Detailed information for compound 620339

Basic information

Technical information
  • TDR Targets ID: 620339
  • Name: N-(4-fluoro-1,3-benzothiazol-2-yl)-4-pyrrolid in-1-ylsulfonylbenzamide
  • MW: 405.466 | Formula: C18H16FN3O3S2
  • H donors: 1 H acceptors: 4 LogP: 3.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)S(=O)(=O)N1CCCC1)Nc1sc2c(n1)c(F)ccc2
  • InChi: 1S/C18H16FN3O3S2/c19-14-4-3-5-15-16(14)20-18(26-15)21-17(23)12-6-8-13(9-7-12)27(24,25)22-10-1-2-11-22/h3-9H,1-2,10-11H2,(H,20,21,23)
  • InChiKey: XFOCYGWATKTIGA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-fluoro-1,3-benzothiazol-2-yl)-4-pyrrolidin-1-ylsulfonyl-benzamide
  • N-(4-fluoro-1,3-benzothiazol-2-yl)-4-1-pyrrolidinylsulfonylbenzamide
  • ZINC04264234

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0563 0.0646
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0015 0.0017
Trypanosoma cruzi ISWI complex protein 0.0032 0.0722 0.5
Loa Loa (eye worm) hypothetical protein 0.0028 0.0563 0.0646
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.1371 0.2894
Schistosoma mansoni hypothetical protein 0.0032 0.0722 0.1412
Brugia malayi Bromodomain containing protein 0.0155 0.6072 0.6974
Trypanosoma cruzi ISWI complex protein 0.0032 0.0722 0.5
Loa Loa (eye worm) hypothetical protein 0.0084 0.3001 0.3447
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0879 0.1726
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0123 0.4701 1
Echinococcus granulosus zinc finger protein 0.004 0.1105 0.2327
Onchocerca volvulus 0.0031 0.0693 0.0137
Schistosoma mansoni lamin 0.0028 0.0563 0.1095
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0017
Echinococcus granulosus lamin 0.0028 0.0563 0.117
Schistosoma mansoni hypothetical protein 0.0033 0.0785 0.1539
Echinococcus multilocularis zinc finger protein 0.004 0.1105 0.2327
Brugia malayi PHD-finger family protein 0.0051 0.1583 0.1818
Schistosoma mansoni intermediate filament proteins 0.0028 0.0563 0.1095
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0693 0.1354
Loa Loa (eye worm) hypothetical protein 0.0033 0.0785 0.0902
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0879 0.1844
Trichomonas vaginalis set domain proteins, putative 0.0245 1 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0693 0.5
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.2221 0.4708
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0879 0.1844
Echinococcus multilocularis lamin dm0 0.0028 0.0563 0.117
Loa Loa (eye worm) hypothetical protein 0.0048 0.1449 0.1664
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.1371 0.2894
Echinococcus granulosus intermediate filament protein 0.0028 0.0563 0.117
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0123 0.4701 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.1449 0.1664
Loa Loa (eye worm) hypothetical protein 0.0079 0.2789 0.3203
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.12 0.1378
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.8707 1
Brugia malayi intermediate filament protein 0.0028 0.0563 0.0646
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.2571 0.5455
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0015 0.0017
Schistosoma mansoni bromodomain containing protein 0.0131 0.5022 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0693 0.1447
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0643 0.1342
Plasmodium vivax SET domain protein, putative 0.0031 0.0693 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0563 0.0646
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0693 0.1354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.2221 0.4406
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.2221 0.4406
Schistosoma mansoni zinc finger protein 0.004 0.1105 0.2178
Brugia malayi Bromodomain containing protein 0.0079 0.2783 0.3196
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0934 0.1072
Schistosoma mansoni zinc finger protein 0.0032 0.0722 0.1412
Loa Loa (eye worm) hypothetical protein 0.0146 0.5689 0.6533
Loa Loa (eye worm) hypothetical protein 0.0066 0.2221 0.2551
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0879 0.1726
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.1371 0.2709
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.1449 0.1664
Echinococcus multilocularis lamin 0.0028 0.0563 0.117
Brugia malayi Pre-SET motif family protein 0.0031 0.0693 0.0795
Schistosoma mansoni lamin 0.0028 0.0563 0.1095
Schistosoma mansoni hypothetical protein 0.0043 0.12 0.2367
Leishmania major hypothetical protein, conserved 0.0032 0.0722 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.1449 0.1664
Trypanosoma brucei ISWI complex protein 0.0032 0.0722 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.2571 0.5455
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.2221 0.4708
Echinococcus multilocularis musashi 0.0028 0.0563 0.117
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0785 0.0902
Echinococcus granulosus lamin dm0 0.0028 0.0563 0.117
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0015 0.0017
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0563 0.0646
Loa Loa (eye worm) hypothetical protein 0.0088 0.3173 0.3644
Brugia malayi Pre-SET motif family protein 0.0216 0.8707 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0541 0.0621

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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