Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0165 | 0.0036 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0165 | 0.0543 |
Echinococcus multilocularis | musashi | 0.011 | 0.1255 | 0.114 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0165 | 0.0476 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0165 | 0.0543 |
Onchocerca volvulus | 0.0036 | 0.0165 | 0.1314 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0165 | 0.0476 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0165 | 0.0543 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0165 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0385 | 0.1111 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0165 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0259 | 0.3466 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0104 | 0.1164 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.0713 | 0.1748 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0713 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0165 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0165 | 0.0476 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0319 | 0.0566 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.1207 | 0.3482 |
Schistosoma mansoni | intermediate filament proteins | 0.011 | 0.1255 | 0.3372 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0165 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0259 | 0.3466 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0165 | 0.0476 |
Schistosoma mansoni | tar DNA-binding protein | 0.0259 | 0.3466 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0259 | 0.3466 | 1 |
Brugia malayi | RNA binding protein | 0.0259 | 0.3466 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0259 | 0.3466 | 0.338 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0713 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0165 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0053 | 0.0415 | 0.0289 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.011 | 0.1255 | 0.362 |
Echinococcus granulosus | intermediate filament protein | 0.011 | 0.1255 | 0.114 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0165 | 0.5 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0165 | 0.0476 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0165 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0165 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0165 | 0.0476 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0165 | 1 |
Onchocerca volvulus | 0.0036 | 0.0165 | 0.1314 | |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0165 | 0.0543 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0165 | 0.0476 |
Brugia malayi | hypothetical protein | 0.0067 | 0.0621 | 0.1791 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.023 | 0.3041 | 1 |
Schistosoma mansoni | lamin | 0.011 | 0.1255 | 0.3372 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0053 | 0.0415 | 0.0289 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.0709 | 0.1734 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0249 | 0.3316 | 0.9566 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0165 | 0.0476 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0165 | 0.1417 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0046 | 0.0319 | 0.0191 |
Echinococcus multilocularis | tumor protein p63 | 0.07 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.013 | 0.0375 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.1207 | 0.3482 |
Schistosoma mansoni | lamin | 0.011 | 0.1255 | 0.3372 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.013 | 0.0375 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0104 | 0.1164 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.1207 | 0.3482 |
Onchocerca volvulus | 0.0036 | 0.0165 | 0.1314 | |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0059 | 0.0501 | 0.1446 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0249 | 0.3316 | 0.9566 |
Loa Loa (eye worm) | TAR-binding protein | 0.0259 | 0.3466 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0259 | 0.3466 | 1 |
Onchocerca volvulus | 0.011 | 0.1255 | 1 | |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0165 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0165 | 0.0476 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0165 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0259 | 0.3466 | 0.338 |
Loa Loa (eye worm) | RNA binding protein | 0.0259 | 0.3466 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.1255 | 0.362 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0165 | 0.0543 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0104 | 0.1164 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0165 | 0.0543 |
Echinococcus multilocularis | lamin | 0.011 | 0.1255 | 0.114 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0165 | 0.0476 |
Brugia malayi | hypothetical protein | 0.0104 | 0.1164 | 0.3359 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0709 | 0.2044 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0059 | 0.0501 | 0.1446 |
Schistosoma mansoni | tar DNA-binding protein | 0.0259 | 0.3466 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0165 | 0.0036 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.013 | 0.0375 |
Onchocerca volvulus | 0.0103 | 0.1149 | 0.9155 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0165 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1164 | 0.3359 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1207 | 0.3482 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0713 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0165 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0259 | 0.3466 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0104 | 0.1164 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.0709 | 0.2044 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.0713 | 0.0591 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0165 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0046 | 0.0319 | 0.0191 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0104 | 0.1164 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0103 | 0.1149 | 0.3054 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0165 | 0.0543 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.011 | 0.1255 | 0.362 |
Brugia malayi | intermediate filament protein | 0.011 | 0.1255 | 0.362 |
Schistosoma mansoni | tar DNA-binding protein | 0.0259 | 0.3466 | 1 |
Echinococcus granulosus | lamin dm0 | 0.011 | 0.1255 | 0.114 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0104 | 0.1164 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.011 | 0.1255 | 0.362 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.0713 | 0.0591 |
Echinococcus granulosus | lamin | 0.011 | 0.1255 | 0.114 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0165 | 0.0476 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.1225 | 0.3535 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1149 | 0.3315 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0165 | 0.0543 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0385 | 0.1111 |
Leishmania major | hypothetical protein, conserved | 0.0104 | 0.1164 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0165 | 0.0543 |
Onchocerca volvulus | 0.011 | 0.1255 | 1 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.013 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0415 | 0.1197 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0165 | 0.0105 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.0713 | 0.1748 |
Brugia malayi | MH2 domain containing protein | 0.0249 | 0.3316 | 0.9566 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0165 | 0.0476 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0165 | 0.0543 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0104 | 0.1164 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.011 | 0.1255 | 0.114 |
Brugia malayi | hypothetical protein | 0.0073 | 0.0713 | 0.2057 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.