Detailed information for compound 619368

Basic information

Technical information
  • TDR Targets ID: 619368
  • Name: N-(2-methylphenyl)benzenesulfonamide
  • MW: 247.313 | Formula: C13H13NO2S
  • H donors: 1 H acceptors: 2 LogP: 2.81 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1NS(=O)(=O)c1ccccc1
  • InChi: 1S/C13H13NO2S/c1-11-7-5-6-10-13(11)14-17(15,16)12-8-3-2-4-9-12/h2-10,14H,1H3
  • InChiKey: BIZZAMCVUWYVCZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 18457-86-8
  • IFLab1_003800
  • Benzenesulfonamide, N-(2-methylphenyl)-
  • Benzenesulfono-o-toluidide
  • NSC48376
  • BRN 2696439
  • EINECS 242-343-0
  • N-(o-Tolyl)benzenesulphonamide
  • N-o-Tolylbenzenesulfonamide
  • o-Benzenesulfonotoluidide
  • 2'-Methylbenzenesulfonanilide
  • 4-12-00-01783 (Beilstein Handbook Reference)
  • ZINC00393968
  • T5427778

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0076 0.0481 0.1687
Mycobacterium tuberculosis Conserved protein 0.0076 0.0481 0.1091
Echinococcus multilocularis lamin 0.011 0.081 0.0734
Loa Loa (eye worm) transcription factor SMAD2 0.0252 0.2173 0.7625
Schistosoma mansoni tar DNA-binding protein 0.0322 0.285 1
Onchocerca volvulus 0.011 0.081 0.6466
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0481 0.1091
Echinococcus multilocularis musashi 0.011 0.081 0.0734
Loa Loa (eye worm) hypothetical protein 0.0108 0.0793 0.2782
Mycobacterium ulcerans hypothetical protein 0.0076 0.0481 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0481 0.1687
Entamoeba histolytica hypothetical protein 0.0112 0.0828 1
Entamoeba histolytica hypothetical protein 0.0112 0.0828 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0481 0.0403
Schistosoma mansoni tar DNA-binding protein 0.0322 0.285 1
Leishmania major hypothetical protein, conserved 0.0076 0.0481 0.5029
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0056 0.0292 0.0212
Mycobacterium ulcerans lipase LipD 0.0076 0.0481 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0828 0.0753
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0481 0.1091
Brugia malayi hypothetical protein 0.0125 0.0956 0.3355
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0053 0.0263 0.0183
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0481 0.1091
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0828 0.2697
Brugia malayi cytoplasmic intermediate filament protein 0.0059 0.0319 0.1119
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0481 1
Echinococcus granulosus tar DNA binding protein 0.0322 0.285 0.2791
Loa Loa (eye worm) hypothetical protein 0.0108 0.079 0.2773
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0481 0.1091
Loa Loa (eye worm) MH2 domain-containing protein 0.0252 0.2173 0.7625
Loa Loa (eye worm) RNA binding protein 0.0322 0.285 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0481 0.0403
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0481 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0481 0.1687
Leishmania major hypothetical protein, conserved 0.0125 0.0956 1
Schistosoma mansoni tar DNA-binding protein 0.0322 0.285 1
Entamoeba histolytica hypothetical protein 0.0112 0.0828 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0793 0.2782
Mycobacterium tuberculosis Conserved protein 0.0076 0.0481 0.1091
Schistosoma mansoni hypothetical protein 0.0056 0.0292 0.0761
Onchocerca volvulus 0.011 0.081 0.6466
Schistosoma mansoni lamin 0.011 0.081 0.263
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0082 0.0286
Echinococcus multilocularis lamin dm0 0.011 0.081 0.0734
Mycobacterium leprae Probable lipase LipE 0.0076 0.0481 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0053 0.0263 0.0183
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0481 0.1091
Brugia malayi beta-lactamase family protein 0.0076 0.0481 0.1687
Echinococcus multilocularis tar DNA binding protein 0.0322 0.285 0.2791
Loa Loa (eye worm) hypothetical protein 0.0125 0.0956 0.3355
Onchocerca volvulus 0.0076 0.0481 0.384
Schistosoma mansoni intermediate filament proteins 0.011 0.081 0.263
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0481 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0263 0.0922
