Detailed information for compound 619099

Basic information

Technical information
  • TDR Targets ID: 619099
  • Name: 4-fluoro-N-(2-phenyl-4,6-dihydrothieno[3,4-d] pyrazol-3-yl)benzamide
  • MW: 339.387 | Formula: C18H14FN3OS
  • H donors: 1 H acceptors: 2 LogP: 3.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C(=O)Nc1c2CSCc2nn1c1ccccc1
  • InChi: 1S/C18H14FN3OS/c19-13-8-6-12(7-9-13)18(23)20-17-15-10-24-11-16(15)21-22(17)14-4-2-1-3-5-14/h1-9H,10-11H2,(H,20,23)
  • InChiKey: AZKFWUSEIMGHSF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_144867

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.028 0.0838
Echinococcus multilocularis smad 0.0016 0.0036 0.0046
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.01 0.0959 0.3014
Echinococcus multilocularis Smad4 0.0016 0.0036 0.0046
Onchocerca volvulus 0.0107 0.1036 0.3913
Echinococcus granulosus neuropeptide s receptor 0.0461 0.4953 0.6258
Trypanosoma cruzi NADH dehydrogenase, putative 0.0026 0.015 0.0293
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0026 0.015 0.0018
Mycobacterium tuberculosis Conserved protein 0.0036 0.025 0.025
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0036 0.0046
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0425 0.122
Leishmania major acetoin dehydrogenase e3 component-like protein 0.01 0.0959 0.3014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.028 0.0731
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0425 0.122
Loa Loa (eye worm) hypothetical protein 0.0036 0.025 0.0717
Schistosoma mansoni inositol monophosphatase 0.0073 0.0663 0.0629
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.028 0.0731
Leishmania major GTP-binding protein, putative 0.0023 0.0108 0.0152
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0425 0.122
Toxoplasma gondii ABC1 family protein 0.0036 0.025 0.0632
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0136 0.0162
Leishmania major hypothetical protein, conserved 0.0036 0.025 0.0632
Brugia malayi MAP kinase sur-1 0.0051 0.0425 0.13
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0601 0.1857
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.01 0.0959 0.3014
Treponema pallidum fructose-bisphosphate aldolase 0.0875 0.9529 1
Echinococcus multilocularis lamin 0.0027 0.0153 0.0194
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0663 0.0838
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0026 0.015 0.0018
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.015 0.0092
Plasmodium vivax SET domain protein, putative 0.003 0.019 0.0429
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0049 0.0397 0.371
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0656 0.7112 0.896
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0427 0.1224
Trypanosoma brucei unspecified product 0.0038 0.028 0.0731
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0026 0.015 0.0018
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0427 0.4582 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.087 0.0836
Trichomonas vaginalis mercuric reductase, putative 0.01 0.0959 0.0947
Loa Loa (eye worm) hypothetical protein 0.0025 0.0136 0.0388
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0026 0.015 0.0193
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.099 0.3091
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0096 0.0121
Schistosoma mansoni hypothetical protein 0.0032 0.0216 0.018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.019 0.0154
Brugia malayi follicle stimulating hormone receptor 0.0231 0.2413 0.7605
Giardia lamblia NADH oxidase lateral transfer candidate 0.01 0.0959 0.0947
Brugia malayi hypothetical protein 0.0022 0.0096 0.0253
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0136 0.038
Leishmania major hypothetical protein, conserved 0.0052 0.0427 0.1224
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0026 0.015 0.0122
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.01 0.0959 0.3014
Loa Loa (eye worm) hypothetical protein 0.0174 0.1776 0.5084
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.028 0.0354
Echinococcus multilocularis thioredoxin glutathione reductase 0.0288 0.3038 0.3838
Echinococcus multilocularis L aminoadipate semialdehyde 0.0174 0.1776 0.2244
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0663 0.0635
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.028 0.0731
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0026 0.015 0.0428
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0153 0.0439
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.015 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.087 0.0836
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0026 0.015 0.0092
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.025 0.0198
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0026 0.015 0.0189
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.9529 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.087 0.1099
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0063 0.0148
Schistosoma mansoni intermediate filament proteins 0.0027 0.0153 0.0117
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.1183 0.1494
