Detailed information for compound 619414

Basic information

Technical information
  • TDR Targets ID: 619414
  • Name: 2-chloro-N-(2-fluorophenyl)-5-nitropyrimidine -4,6-diamine
  • MW: 283.646 | Formula: C10H7ClFN5O2
  • H donors: 2 H acceptors: 4 LogP: 3.72 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1nc(Nc2ccccc2F)c(c(n1)N)[N+](=O)[O-]
  • InChi: 1S/C10H7ClFN5O2/c11-10-15-8(13)7(17(18)19)9(16-10)14-6-4-2-1-3-5(6)12/h1-4H,(H3,13,14,15,16)
  • InChiKey: QUJMIQJOMZMKJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-N-(2-fluorophenyl)-5-nitro-pyrimidine-4,6-diamine
  • (6-amino-2-chloro-5-nitro-pyrimidin-4-yl)-(2-fluorophenyl)amine
  • STOCK4S-57480
  • ZINC03893266

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0021 0.0033
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0019 0.0021 0.0012
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0019 0.0021 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0841 0.2827
Mycobacterium tuberculosis Probable dehydrogenase 0.0469 0.7074 0.896
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0151 0.0476
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0837 0.9948
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0021 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0837 0.0826
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0019 0.0021 0.001
Toxoplasma gondii thioredoxin reductase 0.0206 0.2947 1
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0021 0.0033
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0071 0.0841 0.2827
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0151 0.0476
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0124 0.1662 0.1691
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0019 0.0021 0.0012
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0124 0.1662 0.5623
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0021 0.0033
Echinococcus granulosus glutamate synthase 0.0019 0.0021 0.001
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0019 0.0021 0.001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0469 0.7074 0.896
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0151 0.0476
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0019 0.0021 0.0115
Trypanosoma brucei NADH dehydrogenase 0.0019 0.0021 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0422 0.0411
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0019 0.0021 0.001
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0021 0.0033
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0071 0.0841 0.2827
Leishmania major hypothetical protein, conserved 0.0019 0.0021 0.0033
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0019 0.0021 0.001
Plasmodium falciparum glutathione reductase 0.0206 0.2947 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0124 0.1662 1
Entamoeba histolytica hypothetical protein 0.0042 0.0384 0.2255
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0021 0.001
Echinococcus granulosus muscleblind protein 0.0645 0.9828 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0742 0.0744
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0019 0.0021 0.0012
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0021 0.0012
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0019 0.0021 0.0058
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0021 0.001
Trypanosoma brucei trypanothione reductase 0.0206 0.2947 1
Trichomonas vaginalis glutathione reductase, putative 0.0071 0.0841 0.1066
Entamoeba histolytica hypothetical protein 0.0042 0.0384 0.2255
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0837 0.9948
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0019 0.0021 0.0033
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0704 0.0706
Schistosoma mansoni glutamate synthase 0.0019 0.0021 0.001
Brugia malayi Pre-SET motif family protein 0.0065 0.0742 0.0755
Brugia malayi follicle stimulating hormone receptor 0.0504 0.7616 0.7749
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0124 0.1662 0.1681
Trichomonas vaginalis apoptosis inducing factor, putative 0.0019 0.0021 0.0012
Trichomonas vaginalis glutamate synthase, putative 0.0019 0.0021 0.0012
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0019 0.0021 0.0115
Giardia lamblia Thioredoxin reductase 0.0019 0.0021 0.0058
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0071 0.0841 0.2827
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0124 0.1662 0.5623
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0206 0.2947 0.3723
Trypanosoma cruzi trypanothione reductase, putative 0.0071 0.0841 0.2827
Plasmodium falciparum glutathione reductase 0.0071 0.0841 0.2827
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0071 0.0841 0.2827
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0837 0.0841
Leishmania major NADH dehydrogenase, putative 0.0019 0.0021 0.0033
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0071 0.0841 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0469 0.7074 0.896
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0019 0.0021 0.0012
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0384 0.0379
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0071 0.0841 0.2827
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0071 0.0841 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0522 0.7895 1
Trichomonas vaginalis mercuric reductase, putative 0.0071 0.0841 0.1066
Brugia malayi glutamate synthase 0.0019 0.0021 0.0021
Echinococcus granulosus thioredoxin glutathione reductase 0.0206 0.2947 0.299
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0019 0.0021 0.0058
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0469 0.7074 0.8958
Plasmodium falciparum thioredoxin reductase 0.0206 0.2947 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0071 0.0841 0.2827
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0019 0.0021 0.0115
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0124 0.1662 0.1681
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0019 0.0021 0.0012