Trypanosoma brucei PAB1-binding protein , putative 0.0125 0.0956 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0481 0.1687
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0481 0.1687
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0481 0.1091
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.011 0.081 0.2841
Brugia malayi intermediate filament protein 0.011 0.081 0.2841
Onchocerca volvulus 0.0076 0.0481 0.384
Loa Loa (eye worm) TAR-binding protein 0.0322 0.285 1
Schistosoma mansoni cellular tumor antigen P53 0.0156 0.1252 0.4229
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0481 0.5
Schistosoma mansoni hypothetical protein 0.0074 0.0464 0.138
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0793 0.2782
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0828 0.0753
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0286
Brugia malayi Intermediate filament tail domain containing protein 0.011 0.081 0.2841
Brugia malayi hypothetical protein 0.0081 0.053 0.1858
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0481 0.5
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0059 0.0319 0.1119
Brugia malayi TAR-binding protein 0.0322 0.285 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0322 0.285 1
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0481 0.5
Brugia malayi beta-lactamase family protein 0.0076 0.0481 0.1687
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0056 0.0292 0.0212
Schistosoma mansoni hypothetical protein 0.0112 0.0828 0.2697
Echinococcus granulosus lamin 0.011 0.081 0.0734
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0481 0.5
Schistosoma mansoni tar DNA-binding protein 0.0322 0.285 1
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0082 0.0286
Loa Loa (eye worm) beta-lactamase 0.0076 0.0481 0.1687
Schistosoma mansoni lamin 0.011 0.081 0.263
Echinococcus multilocularis tumor protein p63 0.1067 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0243 0.0854
Brugia malayi beta-lactamase 0.0076 0.0481 0.1687
Brugia malayi RNA binding protein 0.0322 0.285 1
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0481 1
Onchocerca volvulus 0.0076 0.0481 0.384
Loa Loa (eye worm) hypothetical protein 0.0076 0.0481 0.1687
Toxoplasma gondii LsmAD domain-containing protein 0.0125 0.0956 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0481 0.1442
Loa Loa (eye worm) hypothetical protein 0.0156 0.1252 0.4394
Trypanosoma cruzi PAB1-binding protein , putative 0.0125 0.0956 1
Loa Loa (eye worm) hypothetical protein 0.011 0.081 0.2841
Brugia malayi hypothetical protein 0.0112 0.0828 0.2906
Brugia malayi RNA recognition motif domain containing protein 0.0322 0.285 1
Trichomonas vaginalis esterase, putative 0.0076 0.0481 0.5
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0481 0.1091
Plasmodium falciparum ataxin-2 like protein, putative 0.0125 0.0956 0.5
Loa Loa (eye worm) hypothetical protein 0.0076 0.0481 0.1687
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0082 0.0286
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0793 0.2782
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0484 0.4406 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0481 0.1687
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0464 0.1627
Trypanosoma cruzi PAB1-binding protein , putative 0.0125 0.0956 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0243 0.0854
Brugia malayi MH2 domain containing protein 0.0252 0.2173 0.7625
Entamoeba histolytica hypothetical protein 0.0112 0.0828 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0125 0.0956 0.5
Plasmodium vivax ataxin-2 like protein, putative 0.0125 0.0956 1
Schistosoma mansoni tar DNA-binding protein 0.0322 0.285 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0464 0.1627
Echinococcus granulosus intermediate filament protein 0.011 0.081 0.0734
Mycobacterium ulcerans beta-lactamase 0.0076 0.0481 1
Loa Loa (eye worm) intermediate filament protein 0.011 0.081 0.2841
Mycobacterium tuberculosis Conserved protein 0.0076 0.0481 0.1091
Onchocerca volvulus 0.0156 0.1252 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0481 0.1442
Echinococcus granulosus lamin dm0 0.011 0.081 0.0734

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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