Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1204 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.29 | 0.5 | |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.1204 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1204 | 0.0663 |
Echinococcus granulosus | lamin | 0.0027 | 0.29 | 0.29 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.1204 | 1 |
Onchocerca volvulus | 0.0027 | 0.29 | 0.5 | |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1204 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.1204 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0027 | 0.29 | 0.29 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0579 | 0.029 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.1204 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.1204 | 0.0934 |
Schistosoma mansoni | lamin | 0.0027 | 0.29 | 0.2464 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.1204 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.1204 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.29 | 0.29 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.29 | 0.29 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0579 | 0.0579 |
Echinococcus multilocularis | musashi | 0.0027 | 0.29 | 0.29 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0579 | 0.0579 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.1204 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.29 | 0.29 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.29 | 0.2464 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0579 | 0.0579 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2797 | 0.2797 |
Schistosoma mansoni | lamin | 0.0027 | 0.29 | 0.2464 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.1204 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.29 | 0.2682 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0298 | 0.0298 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.1204 | 0.0663 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0579 | 0.0579 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.1204 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.1204 | 0.1204 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.1204 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.1204 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.29 | 0.29 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.29 | 0.2682 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.29 | 0.29 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0579 | 0.0579 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.1204 | 0.1204 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0579 | 0.029 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.1204 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0579 | 0.0579 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.1204 | 0.1204 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0579 | 0.0579 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.29 | 0.29 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.1204 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.