TDR Targets

Basic information

Technical information

TDR Targets ID: 618727
Name: N-(4-methoxyphenyl)-2-(5,6,7,8-tetrahydro-[1] benzothiolo[3,2-e]pyrimidin-4-ylsulfanyl)acet amide
MW: 385.503 | Formula: C19H19N3O2S2
H donors: 1 H acceptors: 3 LogP: 4.5 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)NC(=O)CSc1ncnc2c1c1CCCCc1s2
InChi: 1S/C19H19N3O2S2/c1-24-13-8-6-12(7-9-13)22-16(23)10-25-18-17-14-4-2-3-5-15(14)26-19(17)21-11-20-18/h6-9,11H,2-5,10H2,1H3,(H,22,23)
InChiKey: USIPQEZYBILYBN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-methoxyphenyl)-2-(5,6,7,8-tetrahydrobenzothiopheno[3,2-e]pyrimidin-4-ylsulfanyl)acetamide
N-(4-methoxyphenyl)-2-(5,6,7,8-tetrahydrobenzothiopheno[3,2-e]pyrimidin-4-ylthio)acetamide
N-(4-methoxyphenyl)-2-(5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyrimidin-4-ylsulfanyl)ethanamide
ST5051673
ZINC00943174

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0147	0.5079	0.5079
Brugia malayi	nuclear receptor NHR-88	0.0147	0.5079	0.5079
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0069	0.2086	0.2086
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.177	0.177
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1202	0.1202
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0069	0.2086	0.3423
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0046	0.1202	0.1202
Plasmodium falciparum	hexokinase	0.0159	0.5526	1
Onchocerca volvulus		0.0159	0.5526	1
Brugia malayi	hypothetical protein	0.0046	0.1202	0.1202
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0127	0.0127
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0147	0.5079	0.9145
Entamoeba histolytica	hypothetical protein	0.0035	0.0778	0.1206
Brugia malayi	conserved hypotetical protein	0.0069	0.2086	0.2086
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0295	0.0295
Schistosoma mansoni	zinc finger protein	0.0069	0.2086	0.2086
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0147	0.5079	0.5079
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0069	0.2086	0.2086
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0147	0.5079	0.5079
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2086	0.2086
Entamoeba histolytica	hypothetical protein	0.0035	0.0778	0.1206
Brugia malayi	Nuclear hormone receptor-like 1	0.0078	0.2406	0.2406
Trypanosoma brucei	hexokinase	0.0159	0.5526	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0147	0.5079	0.5079
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0295	0.1974
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0046	0.1202	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0147	0.5079	0.5079
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1202	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0275	1	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0778	0.1206
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0147	0.5079	0.5079
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0147	0.5079	0.5079
Loa Loa (eye worm)	hypothetical protein	0.0147	0.5079	0.5079
Onchocerca volvulus		0.0147	0.5079	0.9145
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0681	0.0681
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.1268	0.1268
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0147	0.5079	0.5079
Schistosoma mansoni	thyroid hormone receptor	0.0147	0.5079	0.5079
Loa Loa (eye worm)	acetylcholinesterase 1	0.0275	1	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0069	0.2086	0.2086
Brugia malayi	Carboxylesterase family protein	0.0046	0.1202	0.1202
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0147	0.5079	0.5079
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2086	0.2086
Schistosoma mansoni	RAR-like nuclear receptor	0.0147	0.5079	0.5079
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1202	0.1202
Brugia malayi	Hexokinase family protein	0.0049	0.1305	0.1305
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0778	0.0778
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0147	0.5079	0.5079
Brugia malayi	Hexokinase family protein	0.01	0.3248	0.3248
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0069	0.2086	0.2086
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0295	0.0313
Toxoplasma gondii	hexokinase	0.0159	0.5526	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.1268	0.1268
Brugia malayi	nuclear receptor RXR	0.0069	0.2086	0.2086
Brugia malayi	nuclear hormone receptor	0.0147	0.5079	0.5079
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0295	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1202	0.1202
Loa Loa (eye worm)	DR-78	0.0069	0.2086	0.2086
Onchocerca volvulus		0.0069	0.2086	0.3423
Echinococcus multilocularis	hexokinase	0.0159	0.5526	0.5526
Echinococcus granulosus	thyroid hormone receptor alpha	0.0069	0.2086	0.2086
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0147	0.5079	0.5079
Loa Loa (eye worm)	hexokinase	0.0049	0.1305	0.1305
Brugia malayi	Nuclear hormone receptor E75	0.0069	0.2086	0.2086
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0295	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0147	0.5079	0.5079
