TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 355.371 | Formula: C16H13N5O3S
H donors: 1 H acceptors: 4 LogP: 1.26 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C=C(C(=O)N1Nc1nc(ncc1C1=NCCO1)c1cccs1)C
InChi: 1S/C16H13N5O3S/c1-9-7-12(22)21(16(9)23)20-13-10(15-17-4-5-24-15)8-18-14(19-13)11-3-2-6-25-11/h2-3,6-8H,4-5H2,1H3,(H,18,19,20)
InChiKey: PTHWPWGFLGQPPP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Starlite/ChEMBL	References
Homo sapiens	FBJ murine osteosarcoma viral oncogene homolog	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR011616,bZIP transcription factor, bZIP_1;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic tran	Get druggable targets OG5_142533	All targets in OG5_142533

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable glycosyltransferase	0.0039	0.0037	0.0037
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0025	0.0999
Plasmodium vivax	N-acetylglucosamine-1-phosphate transferase, putative	0.0034	0.0027	0.1095
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0164	0.025	1
Brugia malayi	hypothetical protein	0.0056	0.0064	0.1811
Chlamydia trachomatis	dihydrofolate reductase	0.0048	0.0051	0.1032
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0028	0.0017	0.0688
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0028	0.0017	0.0483
Wolbachia endosymbiont of Brugia malayi	cysteinyl-tRNA synthetase	0.0086	0.0116	0.0862
Echinococcus multilocularis	flap endonuclease 1	0.0028	0.0018	0.0717
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0048	0.0051	0.0051
Brugia malayi	Pre-SET motif family protein	0.0226	0.0355	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0028	0.0017	0.0688
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0117	0.017	0.017
Plasmodium falciparum	cysteine--tRNA ligase	0.0086	0.0116	0.4637
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.0017	0.0687
Echinococcus granulosus	thioredoxin glutathione reductase	0.0051	0.0057	0.2293
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0028	0.0017	0.0688
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0164	0.025	1
Trichomonas vaginalis	set domain proteins, putative	0.0257	0.0409	1
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0164	0.025	1
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0028	0.0017	0.0688
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0028	0.0017	0.0688
Echinococcus multilocularis	UDP N acetylglucosamine dolichyl phosphate	0.0034	0.0027	0.1096
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0025	0.0999
Brugia malayi	Thioredoxin reductase	0.0051	0.0057	0.1612
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0028	0.0017	0.0688
Chlamydia trachomatis	phospho-N-acetylmuramoyl-pentapeptide-transferase	0.0306	0.0492	1
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0117	0.0169	0.6759
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0023	0.0918
Onchocerca volvulus		0.0117	0.0169	0.387
Schistosoma mansoni	sodium/chloride dependent transporter	0.0028	0.0017	0.0688
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0028	0.0017	0.0483
Loa Loa (eye worm)	cysteinyl tRNA synthetase 1	0.0086	0.0116	0.292
Loa Loa (eye worm)	serotonin transporter b	0.0164	0.025	0.6876
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0116	0.292
Echinococcus granulosus	leucyl tRNA synthetase	0.0086	0.0116	0.4642
Mycobacterium tuberculosis	Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC	0.5878	1	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0028	0.0017	0.0688
Echinococcus multilocularis	cysteinyl tRNA synthetase	0.0086	0.0116	0.4642
Echinococcus granulosus	thymidylate synthase	0.0117	0.0169	0.6759
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0048	0.0051	0.0051
Brugia malayi	dihydrofolate reductase family protein	0.0048	0.0051	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0164	0.025	0.6876
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0082	0.0082
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.0086	0.0116	0.4637
Trichomonas vaginalis	flap endonuclease-1, putative	0.0028	0.0018	0.0438
Brugia malayi	thymidylate synthase	0.0117	0.0169	0.4749
Loa Loa (eye worm)	hypothetical protein	0.0164	0.025	0.6876
Brugia malayi	glutathione reductase	0.0051	0.0057	0.1612
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0025	0.0999
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0028	0.0017	0.0687
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0028	0.0018	0.0716
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0051	0.0057	0.0057
Plasmodium vivax	flap endonuclease 1, putative	0.0028	0.0018	0.0716
Toxoplasma gondii	hypothetical protein	0.0028	0.0017	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0025	0.023
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0117	0.017	0.017
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.013	0.0192	0.0156
Schistosoma mansoni	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	0.0034	0.0027	0.1096
Toxoplasma gondii	cysteine-tRNA synthetase (CysRS)	0.0086	0.0116	0.4637
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0028	0.0018	0.0716
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.0086	0.0116	0.4642
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.0082	0.329
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.0082	0.3287
