Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3378 | 0.2673 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.405 | 0.3419 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7897 | 0.8737 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9228 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.9039 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.405 | 0.3419 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.7897 | 0.8527 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.7897 | 0.7673 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1992 | 0.1993 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.724 | 0.801 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.9039 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.7897 | 0.8527 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.405 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0535 | 0.0592 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.3514 | 0.2714 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.3514 | 0.2824 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3391 | 0.3541 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3818 | 0.4014 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7897 | 0.8737 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4163 | 0.4395 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.9039 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7886 | 0.8724 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.9039 | 0.8936 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.7897 | 0.8527 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7897 | 0.8737 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0535 | 0.0592 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.3514 | 0.2714 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0191 | 0.0211 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.7897 | 0.8737 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2951 | 0.3265 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.9039 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.7897 | 0.7673 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.3514 | 0.3678 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0535 | 0.0592 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7897 | 0.8737 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7897 | 0.8737 |
Brugia malayi | RNA binding protein | 0.0076 | 0.7897 | 0.7673 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.3514 | 0.7399 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.9039 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.7897 | 0.8737 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2951 | 0.3265 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.724 | 0.801 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.9039 | 0.979 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1995 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.