Loa Loa (eye worm)	nuclear hormone receptor	0.0069	0.2086	0.2086
Schistosoma mansoni	nuclear hormone receptor	0.0147	0.5079	0.5079
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0295	0.1974
Plasmodium vivax	hexokinase, putative	0.0159	0.5526	1
Loa Loa (eye worm)	carboxylesterase	0.0275	1	1
Echinococcus granulosus	neuroligin	0.0046	0.1202	0.1202
Loa Loa (eye worm)	hexokinase	0.01	0.3248	0.3248
Echinococcus granulosus	acetylcholinesterase	0.0275	1	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0046	0.1202	0.1202
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.177	0.177
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1202	0.1202
Brugia malayi	Hexokinase family protein	0.0159	0.5526	0.5526
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0295	0.1974
Brugia malayi	hypothetical protein	0.0078	0.2406	0.2406
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0147	0.5079	0.5079
Brugia malayi	Nuclear hormone receptor E75	0.0069	0.2086	0.2086
Schistosoma mansoni	ap endonuclease	0.0019	0.0127	0.0127
Schistosoma mansoni	acetylcholinesterase	0.0046	0.1202	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2086	0.2086
Echinococcus granulosus	BC026374 protein S09 family	0.0046	0.1202	0.1202
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0046	0.1202	0.1202
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0295	0.1974
Brugia malayi	nuclear receptor RXR	0.0078	0.2406	0.2406
Trypanosoma cruzi	hexokinase, putative	0.0159	0.5526	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.2406	0.2406
Brugia malayi	Nuclear hormone receptor-like 1	0.0147	0.5079	0.5079
Entamoeba histolytica	hexokinase 2	0.0159	0.5526	1
Brugia malayi	RNA binding protein	0.0061	0.177	0.177
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0127	0.01
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0069	0.2086	0.2086
Loa Loa (eye worm)	steroid hormone receptor	0.0147	0.5079	0.5079
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0127	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0147	0.5079	0.5079
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0778	0.0778
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0147	0.5079	0.5079
Brugia malayi	nuclear hormone receptor family member odr-7	0.0069	0.2086	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0108	0.3582	0.3582
Leishmania major	hexokinase, putative	0.0159	0.5526	1
Schistosoma mansoni	nuclear hormone receptor	0.0069	0.2086	0.2086
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0046	0.1202	0.1202
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0295	0.0313
Brugia malayi	tailless protein	0.0069	0.2086	0.2086
Onchocerca volvulus		0.0159	0.5526	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0778	0.0778
Brugia malayi	nuclear receptor NHR-88	0.0069	0.2086	0.2086
Onchocerca volvulus	Protein ultraspiracle homolog	0.0147	0.5079	0.9145
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0078	0.2406	0.2406
Echinococcus multilocularis	acetylcholinesterase	0.0275	1	1
Schistosoma mansoni	nuclear receptor	0.0069	0.2086	0.2086
Echinococcus granulosus	ecdysone induced protein 78C	0.0147	0.5079	0.5079
Schistosoma mansoni	nuclear hormone receptor	0.0069	0.2086	0.2086
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0069	0.2086	0.2086
Brugia malayi	hypothetical protein	0.0069	0.2086	0.2086
Brugia malayi	nuclear receptor NHR-67	0.0069	0.2086	0.2086
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0069	0.2086	0.2086
Schistosoma mansoni	nuclear receptor	0.0069	0.2086	0.2086
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0295	0.1974
Loa Loa (eye worm)	hypothetical protein	0.0147	0.5079	0.5079
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0295	0.0295
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0147	0.5079	0.5079
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0147	0.5079	0.5079
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0295	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0078	0.2406	0.2406
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0078	0.2406	0.2406
Brugia malayi	hypothetical protein	0.0078	0.2406	0.2406
Onchocerca volvulus		0.0159	0.5526	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0127	0.0127
Brugia malayi	Steroid receptor seven-up type 2	0.0147	0.5079	0.5079
Echinococcus multilocularis	para nitrobenzyl esterase	0.0046	0.1202	0.1202
Onchocerca volvulus		0.0046	0.1202	0.1733
Echinococcus granulosus	hexokinase	0.0159	0.5526	0.5526
Trypanosoma cruzi	hexokinase, putative	0.0159	0.5526	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0078	0.2406	0.2406
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0295	0.0313
Onchocerca volvulus	Bile acid receptor homolog	0.0147	0.5079	0.9145
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0069	0.2086	0.2086
Schistosoma mansoni	nuclear receptor nhr-48	0.0069	0.2086	0.2086
Entamoeba histolytica	hypothetical protein	0.0035	0.0778	0.1206
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0147	0.5079	0.5079