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0098 0.0941 0.3517
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2179 0.6236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.9529 1
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0026 0.015 0.0293
Echinococcus granulosus polycomb protein SCMH1 0.0098 0.0941 0.1189
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0656 0.7112 0.8971
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0026 0.015 0.0189
Trichomonas vaginalis apoptosis inducing factor, putative 0.0026 0.015 0.0092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.9529 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.2413 0.6908
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0663 0.0635
Plasmodium vivax thioredoxin reductase, putative 0.0288 0.3038 1
Mycobacterium tuberculosis Probable oxidoreductase 0.073 0.7922 1
Brugia malayi Inositol-1 0.0073 0.0663 0.2054
Trypanosoma cruzi NADH dehydrogenase, putative 0.0026 0.015 0.0293
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.1183 0.1494
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0036 0.0046
Echinococcus multilocularis polycomb protein SCMH1 0.0098 0.0941 0.1189
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0026 0.015 0.0193
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0016 0.0045
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0136 0.0246
Echinococcus granulosus importin subunit beta 1 0.0031 0.0198 0.025
Onchocerca volvulus 0.0174 0.1776 0.6989
Mycobacterium leprae Probable lipase LipE 0.0036 0.025 0.0147
Plasmodium falciparum thioredoxin reductase 0.0288 0.3038 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0026 0.015 0.0293
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.028 0.023
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1183 0.2478
Schistosoma mansoni disulfide oxidoreductase 0.0026 0.015 0.0114
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.028 0.0731
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0026 0.015 0.0293
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.015 0.0293
Loa Loa (eye worm) hypothetical protein 0.0052 0.0427 0.1221
Schistosoma mansoni ap endonuclease 0.0019 0.0063 0.0026
Echinococcus granulosus tar DNA binding protein 0.0067 0.0601 0.076
Mycobacterium ulcerans flavoprotein disulfide reductase 0.01 0.0959 0.1984
Loa Loa (eye worm) hypothetical protein 0.0125 0.1244 0.356
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1183 0.2478
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.028 0.0244
Echinococcus multilocularis muscleblind protein 1 0.03 0.3168 0.4003
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0198 0.0454
Onchocerca volvulus 0.0239 0.25 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0049 0.0397 0.0436
Onchocerca volvulus Huntingtin homolog 0.0125 0.1244 0.4775
Echinococcus granulosus arachidonate 5 lipoxygenase 0.006 0.0525 0.0663
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0425 0.0383
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0065 0.0006
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.1183 0.115
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.025 0.0416
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.015 0.0293
Loa Loa (eye worm) programmed cell death 8 0.0026 0.015 0.0428
Echinococcus granulosus lamin dm0 0.0027 0.0153 0.0194
Loa Loa (eye worm) hypothetical protein 0.0036 0.025 0.0717
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.025 0.0717
Loa Loa (eye worm) hypothetical protein 0.0032 0.0216 0.0617
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.01 0.0959 0.1151
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0065 0.0009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0063 0.0011
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0026 0.015 0.0425
Mycobacterium ulcerans monoxygenase 0.0026 0.015 0.0193
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0108 0.0152
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0397 0.1124
Mycobacterium tuberculosis Probable reductase 0.0656 0.7112 0.8971
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.025 0.0632
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0397 0.1124
Loa Loa (eye worm) hypothetical protein 0.03 0.3168 0.9069
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.01 0.0959 1
Brugia malayi RNA binding protein 0.0067 0.0601 0.1857
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0026 0.015 0.0189
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0108 0.0048
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0427 0.1224
Mycobacterium ulcerans hypothetical protein 0.0025 0.0136 0.0162
Schistosoma mansoni sex comb on midleg homolog 0.0098 0.0941 0.0908
Brugia malayi Smad1 0.0016 0.0036 0.0066
Onchocerca volvulus Huntingtin homolog 0.0125 0.1244 0.4775
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.025 0.025
Entamoeba histolytica hypothetical protein 0.0025 0.0133 0.0075
Loa Loa (eye worm) inositol-1 0.0073 0.0663 0.1899
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0026 0.015 0.0971
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.237 0.2944
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0096 0.0121
