Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | jumonji domain containing protein | 0.0039 | 0.0139 | 0.0479 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.026 | 0.2897 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2897 | 1 |
Brugia malayi | RNA binding protein | 0.026 | 0.2897 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2897 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.026 | 0.2897 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0124 | 0.119 | 0.4108 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0062 | 0.0215 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.0782 | 0.2699 |
Onchocerca volvulus | 0.0037 | 0.0113 | 1 | |
Giardia lamblia | PHD finger protein 15 | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0113 | 0.0389 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0039 | 0.0135 | 0.009 |
Loa Loa (eye worm) | glutathione reductase | 0.0039 | 0.0135 | 0.0467 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0255 | 0.088 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2897 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0113 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0113 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0113 | 0.0389 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0113 | 0.0389 |
Brugia malayi | jmjC domain containing protein | 0.0034 | 0.0075 | 0.0257 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0113 | 0.0389 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0113 | 0.0389 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0113 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 0.0782 | 0.2699 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0062 | 0.0215 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.0782 | 0.2699 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0089 | 0.0762 | 0.2582 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.0377 | 0.1302 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0124 | 0.119 | 0.4108 |
Loa Loa (eye worm) | RNA binding protein | 0.026 | 0.2897 | 1 |
Onchocerca volvulus | 0.0037 | 0.0113 | 1 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0113 | 0.0389 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1716 | 0.5924 |
Plasmodium falciparum | thioredoxin reductase | 0.0039 | 0.0135 | 1 |
Onchocerca volvulus | 0.0037 | 0.0113 | 1 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0099 | 0.0887 | 0.3077 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1716 | 0.5924 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.0135 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0113 | 0.0389 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0113 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0113 | 0.0389 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0062 | 0.0215 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0113 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0034 | 0.0075 | 0.0257 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0113 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0099 | 0.0887 | 0.3077 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.0782 | 0.2699 |
Trypanosoma brucei | trypanothione reductase | 0.0039 | 0.0135 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0075 | 0.0257 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.0075 | 0.0075 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.004 | 0.0142 | 0.0142 |
Leishmania major | trypanothione reductase | 0.0039 | 0.0135 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.0567 | 0.1958 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2897 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0113 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0039 | 0.0135 | 0.0467 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0089 | 0.0762 | 0.2582 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0089 | 0.0762 | 0.2582 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0075 | 0.0257 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.004 | 0.0142 | 0.0489 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0113 | 0.0389 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.0135 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.026 | 0.2897 | 0.2897 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0039 | 0.0135 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0089 | 0.0762 | 0.8391 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.0782 | 0.0782 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0034 | 0.0075 | 0.0257 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0113 | 0.8332 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0089 | 0.0762 | 0.2582 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0113 | 0.8332 |
Brugia malayi | jmjC domain containing protein | 0.0093 | 0.0806 | 0.2781 |
Schistosoma mansoni | tar DNA-binding protein | 0.026 | 0.2897 | 1 |
Brugia malayi | TAR-binding protein | 0.026 | 0.2897 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0113 | 0.0389 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0113 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0239 | 0.2628 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0093 | 0.0806 | 0.2781 |
Loa Loa (eye worm) | TAR-binding protein | 0.026 | 0.2897 | 1 |
Echinococcus multilocularis | geminin | 0.0166 | 0.1716 | 0.1716 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0039 | 0.0139 | 0.0139 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0113 | 0.5 |
Brugia malayi | glutathione reductase | 0.0039 | 0.0135 | 0.0467 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0089 | 0.0762 | 0.2582 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0093 | 0.0806 | 0.0806 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0113 | 0.0389 |
Echinococcus granulosus | geminin | 0.0166 | 0.1716 | 0.5924 |
Plasmodium falciparum | glutathione reductase | 0.0039 | 0.0135 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0099 | 0.0887 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0113 | 0.0113 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0113 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0113 | 0.0389 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0255 | 0.088 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0113 | 0.0389 |
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.0135 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0124 | 0.119 | 0.4108 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0255 | 0.088 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.0782 | 0.2699 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0113 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0039 | 0.0135 | 0.0467 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.0782 | 0.2699 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0253 | 0.0873 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0099 | 0.0887 | 0.3077 |
Echinococcus granulosus | tar DNA binding protein | 0.026 | 0.2897 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0091 | 0.0782 | 0.2699 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.0782 | 0.0782 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0113 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0255 | 0.088 |
Mycobacterium tuberculosis | Probable reductase | 0.0089 | 0.0762 | 0.2582 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0113 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.