Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0176 | 0.5765 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0509 | 0.0362 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0037 | 0.0702 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.5765 | 0.6244 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0032 | 0.0509 | 0.0367 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0863 | 0.281 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0032 | 0.0509 | 0.2979 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0863 | 0.1623 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.0863 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0968 | 0.1061 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0863 | 0.0863 |
Brugia malayi | PHD-finger family protein | 0.0026 | 0.0297 | 0.0106 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0863 | 0.0762 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0037 | 0.0702 | 0.2176 |
Plasmodium falciparum | heat shock protein 90 | 0.0037 | 0.0702 | 0.2079 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0714 | 0.1239 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0509 | 0.1417 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0032 | 0.0509 | 0.1417 |
Echinococcus granulosus | heat shock protein | 0.0037 | 0.0702 | 0.1218 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0135 | 0.0148 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0032 | 0.0509 | 0.1417 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0208 | 0.6955 | 0.7624 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.5765 | 0.5765 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Schistosoma mansoni | heat shock protein | 0.0037 | 0.0702 | 0.0702 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0137 | 0.4355 | 0.4773 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0509 | 0.1417 |
Trichomonas vaginalis | heat shock protein, putative | 0.0037 | 0.0702 | 0.0582 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0806 | 0.0884 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5311 | 0.5821 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0208 | 0.6955 | 0.7624 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0037 | 0.0702 | 0.0769 |
Echinococcus multilocularis | endoplasmin | 0.0029 | 0.0428 | 0.0742 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0268 | 0.9125 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0037 | 0.0702 | 0.2176 |
Echinococcus granulosus | heat shock protein 90 | 0.0037 | 0.0702 | 0.1218 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Echinococcus multilocularis | heat shock protein | 0.0037 | 0.0702 | 0.1218 |
Brugia malayi | Thioredoxin reductase | 0.0091 | 0.2687 | 0.2784 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0.0863 | 0.059 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0032 | 0.0509 | 0.0884 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0091 | 0.2687 | 0.2639 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0095 | 0.0095 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0029 | 0.0428 | 0.1095 |
Plasmodium falciparum | glutathione reductase | 0.0091 | 0.2687 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0863 | 0.0508 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0041 | 0.0863 | 0.0508 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.9125 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0032 | 0.0509 | 0.0509 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0509 | 0.1417 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0208 | 0.6955 | 0.885 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0702 | 0.0885 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.5765 | 0.6244 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0232 | 0.7803 | 0.8615 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0.0863 | 0.059 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0702 | 0.0885 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0509 | 0.1417 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0041 | 0.0863 | 0.0508 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.5765 | 0.6244 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0509 | 0.1417 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0702 | 0.0885 |
Echinococcus multilocularis | geminin | 0.0176 | 0.5765 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0176 | 0.5765 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0032 | 0.0509 | 0.131 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0702 | 0.0885 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0032 | 0.0509 | 0.1417 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0032 | 0.0509 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0863 | 0.0946 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0037 | 0.0702 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.0863 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Loa Loa (eye worm) | endoplasmin | 0.0037 | 0.0702 | 0.0769 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Schistosoma mansoni | heat shock protein | 0.0037 | 0.0702 | 0.0702 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.5765 | 0.5765 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0041 | 0.0863 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0896 | 0.0982 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0863 | 0.0863 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.1613 | 0.2798 |
Plasmodium vivax | heat shock protein 86, putative | 0.0037 | 0.0702 | 0.0885 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0095 | 0.0166 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0863 | 0.0508 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.0804 | 0.0673 |
Trichomonas vaginalis | heat shock protein, putative | 0.0029 | 0.0428 | 0.0276 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.9125 | 1 |
Onchocerca volvulus | 0.0163 | 0.5311 | 0.9074 | |
Mycobacterium tuberculosis | Probable reductase | 0.0208 | 0.6955 | 0.7624 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0232 | 0.7803 | 0.8615 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0092 | 0.2706 | 0.4694 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.5765 | 0.6244 |
Plasmodium vivax | endoplasmin, putative | 0.0037 | 0.0702 | 0.0885 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0032 | 0.0509 | 0.0367 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0037 | 0.0702 | 0.0885 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0863 | 0.1926 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0509 | 0.0362 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.9125 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0702 | 0.0885 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.0863 | 0.1623 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0032 | 0.0509 | 0.0362 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0032 | 0.0509 | 0.0095 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0863 | 0.074 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0863 | 0.0946 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.2192 | 0.223 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0208 | 0.6955 | 0.7624 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0032 | 0.0509 | 0.1878 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0032 | 0.0509 | 0.131 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0032 | 0.0509 | 0.1878 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0037 | 0.0702 | 0.0885 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0092 | 0.2706 | 0.4694 |