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.019 0.0429
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0601 0.0567
Loa Loa (eye worm) hypothetical protein 0.0026 0.015 0.0428
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.9529 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.028 0.0801
Brugia malayi MH2 domain containing protein 0.0016 0.0036 0.0066
Brugia malayi MH1 domain containing protein 0.0016 0.0036 0.0066
Leishmania major trypanothione reductase 0.0288 0.3038 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.01 0.0959 0.3014
Echinococcus multilocularis SAM and MBT domain containing protein 0.0098 0.0941 0.1189
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.028 0.0838
Loa Loa (eye worm) RNA binding protein 0.0067 0.0601 0.1721
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0112 0.1091 0.1379
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.015 0.0293
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.073 0.7922 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0036 0.0104
Brugia malayi MH1 domain containing protein 0.0016 0.0036 0.0066
Treponema pallidum NADH oxidase 0.01 0.0959 0.0947
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0026 0.015 0.0293
Loa Loa (eye worm) hypothetical protein 0.0031 0.0198 0.0566
Echinococcus granulosus lamin 0.0027 0.0153 0.0194
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.1183 0.3765
Echinococcus multilocularis dna polymerase eta 0.0038 0.028 0.0354
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0026 0.015 0.0193
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0601 0.076
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0425 0.0383
Schistosoma mansoni lipoxygenase 0.0022 0.0096 0.0059
Echinococcus multilocularis snurportin 1 0.0329 0.3494 0.4414
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0073 0.0667 0.2065
Schistosoma mansoni glutamate synthase 0.0026 0.015 0.0114
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0065 0.0009
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0026 0.015 0.0293
Brugia malayi beta-lactamase family protein 0.0036 0.025 0.0744
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.025 0.0316
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.019 0.0154
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0136 0.0162
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.01 0.0959 0.3014
Schistosoma mansoni hypothetical protein 0.0032 0.0216 0.018
Onchocerca volvulus 0.0036 0.025 0.0644
Schistosoma mansoni sulfide quinone reductase 0.0026 0.015 0.0114
Echinococcus granulosus endonuclease exonuclease phosphatase 0.039 0.4171 0.527
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.025 0.0416
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0026 0.015 0.0293
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.025 0.025
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0149 0.029
Brugia malayi MH2 domain containing protein 0.0238 0.2489 0.7846
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.1183 0.3765
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.028 0.0731
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.025 0.0215
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0026 0.015 0.0018
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0632 0.1954
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.01 0.0959 0.3014
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.01 0.0959 0.1212
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0026 0.015 0.0425
Brugia malayi TAR-binding protein 0.0067 0.0601 0.1857
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0113 0.0142
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0136 0.0104
Loa Loa (eye worm) thioredoxin reductase 0.0288 0.3038 0.8694
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0198 0.025
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0425 0.0538
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0026 0.015 0.0189
Onchocerca volvulus 0.0036 0.025 0.0644
Mycobacterium ulcerans dehydrogenase 0.0026 0.015 0.0193
Echinococcus granulosus tumor protein p63 0.0729 0.7915 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0133 0.0238
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0875 0.9529 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0601 0.0567
Mycobacterium ulcerans hypothetical protein 0.0026 0.015 0.0193
Loa Loa (eye worm) Smad1 0.0016 0.0036 0.0104
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.01 0.0959 0.3014
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0036 0.0046
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.073 0.7922 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.087 0.1099
Trichomonas vaginalis ran, putative 0.0023 0.0108 0.0048
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0153 0.0436
Echinococcus granulosus snurportin 1 0.0329 0.3494 0.4414
Schistosoma mansoni sex comb on midleg homolog 0.0098 0.0941 0.0908
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0425 0.039
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0063 0.0079
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.2489 0.7125