Treponema pallidum	cysteinyl-tRNA synthetase	0.0086	0.0116	0.2354
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.5878	1	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0051	0.0057	0.2291
Loa Loa (eye worm)	thymidylate synthase	0.0117	0.0169	0.4483
Trypanosoma cruzi	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0027	0.1095
Loa Loa (eye worm)	flap endonuclease-1	0.0028	0.0018	0.0021
Mycobacterium tuberculosis	Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX	0.0806	0.1345	0.1345
Mycobacterium ulcerans	phospho-N-acetylmuramoyl-pentapeptide-transferase	0.0806	0.1345	0.1345
Echinococcus granulosus	cysteinyl tRNA synthetase	0.0086	0.0116	0.4642
Treponema pallidum	phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY)	0.0306	0.0492	1
Plasmodium falciparum	amino acid transporter, putative	0.0028	0.0017	0.0687
Trypanosoma brucei	trypanothione reductase	0.0051	0.0057	0.2291
Mycobacterium ulcerans	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	0.0186	0.0287	0.0287
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0028	0.0017	0.0688
Plasmodium falciparum	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0027	0.1095
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0051	0.0057	0.2293
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.0082	0.329
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0025	0.0999
Entamoeba histolytica	cysteinyl-tRNA synthetase, putative	0.0086	0.0116	1
Mycobacterium tuberculosis	Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG	0.0136	0.0202	0.0202
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.013	0.0192	0.0192
Plasmodium vivax	glutathione reductase, putative	0.0051	0.0057	0.2291
Mycobacterium tuberculosis	Probable dehydrogenase	0.0117	0.017	0.017
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0028	0.0017	0.0687
Treponema pallidum	sodium- and chloride- dependent transporter	0.0164	0.025	0.5071
Loa Loa (eye worm)	hypothetical protein	0.0164	0.025	0.6876
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase	0.0186	0.0287	0.2134
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0117	0.017	0.017
Trypanosoma brucei	cysteinyl-tRNA synthetase, putative	0.0086	0.0116	0.4637
Schistosoma mansoni	sodium/chloride dependent transporter	0.0028	0.0017	0.0688
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0082	0.0082
Brugia malayi	Flap endonuclease-1	0.0028	0.0018	0.0504
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0028	0.0017	0.0688
Onchocerca volvulus		0.0032	0.0025	0.0199
Schistosoma mansoni	flap endonuclease-1	0.0026	0.0013	0.0531
Loa Loa (eye worm)	norepinephrine transporter	0.0164	0.025	0.6876
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0028	0.0017	0.0687
Mycobacterium leprae	Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX	0.0806	0.1345	0.1313
Mycobacterium ulcerans	undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe	0.0034	0.0027	0.0027
Brugia malayi	Dihydrofolate reductase	0.0048	0.0051	0.1431
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0082	0.329
Plasmodium falciparum	thioredoxin reductase	0.0051	0.0057	0.2291
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0025	0.0999
Plasmodium falciparum	glutathione reductase	0.0051	0.0057	0.2291
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0028	0.0018	0.0716
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0025	0.0999
Echinococcus granulosus	sodium and chloride dependent glycine	0.0028	0.0017	0.0688
Schistosoma mansoni	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	0.0034	0.0027	0.1096
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0226	0.0355	1
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0048	0.0051	0.0014
Mycobacterium tuberculosis	Hypothetical protein	0.0056	0.0064	0.0064
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0028	0.0017	0.0688
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0064	0.1575
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0089	0.0121	0.4861
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0028	0.0017	0.0688
Plasmodium vivax	SET domain protein, putative	0.0032	0.0025	0.0998
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.0082	0.3287
Onchocerca volvulus		0.0164	0.025	0.5936
Toxoplasma gondii	thioredoxin reductase	0.0051	0.0057	0.2291
Schistosoma mansoni	dihydrofolate reductase	0.0048	0.0051	0.2036
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0117	0.017	0.0133
Echinococcus granulosus	UDP N acetylglucosamine dolichyl phosphate	0.0034	0.0027	0.1096
Plasmodium vivax	thioredoxin reductase, putative	0.0051	0.0057	0.2291
Echinococcus granulosus	sodium and chloride dependent glycine	0.0028	0.0017	0.0688
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0028	0.0017	0.0349
Chlamydia trachomatis	cysteine--tRNA ligase	0.0086	0.0116	0.2354
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0164	0.025	0.6876
Chlamydia trachomatis	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	0.0186	0.0287	0.583
Mycobacterium ulcerans	thymidylate synthase	0.0117	0.0169	0.0169
Leishmania major	cysteinyl-tRNA synthetase, putative	0.0086	0.0116	0.4637
Echinococcus multilocularis	thymidylate synthase	0.0117	0.0169	0.6759
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0117	0.017	0.017
Toxoplasma gondii	glycosyl transferase, group 4 family protein	0.0034	0.0027	0.1095