Entamoeba histolytica thioredoxin reductase, putative 0.0019 0.0021 0.0058
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0019 0.0021 0.0012
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0019 0.0021 0.0033
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0124 0.1662 0.5623
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0052 0.0545 0.0554
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0071 0.0841 0.2827
Schistosoma mansoni hypothetical protein 0.0042 0.0384 0.0373
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0124 0.1662 0.212
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0019 0.0021 0.0115
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0021 0.0021
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0019 0.0021 0.0115
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0021 0.0012
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0019 0.0021 0.0058
Brugia malayi hypothetical protein 0.0027 0.0151 0.0154
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0021 0.0033
Brugia malayi Muscleblind-like protein 0.0645 0.9828 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0504 0.7616 0.7746
Schistosoma mansoni disulfide oxidoreductase 0.0019 0.0021 0.001
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0742 0.0744
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0124 0.1662 0.1652
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0151 0.0476
Echinococcus multilocularis glutamate synthase 0.0019 0.0021 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0841 0.2827
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0837 0.2812
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0011 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0841 0.2827
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0021 0.0033
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0071 0.0841 0.2827
Brugia malayi Thioredoxin reductase 0.0206 0.2947 0.2998
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0071 0.0841 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0071 0.0841 0.0856
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0019 0.0021 0.0115
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0021 0.001
Entamoeba histolytica hypothetical protein 0.0042 0.0384 0.2255
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0124 0.1662 1
Trichomonas vaginalis glutamate synthase, putative 0.0019 0.0021 0.0012
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0021 0.0033
Echinococcus granulosus ubiquitin specific protease 41 0.0124 0.1662 0.1681
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0071 0.0841 0.2827
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0019 0.0021 0.0115
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0837 0.0841
Mycobacterium ulcerans dehydrogenase 0.0019 0.0021 0.0115
Plasmodium vivax glutathione reductase, putative 0.0206 0.2947 1
Brugia malayi Pre-SET motif family protein 0.0453 0.6815 0.6935
Toxoplasma gondii NADPH-glutathione reductase 0.0071 0.0841 0.2827
Plasmodium falciparum ferrodoxin reductase-like protein 0.0019 0.0021 0.0033
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0021 0.0033
Mycobacterium tuberculosis Probable oxidoreductase 0.0522 0.7895 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0019 0.0021 0.0115
Plasmodium falciparum thioredoxin reductase 0.0071 0.0841 0.2827
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0071 0.0841 0.2827
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0151 0.0476
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0021 0.0033
Schistosoma mansoni hypothetical protein 0.0019 0.0021 0.001
Entamoeba histolytica hypothetical protein 0.0042 0.0384 0.2255
Treponema pallidum thioredoxin reductase (trxB) 0.0019 0.0021 0.0115
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0453 0.6815 0.6931
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0019 0.0021 0.0012
Loa Loa (eye worm) hypothetical protein 0.0645 0.9828 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0071 0.0841 0.2827
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0071 0.0841 0.1053
Trypanosoma cruzi trypanothione reductase, putative 0.0206 0.2947 1
Onchocerca volvulus 0.0515 0.7795 1
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0019 0.0021 0.0115
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0021 0.0033
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0021 0.0033
Schistosoma mansoni glutamate synthase 0.0019 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0151 0.0142
Plasmodium vivax SET domain protein, putative 0.0065 0.0742 0.2488
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0071 0.0841 0.2827
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0071 0.0841 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0422 0.0418
Mycobacterium tuberculosis Probable reductase 0.0469 0.7074 0.896
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0522 0.7895 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0071 0.0841 0.0845
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0841 0.2827
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0021 0.0033
Onchocerca volvulus 0.0065 0.0742 0.0927
Echinococcus multilocularis muscleblind protein 1 0.0645 0.9828 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0422 0.0418
Mycobacterium ulcerans ferredoxin reductase 0.0019 0.0021 0.0115
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0841 0.2827
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0019 0.0021 0.0033
Toxoplasma gondii selenide, water dikinase 0.0019 0.0021 0.0033
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0071 0.0841 1
Mycobacterium ulcerans hypothetical protein 0.0019 0.0021 0.0115
Loa Loa (eye worm) thioredoxin reductase 0.0206 0.2947 0.299
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0021 0.0012
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0021 0.0033
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0019 0.0021 0.0012
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0124 0.1662 0.5623
