Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.01 | 0.5166 | 0.823 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.5166 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.3066 | 0.3066 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3066 | 0.3066 |
Schistosoma mansoni | kinase | 0.0051 | 0.203 | 0.203 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.3066 | 0.4884 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.6277 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.01 | 0.5166 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1916 | 0.3053 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3066 | 0.3066 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5166 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0927 | 0.1477 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.3066 | 0.4884 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.01 | 0.5166 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.3066 | 0.4884 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.01 | 0.5166 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.1946 | 0.3767 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0927 | 0.0927 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.1946 | 0.3767 |
Giardia lamblia | Kinase, PLK | 0.01 | 0.5166 | 1 |
Brugia malayi | RNA binding protein | 0.0067 | 0.3066 | 0.4884 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.01 | 0.5166 | 0.823 |
Echinococcus multilocularis | geminin | 0.0176 | 1 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.01 | 0.5166 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3066 | 0.3066 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1916 | 0.3053 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.3066 | 0.4884 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.3066 | 0.4884 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.01 | 0.5166 | 0.5166 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.5166 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5166 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1916 | 0.3053 |
Schistosoma mansoni | serine/threonine protein kinase | 0.01 | 0.5166 | 0.5166 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.01 | 0.5166 | 0.5166 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.3066 | 0.3066 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5166 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.6277 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1916 | 0.3053 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.6277 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5166 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5166 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3066 | 0.3066 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0927 | 0.1477 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5166 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3066 | 0.3066 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5166 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.