Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.0033 | 0.2772 | 0.2772 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2772 | 0.2772 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.9478 | 0.9278 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2674 | 0.2674 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2772 | 0.2772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.6502 | 0.64 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.9478 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.9478 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2772 | 0.2772 |
Onchocerca volvulus | 0.0033 | 0.2772 | 0.5 | |
Onchocerca volvulus | 0.0033 | 0.2772 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2772 | 0.2772 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.6502 | 0.5161 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.6502 | 0.6502 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.9478 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.9478 | 0.9478 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2772 | 0.2772 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.9478 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.9478 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.6502 | 0.5161 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.6502 | 0.5161 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2772 | 0.2561 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2772 | 0.2561 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0285 | 0.0285 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.9478 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2772 | 0.2772 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.9478 | 0.9478 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2772 | 0.2772 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.6502 | 0.6502 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.9478 | 0.9278 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.6502 | 0.6502 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.6502 | 0.6502 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2772 | 0.2772 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.6502 | 0.6502 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.