.0888 |
Leishmania major | trypanothione reductase | 0.0039 | 0.0137 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0141 | 0.0141 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.009 | 0.0773 | 0.2711 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0101 | 0.0348 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0101 | 0.7353 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.1207 | 0.4174 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0257 | 0.2891 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0101 | 0.0348 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.0777 | 0.2688 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0232 | 0.258 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.009 | 0.0773 | 0.8418 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0039 | 0.0137 | 0.0473 |
Brugia malayi | RNA binding protein | 0.0257 | 0.2891 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0076 | 0.0262 |
Loa Loa (eye worm) | glutathione reductase | 0.0039 | 0.0137 | 0.0473 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0101 | 0.0348 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0141 | 0.0487 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0101 | 0.5 |
Onchocerca volvulus | 0.0036 | 0.0101 | 1 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0257 | 0.2891 | 0.2891 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0039 | 0.0137 | 0.0146 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.0576 | 0.1991 |
Giardia lamblia | PHD finger protein 15 | 0.0028 | 0 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0101 | 0.0348 |
Brugia malayi | jmjC domain containing protein | 0.0034 | 0.0076 | 0.0262 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0101 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0034 | 0.0076 | 0.0262 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0101 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.0777 | 0.2688 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0093 | 0.0818 | 0.0818 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0101 | 0.0348 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0101 | 0.0348 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0257 | 0.2891 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.004 | 0.0143 | 0.0143 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0099 | 0.0899 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.009 | 0.0773 | 0.2711 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.009 | 0.0773 | 0.2711 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0101 | 0.0101 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0099 | 0.0899 | 0.322 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0093 | 0.0818 | 0.2828 |
Onchocerca volvulus | 0.0036 | 0.0101 | 1 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.1207 | 0.4174 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0101 | 0.0348 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0101 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0101 | 0.0348 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0101 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.0076 | 0.0076 |
Loa Loa (eye worm) | TAR-binding protein | 0.0257 | 0.2891 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.004 | 0.0143 | 0.0496 |
Onchocerca volvulus | 0.0036 | 0.0101 | 1 | |
Plasmodium falciparum | thioredoxin reductase | 0.0039 | 0.0137 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0101 | 0.0348 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.0777 | 0.2688 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0101 | 0.0348 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0101 | 0.7353 |
Brugia malayi | TAR-binding protein | 0.0257 | 0.2891 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2891 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2891 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2891 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.2891 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0039 | 0.0137 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0034 | 0.0076 | 0.0262 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0101 | 0.0348 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0099 | 0.0899 | 0.322 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.009 | 0.0773 | 0.2711 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.