Brugia malayi	photoreceptor-specific nuclear receptor	0.0147	0.5079	0.5079
Brugia malayi	ecdysteroid receptor	0.0147	0.5079	0.5079
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0295	0.1974
Brugia malayi	hypothetical protein	0.0069	0.2086	0.2086
Echinococcus granulosus	hexokinase type 2	0.0159	0.5526	0.5526
Loa Loa (eye worm)	hypothetical protein	0.0147	0.5079	0.5079
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.177	0.177
Echinococcus multilocularis	carboxylesterase 5A	0.0275	1	1
Brugia malayi	Carboxylesterase family protein	0.0046	0.1202	0.1202
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0147	0.5079	0.5079
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.177	0.177
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0069	0.2086	0.3423
Echinococcus multilocularis	hexokinase type 2	0.0159	0.5526	0.5526
Onchocerca volvulus		0.0046	0.1202	0.1733
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2086	0.2086
Trypanosoma brucei	hexokinase, putative	0.0159	0.5526	1
Brugia malayi	Carboxylesterase family protein	0.0275	1	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0069	0.2086	0.2086
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0147	0.5079	0.5079
Brugia malayi	TAR-binding protein	0.0061	0.177	0.177
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0147	0.5079	0.5079
Brugia malayi	ecdysone receptor	0.0069	0.2086	0.2086
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0147	0.5079	0.5079
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0147	0.5079	0.5079
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0295	0.1974
Loa Loa (eye worm)	hypothetical protein	0.0078	0.2406	0.2406
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0046	0.1202	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0147	0.5079	0.5079
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0147	0.5079	0.5079
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0295	0.0295
Brugia malayi	Carboxylesterase family protein	0.0046	0.1202	0.1202
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0147	0.5079	0.5079
Loa Loa (eye worm)	hypothetical protein	0.0078	0.2406	0.2406
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0147	0.5079	0.5079
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0046	0.1202	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2086	0.2086
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0127	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0069	0.2086	0.2086
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0072	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2086	0.2086
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0295	0.1974
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0069	0.2086	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2086	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2086	0.2086
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0147	0.5079	0.5079
Echinococcus multilocularis	acetylcholinesterase	0.0275	1	1
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.177	0.177
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0295	0.0313
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0295	0.0313
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0275	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0147	0.5079	0.5079
Schistosoma mansoni	gliotactin	0.0046	0.1202	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0147	0.5079	0.5079
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0147	0.5079	0.5079
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0147	0.5079	0.5079
Schistosoma mansoni	coup transcription factor	0.0147	0.5079	0.5079
Echinococcus granulosus	para nitrobenzyl esterase	0.0046	0.1202	0.1202
Schistosoma mansoni	BC026374 protein (S09 family)	0.0046	0.1202	0.1202
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0147	0.5079	0.5079
Treponema pallidum	hexokinase (hxk)	0.0159	0.5526	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0127	0.0127
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0127	0.01
Loa Loa (eye worm)	hypothetical protein	0.0147	0.5079	0.5079
Loa Loa (eye worm)	hexokinase	0.0159	0.5526	0.5526
Loa Loa (eye worm)	hypothetical protein	0.0078	0.2406	0.2406
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0127	0.0774
Echinococcus granulosus	tar DNA binding protein	0.0061	0.177	0.177
Echinococcus granulosus	hexokinase	0.0159	0.5526	0.5526
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0069	0.2086	0.2086
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0778	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2086	0.2086
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0295	0.5
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0046	0.1202	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0072	0.0072
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.1268	0.1268
Loa Loa (eye worm)	hexokinase type II	0.0159	0.5526	0.5526
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0046	0.1202	1
Loa Loa (eye worm)	hexokinase	0.0159	0.5526	0.5526
Onchocerca volvulus		0.0046	0.1202	0.1733