Treponema pallidum oxidoreductase 0.0026 0.015 0.0092
Echinococcus granulosus histone acetyltransferase MYST2 0.0112 0.1091 0.1379
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0096 0.0121
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0026 0.015 0.0293
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0425 0.0383
Mycobacterium leprae conserved hypothetical protein 0.0036 0.025 0.0147
Loa Loa (eye worm) hypothetical protein 0.0125 0.1244 0.356
Onchocerca volvulus 0.0027 0.0153 0.024
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0049 0.0397 0.1124
Echinococcus granulosus Smad4 0.0016 0.0036 0.0046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.025 0.0215
Leishmania major DNA polymerase kappa, putative 0.0038 0.028 0.0731
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.028 0.0287
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0136 0.0162
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0049 0.0397 0.0353
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0136 0.038
Brugia malayi hypothetical protein 0.0033 0.0225 0.0663
Trypanosoma brucei unspecified product 0.0026 0.0149 0.029
Schistosoma mansoni rab6-interacting 0.0022 0.0096 0.0059
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0427 0.1224
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.01 0.0959 0.2993
Schistosoma mansoni ap endonuclease 0.0019 0.0063 0.0026
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0065 0.0579 0.0569
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0112 0.1091 0.1379
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0108 0.0152
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0026 0.015 0.0122
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.028 0.0731
Brugia malayi hypothetical protein 0.0125 0.1244 0.3896
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.0959 0.3014
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0026 0.015 0.0971
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.01 0.0959 0.0926
Echinococcus granulosus L aminoadipate semialdehyde 0.0174 0.1776 0.2244
Echinococcus granulosus glutamate synthase 0.0026 0.015 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.028 0.0731
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0026 0.015 0.0193
Echinococcus granulosus thioredoxin glutathione reductase 0.0288 0.3038 0.3838
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.087 0.2489
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.019 0.024
Entamoeba histolytica Ran family GTPase 0.0023 0.0108 0.0048
Loa Loa (eye worm) pax transcription factor protein 2 0.0239 0.25 0.7157
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0216 0.0272
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0875 0.9529 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0136 0.0162
Schistosoma mansoni lamin 0.0027 0.0153 0.0117
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0601 0.0567
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.015 0.0293
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.028 0.0481
Schistosoma mansoni inositol monophosphatase 0.0073 0.0663 0.0629
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0026 0.015 0.0293
Schistosoma mansoni DNA polymerase eta 0.0038 0.028 0.0244
Brugia malayi beta-lactamase 0.0036 0.025 0.0744
Leishmania major importin beta-1 subunit, putative 0.0025 0.0133 0.0238
Brugia malayi intermediate filament protein 0.0027 0.0153 0.0436
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0026 0.015 0.0425
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0136 0.0162
Echinococcus multilocularis RUN 0.0022 0.0096 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.028 0.0731
Onchocerca volvulus 0.0027 0.0153 0.024
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0425 0.122
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0026 0.015 0.0971
Echinococcus granulosus intermediate filament protein 0.0027 0.0153 0.0194
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0601 0.0567
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0656 0.7112 0.8971
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.01 0.0959 0.1984
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0026 0.015 0.0092
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0026 0.015 0.0293
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.028 0.0731
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.2489 0.7125
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0026 0.015 0.0293
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0026 0.015 0.0122
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0026 0.015 0.0189
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0216 0.0634
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.015 0.0092
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0096 0.0121
Leishmania major NADH dehydrogenase, putative 0.0026 0.015 0.0293
Loa Loa (eye worm) hypothetical protein 0.0027 0.0153 0.0439
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0601 0.0567
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.1183 0.2478
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0026 0.015 0.0092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.9529 1
