Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0048 | 0.1979 | 0.2722 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0155 | 0.7129 | 0.5 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.0201 | 0.0255 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 0.1769 | 0.1626 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0155 | 0.7129 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0082 | 0.0104 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0052 | 0.0066 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0573 | 0.0918 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1277 | 0.1731 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.1085 | 0.1377 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0214 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2669 | 0.3387 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0573 | 0.0727 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0412 | 0.0523 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0101 | 0.4558 | 0.5784 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0412 | 0.0508 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0412 | 0.0523 |
Mycobacterium tuberculosis | Conserved protein | 0.0025 | 0.0857 | 0.1565 |
Brugia malayi | Cytochrome P450 family protein | 0.001 | 0.017 | 0.0166 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0858 | 0.1138 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0858 | 0.07 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0025 | 0.0857 | 0.0987 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0025 | 0.0857 | 0.1087 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Trichomonas vaginalis | Citrate lyase beta chain, putative | 0.0025 | 0.0857 | 1 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0052 | 0.0066 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0101 | 0.4558 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0052 | 0.0066 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0412 | 0.0523 |
Brugia malayi | Cytochrome P450 family protein | 0.001 | 0.017 | 0.0166 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0573 | 0.0736 |
Brugia malayi | Probable ClpP-like protease | 0.0155 | 0.7129 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.001 | 0.017 | 0.0216 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0573 | 0.041 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.001 | 0.017 | 0.0166 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0053 | 0.2238 | 0.2971 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0025 | 0.0857 | 0.0699 |
Loa Loa (eye worm) | cytochrome P450 | 0.001 | 0.017 | 0.0166 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0573 | 0.0727 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0573 | 0.0736 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0573 | 0.041 |
Leishmania major | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0025 | 0.0857 | 0.0699 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0134 | 0.6104 | 0.7747 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.1008 | 0.1351 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0858 | 0.07 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.2669 | 0.3387 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0436 | 0.0542 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.2512 | 0.3188 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.2208 | 0.2929 |
Brugia malayi | RNA binding protein | 0.0062 | 0.2669 | 0.3698 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.5325 | 0.7451 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0025 | 0.0857 | 0.0987 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0134 | 0.6104 | 0.7747 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0155 | 0.7129 | 1 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0052 | 0.0066 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0573 | 0.0918 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0052 | 0.0066 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0858 | 0.07 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0412 | 0.0508 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0573 | 0.0727 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0053 | 0.2238 | 0.22 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.001 | 0.017 | 0.0166 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.2669 | 0.3698 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0134 | 0.6104 | 0.8553 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0412 | 0.0508 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0052 | 0.0066 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.5325 | 0.7451 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.0292 | 0.0124 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0412 | 0.0523 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0155 | 0.7129 | 0.9046 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0008 | 0.0076 | 0.0034 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.1085 | 0.1377 |
Schistosoma mansoni | DNA polymerase eta | 0.0044 | 0.1769 | 0.2244 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0857 | 0.0987 |
Brugia malayi | cytochrome P450 | 0.001 | 0.017 | 0.0166 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0052 | 0.0066 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0082 | 0.0042 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0214 | 1 | 1 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0052 | 0.0066 |
Mycobacterium ulcerans | citrate lyase beta subunit, CitE_2 | 0.0025 | 0.0857 | 0.0987 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0858 | 0.0989 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0573 | 0.041 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.2669 | 0.3698 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2022 | 0.2784 |
Brugia malayi | Cytochrome P450 family protein | 0.001 | 0.017 | 0.0166 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.1144 | 0.0991 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1277 | 0.1621 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0573 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0134 | 0.6104 | 0.8553 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0858 | 0.1138 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2669 | 0.3387 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2669 | 0.3387 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0025 | 0.0857 | 0.0699 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0155 | 0.7129 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0412 | 0.0523 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0573 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2022 | 0.2784 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0155 | 0.7129 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0101 | 0.4558 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0573 | 0.0727 |
Echinococcus multilocularis | 0.001 | 0.017 | 0.0216 | |
Echinococcus multilocularis | dna polymerase eta | 0.0044 | 0.1769 | 0.2244 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0134 | 0.6104 | 0.7747 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0201 | 0.0255 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0134 | 0.6104 | 0.7747 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0573 | 0.0579 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0052 | 0.0066 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.1085 | 0.1377 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0412 | 0.0508 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0857 | 0.0987 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 0.1769 | 0.1626 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0573 | 0.041 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0155 | 0.7129 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Echinococcus granulosus | smad | 0.0008 | 0.0052 | 0.0066 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0573 | 0.0579 |
Echinococcus granulosus | geminin | 0.017 | 0.788 | 1 |
Echinococcus multilocularis | geminin | 0.017 | 0.788 | 1 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.788 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0155 | 0.7129 | 1 |
Echinococcus multilocularis | smad | 0.0008 | 0.0052 | 0.0066 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0858 | 0.07 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.1085 | 0.1377 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.001 | 0.017 | 0.0216 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0292 | 0.0124 |
Mycobacterium tuberculosis | Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) | 0.0025 | 0.0857 | 0.1565 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.1144 | 0.0991 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0044 | 0.1769 | 0.1626 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0155 | 0.7129 | 0.9046 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0412 | 0.0523 |
Schistosoma mansoni | smad | 0.0008 | 0.0052 | 0.0066 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2022 | 0.2784 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0134 | 0.6104 | 0.7747 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.1144 | 0.14 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0155 | 0.7129 | 0.9046 |
Toxoplasma gondii | hypothetical protein | 0.0053 | 0.2238 | 0.2971 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0082 | 0.0104 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2669 | 0.3387 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1769 | 0.2426 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0044 | 0.1769 | 0.2426 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0052 | 0.0066 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.1008 | 0.1351 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0412 | 0.0523 |
Brugia malayi | Cytochrome P450 family protein | 0.0048 | 0.1979 | 0.2722 |
Schistosoma mansoni | hypothetical protein | 0.001 | 0.017 | 0.0216 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0134 | 0.6104 | 0.7747 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0101 | 0.4558 | 0.6306 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0573 | 0.0727 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1277 | 0.1731 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0025 | 0.0857 | 0.1087 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.0201 | 0.0255 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2669 | 0.3387 |
Trypanosoma brucei | unspecified product | 0.0013 | 0.0292 | 0.0124 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0412 | 0.0523 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0292 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.7129 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.001 | 0.017 | 0.0166 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0052 | 0.0066 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.2669 | 0.3698 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.788 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.2669 | 0.3698 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.2669 | 0.3387 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0101 | 0.4558 | 0.5784 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0053 | 0.2238 | 0.22 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0013 | 0.0292 | 0.0124 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.2669 | 0.3698 |
Echinococcus granulosus | dna polymerase eta | 0.0044 | 0.1769 | 0.2244 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0573 | 0.041 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0412 | 0.0523 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0155 | 0.7129 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0155 | 0.7129 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0573 | 0.041 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0573 | 0.0727 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0155 | 0.7129 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0155 | 0.7129 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.1008 | 0.128 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0134 | 0.6104 | 0.7747 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0412 | 0.0523 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0214 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0.1008 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2022 | 0.2784 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.5325 | 0.7451 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.