Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0584 | 0.0815 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.057 | 1 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0584 | 0.1334 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.272 | 0.272 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0215 | 0.0324 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0584 | 0.1174 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0559 | 0.0534 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.057 | 0.0544 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1007 | 0.0983 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0052 | 0.1147 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0584 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0584 | 1 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0022 | 0.0097 | 0.0845 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0215 | 0.0215 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.036 | 0.0334 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0128 | 0.0101 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.1387 | 0.1363 |
Schistosoma mansoni | ran | 0.0022 | 0.0097 | 0.007 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1007 | 0.0983 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.0208 | 0.0304 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0584 | 0.1174 |
Echinococcus multilocularis | tar DNA binding protein | 0.0129 | 0.3748 | 0.3731 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0215 | 0.0324 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0581 | 0.0556 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0515 | 0.1145 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0215 | 0.3689 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0584 | 0.0815 |
Onchocerca volvulus | 0.0036 | 0.0584 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0584 | 0.0584 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0584 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0584 | 0.0584 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0584 | 0.1334 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0584 | 0.0558 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0215 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0584 | 0.0584 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3748 | 0.3731 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0171 | 0.1577 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0025 | 0.0215 | 0.2504 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.0937 | 0.0937 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.3354 | 0.4685 |
Leishmania major | trypanothione reductase | 0.0046 | 0.0937 | 0.8005 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.036 | 0.0721 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.1508 | 0.1485 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0052 | 0.1147 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.057 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0312 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.0937 | 0.0913 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0584 | 0.0815 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0022 | 0.0097 | 0.007 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0584 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.0937 | 0.2302 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.057 | 0.0544 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0105 | 0.2954 | 0.4126 |
Brugia malayi | AMP-binding enzyme family protein | 0.0025 | 0.0215 | 0.0324 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0661 | 0.1547 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.1147 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0584 | 0.0584 |
Leishmania major | hypothetical protein, conserved | 0.0052 | 0.1147 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0584 | 0.0584 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0584 | 0.0584 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0023 | 0.0163 | 0.0137 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.0937 | 0.8174 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0584 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0584 | 0.0815 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0584 | 0.0584 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.1147 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1007 | 0.0983 |
Schistosoma mansoni | hypothetical protein | 0.0312 | 1 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0023 | 0.0163 | 0.0137 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0584 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0171 | 0.0711 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0171 | 0.1533 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0215 | 0.3689 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.036 | 0.3139 |
Schistosoma mansoni | ran | 0.0022 | 0.0097 | 0.007 |
Brugia malayi | Bromodomain containing protein | 0.0075 | 0.1905 | 0.4953 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0559 | 0.1267 |
Brugia malayi | hypothetical protein | 0.0098 | 0.272 | 0.7185 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1113 | 0.2783 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0215 | 0.1128 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0105 | 0.2954 | 0.4126 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.036 | 0.0334 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0584 | 0.0815 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0215 | 0.0301 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0584 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0584 | 0.0558 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0105 | 0.2954 | 0.8724 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1113 | 0.1113 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.176 | 0.176 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1007 | 0.0983 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.057 | 0.0544 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.1007 | 0.1007 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.057 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0128 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0584 | 0.0584 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0215 | 0.3689 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0584 | 0.1334 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.057 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0129 | 0.3748 | 1 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0097 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0215 | 0.0215 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0664 | 0.0664 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0215 | 0.1128 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0584 | 0.0815 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.036 | 0.0334 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0163 | 0.0137 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.0937 | 0.8174 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0129 | 0.3748 | 0.3748 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0809 | 0.0809 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.0937 | 0.8005 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0584 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0063 | 0.0036 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0584 | 0.4637 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.3354 | 0.4685 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0584 | 0.4637 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0171 | 0.1533 |
Brugia malayi | hypothetical protein | 0.0035 | 0.057 | 0.1296 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.0937 | 0.8174 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0584 | 0.4637 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0584 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0063 | 0.0063 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0022 | 0.0097 | 0.007 |
Echinococcus granulosus | tar DNA binding protein | 0.0129 | 0.3748 | 0.3731 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3748 | 0.3731 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3748 | 0.3731 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.7159 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.057 | 0.0544 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0215 | 0.0301 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0105 | 0.2954 | 0.4126 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.272 | 0.272 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.0937 | 0.0913 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0215 | 0.3689 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.036 | 0.036 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0584 | 0.4637 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0584 | 0.0815 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0097 | 0.0845 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0584 | 0.0558 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.0937 | 0.8005 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.036 | 0.3139 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0559 | 0.0559 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0105 | 0.2954 | 0.4126 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.3354 | 0.4685 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0581 | 0.0556 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1147 | 0.1147 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0584 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0584 | 0.4637 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0584 | 0.0815 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3748 | 0.3731 |
Brugia malayi | RNA binding protein | 0.0129 | 0.3748 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0129 | 0.3748 | 0.3748 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.036 | 0.2505 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.0937 | 0.8005 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0584 | 0.0815 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.1007 | 0.2493 |
Brugia malayi | RNA, U transporter 1 | 0.0083 | 0.2197 | 0.5752 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0584 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0584 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0105 | 0.2954 | 0.4126 |
Echinococcus multilocularis | snurportin 1 | 0.0312 | 1 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.036 | 0.2505 |
Loa Loa (eye worm) | TAR-binding protein | 0.0129 | 0.3748 | 0.3748 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.1147 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1113 | 0.1113 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0584 | 0.1334 |
Brugia malayi | TAR-binding protein | 0.0129 | 0.3748 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0215 | 0.2504 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1007 | 0.0983 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1007 | 0.0983 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.1387 | 0.1363 |
Schistosoma mansoni | tar DNA-binding protein | 0.0129 | 0.3748 | 0.3731 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0215 | 0.3689 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0025 | 0.0215 | 0.2504 |
Onchocerca volvulus | 0.0036 | 0.0584 | 1 | |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.0215 | 0.1128 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.036 | 0.2505 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.1147 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0584 | 0.0815 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.0937 | 0.0937 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1113 | 0.2783 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0215 | 0.3689 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0128 | 0.0101 |
Brugia malayi | glutathione reductase | 0.0046 | 0.0937 | 0.2302 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0171 | 0.1533 |
Onchocerca volvulus | 0.0036 | 0.0584 | 1 | |
Brugia malayi | hypothetical protein | 0.0052 | 0.1147 | 0.2876 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.0937 | 0.1309 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1007 | 0.0983 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0171 | 0.0711 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0744 | 0.0744 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.3354 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0584 | 0.509 |
Schistosoma mansoni | eyes absent homolog | 0.0098 | 0.272 | 0.27 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0105 | 0.2954 | 0.4126 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0052 | 0.1147 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0215 | 0.3689 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0215 | 0.3689 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.0937 | 0.8174 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0097 | 0.0097 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.