Schistosoma mansoni ran 0.0023 0.0108 0.0072
Brugia malayi Muscleblind-like protein 0.03 0.3168 1
Plasmodium falciparum importin beta, putative 0.0031 0.0198 0.0454
Trichomonas vaginalis set domain proteins, putative 0.0239 0.25 0.2574
Loa Loa (eye worm) hypothetical protein 0.0036 0.025 0.0717
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0174 0.1776 0.1746
Echinococcus granulosus GPCR family 2 0.0032 0.0216 0.0272
Echinococcus multilocularis tumor protein p63 0.0729 0.7915 1
Mycobacterium ulcerans ferredoxin reductase 0.0026 0.015 0.0193
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0096 0.0274
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0026 0.015 0.0092
Echinococcus multilocularis lamin dm0 0.0027 0.0153 0.0194
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.019 0.0154
Loa Loa (eye worm) hypothetical protein 0.0019 0.0065 0.0187
Echinococcus granulosus microtubule associated protein 2 0.0697 0.7555 0.9545
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0663 0.0838
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0136 0.0104
Schistosoma mansoni hypothetical protein 0.0026 0.015 0.0114
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0136 0.0246
Plasmodium falciparum glutathione reductase 0.01 0.0959 0.3014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.028 0.0731
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.006 0.0525 0.0663
Giardia lamblia Glutamate synthase 0.0026 0.015 0.0092
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0026 0.015 0.0189
Schistosoma mansoni cellular tumor antigen P53 0.0107 0.1036 0.1004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.01 0.0959 0.3014
Leishmania major hypothetical protein, conserved 0.0026 0.015 0.0293
Echinococcus multilocularis microtubule associated protein 2 0.0697 0.7555 0.9545
Loa Loa (eye worm) hypothetical protein 0.0019 0.0065 0.0187
Leishmania major phosphopantetheinyl transferase-like protein 0.0049 0.0397 0.1124
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0136 0.0162
Plasmodium vivax importin-beta 2, putative 0.0031 0.0198 0.0454
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.015 0.0293
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0663 0.202
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.025 0.0632
Treponema pallidum thioredoxin reductase (trxB) 0.0026 0.015 0.0092
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0026 0.015 0.0193
Chlamydia trachomatis thioredoxin reductase 0.0026 0.015 0.0945
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.087 0.1099
Leishmania major DNA polymerase eta, putative 0.0038 0.028 0.0731
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0049 0.0397 0.3728
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0026 0.015 0.0193
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.028 0.0731
Onchocerca volvulus 0.0239 0.25 0.9997
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0026 0.015 0.0293
Brugia malayi glutamate synthase 0.0026 0.015 0.0425
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0174 0.1776 0.5584
Loa Loa (eye worm) hypothetical protein 0.0036 0.025 0.0717
Loa Loa (eye worm) hypothetical protein 0.0038 0.028 0.0801
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.025 0.025
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0427 0.4582 0.5755
Echinococcus granulosus neuropeptide receptor A26 0.0461 0.4953 0.6258
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.01 0.0959 0.3014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.099 0.3091
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0425 0.0538
Loa Loa (eye worm) hypothetical protein 0.0036 0.025 0.0717
Schistosoma mansoni hypothetical protein 0.06 0.649 0.6477
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.028 0.0287
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.01 0.0959 0.3014
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0113 0.0142
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.01 0.0959 0.3014
Giardia lamblia DINP protein human, muc B family 0.0038 0.028 0.023
Onchocerca volvulus 0.0098 0.0941 0.3517
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0663 0.202
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0663 0.202
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0663 0.0635
Brugia malayi Pax transcription factor protein 2 0.0239 0.25 0.7881
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0216 0.0272
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.01 0.0959 0.3014
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.015 0.0293
Mycobacterium ulcerans glutamate synthase subunit beta 0.0026 0.015 0.0193
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0663 0.0635
Mycobacterium tuberculosis Probable dehydrogenase 0.0656 0.7112 0.8971
Echinococcus granulosus RUN 0.0022 0.0096 0.0121
Loa Loa (eye worm) hypothetical protein 0.0019 0.0065 0.0187
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0427 0.1224
Onchocerca volvulus 0.0026 0.015 0.0224
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0153 0.0439
Brugia malayi hypothetical protein 0.0052 0.0427 0.1303
Leishmania major dihydrolipoamide dehydrogenase, putative 0.01 0.0959 0.3014
