Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | transcription factor BTF3, putative | 0.0028 | 0.0335 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0039 | 0.057 | 0.0857 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0016 | 0.0101 | 0.0101 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0012 | 0.0031 | 0.0031 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0335 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0012 | 0.0031 | 0.0046 |
Echinococcus multilocularis | geminin | 0.051 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0016 | 0.0101 | 0.0152 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0016 | 0.0101 | 0.0152 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0692 | 0.104 |
Echinococcus multilocularis | GPCR, family 2 | 0.0012 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0101 | 0.0152 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0016 | 0.0101 | 0.0101 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0692 | 0.0692 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.057 | 0.0857 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0101 | 0.0152 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0012 | 0.0031 | 0.0031 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0016 | 0.0101 | 0.0152 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0016 | 0.0101 | 0.0101 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0016 | 0.0101 | 0.0101 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0031 | 0.0031 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0016 | 0.0101 | 0.0101 |
Schistosoma mansoni | nuclear hormone receptor | 0.0016 | 0.0101 | 0.0101 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0016 | 0.0101 | 0.0101 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0016 | 0.0101 | 0.0101 |
Schistosoma mansoni | transcription factor btf3 | 0.0028 | 0.0335 | 0.0335 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0028 | 0.0335 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0101 | 0.0152 |
Schistosoma mansoni | thyroid hormone receptor | 0.0016 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0016 | 0.0101 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.6503 | 0.9773 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0352 | 0.6823 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0343 | 0.6654 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0343 | 0.6654 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0012 | 0.0031 | 0.0046 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0474 | 0.927 | 0.927 |
Schistosoma mansoni | coup transcription factor | 0.0016 | 0.0101 | 0.0101 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0039 | 0.057 | 0.0857 |
Echinococcus granulosus | transcription factor btf3 | 0.0028 | 0.0335 | 0.0335 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0016 | 0.0101 | 0.0152 |
Echinococcus granulosus | GPCR family 2 | 0.0012 | 0.0031 | 0.0031 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0016 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0101 | 0.0152 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0016 | 0.0101 | 0.0101 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0016 | 0.0101 | 0.0101 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0692 | 0.0692 |
Brugia malayi | ecdysteroid receptor | 0.0016 | 0.0101 | 0.0152 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0016 | 0.0101 | 0.0152 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0016 | 0.0101 | 0.0101 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0016 | 0.0101 | 0.0152 |
Echinococcus granulosus | FTZ F1 alpha | 0.0016 | 0.0101 | 0.0101 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0016 | 0.0101 | 0.0152 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0012 | 0.0031 | 0.0031 |
Brugia malayi | nuclear receptor NHR-88 | 0.0016 | 0.0101 | 0.0152 |
Brugia malayi | beta-NAC-like protein | 0.0028 | 0.0335 | 0.0503 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0016 | 0.0101 | 0.0152 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0016 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0101 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0321 | 0.0321 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0028 | 0.0335 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0016 | 0.0101 | 0.0152 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0012 | 0.0031 | 0.0046 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0692 | 0.0692 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0016 | 0.0101 | 0.0101 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0335 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0016 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0031 | 0.0046 |
Schistosoma mansoni | thyroid hormone receptor | 0.0016 | 0.0101 | 0.0101 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0016 | 0.0101 | 0.0152 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0016 | 0.0101 | 0.0101 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0016 | 0.0101 | 0.0101 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0016 | 0.0101 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0101 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0101 | 0.0152 |
Echinococcus multilocularis | transcription factor btf3 | 0.0028 | 0.0335 | 0.0335 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0039 | 0.057 | 0.0857 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0016 | 0.0101 | 0.0152 |
Leishmania major | basic transcription factor 3a, putative | 0.0028 | 0.0335 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0016 | 0.0101 | 0.0101 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0028 | 0.0335 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0692 | 0.0692 |
Loa Loa (eye worm) | ICD-1 protein | 0.0028 | 0.0335 | 0.0503 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0335 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0016 | 0.0101 | 0.0101 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0016 | 0.0101 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0321 | 0.0482 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0016 | 0.0101 | 0.0152 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0016 | 0.0101 | 0.0101 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0016 | 0.0101 | 0.0101 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0016 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0101 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.051 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0016 | 0.0101 | 0.0101 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0016 | 0.0101 | 0.0101 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0335 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0016 | 0.0101 | 0.0101 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0027 | 0.0321 | 0.0482 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0016 | 0.0101 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0031 | 0.0031 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0016 | 0.0101 | 0.0152 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0474 | 0.927 | 0.927 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0016 | 0.0101 | 0.0152 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0016 | 0.0101 | 0.0152 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0016 | 0.0101 | 0.0152 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0016 | 0.0101 | 0.0101 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0028 | 0.0335 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0016 | 0.0101 | 0.0152 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0016 | 0.0101 | 0.0152 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0016 | 0.0101 | 0.0152 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0028 | 0.0335 | 1 |
Schistosoma mansoni | hypothetical protein | 0.051 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0692 | 0.0692 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0016 | 0.0101 | 0.0101 |
Brugia malayi | steroid hormone receptor | 0.0016 | 0.0101 | 0.0152 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0012 | 0.0031 | 0.0031 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0031 | 0.0031 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0692 | 0.104 |
Toxoplasma gondii | NAC domain-containing protein | 0.0028 | 0.0335 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0692 | 0.0692 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0692 | 0.0692 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0016 | 0.0101 | 0.0152 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0016 | 0.0101 | 0.0152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.