Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.1996 | 0.1996 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0015 | 0.1996 | 0.1996 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.4151 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.4151 | 0.2693 |
Onchocerca volvulus | 0.0026 | 1 | 0.5 | |
Echinococcus multilocularis | musashi | 0.0026 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.1996 | 0.1996 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.4151 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.4151 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0015 | 0.1996 | 0.1996 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.4151 | 1 |
Onchocerca volvulus | 0.0026 | 1 | 0.5 | |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.1996 | 0.1996 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.4151 | 1 |
Schistosoma mansoni | lamin | 0.0026 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.4151 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.4151 | 0.4151 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.4151 | 0.4151 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.4151 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.4151 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.4151 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.1996 | 0.1996 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.4151 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.9646 | 0.9646 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.1026 | 0.1026 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.4151 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.4151 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.4151 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0015 | 0.1996 | 0.108 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.4151 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.4151 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.4151 | 0.3482 |
Brugia malayi | isocitrate dehydrogenase | 0.0015 | 0.1996 | 0.108 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.4151 | 0.4151 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0026 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.4151 | 0.2693 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0015 | 0.1996 | 0.1996 |
Echinococcus granulosus | lamin | 0.0026 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0026 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.