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0019 0.0021 0.0058
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0071 0.0841 0.2827
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0019 0.0021 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0742 0.0731
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0021 0.0033
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0019 0.0021 0.0033
Loa Loa (eye worm) hypothetical protein 0.0645 0.9828 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0019 0.0021 0.001
Treponema pallidum oxidoreductase 0.0019 0.0021 0.0115
Treponema pallidum NADH oxidase 0.0071 0.0841 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0021 0.0033
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0469 0.7074 0.896
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0522 0.7895 1
Entamoeba histolytica disulphide oxidoreductase, putative 0.0019 0.0021 0.0058
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0021 0.0021
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0021 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0422 0.043
Leishmania major hypothetical protein, conserved 0.0019 0.0021 0.0033
Mycobacterium ulcerans glutamate synthase subunit beta 0.0019 0.0021 0.0115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0742 0.0731
Loa Loa (eye worm) hypothetical protein 0.0065 0.0742 0.0744
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0742 0.0731
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0021 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0837 0.0826
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0019 0.0021 0.001
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0019 0.0021 0.0115
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0019 0.0021 0.0058
Giardia lamblia Glutamate synthase 0.0019 0.0021 0.0058
Echinococcus multilocularis thioredoxin glutathione reductase 0.0206 0.2947 0.299
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0124 0.1662 0.1681
Loa Loa (eye worm) hypothetical protein 0.0124 0.1662 0.1681
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0422 0.0418
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0052 0.0545 0.0554
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0071 0.0841 0.0845
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0021 0.0033
Brugia malayi glutathione reductase 0.0206 0.2947 0.2998
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0742 0.2488
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.001
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0151 0.0476
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0019 0.0021 0.0021
Mycobacterium ulcerans NADH dehydrogenase 0.0019 0.0021 0.0115
Brugia malayi hypothetical protein 0.0042 0.0384 0.039
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0071 0.0841 0.2827
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0071 0.0841 0.2827
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0469 0.7074 0.896
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0837 0.9948
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0019 0.0021 0.0033
Plasmodium vivax ferrodoxin reductase, putative 0.0019 0.0021 0.0033
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0019 0.0021 0.0033
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0019 0.0021 0.0012
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0021 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.1662 0.212
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0384 0.0379
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0742 0.0744
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0742 0.0731
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0837 0.1047
Schistosoma mansoni glutamate synthase 0.0019 0.0021 0.001
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0021 0.001
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0021 0.0012
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0384 0.0373
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0021 0.001
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0124 0.1662 0.1652
Leishmania major trypanothione reductase 0.0206 0.2947 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0422 0.0411
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0841 0.2827
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0837 0.2812
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0124 0.1662 0.212
Echinococcus multilocularis ubiquitin specific protease 41 0.0124 0.1662 0.1681
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0422 0.0411
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0019 0.0021 0.001
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0071 0.0841 0.0831
Loa Loa (eye worm) programmed cell death 8 0.0019 0.0021 0.001
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0124 0.1662 0.1681
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0151 0.0476
Giardia lamblia NADH oxidase lateral transfer candidate 0.0071 0.0841 0.5027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0422 0.0418
Loa Loa (eye worm) glutathione reductase 0.0206 0.2947 0.299
Trichomonas vaginalis set domain proteins, putative 0.0515 0.7795 1
Leishmania major hypothetical protein, conserved 0.0027 0.0151 0.0476
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0019 0.0021 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0422 0.0418
Plasmodium vivax thioredoxin reductase, putative 0.0206 0.2947 1
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0019 0.0021 0.0012
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0019 0.0021 0.001
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0021 0.0033
Leishmania major hypothetical protein, conserved 0.0019 0.0021 0.0033
Echinococcus multilocularis muscleblind protein 0.0645 0.9828 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0071 0.0841 1
Mycobacterium ulcerans monoxygenase 0.0019 0.0021 0.0115

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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