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0601 0.1721
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.025 0.0198
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0096 0.0111
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0178 0.0225
Brugia malayi beta-lactamase family protein 0.0036 0.025 0.0744
Leishmania major hypothetical protein, conserved 0.0026 0.015 0.0293
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0065 0.0014
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.028 0.0731
Echinococcus multilocularis glutamate synthase 0.0026 0.015 0.0189
Loa Loa (eye worm) hypothetical protein 0.0103 0.099 0.2834
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.1183 0.115
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.025 0.0198
Leishmania major dihydrolipoamide dehydrogenase, putative 0.01 0.0959 0.3014
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0049 0.0397 0.1124
Trichomonas vaginalis glutathione reductase, putative 0.01 0.0959 0.0947
Schistosoma mansoni sulfide quinone reductase 0.0026 0.015 0.0114
Brugia malayi RNA, U transporter 1 0.0088 0.0826 0.257
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0026 0.015 0.0092
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0026 0.015 0.0293
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.087 0.1099
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.019 0.0154
Entamoeba histolytica disulphide oxidoreductase, putative 0.0026 0.015 0.0092
Brugia malayi mbt repeat family protein 0.0098 0.0941 0.2936
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0049 0.0397 0.074
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0427 0.4582 0.571
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.3494 1
Plasmodium falciparum thioredoxin reductase 0.01 0.0959 0.3014
Mycobacterium leprae conserved hypothetical protein 0.0049 0.0397 0.0336
Echinococcus multilocularis GPCR, family 2 0.0032 0.0216 0.0272
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0026 0.015 0.0293
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0049 0.0397 0.074
Trichomonas vaginalis glutamate synthase, putative 0.0026 0.015 0.0092
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0026 0.015 0.0189
Plasmodium vivax hypothetical protein, conserved 0.0036 0.025 0.0632
Loa Loa (eye worm) hypothetical protein 0.0112 0.1091 0.3124
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0026 0.015 0.0189
Plasmodium vivax ferrodoxin reductase, putative 0.0026 0.015 0.0293
Schistosoma mansoni hypothetical protein 0.0022 0.0096 0.0059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.9529 1
Plasmodium falciparum ferrodoxin reductase-like protein 0.0026 0.015 0.0293
Schistosoma mansoni importin beta-1 0.0031 0.0198 0.0162
Loa Loa (eye worm) hypothetical protein 0.0019 0.0065 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.028 0.0731
Trypanosoma brucei NADH dehydrogenase 0.0026 0.015 0.0293
Toxoplasma gondii thioredoxin reductase 0.0288 0.3038 1
Brugia malayi Pre-SET motif family protein 0.003 0.019 0.0553
Echinococcus multilocularis neuropeptide s receptor 0.0461 0.4953 0.6258
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0149 0.029
Brugia malayi MH2 domain containing protein 0.0016 0.0036 0.0066
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.028 0.023
Loa Loa (eye worm) hypothetical protein 0.0036 0.025 0.0717
Trypanosoma brucei unspecified product 0.0026 0.0149 0.029
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0149 0.029
Loa Loa (eye worm) mbt repeat family protein 0.0098 0.0941 0.2694
Schistosoma mansoni ran 0.0023 0.0108 0.0072
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.025 0.0744
Brugia malayi Thioredoxin reductase 0.0288 0.3038 0.9585
Schistosoma mansoni loxhd1 0.0022 0.0096 0.0059
Schistosoma mansoni hypothetical protein 0.0032 0.0216 0.018
Echinococcus multilocularis musashi 0.0027 0.0153 0.0194
Toxoplasma gondii selenide, water dikinase 0.0026 0.015 0.0293
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0425 0.122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.9529 1
Trypanosoma brucei trypanothione reductase 0.0288 0.3038 1
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0026 0.015 0.0122
Schistosoma mansoni microtubule-associated protein tau 0.0697 0.7555 0.7546
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.015 0.0092
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0136 0.0162
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.019 0.024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0133 0.0075
Plasmodium vivax glutathione reductase, putative 0.0288 0.3038 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.015 0.0092
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0026 0.015 0.0293
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0026 0.015 0.0092
Onchocerca volvulus 0.0036 0.025 0.0644
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0096 0.0121
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0663 0.202
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0063 0.0179
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.01 0.0959 0.3014
