Detailed information for compound 620269

Basic information

Technical information
  • TDR Targets ID: 620269
  • Name: N-(4,7-dichloro-1,3-benzothiazol-2-yl)-2,3-di hydro-1,4-benzodioxine-7-carboxamide
  • MW: 381.233 | Formula: C16H10Cl2N2O3S
  • H donors: 1 H acceptors: 2 LogP: 4.52 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc2c(c1)OCCO2)Nc1nc2c(s1)c(Cl)ccc2Cl
  • InChi: 1S/C16H10Cl2N2O3S/c17-9-2-3-10(18)14-13(9)19-16(24-14)20-15(21)8-1-4-11-12(7-8)23-6-5-22-11/h1-4,7H,5-6H2,(H,19,20,21)
  • InChiKey: SXZJXKRASCPHLW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC04264290

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi intermediate filament protein 0.0027 0.0593 0.0646
Echinococcus granulosus dna polymerase eta 0.002 0.0277 0.082
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.1487 0.6276
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0723 0.2909
Loa Loa (eye worm) hypothetical protein 0.0042 0.1296 0.1456
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0277 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0095 0.0072
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.2313 0.2627
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.1487 0.6276
Loa Loa (eye worm) hypothetical protein 0.0026 0.0571 0.0621
Echinococcus multilocularis zinc finger protein 0.0019 0.0262 0.0754
Loa Loa (eye worm) hypothetical protein 0.0046 0.1487 0.1676
Loa Loa (eye worm) RNA binding protein 0.0065 0.2313 0.2627
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0277 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1387 0.5871
Loa Loa (eye worm) PHD-finger family protein 0.002 0.031 0.0319
Brugia malayi Pre-SET motif family protein 0.003 0.0723 0.0795
Leishmania major DNA polymerase eta, putative 0.002 0.0277 1
Schistosoma mansoni bromodomain containing protein 0.0063 0.2221 0.959
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0277 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0277 1
Schistosoma mansoni zinc finger protein 0.0019 0.0262 0.0855
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.1387 0.1561
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0995 0.4059
Schistosoma mansoni hypothetical protein 0.0016 0.0095 0.0109
Schistosoma mansoni hypothetical protein 0.002 0.031 0.1066
Echinococcus multilocularis dna polymerase eta 0.002 0.0277 0.082
Giardia lamblia DINP protein human, muc B family 0.002 0.0277 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.1104 0.1235
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0277 1
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.2313 0.2627
Echinococcus granulosus tar DNA binding protein 0.0065 0.2313 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0277 1
Onchocerca volvulus 0.003 0.0723 0.0137
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0723 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0277 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0593 0.0646
Schistosoma mansoni DNA polymerase eta 0.002 0.0277 0.092
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1629 0.184
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0277 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.1487 0.6317
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0277 0.0282
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0149 0.0351
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0277 0.082
Echinococcus multilocularis musashi 0.0027 0.0593 0.2248
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0919 0.1022
Loa Loa (eye worm) hypothetical protein 0.004 0.121 0.1357
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0277 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0149 0.0244
Schistosoma mansoni hypothetical protein 0.0016 0.0095 0.0109
Echinococcus multilocularis lamin 0.0027 0.0593 0.2248
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0995 0.4059
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0723 0.283
Echinococcus granulosus lamin dm0 0.0027 0.0593 0.2248
Schistosoma mansoni lamin 0.0027 0.0593 0.2332
Schistosoma mansoni hypothetical protein 0.0016 0.0095 0.0109
Leishmania major DNA polymerase kappa, putative 0.002 0.0277 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1387 0.5871
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2313 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0395 0.1354
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1387 0.5871
Loa Loa (eye worm) hypothetical protein 0.005 0.1629 0.184
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0177 0.0166
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1387 0.5825
Brugia malayi PHD-finger family protein 0.0025 0.0501 0.054
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2313 1
Brugia malayi Bromodomain containing protein 0.0074 0.2746 0.3127
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0395 0.1448
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0395 0.1354
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0277 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0277 0.082
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0095 0.0072
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.206 0.8862
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1629 0.184
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0277 1
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0593 0.0646
Brugia malayi Pre-SET motif family protein 0.0206 0.8711 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0277 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0277 0.0282
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1629 0.184
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.1487 0.6317
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0277 0.5
Brugia malayi TAR-binding protein 0.0065 0.2313 0.2627
Brugia malayi Bromodomain containing protein 0.0038 0.1101 0.1232
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0673 0.2608
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.206 0.8862
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0277 0.092
Echinococcus granulosus lamin 0.0027 0.0593 0.2248
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0095 0.0072
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0593 0.0646
Echinococcus granulosus dna polymerase kappa 0.002 0.0277 0.082
Loa Loa (eye worm) hypothetical protein 0.0016 0.0095 0.0072
Brugia malayi RNA binding protein 0.0065 0.2313 0.2627
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2313 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0277 0.0282
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1387 0.5825
Echinococcus multilocularis dna polymerase kappa 0.002 0.0277 0.082
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.8711 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0277 1
Plasmodium vivax SET domain protein, putative 0.003 0.0723 0.5
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0149 0.0244
Trichomonas vaginalis set domain proteins, putative 0.0234 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0277 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0277 0.5
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0277 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1387 0.5825
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1387 0.5825
Loa Loa (eye worm) hypothetical protein 0.0027 0.0593 0.0646
Trypanosoma brucei ISWI complex protein 0.0015 0.007 0.2545
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0277 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0919 0.1022
Echinococcus granulosus zinc finger protein 0.0019 0.0262 0.0754
Trypanosoma brucei unspecified product 0.002 0.0277 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2313 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0277 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0723 0.2909
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0277 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2554 0.2906
Echinococcus multilocularis lamin dm0 0.0027 0.0593 0.2248
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2313 1
Loa Loa (eye worm) TAR-binding protein 0.0065 0.2313 0.2627
Schistosoma mansoni lamin 0.0027 0.0593 0.2332
Schistosoma mansoni hypothetical protein 0.0034 0.0919 0.3784
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0149 0.0351
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.1387 0.1561
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0277 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0593 0.2332
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0277 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0277 0.0282
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0277 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0277 0.5
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0277 0.092
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0277 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0593 0.2248
Echinococcus multilocularis tar DNA binding protein 0.0065 0.2313 1
Schistosoma mansoni hypothetical protein 0.0016 0.0095 0.0109

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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