Plasmodium falciparum | glutathione reductase | 0.0032 | 0.0509 | 0.131 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0863 | 0.0946 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0095 | 0.0166 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0232 | 0.7803 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0268 | 0.9125 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0091 | 0.2687 | 0.2944 |
Toxoplasma gondii | thioredoxin reductase | 0.0091 | 0.2687 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0863 | 0.0762 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0863 | 0.0946 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0041 | 0.0863 | 0.0508 |
Plasmodium vivax | glutathione reductase, putative | 0.0091 | 0.2687 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0863 | 0.0946 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0863 | 0.0762 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0041 | 0.0863 | 0.0508 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0032 | 0.0509 | 0.1417 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0032 | 0.0509 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0091 | 0.2687 | 0.2944 |
Trichomonas vaginalis | heat shock protein, putative | 0.0029 | 0.0428 | 0.0276 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0037 | 0.0702 | 0.0885 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0702 | 0.0885 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0037 | 0.0702 | 0.0885 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.5765 | 0.6244 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0863 | 0.0946 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.9125 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.0863 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0032 | 0.0509 | 0.0884 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0863 | 0.1623 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0702 | 0.0885 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0037 | 0.0702 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0863 | 0.0762 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0863 | 0.074 |
Brugia malayi | Endoplasmin precursor | 0.0037 | 0.0702 | 0.0559 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0037 | 0.0702 | 0.2176 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0135 | 0.0135 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0863 | 0.074 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0032 | 0.0509 | 0.0362 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0714 | 0.1239 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.203 | 0.2225 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0032 | 0.0509 | 0.1878 |
Echinococcus granulosus | endoplasmin | 0.0029 | 0.0428 | 0.0742 |
Leishmania major | trypanothione reductase | 0.0091 | 0.2687 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.0863 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0863 | 0.1497 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Brugia malayi | hypothetical protein | 0.0163 | 0.5311 | 0.5726 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0863 | 0.281 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0863 | 0.0762 |
Brugia malayi | MH2 domain containing protein | 0.0137 | 0.4355 | 0.4654 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Trypanosoma brucei | heat shock protein, putative | 0.0037 | 0.0702 | 0.0885 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0863 | 0.0946 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0091 | 0.2687 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0029 | 0.0428 | 0.1095 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Echinococcus granulosus | heat shock protein 90 | 0.0029 | 0.0428 | 0.0742 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.1749 | 0.1749 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.9125 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0185 | 0.6111 | 0.663 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0268 | 0.9125 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0091 | 0.2687 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0041 | 0.0863 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0863 | 0.0946 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0032 | 0.0509 | 0.131 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0208 | 0.6955 | 0.7624 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0208 | 0.036 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0037 | 0.0702 | 0.2176 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.0863 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0032 | 0.0509 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0208 | 0.6955 | 0.7624 |
Treponema pallidum | NADH oxidase | 0.0032 | 0.0509 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0029 | 0.0428 | 0.0276 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0037 | 0.0702 | 0.2176 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0091 | 0.2687 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.0863 | 0.0508 |
Schistosoma mansoni | endoplasmin | 0.0037 | 0.0702 | 0.0702 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0029 | 0.0428 | 0.0742 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0208 | 0.036 |
Echinococcus multilocularis | heat shock protein 90 | 0.0037 | 0.0702 | 0.1218 |
Brugia malayi | glutathione reductase | 0.0091 | 0.2687 | 0.2784 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0037 | 0.0702 | 0.0885 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0023 | 0.0025 |
Trypanosoma brucei | trypanothione reductase | 0.0091 | 0.2687 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.5765 | 0.6244 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0176 | 0.5765 | 0.6244 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0863 | 0.1497 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0264 | 0.8989 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0032 | 0.0509 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0041 | 0.0863 | 0.0508 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0137 | 0.4355 | 0.4773 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.1613 | 0.2798 |
Schistosoma mansoni | endoplasmin | 0.0037 | 0.0702 | 0.0702 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0232 | 0.7803 | 0.8615 |
Echinococcus multilocularis | heat shock protein 90 | 0.0029 | 0.0428 | 0.0742 |
Brugia malayi | heat shock protein 90 | 0.0037 | 0.0702 | 0.0559 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0863 | 0.074 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0185 | 0.6111 | 0.663 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0863 | 0.0762 |
Leishmania major | heat shock protein 83-1 | 0.0037 | 0.0702 | 0.1215 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.