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0425 0.0383
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0198 0.0454
Loa Loa (eye worm) hypothetical protein 0.0025 0.0136 0.0388
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.015 0.0092
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0108 0.0136
Onchocerca volvulus 0.003 0.019 0.0393
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.087 0.0836
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0108 0.0292
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0108 0.0152
Mycobacterium ulcerans beta-lactamase 0.0036 0.025 0.0416
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0096 0.0121
Echinococcus granulosus SAM and MBT domain containing protein 0.0098 0.0941 0.1189
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0136 0.038
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.028 0.0731
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0026 0.015 0.0293
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.099 0.2834
Loa Loa (eye worm) hypothetical protein 0.03 0.3168 0.9069
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0425 0.1218
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0096 0.0111
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0425 0.122
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.01 0.0959 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0112 0.1091 0.1379
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0425 0.0383
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.028 0.0731
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0036 0.0104
Mycobacterium ulcerans lipase LipD 0.0036 0.025 0.0416
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.025 0.025
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0108 0.0309
Trichomonas vaginalis esterase, putative 0.0036 0.025 0.0198
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0216 0.0634
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0198 0.0454
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0425 0.122
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.01 0.0959 0.1984
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.01 0.0959 0.3014
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0026 0.015 0.0193
Loa Loa (eye worm) hypothetical protein 0.0019 0.0065 0.0187
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.028 0.0244
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0133 0.0075
Loa Loa (eye worm) hypothetical protein 0.003 0.019 0.0544
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0427 0.1224
Giardia lamblia Fructose-bisphosphate aldolase 0.0875 0.9529 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0063 0.0079
Schistosoma mansoni hypothetical protein 0.0329 0.3494 0.347
Schistosoma mansoni hypothetical protein 0.007 0.0632 0.0597
Loa Loa (eye worm) hypothetical protein 0.0098 0.0941 0.2694
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0026 0.015 0.0189
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0026 0.015 0.0189
Schistosoma mansoni rab6-interacting 0.0022 0.0096 0.0059
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.01 0.0959 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.028 0.023
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0288 0.3038 0.3792
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0108 0.0152
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0136 0.0077
Echinococcus granulosus dna polymerase kappa 0.0038 0.028 0.0354
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0133 0.0075
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.028 0.0481
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0274
Schistosoma mansoni hypothetical protein 0.0023 0.0113 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.028 0.0731
Loa Loa (eye worm) glutathione reductase 0.0288 0.3038 0.8694
Schistosoma mansoni hypothetical protein 0.0032 0.0216 0.018
Loa Loa (eye worm) MBCTL1 0.0112 0.1091 0.3124
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.025 0.0632
Loa Loa (eye worm) hypothetical protein 0.0025 0.0136 0.0388
Loa Loa (eye worm) hypothetical protein 0.007 0.0632 0.1808
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0656 0.7112 0.8971
Loa Loa (eye worm) hypothetical protein 0.0026 0.0148 0.0423
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.025 0.025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0136 0.0077
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0136 0.0246
Schistosoma mansoni lipoxygenase 0.006 0.0525 0.049
Trypanosoma cruzi trypanothione reductase, putative 0.0288 0.3038 1
Toxoplasma gondii NADPH-glutathione reductase 0.01 0.0959 0.3014
Leishmania major hypothetical protein, conserved 0.0026 0.015 0.0293
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.087 0.2709
Echinococcus granulosus dna polymerase eta 0.0038 0.028 0.0354
Loa Loa (eye worm) beta-lactamase 0.0036 0.025 0.0717
Loa Loa (eye worm) hypothetical protein 0.0022 0.0096 0.0274
Echinococcus multilocularis neuropeptide receptor A26 0.0461 0.4953 0.6258
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.0663 0.6701
Echinococcus granulosus smad 0.0016 0.0036 0.0046