Schistosoma mansoni	sodium/chloride dependent transporter	0.0164	0.025	1
Brugia malayi	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase	0.0034	0.0027	0.077
Trichomonas vaginalis	glucosaminephosphotransferase, putative	0.0034	0.0027	0.067
Giardia lamblia	Cysteinyl-tRNA synthetase	0.0086	0.0116	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.0082	0.329
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0056	0.0064	0.2575
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0164	0.025	1
Onchocerca volvulus		0.0034	0.0027	0.026
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.0082	0.0082
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0164	0.025	1
Loa Loa (eye worm)	glutathione reductase	0.0051	0.0057	0.1185
Trypanosoma cruzi	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0027	0.1095
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0028	0.0017	0.0688
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0164	0.025	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0028	0.0017	0.0688
Plasmodium vivax	amine transporter, putative	0.0028	0.0017	0.0687
Onchocerca volvulus		0.0086	0.0116	0.2521
Leishmania major	trypanothione reductase	0.0051	0.0057	0.2291
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.0086	0.0116	0.0116
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0164	0.025	1
Loa Loa (eye worm)	dihydrofolate reductase	0.0048	0.0051	0.0995
Giardia lamblia	UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase	0.0034	0.0027	0.2361
Mycobacterium leprae	ProbableUPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG	0.0136	0.0202	0.0166
Giardia lamblia	Flap structure-specific endonuclease	0.0028	0.0018	0.1544
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0028	0.0018	0.0716
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0028	0.0017	0.0688
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0089	0.0121	0.4861
Echinococcus granulosus	serotonin transporter	0.0164	0.025	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0028	0.0017	0.0688
Trichomonas vaginalis	cysteinyl-tRNA synthetase, putative	0.0086	0.0116	0.2837
Toxoplasma gondii	hypothetical protein	0.0028	0.0017	0.0687
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0025	0.0999
Mycobacterium tuberculosis	Probable reductase	0.0117	0.017	0.017
Plasmodium falciparum	transporter, putative	0.0028	0.0017	0.0687
Echinococcus granulosus	dihydrofolate reductase	0.0048	0.0051	0.2036
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.0086	0.0116	0.4642
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.0086	0.0116	0.4637
Echinococcus multilocularis	serotonin transporter	0.0164	0.025	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0028	0.0017	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0027	0.0302
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0028	0.0017	0.0483
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0117	0.0169	0.0132
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0028	0.0017	0.0688
Trypanosoma brucei	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0027	0.1095
Echinococcus multilocularis	dihydrofolate reductase	0.0048	0.0051	0.2036
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0028	0.0017	0.0483
Mycobacterium ulcerans	glycosyltransferase	0.0039	0.0037	0.0037
Brugia malayi	Pre-SET motif family protein	0.0032	0.0025	0.0702
Brugia malayi	cysteinyl tRNA synthetase protein 1	0.0086	0.0116	0.3262
Mycobacterium tuberculosis	Probable oxidoreductase	0.013	0.0192	0.0192
Plasmodium falciparum	cysteine--tRNA ligase	0.0086	0.0116	0.4637
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0164	0.025	0.7027
Echinococcus granulosus	flap endonuclease 1	0.0028	0.0018	0.0717
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.013	0.0192	0.0192
Plasmodium falciparum	flap endonuclease 1	0.0028	0.0018	0.0716
Mycobacterium tuberculosis	Probable glycosyltransferase	0.0039	0.0037	0.0037
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0028	0.0017	0.0688
Loa Loa (eye worm)	thioredoxin reductase	0.0051	0.0057	0.1185
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.0082	0.0082
Brugia malayi	hypothetical protein	0.0028	0.0017	0.0483
Leishmania major	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0027	0.1095
Plasmodium vivax	cysteine--tRNA ligase, putative	0.0086	0.0116	0.4637
Onchocerca volvulus		0.0257	0.0409	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0025	0.0998
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0117	0.0169	0.0169
Treponema pallidum	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	0.0186	0.0287	0.583
Entamoeba histolytica	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative	0.0034	0.0027	0.0967
Wolbachia endosymbiont of Brugia malayi	phospho-N-acetylmuramoyl-pentapeptide-transferase	0.0806	0.1345	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.2 uM	Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells	ChEMBL.	10937715
IC50 (functional)	= 0.2 uM	Inhibition of NF-kB mediated transcriptional activation in Jurkat T-cells	ChEMBL.	10937715
IC50 (functional)	= 0.2 uM	Inhibition of AP-1 (activator protein-1) mediated transcriptional activation in Jurkat T-cells	ChEMBL.	10937715
IC50 (functional)	= 0.2 uM	Inhibition of NF-kB mediated transcriptional activation in Jurkat T-cells	ChEMBL.	10937715

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 61918