Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0253 | 0.7538 | 0.8424 | |
Onchocerca volvulus | 0.0297 | 0.8949 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.029 | 0.8714 | 0.8714 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0023 | 0.0055 | 0.0055 |
Trichomonas vaginalis | set domain proteins, putative | 0.0253 | 0.7538 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.8949 | 0.8949 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0864 | 0.0864 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.0129 | 0.0264 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0354 | 0.0354 |
Plasmodium falciparum | phd finger protein, putative | 0.0031 | 0.033 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0054 | 0.1078 | 0.1078 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0025 | 0.0129 | 0.01 |
Echinococcus granulosus | geminin | 0.0181 | 0.5198 | 0.5198 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0031 | 0.0319 | 0.8822 |
Echinococcus granulosus | importin subunit beta 1 | 0.0031 | 0.0319 | 0.0319 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0354 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.0354 | 1 |
Echinococcus granulosus | peregrin | 0.0031 | 0.033 | 0.033 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.0864 | 0.0864 |
Brugia malayi | jmjC domain containing protein | 0.0038 | 0.0543 | 0.0606 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0236 | 0.6962 | 0.6962 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0864 | 0.0864 |
Giardia lamblia | PHD finger protein 15 | 0.0031 | 0.033 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0102 | 0.2632 | 0.2941 |
Brugia malayi | Importin beta-1 subunit | 0.0031 | 0.0319 | 0.0356 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.0055 | 0.0055 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0025 | 0.0129 | 0.01 |
Schistosoma mansoni | importin beta-1 | 0.0031 | 0.0319 | 0.0319 |
Schistosoma mansoni | hypothetical protein | 0.0329 | 1 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0031 | 0.0319 | 0.9597 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0354 | 0.0354 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0054 | 0.1078 | 0.1204 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.2898 | 1 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0864 | 0.0965 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1078 | 0.1078 |
Echinococcus multilocularis | geminin | 0.0181 | 0.5198 | 0.5198 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.011 | 0.2898 | 0.2898 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0543 | 0.0543 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0038 | 0.0543 | 0.0543 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.5198 | 0.5198 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0023 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0354 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.033 | 0.033 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0031 | 0.033 | 0.033 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0031 | 0.0319 | 1 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0031 | 0.033 | 0.033 |
Brugia malayi | PHD-finger family protein | 0.0031 | 0.033 | 0.0369 |
Schistosoma mansoni | ran | 0.0023 | 0.0055 | 0.0055 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0031 | 0.033 | 0.033 |
Trichomonas vaginalis | importin beta-1, putative | 0.0025 | 0.0129 | 0.01 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.0055 | 0.0061 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.0354 | 0.0354 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0031 | 0.0319 | 0.0319 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.2898 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0102 | 0.2632 | 0.2632 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0864 | 0.0965 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0054 | 0.1078 | 0.1078 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0543 | 0.0543 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.0864 | 0.0864 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0864 | 0.0864 |
Leishmania major | importin beta-1 subunit, putative | 0.0025 | 0.0129 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0031 | 0.033 | 0.033 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0329 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0297 | 0.8949 | 1 |
Onchocerca volvulus | 0.0032 | 0.0354 | 0.0396 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.033 | 0.9192 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0054 | 0.1078 | 0.1078 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0025 | 0.0129 | 1 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.0864 | 0.0864 |
Echinococcus multilocularis | snurportin 1 | 0.0329 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.011 | 0.2898 | 0.3239 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.033 | 0.9192 |
Brugia malayi | MH2 domain containing protein | 0.0236 | 0.6962 | 0.778 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0319 | 0.0319 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.0316 | 0.0316 |
Brugia malayi | RNA, U transporter 1 | 0.0088 | 0.2164 | 0.2418 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1053 | 0.1053 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0038 | 0.0543 | 0.0543 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0054 | 0.1078 | 0.1078 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.033 | 0.9192 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0188 | 0.5409 | 0.5409 |
Brugia malayi | Bromodomain containing protein | 0.0031 | 0.033 | 0.0369 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0032 | 0.0354 | 0.0354 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.011 | 0.2898 | 0.2898 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0223 | 0.654 | 0.654 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.0354 | 0.0354 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0236 | 0.6962 | 0.6962 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0038 | 0.0543 | 0.0543 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0188 | 0.5409 | 0.5409 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0054 | 0.1078 | 0.1078 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.011 | 0.2898 | 0.2898 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.0726 | 0.0726 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.033 | 0.033 |
Echinococcus multilocularis | peregrin | 0.0031 | 0.033 | 0.033 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.5198 | 0.5198 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0064 | 0.1407 | 0.1407 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.0864 | 0.0864 |
Schistosoma mansoni | ran | 0.0023 | 0.0055 | 0.0055 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.2898 | 0.2898 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.0726 | 0.0726 |
Plasmodium vivax | importin-beta 2, putative | 0.0031 | 0.0319 | 0.8822 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0354 | 0.0354 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.2898 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0031 | 0.0319 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0354 | 0.0354 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.0864 | 0.0864 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.2898 | 1 |
Onchocerca volvulus | 0.0048 | 0.0864 | 0.0965 | |
Loa Loa (eye worm) | MBCTL1 | 0.0054 | 0.1078 | 0.1078 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.0864 | 0.0965 |
Onchocerca volvulus | Alhambra homolog | 0.0031 | 0.033 | 0.0369 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.0354 | 0.0396 |
Schistosoma mansoni | jumonji domain containing protein | 0.0081 | 0.1951 | 0.1951 |
Brugia malayi | Pre-SET motif family protein | 0.0223 | 0.654 | 0.7309 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0102 | 0.2632 | 0.2632 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.