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0663 0.133
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0036 0.0046
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.01 0.0959 0.3014
Mycobacterium tuberculosis Conserved protein 0.0036 0.025 0.025
Schistosoma mansoni myelin transcription factor 1 myt1 0.0112 0.1091 0.1059
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0108 0.0152
Brugia malayi Importin beta-1 subunit 0.0031 0.0198 0.0577
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0216 0.0272
Brugia malayi Doublecortin family protein 0.0022 0.0096 0.0253
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0049 0.0397 0.1124
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0026 0.015 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.015 0.0293
Brugia malayi glutathione reductase 0.0288 0.3038 0.9585
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0026 0.015 0.0293
Trichomonas vaginalis glutamate synthase, putative 0.0026 0.015 0.0092
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0026 0.015 0.0092
Schistosoma mansoni glutamate synthase 0.0026 0.015 0.0114
Trypanosoma brucei protein kinase, putative 0.0051 0.0425 0.122
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0425 0.0538
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0112 0.1091 0.3412
Brugia malayi Pre-SET motif family protein 0.021 0.2179 0.6861
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0427 0.1224
Echinococcus multilocularis muscleblind protein 0.03 0.3168 0.4003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0216 0.0617
Echinococcus granulosus muscleblind protein 0.03 0.3168 0.4003
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.028 0.0731
Echinococcus multilocularis dna polymerase kappa 0.0038 0.028 0.0354
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0026 0.015 0.0189
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.025 0.025
Entamoeba histolytica thioredoxin reductase, putative 0.0026 0.015 0.0092
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.1183 0.1435
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.025 0.025
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0136 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0875 0.9529 1
Brugia malayi mbt repeat family protein 0.0098 0.0941 0.2936
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.01 0.0959 0.3014
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.025 0.0198
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.01 0.0959 0.3014
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.025 0.0198
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0663 0.202
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0026 0.015 0.0189
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0425 0.122
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0656 0.7112 0.8971
Schistosoma mansoni glutamate synthase 0.0026 0.015 0.0114
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.025 0.0316
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.019 0.024
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0065 0.0579 0.0667
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.028 0.0354
Entamoeba histolytica hypothetical protein 0.0049 0.0397 0.0353
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0098 0.0941 0.0908
Mycobacterium tuberculosis Conserved protein 0.0036 0.025 0.025
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.073 0.7922 1
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0026 0.015 0.0122
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.01 0.0959 0.3014
Mycobacterium ulcerans NADH dehydrogenase 0.0026 0.015 0.0193
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0026 0.015 0.0092
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.028 0.0731
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0108 0.0136
Brugia malayi hypothetical protein 0.0022 0.0096 0.0253
Loa Loa (eye worm) hypothetical protein 0.0107 0.1036 0.2967
Schistosoma mansoni polycystin 1-related 0.0022 0.0096 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.028 0.0731
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.039 0.4171 0.527
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0026 0.015 0.0092
Mycobacterium ulcerans hypothetical protein 0.0036 0.025 0.0416
Giardia lamblia Thioredoxin reductase 0.0026 0.015 0.0092
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0216 0.0272
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0108 0.0152
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0427 0.1224
Plasmodium falciparum glutathione reductase 0.0288 0.3038 1
Schistosoma mansoni lamin 0.0027 0.0153 0.0117
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0073 0.0667 0.2065
Onchocerca volvulus 0.0025 0.0136 0.0166
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0601 0.1721
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.01 0.0959 0.1212
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0026 0.015 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.028 0.0731
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0425 0.0538

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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