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0147	0.5079	0.5079
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0072	0.0072
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0069	0.2086	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2086	0.2086
Brugia malayi	hexokinase type II	0.005	0.1357	0.1357
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0147	0.5079	0.5079
Echinococcus granulosus	FTZ F1 alpha	0.0147	0.5079	0.5079
Mycobacterium ulcerans	carboxylesterase, LipT	0.0046	0.1202	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0147	0.5079	0.5079
Echinococcus granulosus	carboxylesterase 5A	0.0275	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0147	0.5079	0.5079
Loa Loa (eye worm)	hypothetical protein	0.005	0.1357	0.1357
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0072	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0078	0.2406	0.2406
Leishmania major	hexokinase, putative	0.0159	0.5526	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.0046	0.1202	1
Onchocerca volvulus	Hexokinase homolog	0.01	0.3248	0.5645
Loa Loa (eye worm)	hypothetical protein	0.0147	0.5079	0.5079
Loa Loa (eye worm)	carboxylesterase	0.0046	0.1202	0.1202
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0147	0.5079	0.5079
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0295	0.2222
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0069	0.2086	0.2086
Entamoeba histolytica	hexokinase 1	0.0159	0.5526	1
Brugia malayi	nuclear hormone receptor	0.0069	0.2086	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1202	0.1202
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0069	0.2086	0.2086
Brugia malayi	Carboxylesterase family protein	0.0046	0.1202	0.1202
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0078	0.2406	0.2406
Loa Loa (eye worm)	hypothetical protein	0.0147	0.5079	0.5079
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1268	0.1268
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0046	0.1202	1
Onchocerca volvulus		0.01	0.3248	0.5645
Echinococcus multilocularis	nuclear receptor nhr 48	0.0069	0.2086	0.2086
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.177	0.177
Schistosoma mansoni	ap endonuclease	0.0019	0.0127	0.0127
Schistosoma mansoni	retinoic acid receptor RXR	0.0147	0.5079	0.5079
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0147	0.5079	0.5079
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0127	0.048
Echinococcus multilocularis	FTZ F1 alpha	0.0147	0.5079	0.5079
Onchocerca volvulus		0.0046	0.1202	0.1733
Brugia malayi	steroid hormone receptor	0.0147	0.5079	0.5079
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0147	0.5079	0.5079
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0147	0.5079	0.5079
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2086	0.2086
Echinococcus multilocularis	neuroligin	0.0046	0.1202	0.1202
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0127	0.0127
Echinococcus granulosus	hexokinase	0.0159	0.5526	0.5526
Brugia malayi	hexokinase	0.0159	0.5526	0.5526
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0295	0.0295
Echinococcus granulosus	nuclear receptor nhr 48	0.0069	0.2086	0.2086
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0295	0.0295
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0147	0.5079	0.5079
Schistosoma mansoni	hypothetical protein	0.0033	0.0681	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2086	0.2086
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0078	0.2406	0.2406
Loa Loa (eye worm)	hypothetical protein	0.005	0.1357	0.1357
Echinococcus multilocularis	hexokinase	0.0159	0.5526	0.5526
Echinococcus granulosus	acetylcholinesterase	0.0275	1	1
Onchocerca volvulus		0.0069	0.2086	0.3423
Echinococcus multilocularis	hexokinase	0.0159	0.5526	0.5526
Loa Loa (eye worm)	hypothetical protein	0.0275	1	1
Loa Loa (eye worm)	RNA binding protein	0.0061	0.177	0.177
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1202	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0072	0.0072
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.177	0.177
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.177	0.177
Trypanosoma brucei	hexokinase	0.0159	0.5526	1
Brugia malayi	hypothetical protein	0.0035	0.0778	0.0778
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0295	0.2222
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0681	0.0681
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0069	0.2086	0.2086
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0069	0.2086	0.2086
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0046	0.1202	0.1202
Schistosoma mansoni	thyroid hormone receptor	0.0147	0.5079	0.5079
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0147	0.5079	0.5079
Loa Loa (eye worm)	carboxylesterase	0.0046	0.1202	0.1202
Schistosoma mansoni	hexokinase	0.0159	0.5526	0.5526
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.177	0.177
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0147	0.5079	0.5079
Onchocerca volvulus		0.0046	0.1202	0.1733

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 618727